Abstract:
:N-methyl-d-aspartate receptors (NMDARs) are expressed abundantly in the brain and play an important role in the regulation of neuronal development, learning, memory, neurodegenerative diseases, and neurogenesis, all of which are extensively discussed in reviews published elsewhere. While the number of research articles on the developmental and neurological cues that trigger NMDAR localization across a developing neuron and the role of the NMDAR in embryonic and adult stem cell proliferation and differentiation have been growing dramatically over the past few years, there is not a single review on this latter general topic. In the proposed review, we will summarize the current understanding of NMDARs in stem cell biology and their involvement in pathophysiological processes of neuron development, especially during early neuronal development (immature neurons) and differentiation.
journal_name
Stem Cells Devjournal_title
Stem cells and developmentauthors
Chakraborty A,Murphy S,Coleman Ndoi
10.1089/scd.2016.0325subject
Has Abstractpub_date
2017-06-01 00:00:00pages
798-807issue
11eissn
1547-3287issn
1557-8534journal_volume
26pub_type
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