Successful Use of Sertindole for Severe Behavioral Dyscontrol in a Pediatric Case of Syndromic Autism Spectrum Disorder.

Abstract:

:Autism spectrum disorder (ASD) is commonly associated with a host of challenging behaviors. Pharmacotherapy is indicated if psychosocial and educational interventions fail. Atypical antipsychotics have the strongest evidence base so far, with both risperidone and aripiprazole being FDA approved. Unfortunately, their use is fraught with metabolic and neurohormonal side effects. In this study, the author is reporting on a case of syndromic ASD/moderate intellectual disability with severe behavioral component that failed multiple psychotropic trials and ultimately responded dramatically to sertindole. Sertindole reversed metabolic derangements and was highly tolerated. This is one of earliest cases to report use of sertindole in autism. This might open new venues in such complicated cases.

authors

Naguy A

doi

10.1089/cap.2016.0182

subject

Has Abstract

pub_date

2017-06-01 00:00:00

pages

471-472

issue

5

eissn

1044-5463

issn

1557-8992

journal_volume

27

pub_type

杂志文章
  • Switching, cycling, and antidepressant-induced effects on cycle frequency and course of illness in adult bipolar disorder: a brief review and commentary.

    abstract::The potential for the induction of mania, increased cycle frequency, and other behavioral adverse events associated with antidepressant exposure in patients with bipolar disorder is becoming an increasingly important area of research study, as this diagnosis receives wider recognition in youth. While the majority of s...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章,评审

    doi:10.1089/104454603322163880

    authors: Papolos DF

    更新日期:2003-07-01 00:00:00

  • Atomoxetine treatment in adolescents with attention-deficit/hyperactivity disorder.

    abstract:INTRODUCTION:This study compared two atomoxetine titration dosing schedules and two atomoxetine maintenance doses for treating adolescent attention-deficit/hyperactivity disorder (ADHD) inattention and hyperactivity/impulsivity. METHODS:Adolescents (N = 267) were randomized to a slow or fast titration schedule. Patien...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章,随机对照试验

    doi:10.1089/cap.2008.074

    authors: Wietecha LA,Williams DW,Herbert M,Melmed RD,Greenbaum M,Schuh K

    更新日期:2009-12-01 00:00:00

  • A systematic review of combination therapy with stimulants and atomoxetine for attention-deficit/hyperactivity disorder, including patient characteristics, treatment strategies, effectiveness, and tolerability.

    abstract:OBJECTIVE:The purpose of this article was to systematically review the literature on stimulant and atomoxetine combination therapy, in particular: 1) Characteristics of patients with attention-deficit/hyperactivity disorder (ADHD) given combination therapy, 2) treatment strategies used, 3) efficacy and effectiveness, a...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章,评审

    doi:10.1089/cap.2012.0093

    authors: Treuer T,Gau SS,Méndez L,Montgomery W,Monk JA,Altin M,Wu S,Lin CC,Dueñas HJ

    更新日期:2013-04-01 00:00:00

  • Adjunctive Amantadine Treatment for Aggressive Behavior in Children: A Series of Eight Cases.

    abstract:PURPOSE:Amantadine has a growing body of evidence for the treatment of aggressive behavior in patients with traumatic brain injury, autism spectrum disorder, and developmental disability. We describe our experience with adjunctive amantadine treatment for aggressive behavior in eight hospitalized children. METHODS:We ...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/cap.2016.0042

    authors: McGrane IR,Loveland JG,Zaluski HJ

    更新日期:2016-12-01 00:00:00

  • A randomized, double-blind, placebo-controlled clinical trial on once-daily atomoxetine in Taiwanese children and adolescents with attention-deficit/hyperactivity disorder.

    abstract:OBJECTIVE:The aim of this study was to assess the efficacy and safety of the once-daily atomoxetine compared with placebo in pediatric patients with attention-deficit/hyperactivity disorder (ADHD) in Taiwan. METHOD:The study sample included 106 patients aged 6-16 years who met the Diagnostic and Statistical Manual of ...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章,随机对照试验

    doi:10.1089/cap.2006.0091

    authors: Gau SS,Huang YS,Soong WT,Chou MC,Chou WJ,Shang CY,Tseng WL,Allen AJ,Lee P

    更新日期:2007-08-01 00:00:00

  • The immunobiology of Tourette's disorder, pediatric autoimmune neuropsychiatric disorders associated with Streptococcus, and related disorders: a way forward.

    abstract::Obsessive-compulsive disorder (OCD) and related conditions including Tourette's disorder (TD) are chronic, relapsing disorders of unknown etiology associated with marked impairment and disability. Associated immune dysfunction has been reported and debated in the literature since the late 80s. The immunologic culprit ...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章,评审

    doi:10.1089/cap.2010.0043

    authors: Murphy TK,Kurlan R,Leckman J

    更新日期:2010-08-01 00:00:00

  • Effects of race on psychiatric diagnosis of hospitalized adolescents: a retrospective chart review.

    abstract:BACKGROUND:Several studies have reported that patient ethnicity influences psychiatric diagnosis, although this has only been examined in adolescents in two prior studies. One study was based on an outpatient sample and the other was a retrospective study involving a relatively small sample of inpatients. We hypothesiz...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/104454601750143528

    authors: DelBello MP,Lopez-Larson MP,Soutullo CA,Strakowski SM

    更新日期:2001-04-01 00:00:00

  • Neuroleptic malignant syndrome in children and adolescents: two case reports and a warning.

    abstract::ABSTRACT Neuroleptic malignant syndrome (NMS) is a potentially fatal disorder associated with the use of neuroleptics. Clinical research on NMS to date has focused exclusively on adults, but increasing numbers of juvenile cases have been reported. Two cases of juvenile NMS treated by the authors are discussed to demon...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/cap.1992.2.123

    authors: Latz SR,McCracken JT

    更新日期:1992-07-01 00:00:00

  • Subjective effects, misuse, and adverse effects of osmotic-release methylphenidate treatment in adolescent substance abusers with attention-deficit/hyperactivity disorder.

    abstract:OBJECTIVE:Psychostimulants are effective treatments for attention-deficit/hyperactivity disorder (ADHD) but may be associated with euphoric effects, misuse/diversion, and adverse effects. These risks are perceived by some clinicians to be greater in substance-abusing adolescents relative to non-substance-abusing adults...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章,随机对照试验

    doi:10.1089/cap.2011.0014

    authors: Winhusen TM,Lewis DF,Riggs PD,Davies RD,Adler LA,Sonne S,Somoza EC

    更新日期:2011-10-01 00:00:00

  • No Differences in Weight Gain Between Risperidone and Aripiprazole in Children and Adolescents After 12 Months.

    abstract:BACKGROUND:Weight gain due to the use of second-generation antipsychotics is a major health care issue for adult and paediatric psychiatric patients. Little is known about long-term weight gain effects of aripiprazole compared to risperidone in children and adolescents. OBJECTIVE:The primary aim of this study is to as...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/cap.2018.0111

    authors: Schoemakers RJ,van Kesteren C,van Rosmalen J,Eussen MLJM,Dieleman HG,Beex-Oosterhuis MM

    更新日期:2019-04-01 00:00:00

  • Lack of effect of risperidone on core autistic symptoms: data from a longitudinal study.

    abstract:OBJECTIVE:The purpose of this study was to investigate the course of autistic symptoms, using a quantitative measure of core autistic traits, among risperidone-treated children who participated in a 10 year life course longitudinal study. METHODS:Parents completed surveys of intervention history, as well as serial sym...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/cap.2014.0055

    authors: Marrus N,Underwood-Riordan H,Randall F,Zhang Y,Constantino JN

    更新日期:2014-11-01 00:00:00

  • A Randomized, Double-Blind Placebo-Controlled Trial on Effectiveness and Safety of Celecoxib Adjunctive Therapy in Adolescents with Acute Bipolar Mania.

    abstract:OBJECTIVE:Recent studies have focused on the role of inflammatory cascades as one of the possible etiologic factors of bipolar disorder. We hypothesize that celecoxib, through its anti-inflammatory properties, may have a therapeutic role in acute bipolar mania. PATIENTS AND METHODS:Forty-two adolescent inpatients with...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章,随机对照试验

    doi:10.1089/cap.2016.0207

    authors: Mousavi SY,Khezri R,Karkhaneh-Yousefi MA,Mohammadinejad P,Gholamian F,Mohammadi MR,Zeinoddini A,Akhondzadeh S

    更新日期:2017-08-01 00:00:00

  • Duloxetine treatment of pediatric chronic pain and co-morbid major depressive disorder.

    abstract::In the United States, the novel compound duloxetine has been approved for the treatment of major depressive disorder (MDD) and diabetic peripheral neuropathic pain in the adult population. There are currently no published data on the use of duloxetine in children and adolescents. This report describes the successful t...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/cap.2006.0042

    authors: Meighen KG

    更新日期:2007-02-01 00:00:00

  • Inhibited Temperament and Hippocampal Volume in Offspring of Parents with Bipolar Disorder.

    abstract:BACKGROUND:Prior studies have suggested that inhibited temperament may be associated with an increased risk for developing anxiety or mood disorder, including bipolar disorder. However, the neurobiological basis for this increased risk is unknown. The aim of this study was to examine temperament in symptomatic and asym...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/cap.2016.0086

    authors: Kim E,Garrett A,Boucher S,Park MH,Howe M,Sanders E,Kelley RG,Reiss AL,Chang KD,Singh MK

    更新日期:2017-04-01 00:00:00

  • Persistence of stimulants in children and adolescents with attention-deficit/hyperactivity disorder.

    abstract:OBJECTIVE:To examine the persistence of three newly initiated stimulant preparations among Medicaid children and adolescents with attention-deficit/hyperactivity disorder (ADHD) diagnosis. METHODS:A retrospective longitudinal claims analysis was conducted by using Medicaid analytical eXtract data of four states. The s...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/cap.2011.0028

    authors: Palli SR,Kamble PS,Chen H,Aparasu RR

    更新日期:2012-04-01 00:00:00

  • Neuroanatomic comparison of bipolar adolescents with and without cannabis use disorders.

    abstract:OBJECTIVE:Co-occurrence of substance use and bipolar disorders is both common and associated with poor treatment response and greater functional impairment than either disorder alone. The neurophysiological correlates of this co-morbidity however, remain unclear. In this pilot study, we compared brain morphometry betwe...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/cap.2008.033

    authors: Jarvis K,DelBello MP,Mills N,Elman I,Strakowski SM,Adler CM

    更新日期:2008-12-01 00:00:00

  • Lamotrigine treatment of adolescents with unipolar and bipolar depression: a retrospective chart review.

    abstract:OBJECTIVE:The purpose of this study was to investigate the preliminary effectiveness and safety of lamotrigine for the treatment of depressive episodes in adolescents. METHODS:This was a 12 week retrospective chart review of lamotrigine treatment among 37 adolescents (mean age 16.3±1.3 years) with depressive episodes ...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/cap.2013.0121

    authors: Shon SH,Joo Y,Lee JS,Kim HW

    更新日期:2014-06-01 00:00:00

  • Placebo Response in Pediatric Anxiety Disorders: Implications for Clinical Trial Design and Interpretation.

    abstract:OBJECTIVES:The characterization and prediction of placebo response in clinical trials of youth with anxiety disorders have received little attention, despite the critical effects of placebo response rate on the success or failure of clinical trials. With this in mind, we sought to examine the factors that predict or in...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/cap.2015.0192

    authors: Dobson ET,Strawn JR

    更新日期:2016-10-01 00:00:00

  • A retrospective review of the effectiveness of aripiprazole in the treatment of sensory abnormalities in autism.

    abstract::Although sensory deficits are frequently observed in autistic individuals, pharmacologic interventions targeting these abnormalities are lacking. The goal of this investigation was to assess the effectiveness of aripiprazole in targeting sensory deficits in children and adolescents with autism. Using an outpatient cli...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/cap.2010.0103

    authors: Fung LK,Chahal L,Libove RA,Bivas R,Hardan AY

    更新日期:2012-06-01 00:00:00

  • Fast vs. slow switching from stimulants to atomoxetine in children and adolescents with attention-deficit/hyperactivity disorder.

    abstract:OBJECTIVE:To compare fast versus slow switching from stimulants to atomoxetine (ATX) in children and adolescents with attention-deficit/hyperactivity disorder (ADHD). METHODS:This was a randomized, controlled, open-label study in 6-16-year-old ADHD patients, previously treated with stimulants and cross-titrated (fast ...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1089/cap.2012.0027

    authors: Cardo E,Porsdal V,Quail D,Fuentes J,Steer C,Montoya A,Anand E,Escobar R

    更新日期:2013-05-01 00:00:00

  • A review of developmental aspects of cytochrome P450.

    abstract::This article surveys the development of human hepatic P450 cytochromes (CYPs) involved in xenobiotic metabolism from the fetus through the life span and explores possible clinical consequences of developmental issues. These hepatic P450 CYPs come "on line" at different times during fetal and infant development, and ea...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章,评审

    doi:10.1089/cap.1998.8.161

    authors: Oesterheld JR

    更新日期:1998-01-01 00:00:00

  • Does comorbid depression predict subsequent adverse life events in youth with attention-deficit/hyperactivity disorders?

    abstract:OBJECTIVES:Studies have primarily focused on adverse life events (ALEs) as potential causes rather than as outcomes of pediatric depression. The current study prospectively examines ALEs in a sample of youth with attention-deficit/hyperactivity disorders (ADHD) to determine whether having a major depressive disorder (M...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/cap.2011.0046

    authors: Daviss WB,Diler R

    更新日期:2012-02-01 00:00:00

  • A brief motivational intervention for preventing medication-associated weight gain among youth with bipolar disorder: treatment development and case report.

    abstract::Bipolar disorder (BP) in youth is an impairing psychiatric disorder associated with high rates of relapse and recurrence. High rates of psychiatric and medical co-morbidities account for additional illness burden in pediatric BP. The elevated risk of overweight and obesity in this population is of particular concern. ...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/cap.2010.0104

    authors: Goldstein TR,Goldstein BI,Mantz MB,Bailey B,Douaihy A

    更新日期:2011-06-01 00:00:00

  • Attention-Deficit/Hyperactivity Disorder-Related Deficits and Psychostimulant Medication Effects on Comprehension of Audiovisually Presented Educational Material in Children.

    abstract:: Objective: We aimed to (1) examine differences in observed visual attention and motor activity, as well as comprehension of a science video between children with and without attention-deficit/hyperactivity disorder (ADHD) and (2) explore if psychostimulant medication impro...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章,随机对照试验

    doi:10.1089/cap.2018.0006

    authors: Orban SA,Karamchandani TA,Tamm L,Sidol CA,Peugh J,Froehlich TE,Brinkman WB,Estell N,Mii AE,Epstein JN

    更新日期:2018-12-01 00:00:00

  • Effectiveness of methylphenidate in the 10-month continuation phase of the Preschoolers with Attention-Deficit/Hyperactivity Disorder Treatment Study (PATS).

    abstract:OBJECTIVE:The aim of this study was to examine immediate-release methylphenidate effectiveness during the 10-month open-label continuation phase of the Preschoolers with Attention-Deficit/Hyperactivity Disorder (ADHD) Treatment Study (PATS). METHODS:One hundred and forty preschoolers with ADHD, who had improved with a...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/cap.2007.0058

    authors: Vitiello B,Abikoff HB,Chuang SZ,Kollins SH,McCracken JT,Riddle MA,Swanson JM,Wigal T,McGough JJ,Ghuman JK,Wigal SB,Skrobala AM,Davies M,Posner K,Cunningham C,Greenhill LL

    更新日期:2007-10-01 00:00:00

  • Effectiveness, safety, and tolerability of risperidone in adolescents with schizophrenia: an open-label study.

    abstract::Data on risperidone's efficacy and tolerability in adolescents with schizophrenia are scarce. We found only one prospective, open-label study in this population. The aim of this open-label, prospective study was to estimate the effectiveness, safety, and tolerability of risperidone treatment in adolescents with first-...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 临床试验,杂志文章

    doi:10.1089/104454603322572651

    authors: Zalsman G,Carmon E,Martin A,Bensason D,Weizman A,Tyano S

    更新日期:2003-10-01 00:00:00

  • Effects of serotonin reuptake inhibitors on aggressive behavior in psychiatrically hospitalized adolescents: results of an open trial.

    abstract::Low concentrations of the neurotransmitter serotonin and its 5-hydroxyindoleacetic acid metabolite in the central nervous system have been associated with increased aggressive behavior in animals and humans. Controlled clinical trials of serotonin agonists in depressed adults have suggested that aggressive behavior is...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 临床试验,杂志文章

    doi:10.1089/cap.1997.7.31

    authors: Constantino JN,Liberman M,Kincaid M

    更新日期:1997-04-01 00:00:00

  • Comparison of Depression and Burnout Levels of Mothers of Children with Attention-Deficit Hyperactivity Disorder Before and After Treatment.

    abstract:OBJECTIVE:This study aimed to compare the depression and burnout levels of mothers of children having attention-deficit/hyperactivity disorder (ADHD) between the child's pre- and posttreatment periods. METHOD:The study sample consisted of 40 children aged between 4 and 10 years and their mothers. Initially, 40 cases p...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/cap.2017.0050

    authors: Gokcen C,Coskun S,Kutuk MO

    更新日期:2018-06-01 00:00:00

  • Psychometric properties of the Children's Depression Rating Scale-Revised in adolescents.

    abstract:OBJECTIVE:The aim of this study was to present the reliability and validity of the Children's Depression Rating Scale-Revised (CDRS-R) in the adolescent age group. METHOD:Adolescents with symptoms of depression were assessed using the CDRS-R and global severity and functioning scales at screening, baseline, and after ...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/cap.2010.0063

    authors: Mayes TL,Bernstein IH,Haley CL,Kennard BD,Emslie GJ

    更新日期:2010-12-01 00:00:00

  • Preschool onset attention-deficit/hyperactivity disorder: course and predictors of stability over 24 months.

    abstract:OBJECTIVE:The present study examined the course of ADHD over 24 months in a preschool population. METHOD:n=48 preschoolers with ADHD, aged 3.0-5.11 years, subjects included in a larger sample of preschoolers with depression and other disorders (n=306) were comprehensively assessed at 3 annual time points over 24 month...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/cap.2010.0045

    authors: Tandon M,Si X,Luby J

    更新日期:2011-08-01 00:00:00