Inhibited Temperament and Hippocampal Volume in Offspring of Parents with Bipolar Disorder.

Abstract:

BACKGROUND:Prior studies have suggested that inhibited temperament may be associated with an increased risk for developing anxiety or mood disorder, including bipolar disorder. However, the neurobiological basis for this increased risk is unknown. The aim of this study was to examine temperament in symptomatic and asymptomatic child offspring of parents with bipolar disorder (OBD) and to investigate whether inhibited temperament is associated with aberrant hippocampal volumes compared with healthy control (HC) youth. METHODS:The OBD group consisted of 45 youth, 24 of whom had current psychiatric symptoms (OBD+s) and 21 without any psychiatric symptoms (OBD-s), and were compared with 24 HC youth. Temperament characteristics were measured by using the Revised Dimensions of Temperament Survey. Magnetic resonance imaging was used to measure hippocampal volumes. The association between temperament and hippocampal volumes was tested by using multiple regression analysis. RESULTS:Compared with the OBD-s group, the OBD+s group had significantly more inhibited temperament traits, less flexibility, more negative mood, and less regular rhythm in their daily routines. In contrast, the OBD-s group was more likely to approach novel situations compared with OBD+s or HC groups. Within the OBD+s group, a more inhibited temperament was associated with smaller right hippocampal volumes. CONCLUSIONS:In this study, symptomatic OBD were characterized by an inhibited temperament that was inversely correlated with hippocampal volume. Additional longitudinal studies are needed to determine whether inverse correlations between hippocampal volume and inhibited temperament represent early markers of risk for later developing bipolar disorder.

authors

Kim E,Garrett A,Boucher S,Park MH,Howe M,Sanders E,Kelley RG,Reiss AL,Chang KD,Singh MK

doi

10.1089/cap.2016.0086

subject

Has Abstract

pub_date

2017-04-01 00:00:00

pages

258-265

issue

3

eissn

1044-5463

issn

1557-8992

journal_volume

27

pub_type

杂志文章
  • Methylphenidate improves Stroop naming speed, but not response interference, in children with attention deficit hyperactivity disorder.

    abstract:OBJECTIVE:The goal of this study was to investigate the effect of methylphenidate (MPH) on response interference, as measured by the Stoop Color and Word Test, in children with attention deficit hyperactivity disorder (ADHD). Response interference is a core component of response inhibition that has been shown to be imp...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1089/104454602762599844

    authors: Bedard AC,Ickowicz A,Tannock R

    更新日期:2002-01-01 00:00:00

  • Aripiprazole in children and adolescents with Tourette's disorder: an open-label safety and tolerability study.

    abstract:OBJECTIVE:The aim of this study was to conduct a prospective safety and tolerability study of aripiprazole for the treatment of tics in children and adolescents with Tourette's disorder (TD). METHOD:Eleven subjects (10 males) with TD (age 9-19 years, mean 13.36, standard deviation [SD] 3.33) who did not respond or wer...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 临床试验,杂志文章

    doi:10.1089/cap.2009.0035

    authors: Lyon GJ,Samar S,Jummani R,Hirsch S,Spirgel A,Goldman R,Coffey BJ

    更新日期:2009-12-01 00:00:00

  • A brief motivational intervention for preventing medication-associated weight gain among youth with bipolar disorder: treatment development and case report.

    abstract::Bipolar disorder (BP) in youth is an impairing psychiatric disorder associated with high rates of relapse and recurrence. High rates of psychiatric and medical co-morbidities account for additional illness burden in pediatric BP. The elevated risk of overweight and obesity in this population is of particular concern. ...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/cap.2010.0104

    authors: Goldstein TR,Goldstein BI,Mantz MB,Bailey B,Douaihy A

    更新日期:2011-06-01 00:00:00

  • Decreasing Trend in the Use and Long-Term Use of Benzodiazepines Among Young Adults.

    abstract:OBJECTIVE:Patterns of benzodiazepine (BZD) use and long-term use among young adults are not well known. Our aim was to study trends in BZD use and long-term use among 18-25-year-old young adults by gender and active substance in a nationwide retrospective longitudinal register-based setting. METHODS:All Finns aged 18-...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/cap.2017.0140

    authors: Tähkäpää SM,Saastamoinen L,Airaksinen M,Tuulio-Henriksson A,Aalto-Setälä T,Kurko T

    更新日期:2018-05-01 00:00:00

  • Efficacy and Safety of HLD200, Delayed-Release and Extended-Release Methylphenidate, in Children with Attention-Deficit/Hyperactivity Disorder.

    abstract:OBJECTIVE:Evening-dosed HLD200 is a delayed-release and extended-release methylphenidate (DR/ER-MPH) formulation consisting of uniform, dual-layered microbeads with an inner drug-loaded core. DR/ER-MPH is designed to delay the initial release of drug by 8-10 hours, and thereafter, provide a controlled, extended drug re...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1089/cap.2017.0084

    authors: Pliszka SR,Wilens TE,Bostrom S,Arnold VK,Marraffino A,Cutler AJ,López FA,DeSousa NJ,Sallee FR,Incledon B,Newcorn JH

    更新日期:2017-08-01 00:00:00

  • A retrospective review of the effectiveness of aripiprazole in the treatment of sensory abnormalities in autism.

    abstract::Although sensory deficits are frequently observed in autistic individuals, pharmacologic interventions targeting these abnormalities are lacking. The goal of this investigation was to assess the effectiveness of aripiprazole in targeting sensory deficits in children and adolescents with autism. Using an outpatient cli...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/cap.2010.0103

    authors: Fung LK,Chahal L,Libove RA,Bivas R,Hardan AY

    更新日期:2012-06-01 00:00:00

  • Bleeding and selective serotonin reuptake inhibitors in childhood and adolescence.

    abstract::The selective serotonin reuptake inhibitors (SSRIs) are becoming widely used in children and adolescents, with possible unexpected side effects being observed over time. SSRIs have been associated with bleeding in adults who have unremarkable routine hematologic laboratory results except abnormal bleeding time or plat...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/cap.2000.10.35

    authors: Lake MB,Birmaher B,Wassick S,Mathos K,Yelovich AK

    更新日期:2000-04-01 00:00:00

  • Childhood hyperactivity and psychostimulants: a review of extended treatment studies.

    abstract::ABSTRACT Clinical trials with a treatment duration of at least 3 months were reviewed to determine the effect of psychostimulants on the core symptoms of attention-deficit hyperactivity disorder (ADHD) and on its commonly associated features. Eighteen studies were identified: 17 were studies of methylphenidate, 1 was ...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/cap.1993.3.81

    authors: Schachar R,Tannock R

    更新日期:1993-07-01 00:00:00

  • A Quantitative Comparison Approach for Methylphenidate Drug Regimens in Attention-Deficit/Hyperactivity Disorder Treatment.

    abstract:OBJECTIVE:Different methylphenidate (MPH) formulations, immediate release (IR) or extended release (ER), have been developed to treat Attention-Deficit/Hyperactivity Disorder (ADHD). A better use of these formulations, with a proper choice of their timing, dosage, and combination, can help to attain optimal therapeutic...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/cap.2018.0093

    authors: Soufsaf S,Robaey P,Bonnefois G,Nekka F,Li J

    更新日期:2019-04-01 00:00:00

  • A 52-Week Study of Olanzapine with a Randomized Behavioral Weight Counseling Intervention in Adolescents with Schizophrenia or Bipolar I Disorder.

    abstract:OBJECTIVES:To evaluate the 52-week safety/tolerability of oral olanzapine for adolescents with schizophrenia or bipolar mania and compare effectiveness of a standard versus intense behavioral weight intervention in mitigating risk of weight gain. METHODS:Patients 13-17 years old with schizophrenia (Brief Psychiatric R...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1089/cap.2016.0010

    authors: Detke HC,DelBello MP,Landry J,Hoffmann VP,Heinloth A,Dittmann RW

    更新日期:2016-12-01 00:00:00

  • A randomized, double-blind, placebo-controlled clinical trial on once-daily atomoxetine in Taiwanese children and adolescents with attention-deficit/hyperactivity disorder.

    abstract:OBJECTIVE:The aim of this study was to assess the efficacy and safety of the once-daily atomoxetine compared with placebo in pediatric patients with attention-deficit/hyperactivity disorder (ADHD) in Taiwan. METHOD:The study sample included 106 patients aged 6-16 years who met the Diagnostic and Statistical Manual of ...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章,随机对照试验

    doi:10.1089/cap.2006.0091

    authors: Gau SS,Huang YS,Soong WT,Chou MC,Chou WJ,Shang CY,Tseng WL,Allen AJ,Lee P

    更新日期:2007-08-01 00:00:00

  • Switching, cycling, and antidepressant-induced effects on cycle frequency and course of illness in adult bipolar disorder: a brief review and commentary.

    abstract::The potential for the induction of mania, increased cycle frequency, and other behavioral adverse events associated with antidepressant exposure in patients with bipolar disorder is becoming an increasingly important area of research study, as this diagnosis receives wider recognition in youth. While the majority of s...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章,评审

    doi:10.1089/104454603322163880

    authors: Papolos DF

    更新日期:2003-07-01 00:00:00

  • The Child Behavior Checklist (CBCL) and the CBCL-bipolar phenotype are not useful in diagnosing pediatric bipolar disorder.

    abstract:OBJECTIVES:Previous studies have suggested that the sum of Attention, Aggression, and Anxious/Depressed subscales of Child Behavior Checklist (CBCL-PBD; pediatric bipolar disorder phenotype) may be specific to pediatric bipolar disorder (BP). The purpose of this study was to evaluate the usefulness of the CBCL and CBCL...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/cap.2008.067

    authors: Diler RS,Birmaher B,Axelson D,Goldstein B,Gill M,Strober M,Kolko DJ,Goldstein TR,Hunt J,Yang M,Ryan ND,Iyengar S,Dahl RE,Dorn LD,Keller MB

    更新日期:2009-02-01 00:00:00

  • Sertraline treatment of 5 children diagnosed with selective mutism: a single-case research trial.

    abstract::In this single-case research study, we examined the efficacy and acceptability of sertraline treatment in children diagnosed with selective mutism. We utilized a double-blind, placebo-controlled trial of sertraline within a replicated multiple baseline/across participants research design (n = 2; n = 3). Multiple metho...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 临床试验,杂志文章

    doi:10.1089/cap.1999.9.293

    authors: Carlson JS,Kratochwill TR,Johnston HF

    更新日期:1999-01-01 00:00:00

  • Neuroleptic malignant syndrome in children and adolescents: two case reports and a warning.

    abstract::ABSTRACT Neuroleptic malignant syndrome (NMS) is a potentially fatal disorder associated with the use of neuroleptics. Clinical research on NMS to date has focused exclusively on adults, but increasing numbers of juvenile cases have been reported. Two cases of juvenile NMS treated by the authors are discussed to demon...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/cap.1992.2.123

    authors: Latz SR,McCracken JT

    更新日期:1992-07-01 00:00:00

  • Efficacy, long-term safety, and tolerability of ziprasidone in children and adolescents with bipolar disorder.

    abstract:OBJECTIVE:The purpose of this study was to evaluate the short- and long-term efficacy and safety of ziprasidone in children and adolescents with bipolar I disorder. METHODS:Subjects 10-17 years of age with a manic or mixed episode associated with bipolar I disorder participated in a 4 week, randomized, double-blind, p...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1089/cap.2012.0029

    authors: Findling RL,Cavuş I,Pappadopulos E,Vanderburg DG,Schwartz JH,Gundapaneni BK,DelBello MP

    更新日期:2013-10-01 00:00:00

  • Open-label treatment of comorbid depression and attentional disorders with co-administration of serotonin reuptake inhibitors and psychostimulants in children, adolescents, and adults: a case series.

    abstract::Attention-deficit hyperactivity disorder (ADHD) and major depression are common ailments that can cause significant dysfunction throughout the life cycle. These two disorders may occur comorbidly. This case series describes 7 pediatric patients (aged 10-16 years) and 4 adults (aged 38-44 years) whose ADHD and comorbid...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/cap.1996.6.165

    authors: Findling RL

    更新日期:1996-10-01 00:00:00

  • Guanfacine treatment of hyperactivity and inattention in pervasive developmental disorders: a retrospective analysis of 80 cases.

    abstract:OBJECTIVE:The aim of this study was to retrospectively review a large sample of children and adolescents with pervasive developmental disorders (PDDs) treated with open-label guanfacine in order to gather preliminary data as to its effectiveness and safety. METHOD:Eighty (80) subjects with PDDs (10 females, 70 males) ...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/1044546041649084

    authors: Posey DJ,Puntney JI,Sasher TM,Kem DL,McDougle CJ

    更新日期:2004-07-01 00:00:00

  • Quetiapine monotherapy in adolescents with bipolar disorder comorbid with conduct disorder.

    abstract::Bipolar Disorders (BD) are often comorbid with disruptive behaviour disorders (DBDs) (oppositional-defiant disorder or conduct disorder), with negative implications on treatment strategy and outcome. The aim of this study was to assess the efficacy of quetiapine monotherapy in adolescents with BD comorbid with conduct...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/cap.2013.0063

    authors: Masi G,Pisano S,Pfanner C,Milone A,Manfredi A

    更新日期:2013-10-01 00:00:00

  • Guanfacine Extended Release for the Reduction of Aggression, Attention-Deficit/Hyperactivity Disorder Symptoms, and Self-Injurious Behavior in Prader-Willi Syndrome-A Retrospective Cohort Study.

    abstract:: Objective: To examine the role of Guanfacine Extended Release (GXR) in the management of behavioral disturbances in patients with Prader-Willi Syndrome (PWS). Methods: Twenty from a total of 27 individuals with genetically conf...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/cap.2018.0102

    authors: Singh D,Wakimoto Y,Filangieri C,Pinkhasov A,Angulo M

    更新日期:2019-05-01 00:00:00

  • Childhood inattention-overactivity, aggression, and stimulant medication history as predictors of young adult outcomes.

    abstract::This study examined the contributions of childhood symptom dimensions and aspects of methylphenidate (MPH) treatment to the prediction of young adult outcomes in boys who were referred to a child psychiatry outpatient clinic. They were diagnosed with hyperkinetic reaction of childhood/minimal brain dysfunction, and gi...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/cap.1999.9.169

    authors: Paternite CE,Loney J,Salisbury H,Whaley MA

    更新日期:1999-01-01 00:00:00

  • Nutritional supplements and complementary/alternative medicine in Tourette syndrome.

    abstract:OBJECTIVE:Tourette syndrome (TS) is a neuropsychiatric disorder associated with motor and vocal tics. Some people with TS have reported using alternative or complementary medicine (CAM), including nutritional supplements to control their tics. In a recent national survey, approximately 40% of people reported having use...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/cap.2004.14.582

    authors: Mantel BJ,Meyers A,Tran QY,Rogers S,Jacobson JS

    更新日期:2004-01-01 00:00:00

  • A systematic review of combination therapy with stimulants and atomoxetine for attention-deficit/hyperactivity disorder, including patient characteristics, treatment strategies, effectiveness, and tolerability.

    abstract:OBJECTIVE:The purpose of this article was to systematically review the literature on stimulant and atomoxetine combination therapy, in particular: 1) Characteristics of patients with attention-deficit/hyperactivity disorder (ADHD) given combination therapy, 2) treatment strategies used, 3) efficacy and effectiveness, a...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章,评审

    doi:10.1089/cap.2012.0093

    authors: Treuer T,Gau SS,Méndez L,Montgomery W,Monk JA,Altin M,Wu S,Lin CC,Dueñas HJ

    更新日期:2013-04-01 00:00:00

  • Omega-3 Fatty Acid Plasma Levels Before and After Supplementation: Correlations with Mood and Clinical Outcomes in the Omega-3 and Therapy Studies.

    abstract:OBJECTIVE:To examine fatty acid profiles, their response to omega-3 fatty acid (Ω3) supplementation, and associations with clinical status and treatment response in youth with mood disorders. METHODS:In a placebo-controlled 2X2 design, 7-14 year-olds (N = 95) in parallel pilot trials (depression N = 72; bipolar N = 23...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章,随机对照试验

    doi:10.1089/cap.2016.0123

    authors: Arnold LE,Young AS,Belury MA,Cole RM,Gracious B,Seidenfeld AM,Wolfson H,Fristad MA

    更新日期:2017-04-01 00:00:00

  • Serotonin-selective reuptake inhibitor-induced enuresis in three pediatric cases.

    abstract::Although there are reports on their use for the treatment of enuresis, we present three pediatric cases with serotonin-selective reuptake inhibitor (SSRI)-induced enuresis. Because SSRIs continue to be commonly prescribed in the pediatric population, the need to monitor for the possibility of enuresis precipitated by ...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/cap.2006.0070

    authors: Hergüner S,Kilinçaslan A,Görker I,Tüzün U

    更新日期:2007-06-01 00:00:00

  • Evaluation of suicidal thoughts and behaviors in children and adolescents taking paroxetine.

    abstract:OBJECTIVE:The aim of this study was to summarize results of a blinded review of potential suicidal events and analyses comparing incidence rates between paroxetine- and placebo-treated pediatric patients. METHOD:One thousand one hundred ninety-one (1191) children and adolescents received paroxetine (n = 642) or placeb...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章,评审

    doi:10.1089/cap.2006.16.77

    authors: Apter A,Lipschitz A,Fong R,Carpenter DJ,Krulewicz S,Davies JT,Wilkinson C,Perera P,Metz A

    更新日期:2006-02-01 00:00:00

  • Evaluation of patients' and parents' quality of life in a randomized placebo-controlled atomoxetine study in attention-deficit/hyperactivity disorder.

    abstract:OBJECTIVE:The aim of this study was to demonstrate the superior efficacy of atomoxetine with respect to placebo and to compare parent and child perceptions of health-related quality of life (HRQoL). METHOD:This randomized, placebo-controlled, 12-week parallel clinical trial included 151 untreated children/adolescents ...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章,随机对照试验

    doi:10.1089/cap.2008.0109

    authors: Escobar R,Montoya A,Polavieja P,Cardo E,Artigas J,Hervas A,Fuentes J

    更新日期:2009-06-01 00:00:00

  • Psychometric properties of the Children's Depression Rating Scale-Revised in adolescents.

    abstract:OBJECTIVE:The aim of this study was to present the reliability and validity of the Children's Depression Rating Scale-Revised (CDRS-R) in the adolescent age group. METHOD:Adolescents with symptoms of depression were assessed using the CDRS-R and global severity and functioning scales at screening, baseline, and after ...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/cap.2010.0063

    authors: Mayes TL,Bernstein IH,Haley CL,Kennard BD,Emslie GJ

    更新日期:2010-12-01 00:00:00

  • Psychotropic medication use and clinical outcomes among children and adolescents receiving system of care services.

    abstract:OBJECTIVE:Few studies of psychotropic medication use among children and adolescents address the effectiveness of this medication, as it is typically used in naturalistic treatment settings. The objective of this study was to investigate psychotropic medication use among children and adolescents treated in system of car...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/cap.2012.0026

    authors: Drilea SK,Jowers K,Lichtenstein C,Hale M,Blau G,Stromberg S

    更新日期:2013-02-01 00:00:00

  • Maintenance study for adolescent depression.

    abstract:OBJECTIVE:Although recent studies and meta-analyses confirm the efficacy of antidepressants in the acute phase of treatment for adolescent depression, there are few data available to allow assessment of the value of continued use of antidepressants in depressed adolescents after acute response. This study examines the ...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1089/cap.2008.0001

    authors: Cheung A,Kusumakar V,Kutcher S,Dubo E,Garland J,Weiss M,Kiss A,Levitt A

    更新日期:2008-08-01 00:00:00