Atomoxetine treatment in adolescents with attention-deficit/hyperactivity disorder.

Abstract:

INTRODUCTION:This study compared two atomoxetine titration dosing schedules and two atomoxetine maintenance doses for treating adolescent attention-deficit/hyperactivity disorder (ADHD) inattention and hyperactivity/impulsivity. METHODS:Adolescents (N = 267) were randomized to a slow or fast titration schedule. Patients who responded continued on a 40-week maintenance treatment, randomized to either 0.8 or 1.4 mg/kg/day. RESULTS:During the acute period, significant benefit was demonstrated with both titration schedules on the ADHD Rating Scale total score. Although patients in both groups maintained benefit relative to week 0, statistically significant loss of benefit was found for patients maintained on 0.8 mg/kg/day but not on 1.4 mg/kg/day. A similar pattern was observed on the Clinical Global Impressions-ADHD-Severity scores and Life Participation Scale for ADHD-Child Version scores. Mean grades for most subjects improved for patients in both maintenance treatment groups although most improvements were not statistically significant. CONCLUSIONS:In adolescents with ADHD, treatment benefit at 8 weeks was better maintained long-term with 1.4 mg/kg/day than with 0.8 mg/kg/day. Improvement in adaptive functioning and age-appropriate developmental function was also demonstrated. Atomoxetine 0.8 and 1.4 mg/kg/day were equally well tolerated. CLINICAL TRIALS REGISTRY:Maintenance of benefit with atomoxetine hydrochloride in adolescents with ADHD, NCT00191035.

authors

Wietecha LA,Williams DW,Herbert M,Melmed RD,Greenbaum M,Schuh K

doi

10.1089/cap.2008.074

subject

Has Abstract

pub_date

2009-12-01 00:00:00

pages

719-30

issue

6

eissn

1044-5463

issn

1557-8992

journal_volume

19

pub_type

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