CA125 is a potential biomarker to predict surgically incurable gastric and cardia cancer: A retrospective study.

Abstract:

:Preoperative evaluation of the curability of gastric and cardia cancer is important to avoid risks of unnecessary surgery. Our previous study has reported several clinical parameters associated with incurable gastric surgery. In this study, we aimed to evaluate the correlation between CA125 and the curability of gastric and cardia cancer.A total of 297 cases of gastric and cardia cancer were analyzed retrospectively, including 153 cases with radical surgery and 144 with surgery for incurable gastric or cardia cancer. χ test was performed to analyze the associations between curability or incurable factors and clinicopathological data, including CA125 value. ROC curves were generated, and cutoff points for curability, T status, N status, peritoneal metastasis, and distant metastasis were found, respectively. Binary logistic regression was performed to verify the associations between dependent variables (curability, T status, N status, peritoneal metastasis, and distant metastasis) and covariates (related clinicopathological data from step 1 and cutoff points from step 2).Esophageal involvement, T grade, and CA125 were risk factors of curability. T grade and Borrmann type were risk factors of T status. T grade and CA125 were risk factors of N status. Age, esophageal involvement, T grade, and CA125 were risk factors of peritoneal metastasis. CA125 was risk factor of distant metastasis.CA125 is a potential biological marker for curability prediction of gastric and cardia cancer.

journal_name

Medicine (Baltimore)

journal_title

Medicine

authors

Luo T,Chen W,Wang L,Zhao H

doi

10.1097/MD.0000000000005297

subject

Has Abstract

pub_date

2016-12-01 00:00:00

pages

e5297

issue

51

eissn

0025-7974

issn

1536-5964

pii

00005792-201612230-00008

journal_volume

95

pub_type

杂志文章

相关文献

MEDICINE文献大全
  • Effects of receptor activator nuclear factor κB gene polymorphisms on the susceptibility to knee osteoarthritis: A case-control study.

    abstract::The present study aimed to explore genetic association of receptor activator nuclear factor κB (RANK) polymorphisms with individual susceptibility to knee osteoarthritis (OA) in different Kellgren-Lawrence (KL) grades.This case-control study included 138 knee OA patients and 145 healthy individuals. RANK rs1805034 and...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000014933

    authors: Wang C,Luo L,Tian F,An N,Zhang Y,Hao R,Li D,Zhou Z,Xiao P,Guo L

    更新日期:2019-03-01 00:00:00

  • Relationship between skeletal muscle mass and liver fibrosis markers for patients with hepatitis C virus related liver disease.

    abstract::We aimed to elucidate the relationship between serum liver fibrosis markers (Mac-2 binding protein glycosylation isomer (M2BPGi), FIB-4 index, aspartate aminotransferase to platelet ratio index and hyaluronic acid), and skeletal muscle mass and to investigate factors linked to skeletal muscle mass loss (SMML) in patie...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000008761

    authors: Takata R,Nishikawa H,Enomoto H,Iwata Y,Ishii A,Miyamoto Y,Ishii N,Yuri Y,Hasegawa K,Nakano C,Nishimura T,Yoh K,Aizawa N,Sakai Y,Ikeda N,Takashima T,Iijima H,Nishiguchi S

    更新日期:2017-12-01 00:00:00

  • Dab2 gene variant is associated with increased coronary artery disease risk in Chinese Han population.

    abstract::Disabled-2 (Dab2) is a clathrin and cargo-binding endocytic adaptor protein that plays a role in cellular trafficking of low-density lipoprotein receptor (LDLR). However, little is known about its involvement in coronary artery disease (CAD). Here, we aimed to investigate the association between Dab2 single-nucleotide...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000020924

    authors: Wang Y,Wang Y,Adi D,He X,Liu F,Abudesimu A,Fu Z,Ma Y

    更新日期:2020-07-02 00:00:00

  • Effects of cinnamaldehyde on anti-respiratory syncytial virus: A protocol of systematic review and meta-analysis.

    abstract:BACKGROUND:Previous reports found that cinnamaldehyde has effects on anti-respiratory syncytial virus (ARSV). However, their results are still contradictory. Therefore, this study will systematically address the effects of cinnamaldehyde on ARSV. METHODS:The following electronic bibliographic databases will be retriev...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析

    doi:10.1097/MD.0000000000020266

    authors: Feng L,Li J,Yu HB,Xue Q,Dai LJ

    更新日期:2020-05-01 00:00:00

  • Woven coronary anomaly leading to silent myocardial infarction: A case report.

    abstract:RATIONALE:Woven coronary artery is an extremely unusual congenital anomaly with unknown etiology. Because of normal flow after anomalous segment, this anomaly is considered to be benign. PATIENT CONCERNS:A 51-year-old man was admitted to our hospital with exertional dyspnea that he had experienced for half a year. Wov...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000008302

    authors: Xing Z,Tang L,Huang J,Hu X

    更新日期:2017-11-01 00:00:00

  • The timing of urinary catheter removal after gynecologic surgery: A meta-analysis of randomized controlled trials.

    abstract::The present study aimed to assess the effect of removing an indwelling urinary catheter at different times on urinary retention and urinary infection in patients undergoing gynecologic surgery.Electronic databases including PubMed, EMbase, the Cochrane Central Register of Controlled Trials, and Ovid from inception to ...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析

    doi:10.1097/MD.0000000000018710

    authors: Huang H,Dong L,Gu L

    更新日期:2020-01-01 00:00:00

  • Comparison of efficacy and safety of combination therapy with statins and omega-3 fatty acids versus statin monotherapy in patients with dyslipidemia: A systematic review and meta-analysis.

    abstract:OBJECTIVE:Dyslipidemia is a major risk factor for the development of cardiovascular disease. Both statins and omega-3 fatty acids demonstrate beneficial effects on lipid concentrations. The goal was to evaluate the safety and efficacy of combination therapy with statins and omega-3 fatty acids. METHODS:We performed a ...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析

    doi:10.1097/MD.0000000000013593

    authors: Choi HD,Chae SM

    更新日期:2018-12-01 00:00:00

  • CT-Guided Percutaneous Radiofrequency Thermocoagulation for Recurrent Trigeminal Neuralgia After Microvascular Decompression: A Cohort Study.

    abstract::This article evaluates the long-term outcomes of computed tomography (CT)-guided percutaneous radiofrequency thermocoagulation (PRT) for patients with recurrent trigeminal neuralgia (TN) after microvascular decompression (MVD).This is a retrospective study of 41 patients with intractable TN who after MVD underwent CT-...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000001176

    authors: Lai GH,Tang YZ,Wang XP,Qin HJ,Ni JX

    更新日期:2015-08-01 00:00:00

  • Clinical efficacy of xenon versus propofol: A systematic review and meta-analysis.

    abstract:BACKGROUND:Interest in the anesthetic use of xenon, a noble gas, has waxed and waned for decades, and the clinical effects of xenon are still debated. We performed a meta-analysis to compare the clinical efficacy of xenon with that of propofol. METHODS:Electronic searches were performed through December 2017 using var...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析

    doi:10.1097/MD.0000000000010758

    authors: Xia Y,Fang H,Xu J,Jia C,Tao G,Yu B

    更新日期:2018-05-01 00:00:00

  • Atheroma of the facial artery mimicking a parotid gland tumor: A case report.

    abstract:INTRODUCTION:Atheroma of the facial artery is an extremely rare disease. CLINICAL FINDINGS/PATIENT CONCERNS:Herein, we report an extremely rare case of an atheroma arising from the facial artery, mimicking a parotid gland tumor. DIAGNOSES:The preoperative diagnosis was a right-sided parotid gland tumor. INTERVENTION...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000005403

    authors: Lee DH,Yoon TM,Lee JK,Lim SC

    更新日期:2016-11-01 00:00:00

  • Investigation of the interaction between proton pump inhibitors and clopidogrel using VerifyNow P2Y12 assay.

    abstract:BACKGROUND:Randomized trials and observation studies have revealed conflicting results regarding the interaction between clopidogrel and proton pump inhibitors (PPIs). The aim of our study was to provide laboratory evidence regarding whether PPIs blunt the antiplatelet reactivity of clopidogrel. METHODS:We included re...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000023695

    authors: Lin SF,Lin PC,Chang CC,Chang WL,Chu FY

    更新日期:2020-12-11 00:00:00

  • Clinical analysis of hyperkalemia after esophagectomy: A case report.

    abstract:RATIONALE:The occurrence of hyperkalemia after esophagectomy is clinically rare. Patients who underwent esophagectomy often have a serum potassium level due to perioperative reduced intake, fluids loss, consumption and other reasons. These patients often require the artificial administration of potassium. Rapid fluid l...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000008966

    authors: Chen Q,Zhang WG,Chen SC

    更新日期:2017-12-01 00:00:00

  • Optimal intervention time and risk of the activating blood and removing stasis method in acute cerebral hemorrhage patients: A randomized placebo-controlled trial.

    abstract:INTRODUCTION:Stroke is the leading cause of disability-adjusted life years in neurological diseases and has become one of the top 3 fatal diseases in the world. Cerebral hemorrhage accounts for approximately 18% to 24% of all strokes in Asian countries. Cerebral hemorrhage is one of the most destructive subtypes of str...

    journal_title:Medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1097/MD.0000000000024214

    authors: Ma Y,Zhang D,Lv Z,Cui Y,Fei Y,Chang T,Yu M,Lu J,Huang Q,Zhang Y,Xu P,Lan T,Wang J

    更新日期:2021-01-15 00:00:00

  • Successful Pregnancy Following Assisted Reproduction in Woman With Systemic Lupus Erythematosus and Hypertension: A Case Report.

    abstract::Patients with systemic lupus erythematosus have a poor prognosis of pregnancy, since it is associated with significant maternal and fetal morbidity, including spontaneous miscarriage, pre-eclampsia, intrauterine growth restriction, fetal death and pre-term delivery. We report a case with successful pregnancy in a pati...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000001531

    authors: de Macedo JF,de Macedo GC,Campos LA,Baltatu OC

    更新日期:2015-09-01 00:00:00

  • Development and internal validation of a novel model and markers to identify the candidates for lymph node metastasis in patients with prostate cancer.

    abstract:BACKGROUND:High-grade prostate cancer (PCa) has a poor prognosis, and up to 15% of patients worldwide experience lymph node invasion (LNI). To further improve the prediction lymph node invasion in prostate cancer, we adopted risk scores of the genes expression based on the nomogram in guidelines. METHODS:We analyzed c...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000016534

    authors: Cao HM,Wan Z,Wu Y,Wang HY,Guan C

    更新日期:2019-07-01 00:00:00

  • Retrospective comparison of fludarabine in combination with intermediate-dose cytarabine versus high-dose cytarabine as consolidation therapies for acute myeloid leukemia.

    abstract::This retrospective study compared efficacy and safety of fludarabine combined with intermediate-dose cytarabine (FA regimen) versus high-dose cytarabine (HiDAC regimen) as consolidation therapy in acute myeloid leukemia (AML) patients who achieved complete remission. Disease-free survival (DFS) and overall survival (O...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000000134

    authors: Zhang W,Ding Y,Wu H,Chen Y,Lu H,Chen C,Fu J,Wang W,Liang A,Zou S

    更新日期:2014-12-01 00:00:00

  • Interventions to improve physical performances of older people with cancer before complex medico-surgical procedures: Protocol for an umbrella review of systematic reviews and meta-analyses.

    abstract:BACKGROUND:Current demographics lead increasing older cancer patients to undergo complex medico-surgical procedures, with substantial risk of decompensations and deconditioning. The Prehabilitation & Rehabilitation in Oncology: Adaptation to Disease and Accompaniment of Patients' Trajectories (PROADAPT) project is curr...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000021780

    authors: Falandry C,Stefani L,Andre L,Granger M,Barbavara C,Habchi H,Bourgeois C,Cure H,Passot G,Gilbert T,PROADAPT working group.

    更新日期:2020-09-25 00:00:00

  • Nocardia bacteremia. Report of 4 cases and review of the literature.

    abstract::Bacteremic nocardiosis is reported rarely. We discuss 4 recent cases seen at our institution and 32 other cases described in the English literature. We found that patients with bacteremic nocardiosis were similar in presentation, risk factors, course, and therapeutic outcome to nonbacteremic patients with nocardiosis....

    journal_title:Medicine

    pub_type: 杂志文章,评审

    doi:10.1097/00005792-199807000-00004

    authors: Kontoyiannis DP,Ruoff K,Hooper DC

    更新日期:1998-07-01 00:00:00

  • Echinococcosis in left ventricle: a case report.

    abstract:INTRODUCTION:Echinococcosis, also called hydatid disease, is a common parasitic infection of the liver. However, echinococcus lesions rarely involve the heart, especially in children. PATIENT CONCERNS:An 8-year-old child from grazing areas of northwest China was referred to our hospital for the complaint of inpersiste...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000015267

    authors: Su L,Yu J,Dai C,Liu Y,Peng L

    更新日期:2019-04-01 00:00:00

  • Association of polymorphisms in STRA6 gene with gestational diabetes mellitus in a Chinese Han population.

    abstract::Cell and animal experiments have found that in addition to being a retinol transporter, Stimulated by Retinoic Acid 6 (STRA6) also functions as a surface signaling receptor by which retinol regulates insulin responses. Several studies revealed that the STRA6 gene may contribute to the pathogenesis of type 2 diabetes m...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000014885

    authors: Hu S,Yan J,You Y,Yang G,Zhou H,Li X,Liao X,Tan H

    更新日期:2019-03-01 00:00:00

  • Impact of bedside assistant on outcomes of robotic thyroid surgery: A STROBE-compliant retrospective case-control study.

    abstract::The importance of bedside assistants has been well established in various robotic procedures. However, the effect of assistants on the surgical outcomes of thyroid surgery remains unclear. We investigated the effects of a dedicated robot assistant (DRA) in robotic thyroidectomy. We also evaluated the learning curve of...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000022133

    authors: Kwon H

    更新日期:2020-09-04 00:00:00

  • Roentgenographic Evaluation of the Spine in Patients With Osteogenesis Imperfecta.

    abstract::Osteogenesis imperfecta (OI) is a hereditary connective tissue disorder that leads to bone weakness and deformities, especially in the spine, which can lead to poor outcomes.The aim of this study was to find patterns and risk factors in spinal deformities in patients with OI.In a retrospective study, 70 patients with ...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000001841

    authors: de Lima MV,de Lima FV,Akkari M,Resende VR,Santili C

    更新日期:2015-11-01 00:00:00

  • Nutritional therapy and effect assessment of infants with primary intestinal lymphangiectasia: Case reports.

    abstract:RATIONALE:Intestinal lymphangiectasia (IL) is a rare enteropathy involving the expansion and rupture of intestinal lymphatic channels. Although several reports have studied cases of primary IL (PIL), this condition is very rare, and is even less commonly encountered in infants. This study aimed to investigate the nutri...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000009240

    authors: Li S,Liu X,He Y,Li Q,Ji L,Shen W,Tong G

    更新日期:2017-12-01 00:00:00

  • Risk factors for drug-resistant epilepsy: A systematic review and meta-analysis.

    abstract:BACKGROUND:Drug resistant epilepsy (DRE) is very common among children and adults and studies had found some related risk factors for DRE, while the results were not consistent. The aim of this study was to identify risk factors for drug-resistant epilepsy. METHODS:Three electronic databases (Medline, Embase and Cochr...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析

    doi:10.1097/MD.0000000000016402

    authors: Xue-Ping W,Hai-Jiao W,Li-Na Z,Xu D,Ling L

    更新日期:2019-07-01 00:00:00

  • Analysis of 2 novel mutations of PHEX gene inducing X-linked dominant hypophosphatemia rickets in 2 families: Two case reports.

    abstract:RATIONALE:X-linked dominant hypophosphatemia rickets (XLH, OMIM 307800) is the most common hereditary hypophosphatemic rickets and characterized by growth retardation, skeletal malformations, dental dysplasia, spontaneous fractures and osteomalacia. PHEX gene was identified for XLH and novel mutations were consistent w...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000011453

    authors: Gao Y,Wang ZM,Li XL

    更新日期:2018-08-01 00:00:00

  • Prevalence and Predictive Factors of Chronic Postsurgical Pain and Global Surgical Recovery 1 Year After Outpatient Knee Arthroscopy: A Prospective Cohort Study.

    abstract::Outpatient knee arthroscopy is one of the most commonly performed surgical procedures. Previous research has demonstrated that chronic postsurgical pain (CPSP) after outpatient surgery is prevalent. Our objective was to determine the prevalence and predictive factors of CPSP and Global Surgical Recovery (GSR) 1 year a...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000002017

    authors: Hoofwijk DMN,Fiddelers AAA,Emans PJ,Joosten EA,Gramke HF,Marcus MAE,Buhre WFFA

    更新日期:2015-11-01 00:00:00

  • Neutrophil-lymphocyte ratio, gamma-glutamyl transpeptidase, lipase, high-density lipoprotein as a panel of factors to predict acute pancreatitis in pregnancy.

    abstract::Acute pancreatitis in pregnancy (APIP) is a rare but dangerous complication. APIP has common symptoms with acute abdomen. Assessment of an acute abdomen is more complicated during pregnancy because the gravid uterus could mask most of symptomatic signs. It has been a challenge to diagnose APIP by physical examination ...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000011189

    authors: Zhang L,Wang Y,Han J,Shen H,Zhao M,Cai S

    更新日期:2018-06-01 00:00:00

  • Computed tomography-guided percutaneous transthoracic needle biopsy for solitary pulmonary nodules in diameter less than 20 mm.

    abstract::To evaluate the diagnostic value of computed tomography (CT)-guided percutaneous lung biopsy for solitary pulmonary nodules (SPN) < 20 mm.A total of 248 patients who were diagnosed a SPN of < 20 mm underwent CT-guided percutaneous transthoracic needle biopsy were reviewed.Specimens of 248 patients were obtained succes...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000010154

    authors: Xu C,Yuan Q,Chi C,Zhang Q,Wang Y,Wang W,Yu L,Zhan P,Lin Y

    更新日期:2018-04-01 00:00:00

  • Ultrasound image analysis using deep learning algorithm for the diagnosis of thyroid nodules.

    abstract::Fine needle aspiration (FNA) is the procedure of choice for evaluating thyroid nodules. It is indicated for nodules >2 cm, even in cases of very low suspicion of malignancy. FNA has associated risks and expenses. In this study, we developed an image analysis model using a deep learning algorithm and evaluated if the a...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000015133

    authors: Song J,Chai YJ,Masuoka H,Park SW,Kim SJ,Choi JY,Kong HJ,Lee KE,Lee J,Kwak N,Yi KH,Miyauchi A

    更新日期:2019-04-01 00:00:00

  • Diffusion tensor imaging for evaluating perianal fistula: Feasibility study.

    abstract::To explore the feasibility of using diffusion tensor imaging (DTI) in the diagnosis of anal fistula and evaluating its activity.Thirty-four patients with perianal fistulas were examined with DTI on a 3.0 T magnetic resonance imaging (MRI) before undergoing surgery. Based on the surgery requirement and preoperative exa...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000011570

    authors: Wang Y,Gu C,Huo Y,Han W,Yu J,Ding C,Zhao X,Meng Y,Li C

    更新日期:2018-07-01 00:00:00