Comparison of efficacy and safety of combination therapy with statins and omega-3 fatty acids versus statin monotherapy in patients with dyslipidemia: A systematic review and meta-analysis.


OBJECTIVE:Dyslipidemia is a major risk factor for the development of cardiovascular disease. Both statins and omega-3 fatty acids demonstrate beneficial effects on lipid concentrations. The goal was to evaluate the safety and efficacy of combination therapy with statins and omega-3 fatty acids. METHODS:We performed a systematic review and meta-analysis of published data to compare the safety and efficacy of combination therapy with statins and omega-3 fatty acids versus statin monotherapy in patients with dyslipidemia. Six articles were assessed in the present meta-analysis (quantitative assessment) and qualitative assessment. RESULTS:In terms of efficacy, the combination treatment afforded a significantly greater reduction in total cholesterol/high-density lipoprotein cholesterol than statin alone did [standard difference in means = -0.215; 95% confidence interval (CI) -0.359--0.071]. However, there was no significant difference in low-density lipoprotein (LDL) cholesterol between the 2 groups. Qualitative assessment of other lipid parameters was performed. Combination therapy with statins and omega-3 fatty acids was generally more effective on lipid concentration than statin monotherapy. In terms of safety, there were no significant differences in total adverse events between the 2 groups. Gastrointestinal adverse events were found to be significantly increased in patients receiving combination therapy using the fixed-effects model (relative risk = 0.547; 95% CI 0.368-0.812). CONCLUSIONS:We suggest that combination therapy with statins and omega-3 fatty acids enhances lipid profile, except LDL cholesterol, compared with statin monotherapy. Nevertheless, statin and omega-3 fatty acid combination should be cautiously recommended, taking into account the clinical importance of LDL cholesterol and safety issues associated with their concomitant use.


Medicine (Baltimore)




Choi HD,Chae SM




Has Abstract


2018-12-01 00:00:00
















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    abstract::Remifentanil and nitrous oxide (N2O) are 2 commonly used anesthetic agents. Both these agents are known risk factors for postoperative nausea and vomiting (PONV). However, remifentanil and N2O have not been directly compared in a published study. Remifentanil can induce acute tolerance or hyperalgesia, thus affecting ...


    pub_type: 杂志文章


    authors: Kim MK,Yi MS,Kang H,Choi GJ

    更新日期:2016-10-01 00:00:00

  • The relationship of MicroRNA-21 and plaque stability in acute coronary syndrome.

    abstract::Acute coronary syndrome (ACS) leads to clinical symptoms such as chest pain, dyspnea, and arrhythmia. The occurrence of ACS is mainly related to the vulnerable plaques in the coronary arteries. MicroRNA-21 (miR-21) is widely expressed in cardiovascular disease and considered as a marker of myocardial infarction, but i...


    pub_type: 杂志文章


    authors: He W,Zhu L,Huang Y,Zhang Y,Shen W,Fang L,Li J,Wang Z,Xie Q

    更新日期:2019-11-01 00:00:00

  • What Do Stroke Patients Look for in Game-Based Rehabilitation: A Survey Study.

    abstract::Stroke is one of the most common causes of physical disability, and early, intensive, and repetitive rehabilitation exercises are crucial to the recovery of stroke survivors. Unfortunately, research shows that only one third of stroke patients actually perform recommended exercises at home, because of the repetitive a...


    pub_type: 杂志文章


    authors: Hung YX,Huang PC,Chen KT,Chu WC

    更新日期:2016-03-01 00:00:00

  • Calcified inferior vena cava and right atrial myxoma in an 18-month-old male: A case report.

    abstract:INTRODUCTION:Cardiac myxomas are the most frequent primary cardiac tumor in adults. The incidence in pediatric patients is extremely low. Heavy calcification of an atrial myxoma is uncommon in children. CASE PRESENTATION:An 18-month-old boy was admitted for a significant precordial systolic murmur. Transthoracic echoc...


    pub_type: 杂志文章


    authors: Chen R,Deng X,Luo J,Huang P

    更新日期:2018-06-01 00:00:00

  • Successful treatment of a critically ill patient with acute respiratory distress syndrome from COVID-19 using mechanical ventilation strategy with low levels of positive end-expiratory pressure: A CARE-compliant case report.

    abstract:INTRODUCTION:Acute respiratory distress syndrome (ARDS) secondary to COVID-19 is different from the ARDS caused by other infections. Conventional mechanical ventilation strategies using high levels of PEEP may not be beneficial and can even be harmful to patient with ARDS from COVID-19. So the ventilation strategies sh...


    pub_type: 杂志文章


    authors: Guo WG,Fang B,Xian YS,Yu ZH,Zhou LX

    更新日期:2020-12-04 00:00:00

  • Acupuncture for the treatment of allergic rhinitis: A systematic review protocol.

    abstract:BACKGROUND:Allergic rhinitis is a major chronic inflammatory disease of the respiratory tract. A large number of epidemiological investigations have shown that the prevalence of allergic rhinitis (AR) is increasing, resulting in a large burden of disease. Desensitizing drugs such as nasal glucocorticoids and antihistam...


    pub_type: 杂志文章


    authors: Bao H,Si D,Gao L,Sun H,Shi Q,Yan Y,Damchaaperenlei D,Li C,Yu M,Li Y

    更新日期:2018-12-01 00:00:00

  • Clinical utilization of serum- or plasma-based miRNAs as early detection biomarkers for pancreatic cancer: A meta-analysis up to now.

    abstract:BACKGROUND:Pancreatic cancer (PC) is a lethal disease, however current screening methods unable to achieve early diagnosis. Blood-based microRNAs (miRNAs) are promising molecular biomarkers for detecting PC. This meta-analysis summaries studies identifying serum- or plasma-based miRNAs dysregulated in PC patients compa...


    pub_type: 杂志文章,meta分析,评审


    authors: Wei L,Yao K,Gan S,Suo Z

    更新日期:2018-08-01 00:00:00

  • A Case Report of High 18F-FDG PET/CT Uptake in Progressive Transformation of the Germinal Centers.

    abstract::Progressive transformation of the germinal centers (PTGC) is a benign reaction pattern in lymph nodes. An association with Hodgkin disease (HD) has been reported and PTGC may precede, coexist, or present after the diagnosis of HD. This case report describes a patient who presented with unprovoked pulmonary embolism an...


    pub_type: 杂志文章


    authors: Chang CA,Kumar B,Nandurkar D

    更新日期:2015-06-01 00:00:00

  • Candidate genes investigation for severe nonalcoholic fatty liver disease based on bioinformatics analysis.

    abstract:BACKGROUND:Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver condition worldwide. However, its etiology and fundamental pathophysiology for the disease process are poorly understood. In this study, we thus used bioinformatics to identify candidate genes potentially causative of severe NAFLD. ME...


    pub_type: 杂志文章


    authors: Qi S,Wang C,Li C,Wang P,Liu M

    更新日期:2017-08-01 00:00:00

  • Predictive value of soluble ST-2 for changes of cardiac function and structure in breast cancer patients receiving chemotherapy.

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    pub_type: 杂志文章


    authors: Huang G,Zhai J,Huang X,Zheng D

    更新日期:2018-09-01 00:00:00

  • Clinical risk assessment for gastric cancer in asymptomatic population after a health check-up: An individualized consideration of the risk factors.

    abstract::For the prevention of gastric cancer, the detection of risk factors associated with precancerous conditions may be more informative. The aim of this study was to identify the risk factors of gastric cancer, including precancerous conditions: atrophic gastritis (AG), intestinal metaplasia (IM), and dysplasia.The clinic...


    pub_type: 杂志文章


    authors: Park YM,Kim JH,Baik SJ,Park JJ,Youn YH,Park H

    更新日期:2016-11-01 00:00:00

  • Successful open reduction and internal fixation for displaced femoral fracture in a patient with osteopetrosis: Case report and lessons learned.

    abstract:RATIONALE:Osteopetrosis is a rare disease that predominantly occurs in descendants of inbreeding families. In the case of fractures happen in patients with osteopetrosis, the choice between operative or conservative treatment is still controversial. Open reduction and internal fixation (ORIF) is a conventional treatmen...


    pub_type: 杂志文章


    authors: Huang J,Pan J,Xu M,Xu S

    更新日期:2017-08-01 00:00:00

  • Economic and health impacts of infectious diseases in China: A protocol for systematic review and meta analysis.

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    pub_type: 杂志文章


    authors: Li M,Fan D,Wang X

    更新日期:2020-07-24 00:00:00

  • Cisplatin-induced cardiotoxicity with midrange ejection fraction: A case report and review of the literature.

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    pub_type: 杂志文章,评审


    authors: Hu Y,Sun B,Zhao B,Mei D,Gu Q,Tian Z

    更新日期:2018-12-01 00:00:00

  • Will surgeries performed at night lead to worse outcomes? Findings from a trauma center in Riyadh.

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    authors: Alnajashi SS,Alayed SA,Al-Nasher SM,Aldebasi B,Khan MM

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    pub_type: 杂志文章,多中心研究


    authors: He ZY,Wu SG,Yang Q,Sun JY,Li FY,Lin Q,Lin HX

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  • Association Between Race/Ethnicity and Survival of Melanoma Patients in the United States Over 3 Decades: A Secondary Analysis of SEER Data.

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    pub_type: 杂志文章


    authors: Ward-Peterson M,Acuña JM,Alkhalifah MK,Nasiri AM,Al-Akeel ES,Alkhaldi TM,Dawari SA,Aldaham SA

    更新日期:2016-04-01 00:00:00

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    pub_type: 杂志文章,meta分析,评审


    authors: Fu Y,Lan T,Cai H,Lu A,Yu W

    更新日期:2018-05-01 00:00:00

  • Kidney Transplantation from an extracorporeal membrane oxygenation-supported brain-dead donor: A case report.

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    pub_type: 杂志文章


    authors: Chiang PJ,Tang SH,Li CC,Chou MH,Lin YC,Wu ST

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  • Efficacy and safety of Xiaofeng powder (xiao feng san) in treating urticaria: A protocol for a systematic review and meta-analysis of randomized controlled trials.

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    pub_type: 杂志文章,meta分析


    authors: Chen G,Zhao J,Chen T,Zhang Z,Huang C,Xu Z,Xu H

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  • Combined intravenous and intra-articular tranexamic acid administration in total knee arthroplasty for preventing blood loss and hyperfibrinolysis: A randomized controlled trial.

    abstract:BACKGROUND:Total knee arthroplasty (TKA) is a surgical procedure to replace the weight-bearing surfaces of the knee joint to relieve pain and disability. However, blood loss and fibrinolytic activity, accounting for a poor prognosis following TKA operation, were relieved by fibrinolytic inhibitor tranexamic acid (TXA)....


    pub_type: 杂志文章,随机对照试验


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  • Coreceptor usage of Chinese HIV-1 and impact of X4/DM transmission clusters among recently infected men who have sex with men.

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    authors: Li X,Zhu K,Li W,Fang K,Musa TH,Song Y,Du G,Gao R,Guo Y,Yan W,Xuan Y,Zhong P,Wei P

    更新日期:2016-09-01 00:00:00

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    authors: Ayuse T,Okayasu I,Tachi-Yoshida M,Sato J,Saisu H,Shimada M,Yamazaki Y,Imura H,Hosogaya N,Nakashima S

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  • Effects of mitochondrial ATP-sensitive potassium channel activation (nicorandil) in patients with angina pectoris undergoing elective percutaneous coronary interventions: A meta-analysis of randomized controlled trials.

    abstract:AIMS:Nicorandil, which is a mitochondrial ATP-sensitive potassium channel opener, is believed to improve perioperative myocardial injury (PMI) in patients undergoing percutaneous coronary intervention (PCI), but recent studies have shown that nicorandil treatment did not improve functional and clinical outcomes in pati...


    pub_type: 杂志文章,meta分析,评审


    authors: Zhu H,Xu X,Fang X,Zheng J,Chen T,Huang J

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  • 3-Dimensional shear wave elastography of breast lesions: Added value of color patterns with emphasis on crater sign of coronal plane.

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    pub_type: 杂志文章


    authors: Chen YL,Chang C,Zeng W,Wang F,Chen JJ,Qu N

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    pub_type: 杂志文章


    authors: Beyt BE Jr,Ortbals DW,Santa Cruz DJ,Kobayashi GS,Eisen AZ,Medoff G

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  • Risk factors for heart valve calcification in chronic kidney disease.

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    authors: Rong S,Qiu X,Jin X,Shang M,Huang Y,Tang Z,Yuan W

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  • Preoperative Plasma Fibrinogen Level as a Significant Prognostic Factor in Patients With Localized Renal Cell Carcinoma After Surgical Treatment.

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    authors: Lee H,Lee SE,Byun SS,Kim HH,Kwak C,Hong SK

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    authors: Cao Q,Yu S,Xiong W,Li Y,Li H,Li J,Li F

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  • Erratum: Alström syndrome: A novel mutation in Saudi girl with insulin-resistant diabetes: Erratum.

    abstract::[This corrects the article DOI: 10.1097/MD.0000000000006192.]. ...


    pub_type: 已发布勘误



    更新日期:2017-06-02 00:00:00