Abstract:
BACKGROUND:Drug resistant epilepsy (DRE) is very common among children and adults and studies had found some related risk factors for DRE, while the results were not consistent. The aim of this study was to identify risk factors for drug-resistant epilepsy. METHODS:Three electronic databases (Medline, Embase and Cochrane library) were searched to identify studies with a cohort design reporting on epidemiologic evidence regarding risk factors for DRE. RESULTS:The pooled prevalence of DRE in newly diagnosed epilepsy patients was 25% (95% CI 17-32%). Abnormal electroencephalography (EEG) (both slow wave and epileptiform discharges) (RR 2.80; 95% CI 1.95-4.0), status epilepticus (SE) (RR 11.60; 95% CI 7.39-18.22), symptomatic etiology (RR 3.36; 95% CI 2.53-4.46), multiple seizure types (RR 3.66; 95% CI 2.37-5.64) and febrile seizures (RR 3.43; 95% CI 1.95-6.02) were identified as strong risk factors for DRE. In addition, firm conclusions cannot be drawn for poor short-term outcomes of therapy, neurodevelopment delay and high initial seizure frequency for the heterogeneity of study results. The predictive effect of focus onset seizure was not stable after removing one study and switching the effect model. Age of onset was not risk factors for DRE. CONCLUSIONS:The current meta-analysis identified potential risk factors for DRE. The results may contribute to better prevention strategies and treatments for DRE.
journal_name
Medicine (Baltimore)journal_title
Medicineauthors
Xue-Ping W,Hai-Jiao W,Li-Na Z,Xu D,Ling Ldoi
10.1097/MD.0000000000016402subject
Has Abstractpub_date
2019-07-01 00:00:00pages
e16402issue
30eissn
0025-7974issn
1536-5964pii
00005792-201907260-00015journal_volume
98pub_type
杂志文章,meta分析相关文献
MEDICINE文献大全abstract:BACKGROUND:Pediatric inguinal hernia is one of the most common diseases in children, and laparoscopy is the main surgical method. This study aims to evaluate the efficacy of a new modified 2-port laparoscopic herniorrhaphy with Kirschner wire (TLHK) for inguinal hernia in children. METHODS:A total of 5304 children wit...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000012790
更新日期:2018-10-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to observe the counter-effect of carbon monoxide-releasing molecule-2 (CORM-2) on lipopolysaccharide (LPS)-suppressed thrombomodulin (TM) and endothelial protein C receptor (EPCR) expressions from human umbilical vein endothelial cell (HUVEC), and to reveal its mechanisms. METHODS:H...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000006978
更新日期:2017-05-01 00:00:00
abstract:BACKGROUND:To explore the correlation between recurrent risk and CYP2C19 gene polymorphisms in patients with ischemic stroke (IS) treated with clopidogrel for prevention. METHODS:A total of 289 patients with IS treated with clopidogrel regularly were enrolled in this study, and stroke recurrence of all patients were r...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000019143
更新日期:2020-03-01 00:00:00
abstract:BACKGROUND:Esophageal carcinoma (EC) is one of the worst malignant digestive neoplasms with a strong tendency of invasion and metastasis. Despite the improvement of diagnostic and therapeutic methods in the past decades, the prognosis of EC remains unsatisfactory. Xiaoaiping injection (XAPI), a famous traditional Chine...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000020984
更新日期:2020-06-26 00:00:00
abstract:BACKGROUND:The value of layer-specific two-dimensional speckle tracking echocardiography (LS2D-STE) for evaluating viable myocardium (VM) in patients with acute myocardial infarction (AMI) was unclear, this study provides new insights into it and to make a comparison with dualisotope simultaneous acquisition single pho...
journal_title:Medicine
pub_type: 临床试验,杂志文章
doi:10.1097/MD.0000000000013959
更新日期:2019-01-01 00:00:00
abstract::The role of 18F-fuorodexoyglucose-positron emission tomography/computed tomography (18F-FDG-PET/CT) in the staging of Hodgkin lymphoma (HL) and aggressive B-cell non-Hodgkin lymphomas (NHL) has been demonstrated extensively. Nevertheless, the role of PET/CT in the diagnosis, staging, prognosis, and treatment evaluatio...
journal_title:Medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1097/MD.0000000000000258
更新日期:2014-12-01 00:00:00
abstract:BACKGROUND:Hypertension drives the global burden of cardiovascular disease and its prevalence is estimated to increase by 30% by the year 2025. Nonadherence to chronic medication regimens is common; approximately 43% to 65.5% of patients who fail to adhere to prescribed regimens are hypertensive patients. Nonadherence ...
journal_title:Medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1097/MD.0000000000005641
更新日期:2017-01-01 00:00:00
abstract::Deep sternal wound infection is a severe complication after open heart surgery. According to the different severity and dimensions of the deep sternal wound infection, the treatment method is different. In this study, we aimed to describe our experience with the rectus abdominis myocutaneous flap for large sternal wou...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000006391
更新日期:2017-04-01 00:00:00
abstract:RATIONALE:Hepatoid adenocarcinoma of lung (HAL) is a rare malignant tumor, which can be defined as a primary alpha-fetoprotein (AFP)-producing lung carcinoma. The majority of hepatoid adenocarcinoma (HAC) expressed AFP in tumor cells, but AFP expression is not required for its diagnosis according to the modified diagno...
journal_title:Medicine
pub_type: 杂志文章,评审
doi:10.1097/MD.0000000000015053
更新日期:2019-04-01 00:00:00
abstract::Acute acquired concomitant esotropia (AACE) is a rare, distinct subtype of esotropia. The purpose of this retrospective study was to describe the clinical characteristics and discuss the classification and etiology of AACE.Charts from 47 patients with AACE referred to our institute between October 2010 and November 20...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000002273
更新日期:2015-12-01 00:00:00
abstract::The standard treatment for patients with advanced gastric cancer (AGC) is still a matter of debate. The chemotherapy regimen of paclitaxel (PTX) combined with S-1 has been used to treat AGC or metastatic gastric cancer.We conducted a meta-analysis to compare oral S-1 and infusional 5-fluorouracil (5-FU) to determine w...
journal_title:Medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1097/MD.0000000000000164
更新日期:2014-11-01 00:00:00
abstract:BACKGROUND:Surgical treatment for terrible triad injuries remains a challenging clinical problem, and controversy exists of whether it is better to repair or replace the radial head. The objective of this systematic review was to evaluate the clinical outcomes of repair and arthroplasty replacement of the radial head i...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000013054
更新日期:2019-02-01 00:00:00
abstract::As detection rates of non-albicans Candida species are increasing, determining their pathogen profiles and antifungal susceptibilities is important for antifungal treatment selection. We identified the antifungal susceptibility patterns and predictive factors for mortality in candidemia.A multicenter retrospective ana...
journal_title:Medicine
pub_type: 杂志文章,多中心研究
doi:10.1097/MD.0000000000019494
更新日期:2020-03-01 00:00:00
abstract::This study was conducted to investigate the clinicopathological features of synchronous cancers and treatment options according to their locations.Records of 8368 patients with colorectal cancer treated at our center between July 2003 and December 2010 were analyzed retrospectively. All synchronous colorectal cancer p...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000006224
更新日期:2017-03-01 00:00:00
abstract::Chronic postsurgical pain (CPSP) is an important clinic problem. It is assessed that prevalence of chronic pain extends to 30% but it is contended that there are various risk factors. We aimed to evaluate the prevalence of chronic pain after hysterectomy, risk factors of chronicity, neuropathic features of pain, and s...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000004484
更新日期:2016-08-01 00:00:00
abstract::Patients with myotonic muscular dystrophy type 1 (DM1) tend to exhibit earlier respiratory insufficiency than patients with other neuromuscular diseases at similar or higher forced vital capacity (FVC). This study aimed to analyze several pulmonary function parameters to determine which factor contributes the most to ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000015321
更新日期:2019-05-01 00:00:00
abstract::This study aims to examine the expression of p53, p16, and murine double minute 2 (MDM2) protein in normal endometrium and endometriosis, in order to discuss the role of p53, p16, and MDM2 protein and apoptosis in the pathogenesis and development of endometriosis, and provide a theoretical basis for clinical diagnosis...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000014776
更新日期:2019-04-01 00:00:00
abstract::The Glasgow-Blatchford scores (GBS) and Rockall scores (RS) are commonly used for stratifying patients with nonvariceal upper gastrointestinal hemorrhage (NVUGIH). Although predictive value of these scoring methods has been extensively validated, their clinical effectiveness remains unclear. The following study evalua...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000015716
更新日期:2019-05-01 00:00:00
abstract:OBJECTIVE:We conducted this study to compare the efficacy and safety of entecavir and tenofovir in the treatment of treatment-naïve HBV e antigen (HBeAg)-positive patients with chronic hepatitis B (CHB) for 144 weeks. METHODS:A total of 320 treatment-naïve HBeAg-positive CHB patients who received randomly a single reg...
journal_title:Medicine
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1097/MD.0000000000013983
更新日期:2019-01-01 00:00:00
abstract::Olfactory outcomes as well as oronasal postoperative complications of transsphenoidal pituitary surgery have not been well studied. The objective of this study was to investigate nasal symptoms including olfactory function as well as quality of life following transsphenoidal pituitary surgery. The study is designed as...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000000465
更新日期:2015-01-01 00:00:00
abstract::Pyogenic liver abscess is a severe condition and a therapeutic challenge. Treatment failure may be due to an unrecognized ingested foreign body that migrated from the gastrointestinal tract. There has recently been a marked increase in the number of reported cases of this condition, but initial misdiagnosis as cryptog...
journal_title:Medicine
pub_type: 杂志文章,评审
doi:10.1097/MD.0b013e3181d41c38
更新日期:2010-03-01 00:00:00
abstract::Occupational exposure remains a serious problem for medical staff, especially those working in operation rooms. Hepatitis B virus (HBV) is prevalent in patients undergoing surgery, and anesthesiologists are at risk of occupational acquisition of blood-borne HBV infection. To the best of our knowledge, there are no dat...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000016416
更新日期:2019-07-01 00:00:00
abstract:BACKGROUND:Recent studies have shown the efficacy for using spironolactone to treat heart failure with reduced ejection fraction (HFrEF), but the efficacy of spironolactone for heart failure with mid-range ejection fraction (HFmrEF) and heart failure with preserved ejection fraction (HFpEF) is unclear. This meta-analys...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000014967
更新日期:2019-03-01 00:00:00
abstract::This study aimed to assess the efficacy and safety of bevacizumab plus preoperative chemotherapy as first-line treatment for liver-only metastatic colorectal cancer in Chinese patients compared with those of preoperative chemotherapy alone.Patients with histologically confirmed liver-only metastatic colorectal cancer ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000004767
更新日期:2016-08-01 00:00:00
abstract::This article evaluates the long-term outcomes of computed tomography (CT)-guided percutaneous radiofrequency thermocoagulation (PRT) for patients with recurrent trigeminal neuralgia (TN) after microvascular decompression (MVD).This is a retrospective study of 41 patients with intractable TN who after MVD underwent CT-...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000001176
更新日期:2015-08-01 00:00:00
abstract::Awake craniotomy is a unique technique utilized for mapping neuro and motor function during neurosurgical procedures close to eloquent brain tissue. Since active communication is required only during surgical manipulation of eloquent brain tissue and the patient is "sedated" during other parts of the procedure, differ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000017473
更新日期:2019-10-01 00:00:00
abstract::Nonadherence to prescribed medications poses a significant public health problem. Prescription data in electronic medical records (EMRs) linked with pharmacy claims data provides an opportunity to examine the prescription fill rates and factors associated with it.Using a claims-EMR linked data, patients who had a pres...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000013110
更新日期:2018-11-01 00:00:00
abstract:INTRODUCTION:These years, due to dissatisfaction with western medicine treatments, traditional Chinese medicine (TCM) becomes a main treatment for bronchial asthma patients. Lung and kidney yang deficiency syndrome is a common type of asthma and the Chinese herbal medicine formula modified Mahuang-Fuzi-Xixin (MFX) deco...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000021858
更新日期:2020-08-28 00:00:00
abstract:BACKGROUND:Acute chronic liver failure (ACLF) is the most common type of liver failure. The clinical symptoms are complex and changeable, the treatment is difficult and the fatality rate is high. It has become an urgent problem to actively seek effective treatment means and improve the clinical efficacy of ACLF patient...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000022585
更新日期:2020-10-09 00:00:00
abstract:RATIONALE:Elbow injury in children by improper treatment or a delay of more than 3 weeks could lead to old unreduced Monteggia fracture, which are difficult to manage. Conservative or normal surgical methods usually fail. PATIENT CONCERNS:Herein, we present a 6-year-old boy with sustaining injury approximately 1 month...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000006377
更新日期:2017-03-01 00:00:00