Nocardia bacteremia. Report of 4 cases and review of the literature.

Abstract:

:Bacteremic nocardiosis is reported rarely. We discuss 4 recent cases seen at our institution and 32 other cases described in the English literature. We found that patients with bacteremic nocardiosis were similar in presentation, risk factors, course, and therapeutic outcome to nonbacteremic patients with nocardiosis. The presence of endovascular foreign bodies appeared to be the only unique risk factor associated with bacteremic illness. Seeding of the central nervous system appeared to be relatively uncommon. Thirty percent of patients with nocardemia had concomitant bacteremia with other pathogens, mostly Gram-negative organisms. Nocardia grew in a variety of growth media, and the median incubation time to detection was 4 days. Fifty percent of patients with Nocardia bacteremia died. Positive blood cultures were a preterminal finding in the fatal, acute cases and occurred relatively early in the subacute, nonfatal cases. Poor outcome seemed to correlate with acute onset of nocardiosis (duration less than 1 month), late identification of nocardemia, involvement of more than 2 sites, and the lack of treatment with a sulfonamide-containing regimen.

journal_name

Medicine (Baltimore)

journal_title

Medicine

authors

Kontoyiannis DP,Ruoff K,Hooper DC

doi

10.1097/00005792-199807000-00004

subject

Has Abstract

pub_date

1998-07-01 00:00:00

pages

255-67

issue

4

eissn

0025-7974

issn

1536-5964

journal_volume

77

pub_type

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