Abstract：
:There is still no agreement on total plasma homocysteine (tHcy) role in age-related macular degeneration (AMD), the leading cause of new blindness in industrialized countries. We performed a systematic review and meta-analysis of the published data on the correlation between tHcy and AMD. MEDLINE/PubMed and ISI Web of Sciences searches were performed according to MOOSE guidelines. Case-control studies were eligible for inclusion. Participants and controls were AMD patients and subjects without AMD. The main outcome measure was wet AMD. Homocysteine level was the main exposure variable. Data were pooled using a random-effects model. Twelve case-control studies were identified: 10 assessed wet AMD, four dry AMD, one early AMD, one late AMD, and one any AMD. As for wet AMD, there was a total of 453 cases and 514 controls. Mean tHcy was on average 1.1 μmol/l (95% confidence interval [CI] = 0.96-1.25) greater in wet AMD cases, but there was evidence of extreme between-study heterogeneity (p < 0.001, I2 = 91.8%). In a model homogenous for age, including six wet AMD studies (214 cases, 274 controls), mean tHcy was on average 0.58 μmol/l (95% CI = 0.35-0.73) greater in the case group, a not statistically significant result (p = 0.144) associated with moderate heterogeneity (I2 = 39.2%). Our meta-analysis indicates that there is some weak evidence that increased tHcy might be associated with wet AMD; however, this result should be interpreted cautiously, because of a marked between-study heterogeneity and the possible effect of publication bias. Future studies, preferably of cohort design, are necessary before any firm conclusions on the putative role of increased tHcy on AMD can be drawn.
journal_name
Acta Ophthalmoljournal_title
Acta ophthalmologicaauthors
Pinna A,Zaccheddu F,Boscia F,Carru C,Solinas Gdoi
10.1111/aos.13343subject
Has Abstractpub_date
2018-05-01 00:00:00pages
e269-e276issue
3eissn
1755-375Xissn
1755-3768journal_volume
96pub_type
杂志文章,meta分析,评审abstract：PURPOSE:Life expectancy is increasing. When corneal donors become older and corneal-grafted patients live longer with their graft, the need for good-quality donor tissue becomes more crucial. The aim of the present investigation is to study grafted recipients with a donor cornea with a total tissue age of more than 100...
journal_title：Acta ophthalmologica
pub_type： 杂志文章
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abstract：PURPOSE:To assess the surgical and functional outcome of internal direct cyclopexy as therapy of complicated traumatic cyclodialysis. METHODS:The single-centre interventional case-series study included eyes with traumatic cyclodialysis who had consecutively been treated. Internal cyclopexy was performed using double-a...
journal_title：Acta ophthalmologica
pub_type： 杂志文章
doi：10.1111/aos.13463
更新日期：2017-09-01 00:00:00
abstract：PURPOSE:To evaluate short- and long-term intraocular pressure (IOP) changes after temporal clear corneal phacoemulsification in normal eyes. METHODS:The charts of 266 consecutive non-glaucoma patients who underwent uneventful cataract surgery were reviewed. We recorded preoperative and postoperative (1 day, 1 week, 1 ...
journal_title：Acta ophthalmologica
pub_type： 杂志文章
doi：10.1111/j.1755-3768.2009.01569.x
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abstract：PURPOSE:To investigate the value of posterior keratometry in the assessment of surgically induced astigmatic change (AC) in cataract surgery, with particular emphasis on the influence of test-retest variability. METHODS:Seventy-seven eyes of 77 cataract patients scheduled for routine cataract surgery were enrolled. Al...
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pub_type： 杂志文章
doi：10.1111/aos.13003
更新日期：2016-08-01 00:00:00
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journal_title：Acta ophthalmologica
pub_type： 杂志文章
doi：10.1111/j.1755-3768.2008.01305.x
更新日期：2009-08-01 00:00:00
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journal_title：Acta ophthalmologica
pub_type： 杂志文章
doi：10.1111/j.1755-3768.2008.01190.x
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pub_type： 杂志文章
doi：10.1111/j.1755-3768.2012.02476.x
更新日期：2012-11-01 00:00:00
abstract：PURPOSE:To assess retinal perfusion in eyes with unilateral ocular ischaemic syndrome (OIS) and to compare with control subjects. METHODS:Retrospective case series. Linear blood flow velocities in macular vessels were estimated using motion-contrast fundus photography in eight patients with unilateral OIS (eight OIS e...
journal_title：Acta ophthalmologica
pub_type：
doi：10.1111/aos.13950
更新日期：2019-02-01 00:00:00
abstract：:A growing number of studies have reported a link between vascular damage and glaucoma based on optical coherence tomography angiography (OCTA) imaging. This multitude of studies focused on different regions of interest (ROIs) which offers the possibility to draw conclusions on the most discriminative locations to diag...
journal_title：Acta ophthalmologica
pub_type： 杂志文章,评审
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更新日期：2020-09-01 00:00:00
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journal_title：Acta ophthalmologica
pub_type： 杂志文章
doi：10.1111/aos.12418
更新日期：2015-02-01 00:00:00
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journal_title：Acta ophthalmologica
pub_type： 杂志文章
doi：10.1111/aos.13513
更新日期：2018-03-01 00:00:00
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journal_title：Acta ophthalmologica
pub_type： 杂志文章,多中心研究
doi：10.1111/j.1755-3768.2011.02349.x
更新日期：2013-08-01 00:00:00
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journal_title：Acta ophthalmologica
pub_type： 杂志文章,评审
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更新日期：2019-03-01 00:00:00
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journal_title：Acta ophthalmologica
pub_type： 杂志文章
doi：10.1111/aos.12995
更新日期：2016-09-01 00:00:00
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journal_title：Acta ophthalmologica
pub_type： 杂志文章
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更新日期：2018-02-01 00:00:00
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journal_title：Acta ophthalmologica
pub_type： 杂志文章
doi：10.1111/j.1755-3768.2008.01303.x
更新日期：2009-08-01 00:00:00
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journal_title：Acta ophthalmologica
pub_type： 杂志文章
doi：10.1111/aos.14754
更新日期：2021-01-10 00:00:00
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journal_title：Acta ophthalmologica
pub_type： 杂志文章
doi：10.1111/aos.13911
更新日期：2019-03-01 00:00:00
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pub_type： 杂志文章
doi：10.1111/j.1755-3768.2010.01880.x
更新日期：2012-03-01 00:00:00
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pub_type： 杂志文章
doi：10.1111/j.1600-0420.2007.00940.x
更新日期：2008-02-01 00:00:00
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journal_title：Acta ophthalmologica
pub_type： 杂志文章,评审
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更新日期：2015-08-01 00:00:00
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journal_title：Acta ophthalmologica
pub_type： 杂志文章
doi：10.1111/aos.13899
更新日期：2019-03-01 00:00:00
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doi：10.1111/j.1755-3768.2011.02381.x
更新日期：2013-05-01 00:00:00
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pub_type： 杂志文章,随机对照试验
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更新日期：2016-09-01 00:00:00
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更新日期：2015-03-01 00:00:00
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pub_type： 杂志文章
doi：10.1111/j.1755-3768.2009.01585.x
更新日期：2010-12-01 00:00:00
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pub_type： 杂志文章
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更新日期：2016-12-01 00:00:00
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journal_title：Acta ophthalmologica
pub_type： 杂志文章
doi：10.1111/j.1755-3768.2010.01997.x
更新日期：2010-11-01 00:00:00
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pub_type： 杂志文章
doi：10.1111/aos.13007
更新日期：2016-08-01 00:00:00
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pub_type： 杂志文章
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更新日期：2020-05-01 00:00:00
