Abstract:
:Treatment-related neurotoxicity is a potentially life-threatening clinical condition that can represent a diagnostic challenge. Differentiating diagnoses between therapy-associated brain injury and recurrent disease can be difficult, and the immediate recognition of neurotoxicity is crucial to providing correct therapeutic management, ensuring damage reversibility. For these purposes, the knowledge of clinical timing and specific treatment protocols is extremely important for interpreting MRI patterns. Neuroradiologic findings are heterogeneous and sometimes overlapping, representing the compounding effect of the different treatments. Moreover, MRI patterns can be acute, subacute or delayed and involve different brain regions, depending on (1) the mechanism of action of the specific medication and (2) which brain regions are selectively vulnerable to specific toxic effects. This review illustrates the most common radiologic appearance of radiotherapy, chemotherapy and medication-associated brain injury in children, with special focus on the application of advanced MRI techniques (diffusion, perfusion and proton spectroscopy) in the diagnosis of the underlying processes leading to brain toxicity.
journal_name
Pediatr Radioljournal_title
Pediatric radiologyauthors
Rossi Espagnet MC,Pasquini L,Napolitano A,Cacchione A,Mastronuzzi A,Caruso R,Tomà P,Longo Ddoi
10.1007/s00247-016-3750-4subject
Has Abstractpub_date
2017-05-01 00:00:00pages
633-648issue
6eissn
0301-0449issn
1432-1998pii
10.1007/s00247-016-3750-4journal_volume
47pub_type
杂志文章,评审abstract::Anomalous origin of the left pulmonary artery in tetralogy of Fallot was diagnosed in a 4-year-old boy be cardiac catheterization. Corrective surgery was performed. The child died immediately following the surgical procedure. Postmortem examination revealed obstructive pulmonary vascular disease of the left lung and n...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/BF02388368
更新日期:1985-01-01 00:00:00
abstract:BACKGROUND:The magnetic resonance imaging (MRI) characteristics of evolving duodenal hematomas in children are unknown. OBJECTIVE:To describe the MRI changes exhibited by evolving duodenal hematomas and the likely mechanisms behind these changes. MATERIALS AND METHODS:We retrospectively reviewed the MR features of in...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s00247-018-4178-9
更新日期:2018-10-01 00:00:00
abstract::Pyloric atresia is an uncommon congenital gastric outlet obstruction, accounting for only 1% of gastrointestinal atresias. Up to 55% of cases have associated anomalies, the most common of which is epidermolysis bullosa. Fetal MRI findings of the epidermolysis bullosa-pyloric atresia association have not been previousl...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s00247-013-2737-7
更新日期:2013-12-01 00:00:00
abstract:BACKGROUND:Achalasia is a disorder of oesophageal motility and is rare in children. The mainstay of therapy has been surgery with its attendant complications and long postoperative stay. Treatment by hydrostatic balloon dilatation, a less morbid procedure, has not found much favour. OBJECTIVE:To review the overall eff...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s00247-001-0646-7
更新日期:2002-06-01 00:00:00
abstract:BACKGROUND:Internal hernias are uncommon in children and their clinical and imaging findings have not been widely addressed. OBJECTIVE:To determine the spectrum of clinical and imaging findings of internal hernia (IH) in children and to highlight diagnostic features. MATERIALS AND METHODS:Review of clinical, imaging ...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s00247-011-2158-4
更新日期:2011-12-01 00:00:00
abstract::Gadolinium-based contrast agents can increase the accuracy and expediency of an MRI examination. However the benefits of a contrast-enhanced scan must be carefully weighed against the well-documented risks associated with administration of exogenous contrast media. The purpose of this review is to discuss commercially...
journal_title:Pediatric radiology
pub_type: 杂志文章,评审
doi:10.1007/s00247-017-3806-0
更新日期:2017-05-01 00:00:00
abstract::Restrictive dermopathy is an inherited syndrome characterized clinically by severe growth retardation, abnormal skin, characteristic facies, and multiple congenital contractures. Distinctive radiologic features include deficient mineralization of the clavicles and the skull, overtubulation and frequent modeling defect...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/BF02014983
更新日期:1993-01-01 00:00:00
abstract:BACKGROUND:Optic pathway gliomas (OPGs) are common pediatric brain tumors that pose significant clinical challenges with regard to predicting which tumors are likely to become symptomatic and require treatment. These tumors can arise sporadically or in the context of the inherited cancer predisposition syndrome neurofi...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s00247-008-1003-x
更新日期:2008-12-01 00:00:00
abstract::Patient exposure is an important consideration in pediatric radiography. Gadolinium filtration can be used to reduce exposure while maintaining contrast. Matched sets of pediatric radiographs were produced using aluminum and gadolinium filtration. In almost all cases, no difference or only a minimal difference in diag...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/BF01001588
更新日期:1981-01-01 00:00:00
abstract::Basilar impression (BI) assessed by either plain lateral skull radiograph or computerized tomography (CT) sagittal reconstruction of the craniocervical junction is a common finding occurring in 25% of subjects with osteogenesis imperfecta (OI). It appears to occur with highest frequency in a group of subjects with OI ...
journal_title:Pediatric radiology
pub_type: 杂志文章,评审
doi:10.1007/BF02011910
更新日期:1994-01-01 00:00:00
abstract:BACKGROUND:Despite regulations, insufficient information is provided to adult patients prior to their radiologic examinations. Information regarding paediatric patients has not been systematically studied. OBJECTIVE:To survey parents' experience and wishes for information in connection with their child's radiographic ...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s00247-018-4300-z
更新日期:2019-02-01 00:00:00
abstract::Radiologically visible calcification in the wall of a uriniferous perirenal pseudocyst is rare. This unusual finding was seen in a newborn infant who was found to have a left flank mass on the first day of life. When perirenal pseudocysts occur in infants, they are usually caused by congenital obstructive lesions of t...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/BF00973970
更新日期:1980-01-01 00:00:00
abstract:: ...
journal_title:Pediatric radiology
pub_type: 评论,杂志文章
doi:10.1007/s00247-018-4248-z
更新日期:2018-11-01 00:00:00
abstract::Mid-cervical kyphosis in diastrophic dysplasia (DD) with cord compression and weakness has been recognized for the last three decades. A strikingly similar situation exists in Larsen's syndrome (LS), an otherwise unrelated problem of weakness with lay joints and dislocations with typical facies. Forty patients with DD...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/BF02010328
更新日期:1995-01-01 00:00:00
abstract::There are few descriptions of the magnetic resonance (MR) appearance of hyperfunctioning adrenocortical tumours, particularly those occurring in childhood. We studied five patients, two girls and three boys, aged 6-14.3 years, presenting with clinical syndromes of adrenocortical hyperfunction. The diagnoses were Cushi...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/BF01396204
更新日期:1996-11-01 00:00:00
abstract::Necrotizing enterocolitis (NEC) is associated with considerable morbidity and mortality in infants. The diagnosis relies heavily upon radiographic and clinical features. Failure to accurately diagnose NEC is associated with a risk of complications and death, however overdiagnosis also causes both morbidity and mortali...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/BF02395755
更新日期:1988-01-01 00:00:00
abstract::Developmental stenosis of the cervical spine results in a reduction of the caliber of the cervical spinal canal that is greatest in the anteroposterior dimensions. This usually becomes symptomatic in adults when a myelopathy may result from compression of the cervical cord by small osteophytes or by hyperextension inj...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/BF02388241
更新日期:1987-01-01 00:00:00
abstract:BACKGROUND:Dual-energy absorptiometry (DXA) is the current reference standard for assessing pediatric osteoporosis; however due to its areal nature, it has limitations. Thus, quantitative ultrasound (QUS), a modality free of ionizing radiation, has been proposed as a potential surrogate for DXA. OBJECTIVE:To semi-quan...
journal_title:Pediatric radiology
pub_type: 杂志文章,评审
doi:10.1007/s00247-014-3041-x
更新日期:2014-12-01 00:00:00
abstract::This report describes a case of ectopic intra-thoracic kidney, in which there was delayed appearance of this condition after a documented prior normal chest film. ...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/BF02343442
更新日期:1984-01-01 00:00:00
abstract::The congenital subglottic hemangioma typically appears as an asymmetric subglottic narrowing or mass on frontal neck radiographs. Therefore, soft tissue neck radiography has been advocated as a definitive non-operative approach for diagnosing these lesions. However, we have noted similar asymmetric subglottic narrowin...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/BF02388997
更新日期:1988-01-01 00:00:00
abstract::In a group of 70 premature and newborn infants, treated with artificial ventilation, 24.3% developed bronchopulmonary dysplasia (BPD). Only in a very few cases did the typical radiological stages, as described by Northway, succeed each other in a chronological order. It is impossible to differentiate BPD stage I or II...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/BF00973978
更新日期:1977-03-17 00:00:00
abstract::Ligamentous injuries of the pediatric wrist, once thought to be relatively uncommon, are increasingly recognized in the context of acute high-energy mechanism trauma and chronic axial loading, including those encountered in both recreational and high-performance competitive sports. Recent advances in MR-based techniqu...
journal_title:Pediatric radiology
pub_type: 杂志文章,评审
doi:10.1007/s00247-018-4111-2
更新日期:2018-06-01 00:00:00
abstract::Alongside recent advances in treatment strategies for juvenile idiopathic arthritis (JIA), paediatric rheumatologists have taken increasing interest in the use of imaging. Magnetic resonance imaging (MRI) and musculoskeletal ultrasound, by providing more detailed information on disease activity than clinical examinati...
journal_title:Pediatric radiology
pub_type: 杂志文章,评审
doi:10.1007/s00247-017-4014-7
更新日期:2018-06-01 00:00:00
abstract::During a 4-year period 9 out of 35 patients deteriorated following a contrast enema after necrotising enterocolitis (NEC). Two developed Klebsiella septicaemia with one subsequent death. Following the latter two cases the paediatric surgeons instituted intravenous prophylactic antibiotics (benzyl penicillin, metronida...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/BF02015352
更新日期:1992-01-01 00:00:00
abstract::Neuroblastomas are the most common extracranial solid malignancy in children. In contrast, salivary gland tumors are uncommon in children, accounting for only 1% of all pediatric neoplasms. Parotid metastases are rare; only two cases of parotid metastases from neuroblastomas have been reported with an emphasis on the ...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s00247-010-1750-3
更新日期:2010-12-01 00:00:00
abstract::A 15-year-old boy with caecal haematoma required a right hemicolectomy due to development of small bowel obstruction and near caecal perforation having presented several days after an episode of minor trauma. The position of the caecum between intraperitoneal and extraperitoneal bowel requires special treatment consid...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s00247-013-2754-6
更新日期:2014-01-01 00:00:00
abstract::Antenatal detection of mesoblastic nephroma by US is possible. Reviewing the literature, we found 19 previously reported cases, only 1 of which underwent prenatal MRI. We present a further case diagnosed by US and confirmed with MRI. The imaging findings and differential diagnoses are discussed. Early and correct dete...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s002470050033
更新日期:2000-03-01 00:00:00
abstract:BACKGROUND:Knowledge of the synovial and tenosynovial appearance of the clinically non-arthritic symptomatic juvenile wrist using contrast-enhanced magnetic resonance imaging (MRI) is sparse. OBJECTIVES:To analyze contrast-enhanced MRI findings of the clinically non-inflamed symptomatic pediatric wrist, focusing on th...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s00247-020-04739-5
更新日期:2020-09-01 00:00:00
abstract::We describe the previously unreported finding of ossification within a rhabdomyosarcoma of the extremity in the absence of bone destruction. Rhabdomyosarcoma is a highly malignant tumor but could not be radiographically differentiated from benign or other malignant causes of soft-tissue masses containing calcium. Defi...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/BF00971789
更新日期:1981-01-01 00:00:00
abstract::An unusual case is presented of a vascular ring due to a right arch with mirror-image branching and a left ligamentum arteriosum from the descending aorta to the left pulmonary artery. There have been only four previous reports of this rare arch anomaly. In addition, the patient had no underlying congenital heart lesi...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/BF02019065
更新日期:1995-01-01 00:00:00