Abstract：
BACKGROUND:Optic pathway gliomas (OPGs) are common pediatric brain tumors that pose significant clinical challenges with regard to predicting which tumors are likely to become symptomatic and require treatment. These tumors can arise sporadically or in the context of the inherited cancer predisposition syndrome neurofibromatosis type 1 (NF1). Few studies have suggested biological or imaging markers that predict the clinical course of this disease. OBJECTIVE:In this cross-sectional study, we hypothesized that the clinical behavior of OPGs in children can be differentiated by diffusion-weighted (DW) and dynamic contrast-enhanced (DCE) MRI. MATERIALS AND METHODS:A total of 27 children with OPG were studied using DW and DCE MRI protocols. Diffusivity and permeability were calculated and correlated with the clinical behavior the OPG. RESULTS:Mean diffusivity values of 1.39 microm2/ms and mean permeability values of 2.10 ml/min per 100 cm3 of tissue were measured. Clinically aggressive OPGs had significantly higher mean permeability values (P = 0.05) than clinically stable tumors. In addition, there was a strong correlation between clinical aggressiveness and the absence of NF1 (P < 0.01). CONCLUSION:These results suggest that DCE MRI might be a useful biomarker for clinically aggressive OPG, which should be confirmed in larger prospective longitudinal studies.
journal_name
Pediatr Radioljournal_title
Pediatric radiologyauthors
Jost SC,Ackerman JW,Garbow JR,Manwaring LP,Gutmann DH,McKinstry RCdoi
10.1007/s00247-008-1003-xsubject
Has Abstractpub_date
2008-12-01 00:00:00pages
1293-9issue
12eissn
0301-0449issn
1432-1998journal_volume
38pub_type
杂志文章abstract：:The hypothesis that the normal distribution of relative heart volume in the neonatal period is a mixture of two different populations, with different means and variances, has been tested. The definition of the two populations was (i) normally patent ductus and (ii) closed ductus arteriosus. The assumed frequencies of ...
journal_title：Pediatric radiology
pub_type： 杂志文章
doi：10.1007/BF00973155
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abstract：:A patient with Down syndrome is presented who had hypospadias, a large low implanted prostatic utricle, and refluxing ejaculatory ducts entering the utricle. ...
journal_title：Pediatric radiology
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abstract：:Thirteen newborns with lethal short rib-polydactyly (SRP) have been reviewed, 11 with SRP type III (Verma-Naumoff) and 2 with SRP type II (Majewski). In the former group there were three sets of siblings. The excess of males with SRP type III (Verma-Naumoff) is confirmed in this present study. A high frequency of phen...
journal_title：Pediatric radiology
pub_type： 杂志文章
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abstract：BACKGROUND:Prader orchidometry has been the standard method for evaluating testicular size. As this technique is subjective and tends to overestimate the testicular volume, ultrasound (US) has been proposed as more reliable. OBJECTIVE:To evaluate the intra- and interobserver agreement of US measurements of testicular ...
journal_title：Pediatric radiology
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journal_title：Pediatric radiology
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doi：10.1007/BF02010628
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journal_title：Pediatric radiology
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journal_title：Pediatric radiology
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journal_title：Pediatric radiology
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journal_title：Pediatric radiology
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journal_title：Pediatric radiology
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abstract：:Lap belt restraints in motor vehicle collisions have been associated with a variety of injuries, mainly bowel and lumbar spine. Cephalad positioning of the belt over the intended position across the anterior superior iliac spines (which typically occurs in younger children) is thought to be responsible for the observe...
journal_title：Pediatric radiology
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journal_title：Pediatric radiology
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journal_title：Pediatric radiology
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更新日期：1983-01-01 00:00:00
abstract：:Infantile metastatic choriocarcinoma is a rare tumor of placental origin that can be observed with or without maternal metastases. A single cutaneous mass may be the only clinically observed sign. Reports of imaging findings are scarce given the extreme rarity of the tumor, and the disease can be rapidly fatal in the ...
journal_title：Pediatric radiology
pub_type： 杂志文章
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更新日期：2018-08-01 00:00:00
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journal_title：Pediatric radiology
pub_type： 杂志文章
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更新日期：1996-12-01 00:00:00
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journal_title：Pediatric radiology
pub_type： 杂志文章
doi：10.1007/s00247-011-2189-x
更新日期：2012-03-01 00:00:00
abstract：BACKGROUND:Knowledge of the synovial and tenosynovial appearance of the clinically non-arthritic symptomatic juvenile wrist using contrast-enhanced magnetic resonance imaging (MRI) is sparse. OBJECTIVES:To analyze contrast-enhanced MRI findings of the clinically non-inflamed symptomatic pediatric wrist, focusing on th...
journal_title：Pediatric radiology
pub_type： 杂志文章
doi：10.1007/s00247-020-04739-5
更新日期：2020-09-01 00:00:00
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journal_title：Pediatric radiology
pub_type： 杂志文章
doi：10.1007/s00247-010-1749-9
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journal_title：Pediatric radiology
pub_type： 杂志文章,评审
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journal_title：Pediatric radiology
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journal_title：Pediatric radiology
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journal_title：Pediatric radiology
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journal_title：Pediatric radiology
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journal_title：Pediatric radiology
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journal_title：Pediatric radiology
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