Distribution of neurons expressing calcitonin gene-related peptide mRNAs in the brain stem, spinal cord and dorsal root ganglia of rat and guinea-pig.

abstract：:The course of the ascending pathways originating from the anterior gustatory and posterior visceral sensory part of the solitary tract nucleus and the topographic organization of the projections to the hypothalamus in the rat were studied with anterogradely transported Phaseolus vulgaris lectin. In general, the poster...

journal_title：Neuroscience

authors： Ter Horst GJ,de Boer P,Luiten PG,van Willigen JD

更新日期：1989-01-01 00:00:00

abstract：:In addition to triggering vasoconstriction of peripheral blood vessels, which led to its discovery as a circulating neurohormone 50 years ago, serotonin (5-hydroxytryptamine) acts as a neurotransmitter/ modulator in the central nervous system and regulates local cerebral blood flow and vascular permeability through di...

journal_title：Neuroscience

authors： Riad M,Tong XK,el Mestikawy S,Hamon M,Hamel E,Descarries L

更新日期：1998-10-01 00:00:00

abstract：:Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) and its receptor Fibroblast growth factor-inducible 14 (Fn14) are expressed in neurons. Here we demonstrate that TWEAK induces a dose-dependent increase in neuronal death and that this effect is independent of tumor necrosis factor alpha (TNF-α) and mediated...

journal_title：Neuroscience

authors： Haile WB,Echeverry R,Wu F,Guzman J,An J,Wu J,Yepes M

更新日期：2010-12-29 00:00:00

abstract：:The striatum, which processes cortical information for behavioral output, is a key target of Huntington's disease (HD), an autosomal dominant condition characterized by cognitive decline and progressive loss of motor control. Increasing evidence implicates deficient glutamate uptake caused by a down-regulation of GLT1...

journal_title：Neuroscience

authors： Miller BR,Dorner JL,Shou M,Sari Y,Barton SJ,Sengelaub DR,Kennedy RT,Rebec GV

更新日期：2008-04-22 00:00:00

abstract：:Using spinal cord and dorsal root ganglion cell cultures, we have studied the immuno-histochemical distribution of several peptide products of the dynorphin gene. With antibody directed toward the midregion of dynorphin A, peptide-immunoreactivity was found exclusively in the cell bodies of spinal cord neurons. Antibo...

journal_title：Neuroscience

authors： Sweetnam PM,Wrathall JR,Neale JH

更新日期：1986-08-01 00:00:00

abstract：:The enteric nervous system plays an integral role in the gastrointestinal tract. Within this intricate network, enteric glia are crucial in the maintenance of normal bowel function, yet their signaling mechanisms are poorly understood. Enteric glia, and not enteric neurons, selectively responded to lysophosphatidic ac...

journal_title：Neuroscience

authors： Segura BJ,Zhang W,Cowles RA,Xiao L,Lin TR,Logsdon C,Mulholland MW

更新日期：2004-01-01 00:00:00

abstract：:Nociception is the neuronal process of encoding noxious stimuli and could be modulated at peripheral, spinal, brainstem, and cortical levels. At cortical levels, several areas including the anterior cingulate cortex (ACC), prefrontal cortex (PFC), ventrolateral orbital cortex (VLO), insular cortex (IC), motor cortex (...

journal_title：Neuroscience

authors： Gamal-Eltrabily M,Martínez-Lorenzana G,González-Hernández A,Condés-Lara M

更新日期：2021-01-17 00:00:00

abstract：:The 5-HT(6) receptor is predominantly expressed in the CNS and has been implicated in the regulation of cognitive function. Antagonists of the 5-HT(6) receptor improve cognitive performance in a number of preclinical models and have recently been found to be effective in Alzheimer's disease patients. Systemic administ...

journal_title：Neuroscience

authors： West PJ,Marcy VR,Marino MJ,Schaffhauser H

更新日期：2009-12-01 00:00:00

abstract：:Our light and electron microscopic studies (Seress L., Nitsch R. and Leranth C. (1993) Neuroscience 55, 775-796.) indicated that in the hippocampus of the African Green monkey, calretinin is exclusively present in non-pyramidal cells. Calretinin-positive axons formed a prominent band at the border of the dentate molec...

journal_title：Neuroscience

authors： Nitsch R,Leranth C

更新日期：1993-08-01 00:00:00

abstract：:Brain bioenergetic abnormalities in mood disorders were detected by neuroimaging in vivo studies in humans. Because of the increasing importance of mitochondrial pathogenetic hypothesis of Depression, in this study the effects of sub-chronic treatment (21days) with desipramine (15mg/kg) and fluoxetine (10mg/kg) were e...

journal_title：Neuroscience

authors： Villa RF,Ferrari F,Gorini A,Brunello N,Tascedda F

更新日期：2016-08-25 00:00:00

abstract：:Field and intracellular potentials were recorded from CA1 pyramidal stratum in submerged slices (at 33 degrees). During "normal" oxygenation (95% O2 + 5% CO2), tonic depression of population spikes and field excitatory postsynaptic potentials by endogenous adenosine was demonstrated by (i) the marked enhancement by th...

journal_title：Neuroscience

authors： Zhu PJ,Krnjević K

更新日期：1994-11-01 00:00:00

abstract：:Metabotropic glutamate receptors are a major class of excitatory amino acid receptors. Eight metabotropic glutamate receptor subtypes have been cloned, and are classified into three groups (I, II and III) based on amino acid sequence identity, effector systems and pharmacological profile. Previous results have shown t...

journal_title：Neuroscience

authors： Kearney JA,Albin RL

更新日期：2000-01-01 00:00:00

abstract：:The dorsal hippocampus (DH) is a structure of the limbic system that is involved in emotional, learning and memory processes. There is evidence indicating that the DH modulates cardiovascular correlates of behavioral responses to stressful stimuli. Acute restraint stress (RS) is an unavoidable stress situation that ev...

journal_title：Neuroscience

authors： Moraes-Neto TB,Scopinho AA,Biojone C,Corrêa FM,Resstel LB

更新日期：2014-01-31 00:00:00

abstract：:The pontine micturition center or Barrington's nucleus (BN) - besides regulating micturition - co-regulates the activity of other pelvic viscera such as the colon and genitals. At present, this issue is gaining particular importance due to: (i) recent findings of α-synuclein in BN, (ii) known urinary dysfunction in pa...

journal_title：Neuroscience

authors： Blanco L,Ros CM,Tarragón E,Fernández-Villalba E,Herrero MT

更新日期：2014-04-25 00:00:00

abstract：:A variety of postmortem brain studies and clinical investigations have provided evidence that reduced serotonin neurotransmission is associated with suicidal behavior and depression, and several serotonergic parameters have been found to be altered in the prefrontal cortex of suicide victims. However, the integrity of...

journal_title：Neuroscience

authors： Austin MC,Whitehead RE,Edgar CL,Janosky JE,Lewis DA

更新日期：2002-01-01 00:00:00

abstract：:Inflammation is an important event in ischemic injury. These immune responses begin with the expression of pro-inflammatory genes modulating transcription factors, such as nuclear factor-κB (NF-κB), activator protein-1 (AP-1), and signal transducers and activator of transcription-1 (STAT-1). The 70-kDa heat shock prot...

journal_title：Neuroscience

authors： Kim JY,Yenari MA,Lee JE

更新日期：2015-02-12 00:00:00

abstract：:Intracellular microelectrode recordings were used to examine the effects of the potassium channel blockers: 4-aminopyridine, a selective blocker of fast potassium conductances gKf1 and gKf2,13 and tetraethylammonium, a blocker of gKf1, gKf2 and the slow conductance gKs,13 on the repetitive activity of large myelinated...

journal_title：Neuroscience

authors： Poulter MO,Padjen AL

更新日期：1995-09-01 00:00:00

abstract：:Adolescence is a time of continued brain maturation, particularly in limbic and cortical regions, which undoubtedly plays a role in the physiological and emotional changes coincident with adolescence. An emerging line of research has indicated that stressors experienced during this crucial developmental stage may affe...

journal_title：Neuroscience

authors： Eiland L,Romeo RD

更新日期：2013-09-26 00:00:00

abstract：:Studies in experimental animals have revealed important roles of neuroactive steroids in the control of central nervous system functions during physiological and pathological conditions, suggesting that they may represent good candidates for the development of neuroprotective strategies for neurodegenerative and psych...

journal_title：Neuroscience

authors： Melcangi RC,Panzica G,Garcia-Segura LM

更新日期：2011-09-15 00:00:00

abstract：:The bladder and distal colon are innervated by lumbar splanchnic (LSN) and pelvic nerves (PN) whose axons arise from dorsal root ganglia (DRG) neurons at thoracolumbar (TL) and lumbosacral (LS) spinal levels, respectively. In an attempt to understand the molecular basis of differences between LSN and PN mechanosensiti...

journal_title：Neuroscience

authors： La JH,Schwartz ES,Gebhart GF

更新日期：2011-07-14 00:00:00

abstract：:The distribution of axoplasmic organelles at consecutive nodes of Ranvier was investigated light- and electronmicroscopically in horseradish peroxidase-transporting muscle nerve fibres of the adult cat. Three main and apparently temporally interrelated distribution patterns were noted. These patterns were referred to ...

journal_title：Neuroscience

authors： Berthold CH,Mellström A

更新日期：1986-12-01 00:00:00

abstract：:The motor output of hypoglossal motoneurons to tongue muscles takes place in concert with the respiratory rhythm and is determined by the balance between excitatory glutamatergic transmission and inhibitory transmission mediated by glycine or GABA. The relative contribution by these transmitters is a phasic phenomenon...

journal_title：Neuroscience

authors： Pagnotta SE,Lape R,Quitadamo C,Nistri A

更新日期：2005-01-01 00:00:00

abstract：:Free radicals have been implicated in a number of pathological conditions. To evaluate the neurophysiological consequences of free radical exposure, slices of hippocampus isolated from guinea-pigs were exposed to hydrogen peroxide which reacts with tissue iron to generate hydroxyl free radicals. Long-term potentiation...

journal_title：Neuroscience

authors： Pellmar TC,Hollinden GE,Sarvey JM

更新日期：1991-01-01 00:00:00

abstract：:Repetitive transcranial magnetic stimulation (rTMS) is an established technique that can modulate excitability of the motor cortex and corticospinal tract, beyond the duration of the stimulation itself. More recently, a newer repetitive technique, known as I-wave periodicity TMS (iTMS) has been purported to show incre...

journal_title：Neuroscience

authors： Kidgell DJ,Mason J,Frazer A,Pearce AJ

更新日期：2016-05-13 00:00:00

abstract：:Leptin microinjections into the nucleus of the solitary tract (NTS) have been shown to elicit sympathoexcitatory responses, and potentiate the cardiovascular responses to activation of the chemoreflex. In this study, experiments were done in Sprague-Dawley rats initially to provide a detailed mapping within the NTS co...

journal_title：Neuroscience

authors： Ciriello J,Moreau JM

更新日期：2013-01-15 00:00:00

abstract：:The host response to neural injury, which can include axonal sprouting and synaptic reorganization is likely to be under tight genetic regulatory control at the level of the genome and may be implicated in epileptogenesis. Despite its importance, however, the molecular basis of synaptic reorganization is unclear. We h...

journal_title：Neuroscience

authors： Yang J,Houk B,Shah J,Hauser KF,Luo Y,Smith G,Schauwecker E,Barnes GN

更新日期：2005-01-01 00:00:00

abstract：:Peripheral neuropathy represents an important complication of diabetes involving a spectrum of structural, functional and biochemical alterations in peripheral nerves. Recent observations obtained in our laboratory have shown that the levels of neuroactive steroids present in the sciatic nerve of rat raised diabetic b...

journal_title：Neuroscience

authors： Giatti S,Pesaresi M,Cavaletti G,Bianchi R,Carozzi V,Lombardi R,Maschi O,Lauria G,Garcia-Segura LM,Caruso D,Melcangi RC

更新日期：2009-12-01 00:00:00

abstract：:Our working hypothesis is that brain neurotrophins and brain Na(+),K(+)-ATPase may be strongly associated with the occurrence of depression in animals subjected to chronic unpredictable mild stress (CUMS). Still, we believe that chrysin, a natural and bioactive flavonoid found in honey and some plants, can provide sat...

journal_title：Neuroscience

authors： Filho CB,Jesse CR,Donato F,Giacomeli R,Del Fabbro L,da Silva Antunes M,de Gomes MG,Goes AT,Boeira SP,Prigol M,Souza LC

更新日期：2015-03-19 00:00:00

abstract：:Studies were made on the effect of the neuroexcitatory agent kainic acid, microinjected into raphe dorsal nucleus by glass micropipette and an air pressure system in doses ranging from 0.2 to 24.0 nmol (in volumes from 0.05 microliter to 0.47 microliter), on the somatosensory evoked potentials and their cycles of reco...

journal_title：Neuroscience

authors： Moyanova S,Dimov S,Ivanova A

更新日期：1987-07-01 00:00:00

abstract：:The possible irreversible blockade of 5-hydroxytryptamine1 receptor subtypes 5-hydroxytryptamine1A, 5-hydroxytryptamine1B/5-hydroxytryptamine1D and 5-hydroxytryptamine1C by the chloramine 8-methoxy-2-(N-2'-chloropropyl,N-propyl)aminotetralin (8-MeO-2'-chloro-PAT) was investigated in rat brain sections by quantitative ...

journal_title：Neuroscience

authors： Radja F,Daval G,Emerit MB,Gallissot MC,Hamon M,Vergé D

更新日期：1989-01-01 00:00:00