Brodalumab for the treatment of psoriasis.

abstract：:Cancer patients may develop paraneoplastic neurological conditions associated with autoantibodies directed against neural or neuromuscular tissues. These syndromes are frequently manifested in advance of the cancer presentation by several months or years necessitating a detailed and expensive investigation to search f...

journal_title：Expert review of clinical immunology

authors： Sioka C,Fotopoulos A,Kyritsis AP

更新日期：2014-05-01 00:00:00

abstract：:Lung fibrosis is a devastating disease that involves a variable degree of inflammation, alveolar epithelial injury, fibroblast hyperplasia and the deposition of extracellular matrix. Standard therapies that consist of corticosteroids and immunosuppressive agents offer little benefit and most patients experience a prog...

journal_title：Expert review of clinical immunology

authors： Moore BB,Peters-Golden M

更新日期：2006-01-01 00:00:00

abstract：:Ovarian cancer is the leading cause of death from gynecologic malignancy in the United States. While the treatment options have improved with conventional cytotoxic chemotherapy and advanced surgical techniques, disease recurrence is common and fatal in nearly all cases. Current evidence suggests that the immune syste...

journal_title：Expert review of clinical immunology

authors： Menderes G,Schwab CL,Black J,Santin AD

更新日期：2016-06-01 00:00:00

abstract：:Epidemiological and clinical studies have suggested that the pathogenesis of inflammatory bowel disease (IBD) is strongly influenced by genetic predisposition. Beyond the limitations of linkage analysis, multiple genome-wide association studies, their meta-analyses, and targeted genotyping array techniques have broade...

journal_title：Expert review of clinical immunology

authors： Ye BD,McGovern DP

更新日期：2016-10-01 00:00:00

abstract：:Pigs are currently the preferred species for future organ xenotransplantation. With advances in the development of genetically modified pigs, clinical xenotransplantation is becoming closer to reality. In preclinical studies (pig-to-nonhuman primate), the xenotransplantation of livers from pigs transgenic for human CD...

journal_title：Expert review of clinical immunology

authors： Ekser B,Burlak C,Waldman JP,Lutz AJ,Paris LL,Veroux M,Robson SC,Rees MA,Ayares D,Gridelli B,Tector AJ,Cooper DK

更新日期：2012-09-01 00:00:00

abstract：:The past decade has been an exciting period for clinical research and patient care in rheumatoid arthritis. This is mostly due to targeted biologic agents that have changed the outcome of this disease. Certolizumab pegol (Cimzia(®), UCB Inc., GA, USA), which targets TNF-α with a different mechanism of action than wide...

journal_title：Expert review of clinical immunology

authors： Patel AM,Moreland LW

更新日期：2010-11-01 00:00:00

abstract：INTRODUCTION:The transcription factors signal transducer and activator of transcription (STAT) 1 and STAT3 fulfill fundamental functions in nonimmune and immune cells. The description and follow-up of patients with germline mutations that result in either loss-of-function or gain-of-function have contributed to our und...

journal_title：Expert review of clinical immunology

authors： Olbrich P,Freeman AF

更新日期：2018-12-01 00:00:00

abstract：:Patients with sarcoidosis can be subgrouped according to organ engagement and clinical manifestations. One such subgroup is Löfgren's syndrome (LS), constituting a distinct group of sarcoidosis patients with typical clinical manifestations, separate genetic associations and an immune response that seems to differ from...

journal_title：Expert review of clinical immunology

authors： Grunewald J

更新日期：2012-01-01 00:00:00

abstract：:Animal models and clinical studies of asthma have generated important insights into the first effector phase leading to the development of allergic airway disease and bronchial hyper-reactivity. In contrast, mechanisms related to asthma chronicity or persistence are less well understood. The CD4(+) T-helper 2 lymphocy...

journal_title：Expert review of clinical immunology

authors： Aronica MA,Vogel N

更新日期：2005-11-01 00:00:00

abstract：:Metabolic syndrome is a highly atherogenic state in which hyperglycemia, dyslipidemia and hypertension cluster in one individual. Intra-abdominal visceral fat accumulation plays a key role in the development of these disorders and the occurrence of metabolic syndrome. We have investigated adipocyte functions intensive...

journal_title：Expert review of clinical immunology

authors： Matsuzawa Y

更新日期：2007-01-01 00:00:00

abstract：:Glucocorticoids are indispensable for the treatment of systemic inflammatory diseases such as rheumatoid arthritis (RA), though their beneficial effects have to be balanced with potential complications arising from high doses, prolonged use or dose splitting. A glucocorticoid formulation (modified-release prednisone) ...

journal_title：Expert review of clinical immunology

authors： Alten R

更新日期：2012-02-01 00:00:00

abstract：:The measuring tools for disease activity of rheumatoid arthritis have long been adapted for assessing the disease activity of psoriatic arthritis (PsA), particularly as regards peripheral arthritis. However, because of the multifactorial aspects and multiple domains of PsA, such as axial and peripheral joints, skin an...

journal_title：Expert review of clinical immunology

authors： Her M,Kavanaugh A

更新日期：2014-09-01 00:00:00

abstract：:Chronic activation of immune responses, mediated by inflammatory mediators and involving different effector cells of the innate and acquired immune system characterizes autoimmune disorders, such as rheumatoid arthritis, inflammatory bowel disease, psoriasis and septic shock syndrome. MAPKs are crucial intracellular m...

journal_title：Expert review of clinical immunology

authors： Kaminska B,Swiatek-Machado K

更新日期：2008-01-01 00:00:00

abstract：INTRODUCTION:Despite the emergence of newer immunomodulating agents for systemic lupus erythematosus (SLE), a substantial proportion of patients still do not respond optimally. While the mechanisms for the differential responses to drug therapy are unclear, variation in drug exposure with the same dosing protocol relat...

journal_title：Expert review of clinical immunology

authors： Mok CC

更新日期：2017-01-01 00:00:00

abstract：INTRODUCTION:CD40 ligand (CD40L) deficiency or X-linked Hyper-IgM syndrome is a severe primary immunodeficiency caused by mutations in the CD40L gene. Despite currently available treatments, CD40L-deficient patients remain susceptible to life-threatening infections and have poor long term survival. Areas covered: Here,...

journal_title：Expert review of clinical immunology

authors： França TT,Barreiros LA,Al-Ramadi BK,Ochs HD,Cabral-Marques O,Condino-Neto A

更新日期：2019-05-01 00:00:00

abstract：:Idealized gene therapy of autoimmune diseases would mean getting the right drug to the right place at the right time to affect the right mechanism of action. In other words, a specific gene therapy strategy needs to have functional, spatial and temporal specificity. Functional specificity implies targeting the cellula...

journal_title：Expert review of clinical immunology

authors： Creusot RJ,Fathman CG,Müller-Ladner U,Tarner IH

更新日期：2005-09-01 00:00:00

abstract：INTRODUCTION:Prediction of treatment outcome and clinical relapse in patients with inflammatory bowel disease (IBD), either ulcerative colitis (UC) or Crohn's disease (CD), is particularly important because therapeutics for IBD are not always effective and patients in remission could frequently relapse. Because undergo...

journal_title：Expert review of clinical immunology

authors： Kato J,Yoshida T,Hiraoka S

更新日期：2019-06-01 00:00:00

abstract：:Atherosclerosis is the major cause of cardiovascular disease (CVD), which represents the major cause of death. During recent years, it has become clear that atherosclerosis is a chronic inflammatory condition where immunity could play an important role. Usually, it is when atherosclerotic plaques rupture that CVD foll...

journal_title：Expert review of clinical immunology

authors： Frostegård J

更新日期：2015-02-01 00:00:00

abstract：:Introduction: For late stage organ failure patients, transplantation is the best option to increase life expectancy with a superior quality of life. Unfortunately, after transplantation many patients are at risk of cellular and antibody-mediated rejection (ABMR). The latter is initiated by donor specific antibodies (D...

journal_title：Expert review of clinical immunology

authors： Niu Q,Kraaijeveld R,Li Y,Mendoza Rojas A,Shi Y,Wang L,Van Besouw NM,Baan CC

更新日期：2019-12-01 00:00:00

abstract：:Evaluation of: Tseng CE, Buyon JP, Kim M et al. The effect of moderate-dose corticosteroids in preventing severe flares in patients with serologically active, but clinically stable, systemic lupus erythematosus: findings of a prospective, randomized, double-blind, placebo-controlled trial. Arthritis Rheum. 54, 3623-36...

journal_title：Expert review of clinical immunology

authors： Cardiel MH,Almagro RM

更新日期：2007-05-01 00:00:00

abstract：:The use of antibiotics to treat pathogenic bacterial infections has been one of the greatest contributions to human health, yet antibiotic use also perturbs the communities of commensal and symbiotic bacteria that reside in the intestine of mammals. The microbiota are critical for normal immune development and for mai...

journal_title：Expert review of clinical immunology

authors： Reynolds LA,Finlay BB

更新日期：2013-11-01 00:00:00

abstract：:Giant cell arteritis is a complex immune-mediated disease that involves large blood vessels in individuals older than 50 years. Recent studies have confirmed a strong association of this form of vasculitis with the HLA region, particularly with HLA class II genes. However, other non-HLA loci, such as protein tyrosine ...

journal_title：Expert review of clinical immunology

authors： Carmona FD,Martín J,González-Gay MA

更新日期：2016-01-01 00:00:00

abstract：:Leptospirosis is re-emerging as a worldwide zoonosis and is caused by bacteria of the genus Leptospira. Human leptospirosis is associated with high temperature and humidity. Laboratory tests are indispensible for the early diagnosis and proper disease management. The demand for suitable leptospirosis point-of-care dia...

journal_title：Expert review of clinical immunology

authors： Schreier S,Doungchawee G,Chadsuthi S,Triampo D,Triampo W

更新日期：2013-03-01 00:00:00

abstract：:Introduction: The present status of amifampridine (AFP) for the treatment of Lambert-Eaton myasthenic syndrome (LEMS) is reviewed. Areas covered: All relevant literature identified through a PubMed search under treatment of LEMS, aminopyridine, and amifampridine are reviewed. An expert opinion on AFP was formulated. E...

journal_title：Expert review of clinical immunology

authors： Oh SJ

更新日期：2019-10-01 00:00:00

abstract：:Since its introduction to the antirejection armamentarium in 1994, tacrolimus has become the workhorse of transplant professionals for avoidance of solid organ transplant rejection. Not only does tacrolimus have potent immunosuppressive qualities that prevent rejection, but dosing is straight forward and it is general...

journal_title：Expert review of clinical immunology

authors： Scalea JR,Levi ST,Ally W,Brayman KL

更新日期：2016-01-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is a chronic inflammatory systemic disease characterized by symmetric arthritis leading to progressive erosion of cartilage and bone. Psoriatic arthritis and ankylosing spondylitis are also inflammatory arthritides that belong to the spondyloarthritides. Disease-modifying anti-rheumatic drugs...

journal_title：Expert review of clinical immunology

authors： Voulgari PV

更新日期：2010-09-01 00:00:00

abstract：:There is wide variability in the epidemiology and management of childhood asthma and related atopic diseases globally. Urbanized, affluent Western countries tend to have a higher prevalence of these diseases compared with Asian nations. However, recent studies have shown that the prevalence in Asia is increasing, alth...

journal_title：Expert review of clinical immunology

authors： Gerez IF,Lee BW,van Bever HP,Shek LP

更新日期：2010-03-01 00:00:00

abstract：:Naturally occurring CD4(+)CD25(+) regulatory T cells (Tregs) expressing forkhead transcript factor box P3 have been established as a key regulator for the control of autoimmunity. A growing body of experiments in animal models has provided compelling evidence that the adoptive transfer of CD4(+)CD25(+) Tregs can cure ...

journal_title：Expert review of clinical immunology

authors： Jiang S,Lechler RI,Lombardi G

更新日期：2006-05-01 00:00:00

abstract：OBJECTIVES:Methylation pattern of gene modification is essential for the differentiation of T regulatory cells (Tregs) and 5-Aza-2'-deoxycytidine is a common inhibitor of methylation. This study aimed to investigate the potential effects of Treg polarizing conditions and 5-Aza-2'-deoxycytidine treatment in the differen...

journal_title：Expert review of clinical immunology

authors： Fang Y,Yuan XD,Liu HH,Xiang L,Chen LM,Fan YC,Gao S,Wang K

更新日期：2021-01-13 00:00:00

abstract：:Respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), are a major health burden on society and current treatment modalities for these diseases have not significantly changed over the past 40 years. The only major pharmacological advancement for the treatment of these diseases has been ...

journal_title：Expert review of clinical immunology

authors： Venkatasamy R,Spina D

更新日期：2007-05-01 00:00:00