Abstract：
:Despite the huge health and economic burden of migraine headache, few medications have been approved for its prophylactic treatment, most of which can potentially induce serious adverse effects. Coenzyme Q10 (CoQ10) is a supplement and has shown preliminary benefits in migraine prophylaxis. We aimed to assess this effect in an adult population. This is an open-label, parallel, add-on, match-controlled trial. Eighty patients diagnosed with migraine headache based on International Headache Society criteria were allocated to receiving only their current preventive drugs or their current preventive drugs plus 100 mg CoQ10 daily, matching for their baseline characteristics, and were assessed for frequency and severity of attacks, and ≥50 % reduction in attack frequency per month. Thirty-six and 37 patients were analyzed in CoQ10 and control groups, respectively. Number of attacks per month dropped significantly in the CoQ10 group (mean decrease: 1.6 vs. 0.5 among CoQ10 and control groups, respectively, p < 0.001). A significant reduction was also evident in the severity of headaches (mean decrease: 2.3 vs. 0.6 among CoQ10 and control groups, respectively, p < 0.001). For ≥50 % reduction in the frequency of attacks per month, the number needed to treat was calculated as 1.6. No side effects for CoQ10 were observed. This study suggests that CoQ10 might reduce the frequency of headaches, and may also make them shorter in duration, and less severe, with a favorable safety profile.
journal_name
Acta Neurol Belgjournal_title
Acta neurologica Belgicaauthors
Shoeibi A,Olfati N,Soltani Sabi M,Salehi M,Mali S,Akbari Oryani Mdoi
10.1007/s13760-016-0697-zsubject
Has Abstractpub_date
2017-03-01 00:00:00pages
103-109issue
1eissn
0300-9009issn
2240-2993pii
10.1007/s13760-016-0697-zjournal_volume
117pub_type
临床试验,杂志文章abstract：:Migraine headaches are common in children. Early diagnosis and appropriate interventions are mandatory to prevent decades of suffering and diminished quality of life. There is need for data regarding the efficacy and safety of prophylactic agents in children with migraine; therefore, we designed a randomized clinical ...
journal_title：Acta neurologica Belgica
pub_type： 杂志文章,随机对照试验
doi：10.1007/s13760-012-0011-7
更新日期：2012-03-01 00:00:00
abstract：:In this study, serum triglyceride, total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), very low-density lipoprotein cholesterol (VLDL-C), vitamin B12 and folic acid levels were studied in children with epilepsy who had been receiving long-term valproate (V...
journal_title：Acta neurologica Belgica
pub_type： 杂志文章
doi：
更新日期：2002-09-01 00:00:00
abstract：:Neurosarcoidosis is a diagnostic challenge, especially in the absence of systemic involvement, even when cerebral biopsies show noncaseating granulomas. We report a patient with a pineal germinoma associated with a extensive peri- and intra- tumoural granulomatous reaction, who was first diagnosed as possible neurosar...
journal_title：Acta neurologica Belgica
pub_type： 杂志文章
doi：
更新日期：2009-06-01 00:00:00
abstract：PURPOSE:total removal of spinal hemangioblastomas with satisfactory clinical outcomes remains a challenge. We aimed to evaluate the surgical outcomes of our spinal hemangioblastomas patients, summarize our experiences with this condition and review-related literature. METHODS:records of 18 spinal hemangioblastoma pati...
journal_title：Acta neurologica Belgica
pub_type： 杂志文章
doi：10.1007/s13760-020-01420-4
更新日期：2020-07-07 00:00:00
abstract：:Neuropraxia of the cervical spinal cord is a rare condition which is almost exclusively reported in American football players following cervical hyperextension or hyperflexion trauma. In this entity-neurological symptoms of both arms and legs for a period of up to 15 minutes are observed with complete recovery. We rep...
journal_title：Acta neurologica Belgica
pub_type： 杂志文章
doi：
更新日期：2000-06-01 00:00:00
abstract：BACKGROUND:The present study was designed to describe the characteristics, risk factors and prognosis of patients diagnosed with CVT in our center. METHOD:The present retrospective cross-sectional study was conducted on patients diagnosed with cerebral vein or sinus thrombosis based on the patients' clinical presentat...
journal_title：Acta neurologica Belgica
pub_type： 杂志文章
doi：
更新日期：2010-09-01 00:00:00
abstract：:Progressive supranuclear palsy (PSP) is a severe neurodegenerative disease still lacking of alleviating treatments for either cognitive or motor disturbances. Aimed at widening the spectrum of therapeutic options, here, we describe efficacy and safety of a long-term treatment with Rotigotine, a non-ergolinic dopamine ...
journal_title：Acta neurologica Belgica
pub_type： 杂志文章
doi：10.1007/s13760-018-0993-x
更新日期：2019-03-01 00:00:00
abstract：:The gastrocnemius and quadriceps muscles findings in 18 patients with chronic arterial insufficiency were reviewed with regard to mitochondrial changes. Prominent mitochondrial alterations were present in eight out of 18 patients. The comparison of clinical data between patients with and without mitochondrial changes ...
journal_title：Acta neurologica Belgica
pub_type： 杂志文章
doi：
更新日期：1986-11-01 00:00:00
abstract：:Appropriate treatment of neonatal seizures with an effective therapy is important in reducing long-term neurologic disabilities. Sixty-seven neonates, who received intravenous (IV) levetiracetam (LEV) as first-line therapy for treating seizures between 2013 and 2017 were evaluated retrospectively to investigate the ef...
journal_title：Acta neurologica Belgica
pub_type： 杂志文章
doi：10.1007/s13760-020-01366-7
更新日期：2020-05-18 00:00:00
abstract：:Atomoxetine, a selective noradrenaline reuptake inhibitor, has been reported to enhance brain plasticity, but has not yet been used in stroke patients. We reported the feasibility and clinical benefits on motor functional recovery of the combination of repetitive transcranial magnetic stimulation (rTMS) and intensive ...
journal_title：Acta neurologica Belgica
pub_type： 杂志文章
doi：10.1007/s13760-015-0503-3
更新日期：2016-03-01 00:00:00
abstract：:Clinical records and EEGs of 114 consecutive patients with clinical diagnosis of Alzheimer's disease have been reviewed. The EEGs of 15 patients (13%) contained triphasic waves. Triphasic waves were always atypical as they occurred singularly or in short bursts, and/or they had occipital predominance, and/or they were...
journal_title：Acta neurologica Belgica
pub_type： 杂志文章
doi：
更新日期：1990-01-01 00:00:00
abstract：:The case of a 57-year-old woman is described with a two months history of proximal muscle weakness and pain, marked hypotrophy and brisk reflexes. Clinical investigation demonstrated normal serum CK, myopathic EMG and osteomalacia. Muscle biopsy showed type II fibre atrophy and mitochondrial alterations without inclus...
journal_title：Acta neurologica Belgica
pub_type： 杂志文章
doi：
更新日期：1982-03-01 00:00:00
abstract：:A knowledge of the mechanisms used in adaptation to vestibular lesions is important for both diagnostic and therapeutic purposes. Here we discuss commonly encountered circumstances--habitual wearing of spectacles, unilateral or bilateral labyrinthine dysfunction--that call for adaptation. The context specificity of ve...
journal_title：Acta neurologica Belgica
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
abstract：BACKGROUND:In carotid artery dissections, local and ischemic manifestations usually occur within days or weeks. In some cases, persistent extracranial aneurysms cause thromboembolic complications even years after the initial event. The management of these aneurysms is still controversial. CASE DESCRIPTION:We report th...
journal_title：Acta neurologica Belgica
pub_type： 杂志文章
doi：
更新日期：2003-09-01 00:00:00
abstract：:Guillain-Barré Syndrome (GBS) is best viewed as a clinical syndrome which can have at least two clinical substrates: the commonest is an acquired demyelinating polyradiculoneuropathy and the other is an acute motor axonal neuropathy. An acute acquired neuropathy can also sometimes cause the Miller Fisher syndrome of o...
journal_title：Acta neurologica Belgica
pub_type： 杂志文章,评审
doi：
更新日期：1994-01-01 00:00:00
abstract：:The authors present the clinico-pathological correlation in a women who developed at the age of 43 years progressive pain in the left hemiface with motor and sensitive disorders of the left trigeminal nerve. Progressive involvement of the left IIIrd, IVth and Vth cranial nerves appeared with persistence of intractable...
journal_title：Acta neurologica Belgica
pub_type： 杂志文章
doi：
更新日期：1980-01-01 00:00:00
abstract：:Cyclosporine-A is a highly potent immunosuppressive agent for solid organ transplantation, but has many side effects including nephrotoxicity, hypertension, gum hyperplasia, hepatotoxicity, and neurotoxicity. Neurotoxicity is a less known toxic effect. The pathogenesis of this effect is unclear. However, it has been p...
journal_title：Acta neurologica Belgica
pub_type： 杂志文章
doi：
更新日期：2001-06-01 00:00:00
abstract：:We present a case of partial rhombencephalosynapsis, diagnosed by magnetic resonance imaging (MRI), in fetus aged 27 gestational weeks, in a dizygotic twin pregnancy. The distinctive MRI features of this cerebellar malformation (segmental hypogenesis of the cerebellar vermis, partial fusion of the cerebellar hemispher...
journal_title：Acta neurologica Belgica
pub_type： 杂志文章
doi：
更新日期：2011-06-01 00:00:00
abstract：BACKGROUND:Increased intima-media thickness (IMT) of the common carotid arteries (CCA) and elevated levels of highly sensitive C-reactive protein (hsCRP) are both shown to be associated with the occurrence of stroke. We investigated whether elevated hsCRP level is a risk factor for the increased IMT of the CCA independ...
journal_title：Acta neurologica Belgica
pub_type： 杂志文章
doi：
更新日期：2005-06-01 00:00:00
abstract：:Disorganized sleep patterns, can be found both during normal development and in pathological conditions. Aging could also be accompanied by a disorganization of the night sleep episode; sleep could be interrupted by spontaneous awakening, sleep cycle could be shortened or incomplete, sleep states modified. These patte...
journal_title：Acta neurologica Belgica
pub_type： 杂志文章,评审
doi：
更新日期：1997-06-01 00:00:00
abstract：:Spinal cord stimulation is an accepted treatment for neuropathic pain. Technical advances in electrode design and better patient selection have led to better and sustained pain control by these devices. Multilead electrical stimulation is the latest innovation in implantable electrostimulation (Mattrix, Medtronic Minn...
journal_title：Acta neurologica Belgica
pub_type： 杂志文章
doi：
更新日期：1998-06-01 00:00:00
abstract：:We performed a systematic neurophysiological evaluation of newborns-infants newly diagnosed with congenital hypothyroidism and started on replacement therapy, in order to document the maturation of visual, auditory and somesthetic pathways and to evaluate the influence of treatment. Twenty-one patients (9 boys, 12 gir...
journal_title：Acta neurologica Belgica
pub_type： 杂志文章
doi：10.1007/s13760-014-0331-x
更新日期：2015-06-01 00:00:00
abstract：:Small fiber neuropathy (SFN), due to loss of A-delta and unmyelinated C fibers, is a cause of neuropathic pain. Although the patients with vitamin B12 deficiency are included in SFN studies in the literature, there is no histopathological study investigating the small fiber loss solely in patients with vitamin B12 def...
journal_title：Acta neurologica Belgica
pub_type： 杂志文章
doi：10.1007/s13760-017-0847-y
更新日期：2018-09-01 00:00:00
abstract：: ...
journal_title：Acta neurologica Belgica
pub_type：
doi：10.1007/s13760-018-1035-4
更新日期：2018-12-01 00:00:00
abstract：:A 47-year-old female developed proximal limb weakness after hysterectomy for uterine fibromatosis. Muscle strength slowly improved, but relapse occurred at age 52. She presented with progressive gait difficulty, proximal limb weakness, and painful calves. Family history was not contributory. Cranial nerves, deep tendo...
journal_title：Acta neurologica Belgica
pub_type： 杂志文章
doi：
更新日期：2000-03-01 00:00:00
abstract：:Dopa-responsive dystonia (DRD) and DRD plus are diseases of the dopamine pathway with sizeable genetic diversity and myriad presentations. DRD has onset in childhood or adolescence with focal dystonia, commonly affecting lower limb, diurnal fluctuations with evening worsening of symptoms and a demonstrable sleep benef...
journal_title：Acta neurologica Belgica
pub_type： 杂志文章,评审
doi：10.1007/s13760-020-01574-1
更新日期：2021-01-16 00:00:00
abstract：PURPOSE:A retrospective evaluation of the ictal temporal tracer uptake and the perfusion pattern in other neo- and subcortical structures was performed to define typical extratemporal changes of rCBF that might further aid the differentiation of temporal and extratemporal seizures. METHOD:Ictal and interictal rCBF bra...
journal_title：Acta neurologica Belgica
pub_type： 杂志文章
doi：
更新日期：1998-12-01 00:00:00
abstract：:Various statistical discrimination indices reveal deflections regarded as significant before the 20th ms after stimulation (probably equivalent to Bickford responses or subcortical activity) and between the 20th and 23rd ms (early fractions of MVER). The independence of signal and noise is discussed. Considerations co...
journal_title：Acta neurologica Belgica
pub_type： 杂志文章
doi：
更新日期：1979-01-01 00:00:00
abstract：OBJECTIVE:To study the impact of cognitive impairment and severity of dementia on the quality of life (QoL) of patients and their caregivers. DESIGN:Descriptive cross-sectional study within the NAtional Dementia Economic Study. SETTING:231 general practices and 15 specialist clinics in Belgium. SUBJECTS:605 patients...
journal_title：Acta neurologica Belgica
pub_type： 杂志文章
doi：
更新日期：2003-03-01 00:00:00
abstract：:Friedreich's ataxia (FRDA), an autosomal recessive disorder, is characterized by spinocerebellar degeneration and cardiomyopathy. Here we explore some of the putative mechanisms underlying the cardiomyopathy in FRDA that have been elucidated using different experimental models. FRDA is characterized by a deficiency in...
journal_title：Acta neurologica Belgica
pub_type： 杂志文章,评审
doi：
更新日期：2011-09-01 00:00:00
