Autoimmunity in common variable immunodeficiency: epidemiology, pathophysiology and management.

abstract：BACKGROUND:Biological drugs, mainly interleukin (IL)-1 and IL-6 antagonists, but also tumor necrosis factor (TNF) inhibitors, have been used in the treatment of adult onset Still's disease patients (AOSD). METHODS:We summarised the available evidence for the effectiveness of biologic drugs in AOSD. A systematic review...

journal_title：Expert review of clinical immunology

authors： Ruscitti P,Ursini F,Cipriani P,De Sarro G,Giacomelli R

更新日期：2017-11-01 00:00:00

abstract：:Introduction: Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disease, which affects joints as well as extra-articular tissues. In the last decades, increasing targeted therapeutic options dramatically improved RA management by doubling the rate of patients achieving clinical remission. Currently, there is...

journal_title：Expert review of clinical immunology

authors： Cavalli G,Favalli EG

更新日期：2019-12-01 00:00:00

abstract：:Patients with systemic lupus erythematosus have a significantly increased risk of cardiovascular events due to atherosclerosis. Traditional cardiac risk factors cannot fully explain this increased risk. Recent evidence strongly suggests that atherosclerotic plaque is largely driven by inflammation and an active immuno...

journal_title：Expert review of clinical immunology

authors： McMahon M,Hahn BH,Skaggs BJ

更新日期：2011-03-01 00:00:00

abstract：:Introduction: Patients affected by Inborn Errors of Immunity (IEI) represent a potential group-at-risk in the current COVID-19 pandemic. Studies on large and small cohorts of IEI reported a huge variability clinical manifestations associated to SARS-Cov-2, ranging from asymptomatic, mild, moderate/severe to death. A g...

journal_title：Expert review of clinical immunology

authors： Quinti I,Mezzaroma I,Milito C

更新日期：2021-01-15 00:00:00

abstract：:Asthma is a chronic disease that affects millions of individuals living in the USA. Proper asthma management is essential for controlling asthma symptoms and exacerbations. In recent years, however, there has been increased recognition of individuals using complementary and alternative medicine (CAM) to treat asthma. ...

journal_title：Expert review of clinical immunology

authors： Adams SK,Koinis-Mitchell D

更新日期：2008-11-01 00:00:00

abstract：:Glucocorticoids are indispensable for the treatment of systemic inflammatory diseases such as rheumatoid arthritis (RA), though their beneficial effects have to be balanced with potential complications arising from high doses, prolonged use or dose splitting. A glucocorticoid formulation (modified-release prednisone) ...

journal_title：Expert review of clinical immunology

authors： Alten R

更新日期：2012-02-01 00:00:00

abstract：INTRODUCTION:Allergic conditions such as asthma and atopic dermatitis have a high prevalence but represent a heterogeneous group of diseases despite similar clinical presentation and underlying pathophysiology. A better understanding of the phenotypes and endotypes of these diseases has driven rapid development of biol...

journal_title：Expert review of clinical immunology

authors： Manka LA,Wechsler ME

更新日期：2018-04-01 00:00:00

abstract：:Graft-versus-host disease (GVHD) remains a significant complication that greatly enhances morbidity and mortality associated with hematopoietic stem cell transplantation. Key immunoregulatory molecules have been implicated in the pathogenesis of GVHD, but the mechanisms by which these molecules affect the incidence an...

journal_title：Expert review of clinical immunology

authors： Conway SE,Abdi R

更新日期：2009-09-01 00:00:00

abstract：:Mounting evidence suggests insulin is an important and potentially initiating antigen in the pathogenesis of Type 1 diabetes. High-affinity insulin antibodies are found early in disease development and appear to predict progression. Insulin is the only Type 1 diabetes auto-antigen with exclusive pancreatic expression ...

journal_title：Expert review of clinical immunology

authors： Wicklow BA,Polychronakos C

更新日期：2009-01-01 00:00:00

abstract：INTRODUCTION:Psoriasis is a common, chronic, immune-mediated inflammatory disorder. The disease is associated with several co-morbidities including cardiovascular disease, metabolic syndrome, and psychiatric disorders. It is important to identify and treat these co-morbidities because they have a strongly negative effe...

journal_title：Expert review of clinical immunology

authors： Lønnberg AS,Skov L

更新日期：2017-01-01 00:00:00

abstract：:In the 1990s, elucidation of the primary amino acid sequence of several major allergens using molecular cloning techniques opened the door to T-cell epitope mapping studies. Such analyses underscored the complexity of the allergen-specific T-cell repertoire and the challenges to using allergen-derived peptides to iden...

journal_title：Expert review of clinical immunology

authors： Woodfolk JA

更新日期：2006-03-01 00:00:00

abstract：INTRODUCTION:Dupilumab is a treatment option newly licensed for adolescents with moderate to severe atopic dermatitis (AD). It reduces type 2 inflammation by blocking the shared receptor subunit for IL-4/-13. Dupilumab affects three disease mechanisms in atopic dermatitis: the skin barrier, the Th2-cell differentiation...

journal_title：Expert review of clinical immunology

authors： Senner S,Seegräber M,Frey S,Kendziora B,Eicher L,Wollenberg A

更新日期：2020-07-01 00:00:00

abstract：:Specific allergen immunotherapy has been practiced for allergic rhinoconjunctivitis for over 100 years and is the only treatment option that is disease modifying. In the USA, immunotherapy is usually administered via subcutaneous injection; this is the only route with a US FDA-approved formulation. There is growing in...

journal_title：Expert review of clinical immunology

authors： Park D,Daher N,Blaiss MS

更新日期：2012-08-01 00:00:00

abstract：:Idealized gene therapy of autoimmune diseases would mean getting the right drug to the right place at the right time to affect the right mechanism of action. In other words, a specific gene therapy strategy needs to have functional, spatial and temporal specificity. Functional specificity implies targeting the cellula...

journal_title：Expert review of clinical immunology

authors： Creusot RJ,Fathman CG,Müller-Ladner U,Tarner IH

更新日期：2005-09-01 00:00:00

abstract：:Pigs are currently the preferred species for future organ xenotransplantation. With advances in the development of genetically modified pigs, clinical xenotransplantation is becoming closer to reality. In preclinical studies (pig-to-nonhuman primate), the xenotransplantation of livers from pigs transgenic for human CD...

journal_title：Expert review of clinical immunology

authors： Ekser B,Burlak C,Waldman JP,Lutz AJ,Paris LL,Veroux M,Robson SC,Rees MA,Ayares D,Gridelli B,Tector AJ,Cooper DK

更新日期：2012-09-01 00:00:00

abstract：:In recent years, new insights into the immunological pathways in multiple sclerosis (MS) have been detected. This increasing knowledge has led to more distinct treatment options in modifying the disease course of MS. In 2006, natalizumab, an alpha4-integrin monoclonal antibody, introduced a new era of MS treatment. An...

journal_title：Expert review of clinical immunology

authors： Reske D,Haupt WF

更新日期：2008-09-01 00:00:00

abstract：:Pediatric T-cell hematologic malignancies are a diverse group of rare cancers. The most common pediatric T-cell malignancies include T-cell acute lymphoblastic leukemia (T-ALL) and anaplastic large cell lymphoma (ALCL). Although the overall survival rates have improved markedly in recent years, children with relapsed ...

journal_title：Expert review of clinical immunology

authors： Diorio C,Teachey DT

更新日期：2020-04-01 00:00:00

abstract：:Epidemiological and clinical studies have suggested that the pathogenesis of inflammatory bowel disease (IBD) is strongly influenced by genetic predisposition. Beyond the limitations of linkage analysis, multiple genome-wide association studies, their meta-analyses, and targeted genotyping array techniques have broade...

journal_title：Expert review of clinical immunology

authors： Ye BD,McGovern DP

更新日期：2016-10-01 00:00:00

abstract：:Methotrexate (MTX) is the key treatment in juvenile idiopathic arthritis (JIA). Nevertheless, MTX is not always sufficiently efficacious and can lead to adverse effects, which compromises complete disease control. In such cases, combination therapies with biologicals are given, even at MTX start, before knowing the pa...

journal_title：Expert review of clinical immunology

authors： Ćalasan MB,Wulffraat NM

更新日期：2014-07-01 00:00:00

abstract：:Animal models and clinical studies of asthma have generated important insights into the first effector phase leading to the development of allergic airway disease and bronchial hyper-reactivity. In contrast, mechanisms related to asthma chronicity or persistence are less well understood. The CD4(+) T-helper 2 lymphocy...

journal_title：Expert review of clinical immunology

authors： Aronica MA,Vogel N

更新日期：2005-11-01 00:00:00

abstract：INTRODUCTION:The incidence of inflammatory bowel disease (IBD) has increased over the last 50 years. It is now recognized that several genetic defects can express an IBD-like phenotype at very early onset (<6 years). AREAS COVERED:The aim of this review was to update knowledge concerning the specificity of IBD at onse...

journal_title：Expert review of clinical immunology

authors： Capriati T,Cardile S,Papadatou B,Romano C,Knafelz D,Bracci F,Diamanti A

更新日期：2016-09-01 00:00:00

abstract：INTRODUCTION:Chronic rhinosinusitis (CRS) is a broad clinical syndrome linked by mucosal inflammation. Primary treatment modalities are corticosteroids and antibiotics with surgery an option for failures, but the level of supporting evidence is generally low. The primary reason is that CRS is a symptom complex and not ...

journal_title：Expert review of clinical immunology

authors： Ghogomu N,Kern R

更新日期：2017-03-01 00:00:00

abstract：INTRODUCTION:More women with autoimmune and inflammatory conditions are being treated with monoclonal antibody biologics (mAbs) during their pregnancy, to maintain clinical remission. The use of anti-tumor necrosis factor alpha agents in pregnancy appears to be safe but less is known regarding other mAbs, such as anti-...

journal_title：Expert review of clinical immunology

authors： Pham-Huy A,Sadarangani M,Huang V,Ostensen M,Castillo E,Troster SM,Vaudry W,Nguyen GC,Top KA

更新日期：2019-03-01 00:00:00

abstract：:During pregnancy and after delivery, the maternal thyroid gland faces several metabolic, hemodynamic and immunologic changes. In this article we first summarize the current knowledge on the physiologic adaptation of the healthy thyroid to pregnancy, including variations of thyroid-stimulating hormone and free thyroid ...

journal_title：Expert review of clinical immunology

authors： Gaberšček S,Zaletel K

更新日期：2011-09-01 00:00:00

abstract：:Hematopoietic stem cell transplantation (HSCT), both allogeneic and autologous, has become one of the hottest topics in clinical immunology. One of the main autoimmune diseases in which HSCT has been extensively tried during the last decade is multiple sclerosis (MS). A few original papers and many anecdotal reports h...

journal_title：Expert review of clinical immunology

authors： Karussis D,Vaknin-Dembinsky A

更新日期：2010-05-01 00:00:00

abstract：INTRODUCTION:Secukinumab, an interleukin-17A (IL-17A) antagonist, is the first non-TNF alpha inhibitor agent licensed for ankylosing spondylitis (AS), which opens up a new era of alternative cytokine targets beyond TNF. Areas covered: This review explores the pathophysiology and scientific evidence behind the use of th...

journal_title：Expert review of clinical immunology

authors： Dubash S,Bridgewood C,McGonagle D,Marzo-Ortega H

更新日期：2019-02-01 00:00:00

abstract：:The course of inflammatory bowel diseases is heterogeneous and varies over time. Therefore, the search for predictive factors has increasingly become the focus of research. Mucosal healing has emerged as an important objective, as evidence indicates that it is associated with improved disease outcome. Nevertheless, ma...

journal_title：Expert review of clinical immunology

authors： Miheller P,Mandel MD,Mullner K,Lakatos PL

更新日期：2013-09-01 00:00:00

abstract：:Several 'omics' sciences have been launched. The outstanding diversity of immune system components, together with the complexity of the regulatory pathways and network-type interactions, makes immunology a combinatorial science. Cancer immonomics is a branch of immunomics. The present cancer immunomics project aims at...

journal_title：Expert review of clinical immunology

authors： Wiwanitkit V

更新日期：2007-09-01 00:00:00

abstract：:Evolving data have shown that the toll like receptors (TLRs) family of innate immune receptors has an important role in driving the activation and inhibition of pathogenic pathways involved in multiple sclerosis (MS). While developing clinical trials targeting MS by TLRs modulators are of considerable interest, severa...

journal_title：Expert review of clinical immunology

authors： Gooshe M,Aleyasin AR,Abdolghaffari AH,Rezaei N

更新日期：2014-10-01 00:00:00

abstract：:The term refractory lupus nephritis is generally used to indicate cases that do not respond to traditional treatment. However, the clinical presentation of lupus nephritis is variable and the time to response depends on the typology of the underlying renal syndrome. The criteria and the time for response are different...

journal_title：Expert review of clinical immunology

authors： Moroni G,Ponticelli C

更新日期：2015-02-01 00:00:00