Abstract:
INTRODUCTION:More women with autoimmune and inflammatory conditions are being treated with monoclonal antibody biologics (mAbs) during their pregnancy, to maintain clinical remission. The use of anti-tumor necrosis factor alpha agents in pregnancy appears to be safe but less is known regarding other mAbs, such as anti-integrins and anti-cytokine agents. There are currently no comprehensive guidelines on how to manage the exposed infants. Areas covered: We review recent literature to assess the impact of mAbs on birth and early infant outcomes, including what is currently known about maternal and infant drug levels at birth and drug clearance in the infant. We describe the potential risks of infections and reported hematological and immunological effects of antenatal mAbs exposure on the infant and provide guidance on the management of the exposed infant. Expert opinion: Exposed infants should be monitored closely. Certain mAb exposures require specific testing and management. Safety monitoring should be done in a multidisciplinary approach and should include pediatric care providers. The current clinical experience with anti-tumor necrosis factor agents in pregnancy cannot be extrapolated to other mAbs. Long-term observational studies and a multicenter international registry are needed to better appreciate the impact of exposure, especially to newer mAbs.
journal_name
Expert Rev Clin Immunoljournal_title
Expert review of clinical immunologyauthors
Pham-Huy A,Sadarangani M,Huang V,Ostensen M,Castillo E,Troster SM,Vaudry W,Nguyen GC,Top KAdoi
10.1080/1744666X.2019.1561282subject
Has Abstractpub_date
2019-03-01 00:00:00pages
221-229issue
3eissn
1744-666Xissn
1744-8409journal_volume
15pub_type
杂志文章,评审abstract:INTRODUCTION:Common variable immunodeficiency (CVID) comprises a large heterogeneous group of patients with primary antibody deficiency. Areas covered: The affected patients are characterized by increased susceptibility to infections and low levels of serum immunoglobulin. However, enteropathy, granulomatous organ infi...
journal_title:Expert review of clinical immunology
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doi:10.1080/1744666X.2016.1224664
更新日期:2017-02-01 00:00:00
abstract::Introduction: The majority of the patients with anti-neutrophil cytoplasmic autoantibody (ANCA) associated vasculitis (AAV) achieve remission with effective induction therapy. Therefore, prevention of relapses and avoiding long-term damage and treatment-related toxicity are major challenges.Areas covered: This review ...
journal_title:Expert review of clinical immunology
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abstract:INTRODUCTION:Rheumatoid arthritis (RA) is a complex disease in which different mechanisms are involved. Studies suggest a key role for aberrant pathways of T-cell activation in the initiation and perpetuation of disease. Abatacept is a fusion protein composed of the Fc region of the immunoglobulin G1 (IgG1) fused to th...
journal_title:Expert review of clinical immunology
pub_type: 杂志文章,评审
doi:10.1080/1744666X.2019.1579642
更新日期:2019-04-01 00:00:00
abstract::Epigenetic modifications of gene expression comprise modifications of DNA by DNA methylation and modifications of the histone proteins by acetylation, methylation, SUMOylation or phosphorylation. DNA methylation in the promoter region of genes represses gene transcription. Histone modifications influence the structure...
journal_title:Expert review of clinical immunology
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journal_title:Expert review of clinical immunology
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doi:10.1586/1744666X.3.5.695
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journal_title:Expert review of clinical immunology
pub_type: 杂志文章,评审
doi:10.1080/1744666X.2018.1531704
更新日期:2018-12-01 00:00:00
abstract::Naturally occurring CD4(+)CD25(+) regulatory T cells (Tregs) expressing forkhead transcript factor box P3 have been established as a key regulator for the control of autoimmunity. A growing body of experiments in animal models has provided compelling evidence that the adoptive transfer of CD4(+)CD25(+) Tregs can cure ...
journal_title:Expert review of clinical immunology
pub_type: 杂志文章
doi:10.1586/1744666X.2.3.387
更新日期:2006-05-01 00:00:00
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journal_title:Expert review of clinical immunology
pub_type: 杂志文章
doi:10.1586/1744666X.4.6.703
更新日期:2008-11-01 00:00:00
abstract::Ulcerative colitis is a chronic condition that requires long-term treatment. The first-line therapy remains 5-aminosalicylic acid, which is available in several different formulations and dosing schedules. Several studies have demonstrated that adherence rates to prescribed 5-aminosalicylic acid products are below tho...
journal_title:Expert review of clinical immunology
pub_type: 杂志文章,评审
doi:10.1586/eci.10.28
更新日期:2010-07-01 00:00:00
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journal_title:Expert review of clinical immunology
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journal_title:Expert review of clinical immunology
pub_type: 杂志文章,评审
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更新日期:2012-01-01 00:00:00
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journal_title:Expert review of clinical immunology
pub_type: 杂志文章,评审
doi:10.1080/1744666X.2019.1620601
更新日期:2019-07-01 00:00:00
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journal_title:Expert review of clinical immunology
pub_type: 杂志文章,评审
doi:10.1080/1744666X.2016.1213631
更新日期:2017-01-01 00:00:00
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journal_title:Expert review of clinical immunology
pub_type: 杂志文章,评审
doi:10.1080/1744666X.2016.1208085
更新日期:2016-09-01 00:00:00
abstract::The past decade has been an exciting period for clinical research and patient care in rheumatoid arthritis. This is mostly due to targeted biologic agents that have changed the outcome of this disease. Certolizumab pegol (Cimzia(®), UCB Inc., GA, USA), which targets TNF-α with a different mechanism of action than wide...
journal_title:Expert review of clinical immunology
pub_type: 杂志文章,评审
doi:10.1586/eci.10.69
更新日期:2010-11-01 00:00:00
abstract::Although training and exercise have several benefits, overdoing it might not necessarily be a good thing. For instance, elite athletes have an increased risk for asthma and allergy. Several mechanisms can be implicated for this risk, which include the interplay between environmental training factors and athlete's pers...
journal_title:Expert review of clinical immunology
pub_type: 杂志文章,评审
doi:10.1586/1744666X.2015.1058158
更新日期:2015-01-01 00:00:00
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journal_title:Expert review of clinical immunology
pub_type: 杂志文章,评审
doi:10.1586/1744666X.2014.901887
更新日期:2014-05-01 00:00:00
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journal_title:Expert review of clinical immunology
pub_type: 杂志文章,评审
doi:10.1586/eci.09.82
更新日期:2010-03-01 00:00:00
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journal_title:Expert review of clinical immunology
pub_type: 杂志文章
doi:10.1080/1744666X.2020.1750953
更新日期:2020-05-01 00:00:00
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journal_title:Expert review of clinical immunology
pub_type: 杂志文章
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更新日期:2020-05-01 00:00:00
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journal_title:Expert review of clinical immunology
pub_type: 杂志文章,评审
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更新日期:2019-06-01 00:00:00
abstract::Inflammatory bowel disease includes ulcerative colitis and Crohn's disease, which are both inflammatory disorders of the gastrointestinal tract. Both types of inflammatory bowel disease have a complex etiology, resulting from a genetically determined susceptibility interacting with environmental factors, including the...
journal_title:Expert review of clinical immunology
pub_type: 杂志文章,评审
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更新日期:2013-08-01 00:00:00
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journal_title:Expert review of clinical immunology
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更新日期:2010-05-01 00:00:00
abstract::In this review, recent changes in both treatments and outcomes of rheumatoid arthritis (RA) in Japan were analyzed by viewing the National Database of Rheumatic Diseases by iR-net, one of the largest clinical databases for RA patients in Japan. Regarding drug therapy, the use of methotrexate has been continuously incr...
journal_title:Expert review of clinical immunology
pub_type: 杂志文章,评审
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更新日期:2012-07-01 00:00:00
abstract::Animal models and clinical studies of asthma have generated important insights into the first effector phase leading to the development of allergic airway disease and bronchial hyper-reactivity. In contrast, mechanisms related to asthma chronicity or persistence are less well understood. The CD4(+) T-helper 2 lymphocy...
journal_title:Expert review of clinical immunology
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doi:10.1586/1744666X.1.4.589
更新日期:2005-11-01 00:00:00
abstract::Graft-versus-host disease (GVHD) remains a significant complication that greatly enhances morbidity and mortality associated with hematopoietic stem cell transplantation. Key immunoregulatory molecules have been implicated in the pathogenesis of GVHD, but the mechanisms by which these molecules affect the incidence an...
journal_title:Expert review of clinical immunology
pub_type: 杂志文章
doi:10.1586/eci.09.44
更新日期:2009-09-01 00:00:00
abstract:INTRODUCTION:Psoriasis is a complex disease in which the alteration of the IL-23/Th17 axis appears to be crucial for its pathogenic mechanisms, and anti-IL17 agents are rapidly becoming important therapeutic tools. Brodalumab, a fully human Chinese hamster ovary cell-derived immunoglobulin G2 (IgG2) anti-IL-17RA monocl...
journal_title:Expert review of clinical immunology
pub_type: 杂志文章,评审
doi:10.1080/1744666X.2016.1246957
更新日期:2016-12-01 00:00:00
abstract::Psoriatic arthritis (PsA) is a chronic inflammatory joint disease occurring in 6-39% of patients with psoriasis. Standard therapy of PsA includes nonsteroidal anti-inflammatory drugs, intra-articular steroids and disease-modifying antirheumatic drugs. Failure of standard therapy is an indication for anti-TNF-alpha the...
journal_title:Expert review of clinical immunology
pub_type: 杂志文章
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更新日期:2009-11-01 00:00:00
abstract:INTRODUCTION:Janus kinase (JAK) inhibitors are emerging treatments in dermatology. Also known as JAKinibs, these agents target JAK-signal transducers and activators of transcription (JAK-STAT) pathway for intracellular signaling. Among the various immune-mediated inflammatory skin diseases that the JAK-STAT pathway pla...
journal_title:Expert review of clinical immunology
pub_type: 杂志文章
doi:10.1080/1744666X.2021.1828068
更新日期:2020-10-01 00:00:00
abstract:INTRODUCTION:Hypersensitivity pneumonitis (HP) is an immunologically induced lung disease that develops after inhalation of certain environmental antigens only in subjects with susceptibility to antigens. Therefore, both environmental and host immunological factors play important roles in the aetiology and pathogenesis...
journal_title:Expert review of clinical immunology
pub_type: 杂志文章,评审
doi:10.1080/1744666X.2016.1182426
更新日期:2016-09-01 00:00:00