Abstract:
INTRODUCTION:Dupilumab is a treatment option newly licensed for adolescents with moderate to severe atopic dermatitis (AD). It reduces type 2 inflammation by blocking the shared receptor subunit for IL-4/-13. Dupilumab affects three disease mechanisms in atopic dermatitis: the skin barrier, the Th2-cell differentiation and the class switch to IgE. This report is based on a systematic literature search of the PubMed Database. AREAS COVERED:Dupilumab showed promising results in improving AD signs, symptoms and quality of life in adolescents with moderate to severe AD. The safety profile of dupilumab in adolescents with moderate to severe AD closely resembled the known safety profile of dupilumab in adults with moderate to severe AD. Injection-site reactions and conjunctivitis were the relevant side-effects. Skin infections were less frequently observed compared to placebo. EXPERT COMMENTARY:Dupilumab was approved by the Food and Drug Administration in March 2019 and by the European Medicines Agency in August 2019 for the treatment of adolescents with moderate to severe atopic dermatitis whose disease is not adequately controlled with topical therapies or when those therapies are not advisable. Since it is the first licensed drug it will likely become the reference drug for adolescents with moderate to severe AD.
journal_name
Expert Rev Clin Immunoljournal_title
Expert review of clinical immunologyauthors
Senner S,Seegräber M,Frey S,Kendziora B,Eicher L,Wollenberg Adoi
10.1080/1744666X.2020.1801420subject
Has Abstractpub_date
2020-07-01 00:00:00pages
641-650issue
7eissn
1744-666Xissn
1744-8409journal_volume
16pub_type
杂志文章abstract:INTRODUCTION:Despite the emergence of newer immunomodulating agents for systemic lupus erythematosus (SLE), a substantial proportion of patients still do not respond optimally. While the mechanisms for the differential responses to drug therapy are unclear, variation in drug exposure with the same dosing protocol relat...
journal_title:Expert review of clinical immunology
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journal_title:Expert review of clinical immunology
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journal_title:Expert review of clinical immunology
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journal_title:Expert review of clinical immunology
pub_type: 杂志文章,评审
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journal_title:Expert review of clinical immunology
pub_type: 杂志文章
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journal_title:Expert review of clinical immunology
pub_type: 杂志文章,评审
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journal_title:Expert review of clinical immunology
pub_type: 杂志文章,评审
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journal_title:Expert review of clinical immunology
pub_type: 杂志文章,评审
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journal_title:Expert review of clinical immunology
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journal_title:Expert review of clinical immunology
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journal_title:Expert review of clinical immunology
pub_type: 杂志文章,评审
doi:10.1586/1744666X.2014.930665
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pub_type: 杂志文章,评审
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journal_title:Expert review of clinical immunology
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journal_title:Expert review of clinical immunology
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