Mannose receptor induces T-cell tolerance via inhibition of CD45 and up-regulation of CTLA-4.

abstract：:Electrophysiological mapping of chronic atrial fibrillation (AF) at high throughput and high resolution is critical for understanding its underlying mechanism and guiding definitive treatment such as cardiac ablation, but current electrophysiological tools are limited by either low spatial resolution or electromechani...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu J,Zhang X,Liu Y,Rodrigo M,Loftus PD,Aparicio-Valenzuela J,Zheng J,Pong T,Cyr KJ,Babakhanian M,Hasi J,Li J,Jiang Y,Kenney CJ,Wang PJ,Lee AM,Bao Z

更新日期：2020-06-30 00:00:00

abstract：:The integrin receptor alphavbeta5 controls two independent forms of interactions of the retinal pigment epithelium (RPE) with adjacent photoreceptor outer segments that are essential for vision. Alphavbeta5 localizes specifically to apical microvilli of the RPE and contributes to retinal adhesion that maintains RPE co...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nandrot EF,Anand M,Almeida D,Atabai K,Sheppard D,Finnemann SC

更新日期：2007-07-17 00:00:00

abstract：:The small-component origins of herpes simplex virus 1 DNA synthesis are transcribed late in infection by an RNA with heterogeneous initiation sites approximately 290-360 base pairs from the origins. We report that cellular proteins react with a labeled RNA probe representing the 5' terminus of a subset of this RNA but...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Roller RJ,McCormick AL,Roizman B

更新日期：1989-09-01 00:00:00

abstract：:Immunoaffinity-purified interleukin 2 (IL2) stimulated proliferation of large but not small B cells. Stimulation was observed even when B cells were cultured at very low cell densities (3 X 10(4) per microwell containing 0.2 ml of medium). Addition of small numbers of purified splenic T cells did not enhance the IL2-i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mond JJ,Thompson C,Finkelman FD,Farrar J,Schaefer M,Robb RJ

更新日期：1985-03-01 00:00:00

abstract：:We have studied the effect of the cholinergic agonist carbachol on the spontaneous release of glutamate in cultured rat hippocampal cells. Spontaneous excitatory postsynaptic currents (sEPSCs) through glutamatergic alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type channels were recorded by means of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bouron A,Reuter H

更新日期：1997-10-28 00:00:00

abstract：:The majority of familial Alzheimer disease mutations are linked to the recently cloned presenilin (PS) genes, which encode two highly homologous proteins (PS-1 and PS-2). It was shown that the full-length PS-2 protein is phosphorylated constitutively within its N-terminal domain by casein kinases, whereas the PS-1 pro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Walter J,Grünberg J,Capell A,Pesold B,Schindzielorz A,Citron M,Mendla K,George-Hyslop PS,Multhaup G,Selkoe DJ,Haass C

更新日期：1997-05-13 00:00:00

abstract：:Copper is a required metal nutrient for life, but global or local alterations in its homeostasis are linked to diseases spanning genetic and metabolic disorders to cancer and neurodegeneration. Technologies that enable longitudinal in vivo monitoring of dynamic copper pools can help meet the need to study the complex ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Heffern MC,Park HM,Au-Yeung HY,Van de Bittner GC,Ackerman CM,Stahl A,Chang CJ

更新日期：2016-12-13 00:00:00

abstract：:The DNA from tumors of Nicotiana glauca initiated by strains of Agrobacterium rhizogenes was shown to contain sequences that are homologous to the root-inducing (Ri) plasmid of the bacterium. Two independently established tumor lines contained a similar portion of the Ri-plasmid. The Ri-plasmid also hybridized to DNA ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： White FF,Ghidossi G,Gordon MP,Nester EW

更新日期：1982-05-01 00:00:00

abstract：:Although normal fatty acids (FAs) are degraded via β-oxidation, unusual FAs such as 2-hydroxy (2-OH) FAs and 3-methyl-branched FAs are degraded via α-oxidation. Phytosphingosine (PHS) is one of the long-chain bases (the sphingolipid components) and exists in specific tissues, including the epidermis and small intestin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kitamura T,Seki N,Kihara A

更新日期：2017-03-28 00:00:00

abstract：:During the entry process, the human papillomavirus (HPV) capsid is trafficked to the trans-Golgi network (TGN), whereupon it enters the nucleus during mitosis. We previously demonstrated that the minor capsid protein L2 assumes a transmembranous conformation in the TGN. Here we provide evidence that the incoming viral...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： DiGiuseppe S,Luszczek W,Keiffer TR,Bienkowska-Haba M,Guion LG,Sapp MJ

更新日期：2016-05-31 00:00:00

abstract：:The pyridoxal 5'-phosphate cofactor of glycogen phosphorylase a (1,4-alpha-D-glucan:orthophosphate alpha-glucosyltransferase, EC2.4.1.1.) has been positioned on the protomer with x-ray diffraction data, chemical markers, and sequence information. The electron density was computed from 3.0-A resolution phases calculate...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sygusch J,Madsen NB,Kasvinsky PJ,Fletterick RJ

更新日期：1977-11-01 00:00:00

abstract：:Sterigmatocystin (ST), a potent hepatocarcinogen, was covalently bound to calf thymus DNA by incubation in the presence of phenobarbital-induced rat liver microsomes. Acid hydrolysis of ST-modified DNA liberated a major guanine-containing adduct, present in DNA at an estimated level of 1 ST residue per 100-150 nucleot...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Essigmann JM,Barker LJ,Fowler KW,Francisco MA,Reinhold VN,Wogan GN

更新日期：1979-01-01 00:00:00

abstract：:We have previously observed the spontaneous, pH-dependent insertion of a water-soluble peptide to form a helix across lipid bilayers [Hunt, J. F., Rath, P., Rothschild, K. J. & Engelman, D. M. (1997) Biochemistry 36, 15177-15192]. We now use a related peptide, pH (low) insertion peptide, to translocate cargo molecules...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reshetnyak YK,Andreev OA,Lehnert U,Engelman DM

更新日期：2006-04-25 00:00:00

abstract：:In humans, spontaneous movements are often preceded by early brain signals. One such signal is the readiness potential (RP) that gradually arises within the last second preceding a movement. An important question is whether people are able to cancel movements after the elicitation of such RPs, and if so until which po...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schultze-Kraft M,Birman D,Rusconi M,Allefeld C,Görgen K,Dähne S,Blankertz B,Haynes JD

更新日期：2016-01-26 00:00:00

abstract：:The ability of proteins to locate specific targets among a vast excess of nonspecific DNA is a fundamental theme in biology. Basic principles governing these search mechanisms remain poorly understood, and no study has provided direct visualization of single proteins searching for and engaging target sites. Here we us...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gorman J,Wang F,Redding S,Plys AJ,Fazio T,Wind S,Alani EE,Greene EC

更新日期：2012-11-06 00:00:00

abstract：:The mammalian anx7 gene codes for a Ca(2+)-activated GTPase, which supports Ca(2+)/GTP-dependent secretion events and Ca(2+) channel activities in vitro and in vivo. To test whether anx7 might be involved in Ca(2+) signaling in secreting pancreatic beta cells, we knocked out the anx7 gene in the mouse and tested the i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Srivastava M,Atwater I,Glasman M,Leighton X,Goping G,Caohuy H,Miller G,Pichel J,Westphal H,Mears D,Rojas E,Pollard HB

更新日期：1999-11-23 00:00:00

abstract：:To examine the role of breast cancer stem cells (BCSCs) in metastasis, we generated human-in-mouse breast cancer orthotopic models using patient tumor specimens, labeled with optical reporter fusion genes. These models recapitulate human cancer features not captured with previous models, including spontaneous metastas...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu H,Patel MR,Prescher JA,Patsialou A,Qian D,Lin J,Wen S,Chang YF,Bachmann MH,Shimono Y,Dalerba P,Adorno M,Lobo N,Bueno J,Dirbas FM,Goswami S,Somlo G,Condeelis J,Contag CH,Gambhir SS,Clarke MF

更新日期：2010-10-19 00:00:00

abstract：:Direct measurements of the intracellular level of lambda repressor have been made by a DNA-filter assay and a radioimmune assay. Transcription of cI, the structural gene for repressor, appears to initiate at two different promoters, prm and pre. Promoter pre is activated during the establishment of lysogeny by the act...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reichardt L,Kaiser AD

更新日期：1971-09-01 00:00:00

abstract：:The polypeptide precursor pr76 to the internal viral group specific (gs) antigen proteins of Rous sarcoma virus, synthesized in a cell-free system of ascites cells, has been processed in vitro into the viral proteins by purified viral protein p15 as well as by disrupted Rous sarcoma virus. Disrupted Rauscher murine le...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： von der Helm K

更新日期：1977-03-01 00:00:00

abstract：:The human MHC represents the strongest susceptibility locus for autoimmune diseases. However, the identification of the true predisposing gene(s) has been handicapped by the strong linkage disequilibrium across the region. Furthermore, most studies to date have been limited to the examination of a subset of the HLA an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： International MHC and Autoimmunity Genetics Network.,Rioux JD,Goyette P,Vyse TJ,Hammarström L,Fernando MM,Green T,De Jager PL,Foisy S,Wang J,de Bakker PI,Leslie S,McVean G,Padyukov L,Alfredsson L,Annese V,Hafler DA,Pan-

更新日期：2009-11-03 00:00:00

abstract：:Nitrogen limitation imposes a major transition in the lifestyle of nondiazotrophic cyanobacteria that is controlled by a complex interplay of regulatory factors involving the pervasive signal processor PII Immediately upon nitrogen limitation, newly fixed carbon is redirected toward glycogen synthesis. How the metabol...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Orthwein T,Scholl J,Spät P,Lucius S,Koch M,Macek B,Hagemann M,Forchhammer K

更新日期：2021-02-09 00:00:00

abstract：:The pancreatic beta cell can respond in the long term to hyperglycemia both with an increased capacity for insulin production and, in susceptible individuals, with apoptosis. When glucose-induced apoptosis offsets the increasing beta cell capacity, type 2 diabetes results. Here, we tested the idea that the pathway of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu K,Paterson AJ,Chin E,Kudlow JE

更新日期：2000-03-14 00:00:00

abstract：:Half-cystine peptic peptides representing the intrachain disulfide bonds of the light chain from an apparently homogeneous rabbit anti-p-azobenzoate antibody were isolated in good yields after reduction and alkylation with [(14)C]iodoacetate, and their sequences were determined. The sequence of the first 21 amino-term...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Appella E,Chersi A,Roholt OA,Pressman D

更新日期：1971-10-01 00:00:00

abstract：:Posttranslational modification is an important element in circadian clock function from cyanobacteria through plants and mammals. For example, a number of key clock components are phosphorylated and thereby marked for subsequent ubiquitination and degradation. Through forward genetic analysis we demonstrate that prote...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hong S,Song HR,Lutz K,Kerstetter RA,Michael TP,McClung CR

更新日期：2010-12-07 00:00:00

abstract：:Evolutionary thinking can be applied to both cultural microevolution and macroevolution. However, much of the current literature focuses on cultural microevolution. In this article, we argue that the growing availability of large cross-cultural datasets facilitates the use of computational methods derived from evoluti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gray RD,Watts J

更新日期：2017-07-25 00:00:00

abstract：:The fetal genome regulates maternal physiology and behavior via its placenta, which produces hormones that act on the maternal hypothalamus. At the same time, the fetus itself develops a hypothalamus. In this study we show that many of the genes that regulate placental development also regulate the developing hypothal...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Broad KD,Keverne EB

更新日期：2011-09-13 00:00:00

abstract：:Mutations in fibroblast growth factor receptor 2 (FGFR2) and its ligand, FGF10, are known to cause lacrimo-auriculo-dento-digital (LADD) syndrome. Multiple gain-of-function mutations in FGF receptors have been implicated in a variety of severe skeletal disorders and in many cancers. We aimed to elucidate the mechanism...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lew ED,Bae JH,Rohmann E,Wollnik B,Schlessinger J

更新日期：2007-12-11 00:00:00

abstract：:Genetic data are commonly used to estimate connectivity between putative populations, but translating them to demographic dispersal rates is complicated. Theoretical equations that infer a migration rate based on the genetic estimator F ST , such as Wright's equation, F ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Spies I,Hauser L,Jorde PE,Knutsen H,Punt AE,Rogers LA,Stenseth NC

更新日期：2018-05-08 00:00:00

abstract：:Attending to a stimulus is known to enhance the neural responses to that stimulus. Recent experiments on visual attention have shown that this modulation can have object-based characteristics, such that, when certain parts of a visual object are attended, other parts automatically also receive enhanced processing. Her...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Busse L,Roberts KC,Crist RE,Weissman DH,Woldorff MG

更新日期：2005-12-20 00:00:00

abstract：:Hoxb13 is robustly transcribed in derivatives of posterior endoderm including the colon, rectum, and the prostate gland. Transcriptional activity in the prostate persists unabated under conditions of androgen deprivation and throughout the course of disease progression in a mouse prostate cancer model. To elucidate th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McMullin RP,Dobi A,Mutton LN,Orosz A,Maheshwari S,Shashikant CS,Bieberich CJ

更新日期：2010-01-05 00:00:00