Abstract：
:Stress and recovery from stress significantly affect interactions between the central nervous system, endocrine pathways, and the immune system. However, the influence of acute stress on circulating immune-endocrine mediators in humans is not well known. Using a double-blind, randomized study design, we administered a CO2 stress test to n = 143 participants to identify the effects of acute stress, and recovery from stress, on serum levels of several mediators with immune function (IL-6, TNF-α, leptin, and somatostatin), as well as on noradrenaline, and two hypothalamic-pituitary-adrenal axis hormones (ACTH and cortisol). Moreover, during a 1 h-recovery period, we repeatedly measured these serum parameters, and administered an auditory mood-induction protocol with positive music and a neutral control stimulus. The acute stress elicited increases in noradrenaline, ACTH, cortisol, IL-6, and leptin levels. Noradrenaline and ACTH exhibited the fastest and strongest stress responses, followed by cortisol, IL-6 and leptin. The music intervention was associated with more positive mood, and stronger cortisol responses to the acute stressor in the music group. Our data show that acute (CO2) stress affects endocrine, immune and metabolic functions in humans, and they show that mood plays a causal role in the modulation of responses to acute stress.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Koelsch S,Boehlig A,Hohenadel M,Nitsche I,Bauer K,Sack Udoi
10.1038/srep23008subject
Has Abstractpub_date
2016-03-29 00:00:00pages
23008issn
2045-2322pii
srep23008journal_volume
6pub_type
杂志文章,随机对照试验abstract：:Land-use intensification on arable land is expanding and posing a threat to biodiversity and ecosystem services worldwide. We develop methods to link funding for avian breeding habitat conservation and management at landscape scales to equilibrium abundance of a migratory species at the continental scale. We apply thi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-61058-3
更新日期：2020-03-18 00:00:00
abstract：:The crystallization characteristics in supercooled liquid Zn during isothermal relaxation were investigated using molecular dynamics simulations by adopting the cluster-type index method (CTIM) and the tracing method. Results showed that the crystallization process undergo three different stages. The size of the criti...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep31653
更新日期：2016-08-16 00:00:00
abstract：:Based on the electrical characteristic detection technology, the quantitative prediction models of sensory score and physical and chemical quality Index (theaflavins, thearubigins, and theabrownins) were established by using the fermented products of Congou black tea as the research object. The variation law of electr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-58637-9
更新日期：2020-01-31 00:00:00
abstract：:A microwave domain characterization approach is proposed to determine the properties of high quality factor optical resonators. This approach features a very high precision in frequency and aims to acquire a full knowledge of the complex transfer function (amplitude and phase) characterizing an optical resonator using...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep27208
更新日期：2016-06-02 00:00:00
abstract：:We have investigated the rotating magnetocaloric effect (R-MCE) of TmB4 - an anisotropic magnetic system with geometrical frustration of Shastry-Sutherland type. The R-MCE was obtained from detailed temperature dependencies of heat capacity in various magnetic fields of a single crystalline sample for crystal axes ori...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-29399-2
更新日期：2018-07-19 00:00:00
abstract：:In the present study, we aimed to explore gender differences in infant mortality and neonatal morbidity in mixed-gender twin pairs. Data were obtained from the US National Center for Health Statistics Linked Birth-Infant Death Cohort. A total of 108,038 pairs of mixed-gender twins were included in this analysis. Among...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-08951-6
更新日期：2017-08-18 00:00:00
abstract：:Recent technological advances in remote sensing sensors and platforms, such as high-resolution satellite imagers or unmanned aerial vehicles (UAV), facilitate the availability of fine-grained earth observation data. Such data reveal vegetation canopies in high spatial detail. Efficient methods are needed to fully harn...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-53797-9
更新日期：2019-11-27 00:00:00
abstract：:Autophagy is a crucial and physiological process for cell survival from yeast to mammals, including protozoan parasites. Toxoplasma gondii, an intracellular parasite, typically exploits autophagic machinery of host cell; however host cell upregulates autophagy to combat the infection. Herein we tested the efficacy of ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-01525-6
更新日期：2017-04-28 00:00:00
abstract：:Ubiquitylation is a protein modification implicated in several cellular processes. This process is reversible by the action of deubiquinating enzymes (DUBs). USP45 is a ubiquitin specific protease about which little is known, aside from roles in DNA damage repair and differentiation of the vertebrate retina. Here, by ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-32685-8
更新日期：2018-09-26 00:00:00
abstract：:Recently, minocycline, a tetracycline antibiotic, has been reported to improve symptoms of psychiatric disorders and to facilitate sober decision-making in healthy human subjects. Here we show that minocycline also reduces the risk of the 'honey trap' during an economic exchange. Males tend to cooperate with physicall...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep01685
更新日期：2013-01-01 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-020-60498-1
更新日期：2020-02-27 00:00:00
abstract：:The growing interest in engineered tumor models prompted us to devise a method for the non-invasive assessment of such models. Here, we report on bioluminescence imaging (BLI) for the assessment of engineered tumor models in the fertilized chicken egg, i.e, chick chorioallantoic membrane (CAM) assay. One prostate canc...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-04572-1
更新日期：2017-07-10 00:00:00
abstract：:Photoactivated localization microscopy (PALM) is a super-resolution imaging technique based on the detection and subsequent localization of single fluorescent molecules. PALM is therefore a powerful tool in resolving structures and putative interactions of biomolecules at the ultimate analytical detection limit. Howev...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep13532
更新日期：2015-09-01 00:00:00
abstract：:GDP-mannose pyrophosphorylase (GMP) catalyzed the formation of GDP-mannose, which serves as a donor for the biosynthesis of mannose-containing polysaccharides. In this study, three GMP genes from Dendrobium officinale (i.e., DoGMPs) were cloned and analyzed. The putative 1000 bp upstream regulatory region of these DoG...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep41010
更新日期：2017-02-08 00:00:00
abstract：:Liver failure, whether arising directly from acute liver failure or from decompensated chronic liver disease is an increasing problem worldwide and results in many deaths. In the UK only 10% of individuals requiring a liver transplant receive one. Thus the need for alternative treatments is paramount. A BioArtificial ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-15021-4
更新日期：2017-11-06 00:00:00
abstract：:Light modulates global features of the important human pathogen Acinetobacter baumannii lifestyle including metabolism, tolerance to antibiotics and virulence, most of which depend on the short BLUF-type photoreceptor BlsA. In this work, we show that the ability to circumvent iron deficiency is also modulated by light...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-26127-8
更新日期：2018-05-16 00:00:00
abstract：:We have succeeded in developing hollow branching structure in vitro commonly observed in lung airway using primary lung airway epithelial cells. Cell concentration gradient is the key factor that determines production of the branching cellular structures, as optimization of this component removes the need for heteroty...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep08054
更新日期：2015-01-27 00:00:00
abstract：:Lipofectamine reagents are widely accepted as "gold-standard" for the safe delivery of exogenous DNA or RNA into cells. Despite this, a satisfactory mechanism-based explanation of their superior efficacy has remained mostly elusive thus far. Here we apply a straightforward combination of live cell imaging, single-part...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep25879
更新日期：2016-05-11 00:00:00
abstract：:Caspase-2 is known to be involved in oxidative-stress mediated neuronal cell death. In this study, we demonstrated that rotenone-induced neuronal cell death is mediated by caspase-2 activation via PIDDosome formation. Our newly designed TAT-fused peptides, which contains wild-type helix number3 (H3) from RAIDD and PID...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep31198
更新日期：2016-08-09 00:00:00
abstract：:The present study investigates the biostimulant effects of 18 Crude Bio-Extracts (CBEs) obtained from Microalgae and Cyanobacteria on tomato plant growth, chlorophyll content, nutrient uptake and metabolite profile. Significant root and shoot length improvement (112.65%, 53.70%); was recorded at treatment with Aphanot...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-59840-4
更新日期：2020-02-18 00:00:00
abstract：:It is urgent to find an optimised therapy regimen for the control of MDR-TB globally. This study aimed to evaluate the efficiacy and safety of a combined regimen of rhIL-2 injection and standard chemotherapy within 18-month duration in a randomized controlled trial conducted in 14 centres in eastern China. From Jan. 2...
journal_title：Scientific reports
pub_type： 杂志文章,随机对照试验
doi：10.1038/s41598-017-18200-5
更新日期：2017-12-19 00:00:00
abstract：:Mucociliary clearance is a biomechanical mechanism of airway protection. It consists of the active transport along the bronchial tree of the mucus, a fluid propelled by the coordinated beating of a myriad of cilia on the epithelial surface of the respiratory tract. The physics of mucus transport is poorly understood b...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-20882-4
更新日期：2018-02-05 00:00:00
abstract：:Here we report the study of two bioengineered variants of human trace amine-associated receptor 5 (hTAAR5) that were expressed in stable tetracycline-inducible HEK293S cell lines. A systematic detergent screen showed that fos-choline-14 was the optimal detergent to solubilize and subsequently purify the receptors. Mil...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep00102
更新日期：2011-01-01 00:00:00
abstract：:The ability for magnetite to act as a recyclable electron donor and acceptor for Fe-metabolizing bacteria has recently been shown. However, it remains poorly understood whether microbe-mineral interfacial electron transfer processes are limited by the redox capacity of the magnetite surface or that of whole particles....
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep30969
更新日期：2016-08-05 00:00:00
abstract：:Obesity is highly heritable, but the specific genes influencing obesity related traits are largely unknown. Fibroblast growth factor 2 (FGF2) could influence adipocyte differentiation. However, the association of FGF2 polymorphisms and obesity remains unclear. This study aimed to investigate the associations of both t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep19868
更新日期：2016-02-16 00:00:00
abstract：:The structure of metallic glasses is a long-standing question because the lack of long-range order makes diffraction based techniques difficult to be applied. Here, we used scanning tunneling microscopy with large tunneling resistance of 6 GΩ at low temperature in order to minimize forces between probe and sample and ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep13143
更新日期：2015-08-13 00:00:00
abstract：:NbP is a recently realized Weyl semimetal (WSM), hosting Weyl points through which conduction and valence bands cross linearly in the bulk and exotic Fermi arcs appear. The most intriguing transport phenomenon of a WSM is the chiral anomaly-induced negative magnetoresistance (NMR) in parallel electric and magnetic fie...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep43394
更新日期：2017-03-06 00:00:00
abstract：:Contrast-induced nephropathy (CIN) has become the third-leading cause of hospital-acquired acute renal injury. Although alprostadil has been proposed as an effective preventative measure, this conclusion remains inconsistent. Thus, we performed a meta-analysis of the published studies on this topic to evaluate the pre...
journal_title：Scientific reports
pub_type： 杂志文章,meta分析
doi：10.1038/s41598-017-01160-1
更新日期：2017-04-21 00:00:00
abstract：:One of the major challenges in olfaction research is to relate the structural features of the odorants to different features of olfactory system. However, no relationship has been yet discovered between the structure of the olfactory stimulus, and the structure of respiratory signal. This study reveals the plasticity ...
journal_title：Scientific reports
pub_type： 杂志文章,收录出版
doi：10.1038/srep26948
更新日期：2016-05-31 00:00:00
abstract：:Drought episodes decrease plant growth and productivity, which in turn cause high economic losses. Plants naturally sense and respond to water stress by activating specific signalling pathways leading to physiological and developmental adaptations. Genetically engineering genes that belong to these pathways might impr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-44571-y
更新日期：2019-05-30 00:00:00
