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Noncoding RNAs: Regulators of the Mammalian Transcription Machinery.

Abstract：

:Transcription by RNA polymerase II (Pol II) is required to produce mRNAs and some noncoding RNAs (ncRNAs) within mammalian cells. This coordinated process is precisely regulated by multiple factors, including many recently discovered ncRNAs. In this perspective, we will discuss newly identified ncRNAs that facilitate DNA looping, regulate transcription factor binding, mediate promoter-proximal pausing of Pol II, and/or interact with Pol II to modulate transcription. Moreover, we will discuss new roles for ncRNAs, as well as a novel Pol II RNA-dependent RNA polymerase activity that regulates an ncRNA inhibitor of transcription. As the multifaceted nature of ncRNAs continues to be revealed, we believe that many more ncRNA species and functions will be discovered.

journal_name

J Mol Biol

journal_title

Journal of molecular biology

authors

Eidem TM,Kugel JF,Goodrich JA

doi

10.1016/j.jmb.2016.02.019

subject

Has Abstract

pub_date

2016-06-19 00:00:00

pages

2652-2659

issue

12

eissn

0022-2836

issn

1089-8638

pii

S0022-2836(16)00135-2

journal_volume

428

pub_type

杂志文章,评审

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