A 50th order reaction predicted and observed for sickle hemoglobin nucleation.

Abstract:

:Sickle hemoglobin polymerization exhibits a striking sensitivity to initial concentration, with characteristic reaction times that exhibit 30th power dependence on concentration. This extraordinary reaction order is encompassed by a novel double nucleation mechanism that predicts 50th power dependence of the homogeneous nucleation rate. Using a technique that allows individual homogeneous nucleation events to be monitored, we have measured a concentration dependence of 47+/-, in excellent agreement with the predictions of the model. Absolute nucleation rates agree with predictions as well.

journal_name

J Mol Biol

authors

Cao Z,Ferrone FA

doi

10.1006/jmbi.1996.0079

subject

Has Abstract

pub_date

1996-02-23 00:00:00

pages

219-22

issue

2

eissn

0022-2836

issn

1089-8638

pii

S0022-2836(96)90079-0

journal_volume

256

pub_type

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