Generation and characterization of rat liver stem cell lines and their engraftment in a rat model of liver failure.

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Michelutti N,Sowell P,Tapia PM,Grooms C,Polo M,Gambetta A,Ausejo C,Smol JP

更新日期：2020-06-16 00:00:00

abstract：:The present study aimed to explore the value of intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) in differentiating hepatocellular carcinoma (HCC) from intrahepatic cholangiocarcinoma (ICC). This study included 65 patients with malignant hepatic nodules (55 with HCC, 10 with ICC), and 17 control pati...

journal_title：Scientific reports

authors： Peng J,Zheng J,Yang C,Wang R,Zhou Y,Tao YY,Gong XQ,Wang WC,Zhang XM,Yang L

更新日期：2020-05-07 00:00:00

abstract：:Plant litter is an important component in wetland ecosystems, and the role of plant litter decomposition is considered to be important for wetland ecosystem functions and services. However, the consequences of litter inputs have seldom been experimentally tested in real ecosystems such as constructed wetlands (CWs). T...

journal_title：Scientific reports

authors： Ping Y,Pan X,Li W,Wang J,Cui L

更新日期：2019-09-25 00:00:00

abstract：:Charge density wave (CDW), the periodic modulation of the electronic charge density, will open a gap on the Fermi surface that commonly leads to decreased or vanishing conductivity. On the other hand superconductivity, a commonly believed competing order, features a Fermi surface gap that results in infinite conductiv...

journal_title：Scientific reports

authors： Zhu X,Ning W,Li L,Ling L,Zhang R,Zhang J,Wang K,Liu Y,Pi L,Ma Y,Du H,Tian M,Sun Y,Petrovic C,Zhang Y

更新日期：2016-06-02 00:00:00

abstract：:The increasing demands in security and reliability of infrastructures call for the optimal design of their embedded complex networks topologies. The following question then arises: what is the optimal layout to fulfill best all the demands? Here we present a general solution for this problem with scale-free networks, ...

journal_title：Scientific reports

authors： Sampaio Filho CI,Moreira AA,Andrade RF,Herrmann HJ,Andrade JS Jr

更新日期：2015-03-13 00:00:00

abstract：:Recruitment via settlement of pelagic larvae is critical for the persistence of benthic marine populations. For many benthic invertebrates, larval settlement occurs in response to surface microbial films. Larvae of the serpulid polychaete Hydroides elegans can be induced to settle by single bacterial species. Until no...

journal_title：Scientific reports

authors： Freckelton ML,Nedved BT,Hadfield MG

更新日期：2017-02-14 00:00:00

abstract：:Viruses exploit host factors and environment for their efficient replication. The virus-host interaction mechanisms for achieving an optimal hepatitis B virus (HBV) replication have been largely unknown. Here, a single cell cloning revealed that HepAD38 cells, a widely-used HBV-inducible cell line, contain cell clones...

journal_title：Scientific reports

authors： Iwamoto M,Cai D,Sugiyama M,Suzuki R,Aizaki H,Ryo A,Ohtani N,Tanaka Y,Mizokami M,Wakita T,Guo H,Watashi K

更新日期：2017-09-06 00:00:00

abstract：:COX-2 inhibition may be of benefit in the treatment of tuberculosis (TB) through a number of pathways including efflux pump inhibition (increasing intracellular TB drug levels) and diverse effects on inflammation and the immune response. We investigated celecoxib (a COX-2 inhibitor) alone and with standard anti-tuberc...

journal_title：Scientific reports

authors： Naftalin CM,Verma R,Gurumurthy M,Hee KH,Lu Q,Yeo BCM,Tan KH,Lin W,Yu B,Seng KY,Lee LS,Paton NI

更新日期：2018-09-10 00:00:00

abstract：:Conventional crystalline β-MnO2 usually exhibits poor electrochemical activities due to the narrow tunnels in its rutile-type structure. In this study, we synthesized a novel 2D β-MnO2 network with long-range order assembled by β-MnO2 nanowires and demonstrated that the novel 2D β-MnO2 network exhibits enhanced electr...

journal_title：Scientific reports

authors： Wei C,Pang H,Zhang B,Lu Q,Liang S,Gao F

更新日期：2013-01-01 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Dawson G,Campbell K,Hashemi J,Lippmann SJ,Smith V,Carpenter K,Egger H,Espinosa S,Vermeer S,Baker J,Sapiro G

更新日期：2020-01-14 00:00:00

abstract：:In this paper, an electrically tunable metasuface is designed for visible regime. The device mainly consists of a V-shaped metallic metasurface, an ITO film, an electro-optic (EO) dielectric and a metal layer fabricated on a silica substrate. A continuous electrical modulation of resonant wavelength has been theoretic...

journal_title：Scientific reports

authors： Guo J,Tu Y,Yang L,Zhang R,Wang L,Wang B

更新日期：2017-10-26 00:00:00

abstract：:The clinical associations and correlations with other virulence factors such as cag pathogenicity island (PAI) of the Integrating Conjugative Elements Helicobacter pylori TFSS (ICEHptfs), a new type IV secretion system (TFSS) in H. pylori has not been described. Among 103 studied strains from Indonesia, almost all str...

journal_title：Scientific reports

authors： Waskito LA,Miftahussurur M,Lusida MI,Syam AF,Suzuki R,Subsomwong P,Uchida T,Hamdan M,Nasronudin,Yamaoka Y

更新日期：2018-04-17 00:00:00

abstract：:The replication-incompetent adenovirus (Ad) vector is one of the most promising vectors for gene therapy; however, systemic administration of Ad vectors results in severe hepatotoxicities, partly due to the leaky expression of Ad genes in the liver. Here we show that nuclear factor-kappa B (NF-κB) mediates the leaky e...

journal_title：Scientific reports

authors： Machitani M,Sakurai F,Wakabayashi K,Nakatani K,Shimizu K,Tachibana M,Mizuguchi H

更新日期：2016-01-27 00:00:00

abstract：:Increasing evidence has confirmed that immunoglobulins (Igs) can be expressed in non-B cells. Our previous work demonstrated that mesangial cells and podocytes express IgA and IgG, respectively. The aim of this work was to reveal whether proximal tubular epithelial cells (PTECs) express Igs. High-throughput single-cel...

journal_title：Scientific reports

authors： Deng Z,Wang X,Liu Y,Tian X,Deng S,Sun Y,Wang S,Zheng D,Cui Z,Pan Y,A L,Yan H,Qiu X,Wang Y

更新日期：2020-11-12 00:00:00

abstract：:The relationship between obstructive sleep apnea (OSA) and chronic rhinosinusitis (CRS) still remains unclear. This retrospective cohort study aimed to investigate the relationship between OSA and subsequent CRS using a population-based dataset. The study used data from the Taiwan Longitudinal Health Insurance Databas...

journal_title：Scientific reports

authors： Kao LT,Hung SH,Lin HC,Liu CK,Huang HM,Wu CS

更新日期：2016-02-10 00:00:00

abstract：:Single nucleotide polymorphisms (SNPs) in the 3'-untranslated regions targeted by putative mircoRNA can change its binding strength, affecting the susceptibility and prognosis of cancer. We aimed to investigate the associations between SNPs within miR-148a binding sites and gastric cancer (GC) risk and prognosis. Usin...

journal_title：Scientific reports

authors： Song P,Zhu H,Zhang D,Chu H,Wu D,Kang M,Wang M,Gong W,Zhou J,Zhang Z,Zhao Q

更新日期：2014-11-17 00:00:00

abstract：:Cisplatin, a highly effective and widely used chemotherapeutic agent, has a major limitation for its nephrotoxicity. We recently identified a novel strategy for attenuating its nephrotoxicity in chemotherapy by an effective adjuvant via epigenetic modification through targeting HDAC2. Molecular docking and SPR assay f...

journal_title：Scientific reports

authors： Ma T,Huang C,Meng X,Li X,Zhang Y,Ji S,Li J,Ye M,Liang H

更新日期：2016-05-05 00:00:00

abstract：:The performances of two identical biofilters, filled with a new composite packing material (named CM-5) embedded with functional microorganisms or sterilized CM-5 without microorganisms, were investigated for H2S treatment. Running parameters in terms of microbial counts, pressure drops, and inlet and outlet H2S conce...

journal_title：Scientific reports

authors： Zhu R,Li S,Bao X,Dumont É

更新日期：2017-02-13 00:00:00

abstract：:Knowing the distribution of marine animals is central to understanding climatic and other environmental influences on population ecology. This information has proven difficult to gain through capture-based methods biased by capture location. Here we show that marine location can be inferred from animal tissues. As the...

journal_title：Scientific reports

authors： MacKenzie KM,Palmer MR,Moore A,Ibbotson AT,Beaumont WR,Poulter DJ,Trueman CN

更新日期：2011-01-01 00:00:00

abstract：:Desensitisation with therapeutic plasma exchange (TPE) is essential for ABO-incompatible (ABO-I) liver transplants (LTs). However, excessive citrate load and coagulation disturbances after TPE have been poorly studied, in particular in cirrhotic patients with hypocapnic alkalosis, metabolic compensation and electrolyt...

journal_title：Scientific reports

authors： Kwon HM,Jun IG,Lee J,Moon YJ,Jung KW,Jeong HW,Park YS,Song JG,Hwang GS

更新日期：2018-04-27 00:00:00

abstract：:The majority of individuals with Down syndrome (DS) do not exhibit accurate accommodation, with the aetiology of this deficit unknown. This study examines the mechanism underlying hypoaccommodation in DS by simultaneously investigating the 'near triad' - accommodation, vergence and pupillary response. An objective pho...

journal_title：Scientific reports

authors： Doyle L,Saunders KJ,Little JA

更新日期：2016-02-05 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Cencetti G,Clusella P,Fanelli D

更新日期：2020-02-18 00:00:00

abstract：:Pancreas development requires restrained Hedgehog (Hh) signaling activation. While deregulated Hh signaling in the pancreatic mesenchyme has been long suggested to be detrimental for proper organogenesis, this association was not directly shown. Here, we analyzed the contribution of mesenchymal Hh signaling to pancrea...

journal_title：Scientific reports

authors： Hibsher D,Epshtein A,Oren N,Landsman L

更新日期：2016-11-28 00:00:00

abstract：:The prediction of drug-target interactions is a key step in the drug discovery process, which serves to identify new drugs or novel targets for existing drugs. However, experimental methods for predicting drug-target interactions are expensive and time-consuming. Therefore, the in silico prediction of drug-target inte...

journal_title：Scientific reports

authors： Kuang Q,Xu X,Li R,Dong Y,Li Y,Huang Z,Li Y,Li M

更新日期：2015-09-09 00:00:00

abstract：:A growing proportion of head and neck cancers (HNC) result from HPV infection. Between HNC aetiological groups (HPV positive and HPV negative) clinical evidence demonstrates significantly better treatment response among HPV positive cancers. Cancer stem cells (CSCs) are identified in HNC tumour populations as agents o...

journal_title：Scientific reports

authors： Reid P,Staudacher AH,Marcu LG,Olver I,Moghaddasi L,Brown MP,Bezak E

更新日期：2020-02-17 00:00:00

abstract：:Nicotinamide phosphoribosyltransferase (NAMPT) is a rate-limiting enzyme in the salvage pathway of nicotinamide adenine dinucleotide biosynthesis. NAMPT protein is a secreted plasma biomarker in inflammation and in cancer. The NAMPT enzymatic inhibitor, FK866, acts as an inducer of apoptosis and is a cancer therapeuti...

journal_title：Scientific reports

authors： Zhou T,Wang T,Garcia JG

更新日期：2014-08-22 00:00:00

abstract：:This paper aims to eliminate the disharmony between simulation and experiment, and takes the mechanical properties of 6082-T6 Al alloy as an example. In order to obtain the equivalent distribution of material properties after considering the randomicity of materials, a new inversion method combining with stochastic fi...

journal_title：Scientific reports

authors： Zheng K,Yang K,Shi J,Yuan J,Zhou G

更新日期：2019-11-28 00:00:00

abstract：:Lactobacilli are thought to be beneficial for human health, with lactobacilli-associated infections being confined to immune-compromised individuals. However, Lactobacillus fermentum AGR1487 negatively affects barrier integrity in vitro so we hypothesized that it caused a pro-inflammatory response in the host. We comp...

journal_title：Scientific reports

authors： Anderson RC,Ulluwishewa D,Young W,Ryan LJ,Henderson G,Meijerink M,Maier E,Wells JM,Roy NC

更新日期：2016-02-04 00:00:00

abstract：:A better understanding of the seroprevalence and specificity of influenza HA stem-directed broadly neutralizing antibodies (bNAbs) in the human population could significantly inform influenza vaccine design efforts. Here, we utilized probes comprising headless, HA stabilized stem (SS) to determine the prevalence, bind...

journal_title：Scientific reports

authors： Yassine HM,McTamney PM,Boyington JC,Ruckwardt TJ,Crank MC,Smatti MK,Ledgerwood JE,Graham BS

更新日期：2018-06-05 00:00:00

abstract：:Type 2 diabetes mellitus is a major health concern worldwide; however, the molecular mechanism underlying its development is poorly understood. The hormone amylin is postulated to be involved, as human amylin forms amyloid in the pancreases of diabetic patients, and oligomers have been shown to be cytotoxic to β-cells...

journal_title：Scientific reports

authors： Nie T,Zhang S,Vazhoor Amarsingh G,Liu H,McCann MJ,Cooper GJS

更新日期：2019-10-10 00:00:00