Abstract：
:To assess the influence of DGAVP (des-glycinamide-arginine-8-vasopressin, a synthetic vasopressin analogue) on the processing of stimuli and stimulus deviance in humans in a double-blind cross-over experiment, 13 subjects received 60 IU DGAVP versus placebo intranasally 48, 24, and 1 h prior to the experimental session. Auditory event-related potentials (ERPs) were taken as a tool to investigate central nervous processing in an experimental task that required the subjects to count different kinds of rare tone pips deviating in pitch and probability compared to frequent standard tones. Direction of attention was manipulated by instructing the subject to count a different class of deviating tone pips in each attention condition. DGAVP enhanced the N2 of the ERP to tone pips deviating extremely in pitch from standard tones, whether or not the extremely deviating pips were to be attended to by the subjects. This influence suggests an intensified mismatch processing under DGAVP that may result from a general excitatory effect of this substance on cortical activity.
journal_name
Biol Psycholjournal_title
Biological psychologyauthors
Pietrowsky R,Born J,Fehm-Wolfsdorf G,Fehm HLdoi
10.1016/0301-0511(89)90003-3subject
Has Abstractpub_date
1989-06-01 00:00:00pages
239-50issue
3eissn
0301-0511issn
1873-6246journal_volume
28pub_type
临床试验,杂志文章abstract：:Men engage in aggression at a cost to extrinsic reward, and this behaviour is associated with a rise in testosterone. To characterize the factors underlying aggression, men were assigned to one of the four experimental conditions of a computer game in which they were provoked (points were stolen from them or not) and/...
journal_title：Biological psychology
pub_type： 杂志文章,随机对照试验
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journal_title：Biological psychology
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更新日期：2010-02-01 00:00:00
