Controllability and hippocampal activation during pain expectation in fibromyalgia syndrome.

Abstract:

:To examine the role of perceived control in pain perception, fibromyalgia patients and healthy controls participated in a reaction time experiment under different conditions of pain controllability. No significant differences between groups were found in pain intensity and unpleasantness ratings. However, during the expectation of uncontrollable pain, patients compared to controls showed higher hippocampal activation. In addition, hippocampal activity during the pain expectation period predicted activation of the posterior cingulate cortex (PCC), precuneus and hippocampus during pain stimulation in fibromyalgia patients. The increased activation of the hippocampus during pain expectation and subsequent activation of the PCC/precuneus during the lack of control phase points towards an influence of pain perception through heightening of alertness and anxiety responses to pain in fibromyalgia patients.

journal_name

Biol Psychol

journal_title

Biological psychology

authors

González-Roldán AM,Bomba IC,Diesch E,Montoya P,Flor H,Kamping S

doi

10.1016/j.biopsycho.2016.09.007

subject

Has Abstract

pub_date

2016-12-01 00:00:00

pages

39-48

issue

Pt A

eissn

0301-0511

issn

1873-6246

pii

S0301-0511(16)30284-8

journal_volume

121

pub_type

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