Abstract:
INTRODUCTION:Alkaline phosphatase (ALP) plays an important role in inducing mineralization events in the dental pulp. This study investigated and compared the ALP levels in healthy and inflamed pulp in young and old human pulp. METHODS:Tissue samples were collected from young (<30 years) and old (>60 years) donors. In both age groups, healthy human pulp (n = 18) were collected from extracted wisdom teeth. For reversible and irreversible pulpitis, pulp samples (n = 18 each) were obtained during endodontic treatment. ALP activity was assessed by spectrophotometry and immunhistochemistry. RESULTS:Regardless of age, reversible pulpitis group samples showed a slight elevation in ALP activity compared with normal healthy pulp. In elderly patients, ALP expression with irreversible pulpitis was significantly higher than those with a healthy pulp (P < .05). CONCLUSIONS:In the hyperemic state, both the young and old pulp shows a slight increase in ALP activity, whereas in irreversible pulpitis, only the old pulp shows significantly elevated ALP levels. Such an increase may trigger calcification events, which may eventually cause difficulties in endodontic treatment procedures in elderly individuals.
journal_name
J Endodjournal_title
Journal of endodonticsauthors
Aslantas EE,Buzoglu HD,Karapinar SP,Cehreli ZC,Muftuoglu S,Atilla P,Aksoy Ydoi
10.1016/j.joen.2015.10.003subject
Has Abstractpub_date
2016-01-01 00:00:00pages
131-4issue
1eissn
0099-2399issn
1878-3554pii
S0099-2399(15)00901-2journal_volume
42pub_type
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更新日期:1996-01-01 00:00:00
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更新日期:1990-07-01 00:00:00
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journal_title:Journal of endodontics
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doi:10.1016/j.joen.2005.09.011
更新日期:2006-04-01 00:00:00
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更新日期:2014-02-01 00:00:00
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更新日期:2015-09-01 00:00:00
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更新日期:1993-04-01 00:00:00
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更新日期:2010-11-01 00:00:00
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更新日期:2010-10-01 00:00:00
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更新日期:2017-10-01 00:00:00
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pub_type: 杂志文章
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更新日期:2012-10-01 00:00:00