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eLife文献大全abstract::Anterograde transport of late endosomes or lysosomes (LE/Lys) is crucial for proper axon growth. However, the role of energetic nutrients has been poorly explored. Malonyl-CoA is a precursor of fatty acids, and its intracellular levels highly fluctuate depending on glucose availability or the energy sensor AMP-activat...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.51063
更新日期:2019-12-23 00:00:00
abstract::Understanding temporal dynamics of COVID-19 symptoms could provide fine-grained resolution to guide clinical decision-making. Here, we use deep neural networks over an institution-wide platform for the augmented curation of clinical notes from 77,167 patients subjected to COVID-19 PCR testing. By contrasting Electroni...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.58227
更新日期:2020-07-07 00:00:00
abstract::R-loops are features of chromatin consisting of a strand of DNA hybridized to RNA, as well as the expelled complementary DNA strand. R-loops are enriched at promoters where they have recently been shown to have important roles in modifying gene expression. However, the location of promoter-associated R-loops and the g...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.28306
更新日期:2017-10-26 00:00:00
abstract::Visual perception and behavior are mediated by cortical areas that have been distinguished using architectonic and retinotopic criteria. We employed fluorescence imaging and GCaMP6 reporter mice to generate retinotopic maps, revealing additional regions of retinotopic organization that extend into barrel and retrosple...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.18372
更新日期:2017-01-06 00:00:00
abstract::Compartmentalized oscillations of second messengers affect global cellular signaling. ...
journal_title:eLife
pub_type: 评论,杂志文章
doi:10.7554/eLife.63845
更新日期:2020-11-17 00:00:00
abstract::The β-catenin transcriptional coregulator is involved in various biological and pathological processes; however, its requirements in hematopoietic cells remain controversial. We re-targeted the Ctnnb1 gene locus to generate a true β-catenin-null mutant mouse strain. Ablation of β-catenin alone, or in combination with ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.55360
更新日期:2020-08-21 00:00:00
abstract::Social rank differentially influences how male and female mice respond to chronic stress. ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.63996
更新日期:2020-11-20 00:00:00
abstract::Maintenance of transcription programs is challenged during mitosis when chromatin becomes condensed and transcription is silenced. How do the daughter cells re-establish the original transcription program? Here, we report that the TATA-binding protein (TBP), a key component of the core transcriptional machinery, remai...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.35621
更新日期:2018-06-25 00:00:00
abstract::Auditory processing depends upon inhibitory signaling by interneurons, even at its earliest stages in the ventral cochlear nucleus (VCN). Remarkably, to date only a single subtype of inhibitory neuron has been documented in the VCN, a projection neuron termed the D-stellate cell. With the use of a transgenic mouse lin...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.54350
更新日期:2020-11-03 00:00:00
abstract::The Reproducibility Project: Cancer Biology seeks to address growing concerns about reproducibility in scientific research by conducting replications of selected experiments from a number of high-profile papers in the field of cancer biology. The papers, which were published between 2010 and 2012, were selected on the...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.07420
更新日期:2015-07-31 00:00:00
abstract::Modern neuroscience research often requires the coordination of multiple processes such as stimulus generation, real-time experimental control, as well as behavioral and neural measurements. The technical demands required to simultaneously manage these processes with high temporal fidelity is a barrier that limits the...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.40231
更新日期:2019-02-07 00:00:00
abstract::A mathematical model shows how the shape of early multicellular organisms may have helped cells evolve specialized roles. ...
journal_title:eLife
pub_type: 评论,杂志文章
doi:10.7554/eLife.63328
更新日期:2020-11-03 00:00:00
abstract::Cortical plasticity is fundamental to motor recovery following cortical perturbation. However, it is still unclear how this plasticity is induced at a functional circuit level. Here, we investigated motor recovery and underlying neural plasticity upon optogenetic suppression of a cortical area for eye movement. Using ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.50855
更新日期:2019-11-05 00:00:00
abstract::We collated contact tracing data from COVID-19 clusters in Singapore and Tianjin, China and estimated the extent of pre-symptomatic transmission by estimating incubation periods and serial intervals. The mean incubation periods accounting for intermediate cases were 4.91 days (95%CI 4.35, 5.69) and 7.54 (95%CI 6.76, 8...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.57149
更新日期:2020-06-22 00:00:00
abstract::The mesiotemporal lobe (MTL) is implicated in many cognitive processes, is compromised in numerous brain disorders, and exhibits a gradual cytoarchitectural transition from six-layered parahippocampal isocortex to three-layered hippocampal allocortex. Leveraging an ultra-high-resolution histological reconstruction of ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.60673
更新日期:2020-11-04 00:00:00
abstract::Recent work draws attention to community-community encounters ('coalescence') as likely an important factor shaping natural ecosystems. This work builds on MacArthur's classic model of competitive coexistence to investigate such community-level competition in a minimal theoretical setting. It is shown that the ability...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.15747
更新日期:2016-06-16 00:00:00
abstract::New ages for flowstone, sediments and fossil bones from the Dinaledi Chamber are presented. We combined optically stimulated luminescence dating of sediments with U-Th and palaeomagnetic analyses of flowstones to establish that all sediments containing Homo naledi fossils can be allocated to a single stratigraphic ent...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.24231
更新日期:2017-05-09 00:00:00
abstract::To initiate DNA replication, cells first load an MCM helicase double hexamer at origins in a reaction requiring ORC, Cdc6, and Cdt1, also called pre-replicative complex (pre-RC) assembly. The essential mechanistic role of Cdc6 ATP hydrolysis in this reaction is still incompletely understood. Here, we show that althoug...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.05795
更新日期:2015-08-25 00:00:00
abstract::Analysis of the spatial distribution of endomembrane trafficking is fundamental to understand the mechanisms controlling cellular dynamics, cell homeostasy, and cell interaction with its external environment in normal and pathological situations. We present a semi-parametric framework to quantitatively analyze and vis...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.32311
更新日期:2018-08-09 00:00:00
abstract::Hybrid sterility is one of the earliest postzygotic isolating mechanisms to evolve between two recently diverged species. Here we identify causes underlying hybrid infertility of two recently diverged fission yeast species Schizosaccharomyces pombe and S. kambucha, which mate to form viable hybrid diploids that effici...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.02630
更新日期:2014-06-24 00:00:00
abstract::Massed synchronised neuronal firing is detrimental to information processing. When networks of task-irrelevant neurons fire in unison, they mask the signal generated by task-critical neurons. On a macroscopic level, such synchronisation can contribute to alpha/beta (8-30 Hz) oscillations. Reducing the amplitude of the...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.49562
更新日期:2019-11-29 00:00:00
abstract::The neural control of transition between posture and movement encompasses the regulation of reflex-stabilizing mechanisms to enable motion. Optimal feedback theory suggests that such transitions require the disengagement of one motor control policy before the implementation of another. To test this possibility, we inv...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.36123
更新日期:2018-07-10 00:00:00
abstract::India comprises much of the persisting global childhood measles mortality. India implemented a mass second-dose measles immunization campaign in 2010. We used interrupted time series and multilevel regression to quantify the campaign's impact on measles mortality using the nationally representative Million Death Study...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.43290
更新日期:2019-03-05 00:00:00
abstract::Slo2 potassium channels play important roles in neuronal function, and their mutations in humans may cause epilepsies and cognitive defects. However, it is largely unknown how Slo2 is regulated by other proteins. Here we show that the function of C. elegans Slo2 (SLO-2) depends on adr-1, a gene important to RNA editin...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.53986
更新日期:2020-04-21 00:00:00
abstract::Whether neurons encode information through their spike rates, their activity times or both is an ongoing debate in systems neuroscience. Here, we tested whether humans can discriminate between a pair of temporal odor mixtures (TOMs) composed of the same two components delivered in rapid succession in either one tempor...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.49734
更新日期:2020-02-07 00:00:00
abstract::Actin dynamics generate forces to deform the membrane and overcome the cell's high turgor pressure during clathrin-mediated endocytosis (CME) in yeast, but precise molecular details are still unresolved. Our previous models predicted that actin filaments of the endocytic meshwork continually polymerize and disassemble...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.52355
更新日期:2019-12-19 00:00:00
abstract::The Deleted in Colorectal Carcinoma (Dcc) receptor plays a critical role in optic nerve development. Whilst Dcc is expressed postnatally in the eye, its function remains unknown as Dcc knockouts die at birth. To circumvent this drawback, we generated an eye-specific Dcc mutant. To study the organization of the retina ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.51275
更新日期:2020-02-25 00:00:00
abstract::Axolotls are uniquely able to mobilize neural stem cells to regenerate all missing regions of the spinal cord. How a neural stem cell under homeostasis converts after injury to a highly regenerative cell remains unknown. Here, we show that during regeneration, axolotl neural stem cells repress neurogenic genes and rea...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.10230
更新日期:2015-11-14 00:00:00
abstract::Signaling by the G-protein-coupled receptors (GPCRs) plays fundamental role in a vast number of essential physiological functions. Precise control of GPCR signaling requires action of regulators of G protein signaling (RGS) proteins that deactivate heterotrimeric G proteins. RGS proteins are elaborately regulated and ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.42150
更新日期:2018-12-12 00:00:00
abstract::Synaptic adhesion molecules regulate synapse development and function. However, whether and how presynaptic adhesion molecules regulate postsynaptic NMDAR function remains largely unclear. Presynaptic LAR family receptor tyrosine phosphatases (LAR-RPTPs) regulate synapse development through mechanisms that include tra...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.54224
更新日期:2020-03-06 00:00:00