Abstract:
PURPOSE:To validate ironload T2* by automatic inline Maximum Likelihood Estimate (MLE) with k-space Rician noise correction, against the manual and automated truncation, as well as offset methods, in phantoms and in heart and liver in patients. METHODS:Twenty-five patients and an iron-oxide phantom were scanned at 1.5T using 2 multi-echo gradient-echo sequences. All parameters were identical (voxel 2-3 × 2-3 × 10 mm3 , 10 echoes, TR = 26 ms, FA = 20°, BW = 833 Hz, SENSE = 2) except for TE (cardiac: TE1 = 2·5 ms, ΔTE = 2·5 ms; liver: TE1 = 1·2 ms, ΔTE = 1·5 ms). Phantoms were scanned at 1 and 32 signal averages (NSA), with NSA32 representing low-noise reference. RESULTS:Phantoms: MLE showed low variability between NSA1 and NSA32 (0·02 ± 0·29 ms, CI ±0·21 ms). Between methods, no difference was shown (MLE versus all: <0·31 ms, CI < ±0·35 ms). PATIENTS:No differences were found between methods in heart (MLE versus all: <-0·22 ms, CI < ±0·75 ms) or liver (MLE versus all: <0·12 ms, CI < ±0·26 ms). CONCLUSIONS:The automatic inline MLE method is comparable to the general reference standards for determining cardiac and liver T2* for ironload in man. An automatic inline method may simplify ironload assessment, particularly in centres seeing fewer cases.
journal_name
Clin Physiol Funct Imagingjournal_title
Clinical physiology and functional imagingauthors
Hedström E,Voigt T,Greil G,Schaeffter T,Nagel Edoi
10.1111/cpf.12303subject
Has Abstractpub_date
2017-05-01 00:00:00pages
299-304issue
3eissn
1475-0961issn
1475-097Xjournal_volume
37pub_type
杂志文章abstract:BACKGROUND:The BodyMetrix(®) BX-2000 Ultrasound device (ULTRA) shows prowess in being an effective alternative to the expense and technicality of dual-energy X-ray absorptiometry (DXA). However, this technique has not been investigated using a seven-site methodology. SUBJECT/OBJECTIVE:To employ a cross-over design to ...
journal_title:Clinical physiology and functional imaging
pub_type: 杂志文章
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journal_title:Clinical physiology and functional imaging
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journal_title:Clinical physiology and functional imaging
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journal_title:Clinical physiology and functional imaging
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journal_title:Clinical physiology and functional imaging
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journal_title:Clinical physiology and functional imaging
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journal_title:Clinical physiology and functional imaging
pub_type: 杂志文章
doi:10.1111/j.1475-097X.2006.00705.x
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pub_type: 杂志文章,随机对照试验
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