Abstract:
BACKGROUND:The heat-washout method is an objective method that measures cutaneous blood flow rate (BFR) in ml (100 g. min)(-1), previously found useful for measuring toe BFR in non-diabetic patients with claudication. AIM:The method is used for evaluating the presence of a veno-arteriolar reflex (VAR) in the forefoot and signs of atherosclerosis in the first toe in type 2 diabetics. METHODS:Nine type 2 diabetics for +10 years, peripheral neuropathy, median age 62, and 9 healthy subjects without diabetes, median age 52 were examined for the presence of a VAR in the forefoot. A VAR was present when BFR decreased 25% or more with the foot 50 cm below heart level. Examinations for atherosclerosis were made in the pulp of the first toe. An increase in BFR of 50% or more with the foot 50 cm below heart level indicated the presence of atherosclerosis. RESULTS:The VAR was significantly attenuated in type 2 diabetics with neuropathy compared to controls, (P<0·01). Only one patient with known neuropathy and diabetes showed a reflex compared to eight out of nine controls (P<0·01). The VAR was correlated to the vibration perception threshold measured with biothesiometry (r = -0·661, P = 0·0003). Two patients with type 2 diabetes and neuropathy without clinical sign of peripheral artery disease (PAD) had an abnormal response similar to that seen in subjects with intermittent claudication. CONCLUSION:The heat-washout method seems useful as and objective method for evaluating as well the presence of a VAR as atherosclerosis in type 2 diabetics.
journal_name
Clin Physiol Funct Imagingjournal_title
Clinical physiology and functional imagingauthors
Midttun M,Snorgaard Odoi
10.1111/cpf.12028subject
Has Abstractpub_date
2013-07-01 00:00:00pages
302-6issue
4eissn
1475-0961issn
1475-097Xjournal_volume
33pub_type
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journal_title:Clinical physiology and functional imaging
pub_type: 杂志文章
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journal_title:Clinical physiology and functional imaging
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journal_title:Clinical physiology and functional imaging
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journal_title:Clinical physiology and functional imaging
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journal_title:Clinical physiology and functional imaging
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journal_title:Clinical physiology and functional imaging
pub_type: 杂志文章
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journal_title:Clinical physiology and functional imaging
pub_type: 杂志文章
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更新日期:2014-07-01 00:00:00
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pub_type: 杂志文章
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更新日期:2018-04-27 00:00:00
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journal_title:Clinical physiology and functional imaging
pub_type: 杂志文章
doi:10.1111/j.1475-097X.2005.00620.x
更新日期:2005-09-01 00:00:00
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journal_title:Clinical physiology and functional imaging
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2003-11-01 00:00:00
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更新日期:2017-05-01 00:00:00
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journal_title:Clinical physiology and functional imaging
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更新日期:2009-01-01 00:00:00
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