Cerebral perfusion information obtained by dynamic contrast-enhanced phase-shift magnetic resonance imaging: comparison with model-free arterial spin labelling.

Abstract:

:Phase-shift time curves following a bolus injection of gadolinium contrast agent were registered for grey-matter regions and large vessels in 14 subjects. Deconvolving a tissue phase-shift curve with a phase-based arterial input function resulted in a tissue residue function R(t). The peak value of R(t) provided a relative cerebral blood flow (CBF) index, while the area-to-height ratio of R(t) provided quantitative mean transit time (MTT). For comparison, quantitative CBF values in grey matter were acquired using model-free arterial spin labelling (ASL). The phase-based relative CBF estimates showed good linear correlation with ASL-based CBF (r = 0.82). Grey-matter MTT was 4.9 +/- 1.1 s (mean +/- SD).

authors

Wirestam R,Lindgren E,van Westen D,Bloch KM,Ståhlberg F,Knutsson L

doi

10.1111/j.1475-097X.2010.00947.x

subject

Has Abstract

pub_date

2010-09-01 00:00:00

pages

375-9

issue

5

eissn

1475-0961

issn

1475-097X

pii

CPF947

journal_volume

30

pub_type

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