Autonomic dysfunction, cardio-pulmonary exercise testing and masked heart failure with preserved ejection fraction in non-severe chronic obstructive pulmonary disease.

Abstract:

BACKGROUND:Autonomic dysfunction (AD) and cardiopulmonary exercise testing (CPET) parameters have been associated with masked heart failure with preserved ejection fraction (HFpEF) in the general population. Their clinical significance for masked HFpEF in chronic obstructive pulmonary disease (COPD) is however elusive. AIM:The aim of the study was to determine the prevalence, correlation and clinical significance of AD and CPET with masked HFpEF, in non-severe COPD patients, complaining of exertional dyspnoea, without clinically overt cardio-vascular (CV) comorbidities. METHODS AND RESULTS:We applied CPET and echocardiography in 68 COPD subjects. Echocardiography was performed before CPET and 1-2 min after peak exercise. Patients were divided into two groups: patients with and without masked HFpEF. Peak E/e' - 15 was applied as a cut-off. Chronotropic incompetence (CI) was assumed if both failure to reach the target heart rate (HR) on exercise and diminished heart rate reserve <80% occurred. Abnormal HR recovery (HRR) was taken if the decline is <12 beats within the first minute after exercise cessation. Univariate regression showed association between masked HFpEF, HRR, VO2, VO2 at AT, oxygen pulse and VE/VCO2 slope. The multivariate regression demonstrated HRR as the only independent predictor of masked HFpEF - (OR 10.28; 95% CI (3.55-29.80)). CONCLUSION:Abnormal HRR is the only independent predictor of masked HFpEF in non-severe COPD patients. Despite of being associated with masked HFpEF, the lower VO2, lower oxygen pulse, higher VE/VCO2 slope and lower exercise load seem to be the consequences, rather than the triggers for it.

authors

Cherneva R,Denchev S,Cherneva ZV

doi

10.1111/cpf.12623

subject

Has Abstract

pub_date

2020-07-01 00:00:00

pages

224-231

issue

4

eissn

1475-0961

issn

1475-097X

journal_volume

40

pub_type

杂志文章
  • Effect of exercise intensity on oxygen consumption kinetics in non-exercising muscle during exercise.

    abstract::This study examined the effect of exercise intensity on the kinetics of muscle oxygen consumption in non-exercising forearm flexor muscles (VO(2mf)) during exercise. Seven healthy male subjects performed cycling exercise for 60 min at 30% of maximal oxygen consumption (%VO(2max)) and 30 min at 50% VO(2max) on separate...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1475-097X.2011.01073.x

    authors: Nagasawa T

    更新日期:2012-05-01 00:00:00

  • Carotid artery longitudinal wall motion alterations associated with metabolic syndrome and insulin resistance.

    abstract:BACKGROUND AND AIMS:Our objective was to study relationships between the new biomarker of vascular health, carotid artery longitudinal wall motion (CALM) and metabolic syndrome (MetS). METHODS:Carotid ultrasound and assessment of MetS and its components were performed with 281 subjects aged 30-45 years. In the longitu...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章

    doi:10.1111/cpf.12687

    authors: Taivainen SH,Laitinen TM,Yli-Ollila H,Juonala M,Kähönen M,Raitakari OT,Laitinen TP

    更新日期:2020-12-19 00:00:00

  • Gender aspects on exercise-induced ECG changes in relation to scintigraphic evidence of myocardial ischaemia.

    abstract:BACKGROUND:This retrospective study aimed to determine the diagnostic performance of exercise-induced ST response in relation to findings by myocardial perfusion single photon emission computed tomography (MPS), with focus on gender differences, in patients with suspected or established stable ischemic heart disease. ...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章

    doi:10.1111/cpf.12483

    authors: Akil S,Hedén B,Pahlm O,Carlsson M,Arheden H,Engblom H

    更新日期:2018-09-01 00:00:00

  • Intramuscular water movement during and after isometric muscle contraction: evaluation at different exercise intensities.

    abstract::We aimed at evaluating the effect of isometric muscle contraction on intramuscular water movement at different exercise intensities. Seven men performed 1-min isometric ankle dorsiflexion (20% and 50% maximal voluntary contractions [MVCs]) with a non-magnetic custom-made dynamometer, inside a magnetic resonance (MR) d...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章

    doi:10.1111/cpf.12239

    authors: Yanagisawa O,Kurihara T

    更新日期:2016-09-01 00:00:00

  • Detection of chronic rejection by quantitative ventilation scintigrams in lung-transplanted patients: a pilot study.

    abstract::The suspicion of chronic rejection [bronchiolithis obliterans syndrome (BOS)] is usually based on deteriorating forced expired volume in 1 s. It is however, desirable to develop more sensitive methods as increased anti-inflammatory therapy is thought to stop progression of the rejection. The aim of the present study w...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章

    doi:10.1111/j.1475-097X.2005.00609.x

    authors: Johansson A,Moonen M,Enocson A,Mårtensson G,Bake B

    更新日期:2005-05-01 00:00:00

  • Prognostic impact of ventilation-perfusion defects and pulmonary diffusing capacity after single lung transplantation.

    abstract:BACKGROUND:Ventilation-perfusion (VQ) scintigraphy and lung function testing are often used to assess allograft function after single lung transplantation (SLTX). However, it is unknown whether allograft defects on VQ scintigraphy presage all-cause mortality after SLTX. OBJECTIVE:To investigate whether allograft defec...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章

    doi:10.1111/cpf.12676

    authors: Mohammad M,Kristensen AW,Hedsund C,Greve AM,Perch M,Mortensen J,Berg RMG

    更新日期:2020-11-06 00:00:00

  • The effects of unilateral transcutaneous electrical nerve stimulation of the median nerve on bilateral somatosensory thresholds.

    abstract::Transcutaneous electrical nerve stimulation (TENS) is used to relieve acute and chronic pain. TENS electrodes are applied at the site of pain or in segments related to the pain, although there is limited research to support either approach. This study investigated the effects of unilateral TENS on mechanical and therm...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章

    doi:10.1111/j.1475-097X.2006.00689.x

    authors: Dean J,Bowsher D,Johnson MI

    更新日期:2006-09-01 00:00:00

  • Effect of very low-intensity resistance training with slow movement on muscle size and strength in healthy older adults.

    abstract::We previously reported that low-intensity [50% of one repetition maximum (1RM)] resistance training with slow movement and tonic force generation (LST) causes muscle hypertrophy and strength gain in older participants. The aim of this study was to determine whether resistance training with slow movement and much more ...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/cpf.12117

    authors: Watanabe Y,Madarame H,Ogasawara R,Nakazato K,Ishii N

    更新日期:2014-11-01 00:00:00

  • Relationship between plasma volume and essential blood constituents in patients with heart failure and preserved ejection fraction.

    abstract:INTRODUCTION:Notwithstanding recent progress on molecular mechanisms underlying heart failure with preserved ejection fraction (HFpEF), multiple pathophysiological aspects of this condition including the basis of anaemia and other haematological disorders remain unresolved. In this study, we sought to determine the rel...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章

    doi:10.1111/cpf.12614

    authors: Diaz-Canestro C,Haider T,Lundby C,Montero D

    更新日期:2020-03-01 00:00:00

  • Comparison of stroke volume estimation for non-steady-state and steady-state graded exercise testing.

    abstract::The stroke volume (SV) during exercise is an important index of the heart's functional capacity. A new method has been developed for the non-invasive estimation of exercise SV (SVex). It requires the determination of the slope for the oxygen uptake versus heart rate relationship in the steady state of graded exercise ...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章

    doi:10.1111/j.1475-097X.2004.00585.x

    authors: Davis JA,Sorrentino KM,Soriano AC,Pham PH

    更新日期:2005-01-01 00:00:00

  • Assessment of exercise capacity in women with type 2 diabetes.

    abstract::The primary aim of this study was to compare the maximal oxygen uptake as evaluated from a submaximal exercise test (EVO2peak) to direct measurements of VO2peak during a maximal exercise test as means of monitoring the aerobic endurance capacity in women with type 2 diabetes (T2D). Twenty-seven women with T2D particip...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章

    doi:10.1111/j.1475-097X.2008.00808.x

    authors: Segerström AB,Glans F,Eriksson KF,Groop L,Thorsson O,Wollmer P

    更新日期:2008-09-01 00:00:00

  • Volumetric capnography: reliability and reproducibility in spontaneously breathing patients.

    abstract::Volumetric capnography provides a breath-by-breath analysis of ventilation-perfusion imbalances and deadspace volumes. The technique has been best described in intubated and ventilated patients, but promising clinical applications also concern spontaneously breathing patients. The objective of the study was to verify ...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章

    doi:10.1111/j.1475-097X.2005.00620.x

    authors: Verschuren F,Heinonen E,Clause D,Zech F,Reynaert MS,Liistro G

    更新日期:2005-09-01 00:00:00

  • Cardiovascular effects of ophthalmic 0.5% timolol aqueous solution and 0.1% timolol hydrogel.

    abstract::The objective of this randomized, double-masked, cross-over study was to compare the cardiovascular effects of two glaucoma formulations, ophthalmic 0.5% timolol aqueous solution and 0.1% timolol hydrogel. Twenty-four young healthy subjects received for 2 weeks either twice daily 0.5% timolol solution or once daily 0....

    journal_title:Clinical physiology and functional imaging

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1046/j.1475-097x.2002.00430.x

    authors: Niño J,Tahvanainen K,Uusitalo H,Turjanmaa V,Hutri-Kähönen N,Kaila T,Ropo A,Kuusela T,Kähönen M

    更新日期:2002-07-01 00:00:00

  • Recovery of regional systolic and diastolic myocardial function after acute myocardial infarction evaluated by two-dimensional speckle tracking echocardiography.

    abstract:PURPOSE:The assessment of temporal changes in systolic and diastolic regional left ventricle function by two-dimensional speckle tracking echocardiography (STE) after successful reperfusion therapy of acute myocardial infarction (AMI). METHODS:A total of 97 consecutive patients admitted with AMI and treated with succe...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章

    doi:10.1111/cpf.12553

    authors: Wdowiak-Okrojek K,Wejner-Mik P,Kasprzak JD,Lipiec P

    更新日期:2019-03-01 00:00:00

  • Seven-site versus three-site method of body composition using BodyMetrix ultrasound compared to dual-energy X-ray absorptiometry.

    abstract::Obesity is a steadily growing epidemic affecting all segments of the population including college-aged students. The weight gain that is evidenced amid the transitional stage of college years increases the risks associated with cardiovascular and metabolic diseases. The BodyMetrix® BX-2000 (ULTRA) using a seven-site m...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章

    doi:10.1111/cpf.12307

    authors: Baranauskas MN,Johnson KE,Juvancic-Heltzel JA,Kappler RM,Richardson L,Jamieson S,Otterstetter R

    更新日期:2017-05-01 00:00:00

  • Circulating norepinephrine and cerebrovascular control in conscious humans.

    abstract:BACKGROUND:Cerebral vasoconstriction without concurrent changes in systemic arterial blood pressure has been observed in both normal individuals and those with idiopathic orthostatic intolerance following several minutes of postural stress when circulating catecholamines are elevated. Therefore, we tested the hypothesi...

    journal_title:Clinical physiology and functional imaging

    pub_type: 临床试验,杂志文章

    doi:10.1046/j.1475-0961.2003.00507.x

    authors: Kimmerly DS,Tutungi E,Wilson TD,Serrador JM,Gelb AW,Hughson RL,Shoemaker JK

    更新日期:2003-11-01 00:00:00

  • Comparison of grey scale median (GSM) measurement in ultrasound images of human carotid plaques using two different softwares.

    abstract::Grey scale median (GSM) measured on ultrasound images of carotid plaques has been used for several years now in research to find the vulnerable plaque. Centres have used different software and also different methods for GSM measurement. This has resulted in a wide range of GSM values and cut-off values for the detecti...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章

    doi:10.1111/cpf.12049

    authors: Östling G,Persson M,Hedblad B,Gonçalves I

    更新日期:2013-11-01 00:00:00

  • Heat-washout - an objective method for diagnosing neuropathy and atherosclerosis in diabetic patients.

    abstract:BACKGROUND:The heat-washout method is an objective method that measures cutaneous blood flow rate (BFR) in ml (100 g. min)(-1), previously found useful for measuring toe BFR in non-diabetic patients with claudication. AIM:The method is used for evaluating the presence of a veno-arteriolar reflex (VAR) in the forefoot ...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章

    doi:10.1111/cpf.12028

    authors: Midttun M,Snorgaard O

    更新日期:2013-07-01 00:00:00

  • Pulmonary oedema in healthy SCUBA divers: new physiopathological pathways.

    abstract:INTRODUCTION:The mechanism of immersion pulmonary oedema occurring in healthy divers is a matter of debate. Among consecutive injured divers admitted to our hyperbaric centre, we analysed prospective data about pulmonary oedema. METHOD:A total of 22 divers suffering from immersion pulmonary oedema without cardiac dise...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章

    doi:10.1111/j.1475-097X.2010.00922.x

    authors: Coulange M,Rossi P,Gargne O,Gole Y,Bessereau J,Regnard J,Jammes Y,Barthélémy A,Auffray JP,Boussuges A

    更新日期:2010-05-01 00:00:00

  • Cerebrovascular responses to cold pressor test during static exercise in humans.

    abstract::The purpose of this study was to determine whether exercise modulates the responses of middle cerebral artery blood velocity (MCA V(mean)) and cerebrovascular conductance to sympathetic stimulation (i.e. cold pressor test--CPT). To accomplish this, MCA V(mean) responses were assessed during CPT, static handgrip exerci...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1475-097X.2011.01055.x

    authors: Vianna LC,Sales AR,da Nóbrega AC

    更新日期:2012-01-01 00:00:00

  • Haemostatic and inflammatory responses to blood flow-restricted exercise in patients with ischaemic heart disease: a pilot study.

    abstract::Low-intensity resistance exercise can effectively induce muscle hypertrophy and increases in strength when combined with moderate blood flow restriction (BFR). As this type of exercise does not require lifting heavy weights, it might be a feasible method of cardiac rehabilitation, in which resistance exercise has been...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1475-097X.2012.01158.x

    authors: Madarame H,Kurano M,Fukumura K,Fukuda T,Nakajima T

    更新日期:2013-01-01 00:00:00

  • Poincaré plot indexes of heart rate variability capture dynamic adaptations after haemodialysis in chronic renal failure patients.

    abstract::The hypothesis that the Poincaré plot indexes of heart rate variability (HRV) detect dynamic changes after haemodialysis (HD) over the HRV in haemodynamically stable chronic renal failure (CRF) patients was examined. Minor axis (SD1), major axis (SD2) and the SD1/SD2 ratio were compared against standard HRV indexes in...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章

    doi:10.1046/j.1475-097x.2003.00466.x

    authors: Lerma C,Infante O,Pérez-Grovas H,José MV

    更新日期:2003-03-01 00:00:00

  • Influence of reconstruction algorithms on image quality in SPECT myocardial perfusion imaging.

    abstract:INTRODUCTION:We investigated if image- and diagnostic quality in SPECT MPI could be maintained despite a reduced acquisition time adding Depth Dependent Resolution Recovery (DDRR) for image reconstruction. Images were compared with filtered back projection (FBP) and iterative reconstruction using Ordered Subsets Expect...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章

    doi:10.1111/cpf.12354

    authors: Davidsson A,Olsson E,Engvall J,Gustafsson A

    更新日期:2017-11-01 00:00:00

  • Does postexercise modelled capillary blood flow accurately reflect cardiovascular effects by different exercise intensities?

    abstract::Blood flow (BF) in exercising muscles is an important factor for exercise capacity. Recently, a non-invasive method to estimate capillary BF (Qcap ) was introduced. Using this method, the Fick principle is re-arranged by using relative differences in deoxygenated haemoglobin (ΔHHb) as a surrogate for arteriovenous O2 ...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章

    doi:10.1111/cpf.12434

    authors: Stöcker F,Von Oldershausen C,Paternoster FK,Schulz T,Oberhoffer R

    更新日期:2018-05-01 00:00:00

  • Contractile properties of knee-extensors in one single family with nemaline myopathy: central and peripheral aspects of muscle activation.

    abstract::Patients with nemaline myopathy, a muscle disorder primarily affecting the thin filaments, suffer from weakness which is poorly understood. As disturbed excitation-contraction coupling has been suggested as a possible mechanism, the present study was designed to investigate whether the contractile properties of the kn...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章

    doi:10.1111/j.1475-097X.2007.00740.x

    authors: Gerrits K,Pauw-Gommans I,van Engelen B,de Haan A

    更新日期:2007-07-01 00:00:00

  • Fixed ratio or lower limit of normal for the FEV1 /VC ratio: relation to symptoms and extended lung function tests.

    abstract::There is no general agreement on the spirometric definition of chronic obstructive pulmonary disease (COPD). The global initiative for obstructive lung disease recommends a fixed ratio between forced expiratory volume in one-second (FEV1 ) and forced vital capacity (FVC) of <0·7 (FR) for the diagnosis of COPD. Europea...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章

    doi:10.1111/cpf.12294

    authors: Wollmer P,Frantz S,Engström G,Dencker M,Löfdahl CG,Nihlén U

    更新日期:2017-05-01 00:00:00

  • Tracer kinetics analysis of dynamic contrast-enhanced CT and MR data in patients with squamous cell carcinoma of the upper aerodigestive tract: comparison of the results.

    abstract:PURPOSE:(i) To evaluate the feasibility of tracer kinetics analysis of dynamic contrast-enhanced (DCE) CT and T2-weighted MR data of squamous cell carcinoma (SCCA) of the upper aerodigestive tract. (ii) To compare functional parameters derived by both modalities and examine the interchangeability of them as well as the...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章

    doi:10.1111/j.1475-097X.2009.00876.x

    authors: Bisdas S,Baghi M,Wagenblast J,Bisdas T,Thng CH,Mack MG,Koh TS,Ernemann U

    更新日期:2009-09-01 00:00:00

  • Comparison of hand-to-hand bioimpedance and anthropometry equations versus dual-energy X-ray absorptiometry for the assessment of body fat percentage in 17-18-year-old conscripts.

    abstract::In the present study, hand-to-hand bioelectrical impedance analysis (BIA), skinfold (SKF) thickness and height-weight (body mass index, BMI)-based equations and dual-energy X-ray absorptiometry (DEXA), as a criterion method, were compared with each other in the assessment of body fat percentage (BF%) in 17-18-year-old...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章

    doi:10.1111/j.1475-097X.2004.00534.x

    authors: Lintsi M,Kaarma H,Kull I

    更新日期:2004-03-01 00:00:00

  • Separating the left cardiac ventricle from the atrium in short axis MR images using the equation of the atrioventricular plane.

    abstract::Short axis (SA) images obtained from cardiac magnetic resonance imaging are used to advantage in the calculation of important clinical parameters such as the ejection fraction and stroke volume (SV). A prerequisite for these calculations is the separation of the left ventricle and the left atrium. When only using the ...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章

    doi:10.1111/j.1475-097X.2008.00799.x

    authors: Thunberg P,Emilsson K,Rask P,Kähäri A

    更新日期:2008-07-01 00:00:00

  • The influence of athletic status on maximal and rapid isometric torque characteristics and postural balance performance in Division I female soccer athletes and non-athlete controls.

    abstract::The purpose of this study was to examine the effectiveness of maximal and rapid isometric torque characteristics of the hip extensor muscles and postural balance performance to discriminate between female collegiate soccer athletes and non-athlete controls. Ten athletes (mean ± SE: age = 19·20 ± 0·36 year; mass = 62·2...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章

    doi:10.1111/cpf.12167

    authors: Palmer TB,Hawkey MJ,Thiele RM,Conchola EC,Adams BM,Akehi K,Smith DB,Thompson BJ

    更新日期:2015-07-01 00:00:00