Abstract：
:The role of bone water in the activity of this organ is essential in structuring apatite crystals, providing pathways for nutrients and waste involved in the metabolism of bone cells and participating in bone remodelling mechanotransduction. It is commonly accepted that bone presents three levels of porosity, namely the vasculature, the lacuno-canalicular system and the voids of the collagen-apatite matrix. Due to the observation of bound state of water at the latter level, the interstitial nanoscopic flow that may exist within these pores is classically neglected. The aim of this paper is to investigate the possibility to obtain a fluid flow at the nanoscale. That is why a molecular dynamics based analysis of a water-hydroxyapatite system is proposed to analyze the effect of water confinement on transport properties. The main result here is that free water can be observed inside hydroxyapatite pores of a few nanometers. This result would have strong implications in the multiscale treatment of the poromechanical behaviour of bone tissue. In particular, the mechanical properties of the bone matrix may be highly controlled by nanoscopic water diffusion and the classical idea that osteocytic activity is only regulated by bone fluid flow within the lacuno-canalicular system may be discussed again.
journal_name
J Biomechjournal_title
Journal of biomechanicsauthors
Lemaire T,Pham TT,Capiez-Lernout E,de Leeuw NH,Naili Sdoi
10.1016/j.jbiomech.2015.07.025subject
Has Abstractpub_date
2015-09-18 00:00:00pages
3066-71issue
12eissn
0021-9290issn
1873-2380pii
S0021-9290(15)00418-2journal_volume
48pub_type
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