The destructive effect of botulinum neurotoxins on the SNARE protein: SNAP-25 and synaptic membrane fusion.

abstract：Background:Evidences indicated that non-small-cell lung cancer (NSCLC) and small-cell lung cancer (SCLC) might originate from the same cell type, which however ended up to be two different subtypes of lung carcinoma, requiring different therapeutic regimens. We aimed to identify the differences between these two subtyp...

journal_title：PeerJ

authors： Wu J,Hao Z,Ma C,Li P,Dang L,Sun S

更新日期：2020-04-23 00:00:00

abstract：:We provided chimpanzees (Pan troglodytes) with the ability to improve the quality of food rewards they received in a dyadic test of inequity. We were interested to see if this provision influenced their responses and, if so, whether it was mediated by a social partner's outcomes. We tested eight dyads using an exchang...

journal_title：PeerJ

authors： Hopper LM,Lambeth SP,Schapiro SJ,Brosnan SF

更新日期：2013-09-17 00:00:00

abstract：:We often expect that investigations of the patterns, causes, and consequences of among-individual variation in a trait of interest will reveal how selective pressures or ecological conditions influence that trait. However, many endocrine traits, such as concentrations of glucocorticoid (GC) hormones, exhibit adaptive ...

journal_title：PeerJ

authors： Schoenemann KL,Bonier F

更新日期：2018-02-21 00:00:00

abstract：:Accurate identification of protein-protein interactions (PPI) is the key step in understanding proteins' biological functions, which are typically context-dependent. Many existing PPI predictors rely on aggregated features from protein sequences, however only a few methods exploit local information about specific resi...

journal_title：PeerJ

authors： Zubek J,Tatjewski M,Boniecki A,Mnich M,Basu S,Plewczynski D

更新日期：2015-07-02 00:00:00

abstract：Background:Foam cells (FCs) play crucial roles in the process of all stages of atherosclerosis. Smooth muscle cells (SMCs) and macrophages are the major sources of FCs. This study aimed to identify the common molecular mechanism in these two types of FCs. Methods:GSE28829, GSE43292, GSE68021, and GSE54666 were include...

journal_title：PeerJ

authors： Zhang K,Qin X,Zhou X,Zhou J,Wen P,Chen S,Wu M,Wu Y,Zhuang J

更新日期：2020-11-17 00:00:00

abstract：:Populations of passively dispersed organisms in continental aquatic habitats typically show high levels of neutral genetic differentiation despite their high dispersal capabilities. Several evolutionary factors, including founder events, local adaptation, and life cycle features such as high population growth rates an...

journal_title：PeerJ

authors： Montero-Pau J,Gómez A,Serra M

更新日期：2018-12-11 00:00:00

abstract：Background:Recently, SARS-CoV-2 virus with the D614G mutation has become a public concern due to rapid dissemination of this variant across many countries. Our study aims were (1) to report full-length genome sequences of SARS-CoV-2 collected from four COVID-19 patients in the Special Region of Yogyakarta and Central J...

journal_title：PeerJ

authors： Gunadi,Wibawa H,Marcellus,Hakim MS,Daniwijaya EW,Rizki LP,Supriyati E,Nugrahaningsih DAA,Afiahayati,Siswanto,Iskandar K,Anggorowati N,Kalim AS,Puspitarani DA,Athollah K,Arguni E,Nuryastuti T,Wibawa T

更新日期：2020-12-21 00:00:00

abstract：:Elucidating the molecular mechanism of helix-coil transitions of short peptides is a long-standing conundrum in physical chemistry. Although the helix-coil transitions of poly-glutamic acid (PGA) have been extensively studied, the molecular details of its unfolding process still remain unclear. We performed all-atom c...

journal_title：PeerJ

authors： Ogasawara N,Kasahara K,Iwai R,Takahashi T

更新日期：2018-05-15 00:00:00

abstract：Background:Sexual development in Flammulina velutipes is controlled by two different mating type loci (HD and PR). The HD locus contains homeodomain (Hd) genes on two separate HD subloci: HD-a and HD-b. While the functionality of the HD-b sublocus has been largely confirmed, the status and content of the HD-a sublocus ...

journal_title：PeerJ

authors： Wang W,Mukhtar I,Chou T,Jiang S,Liu X,van Peer AF,Xie B

更新日期：2019-02-22 00:00:00

abstract：:Majority legumes in the temperate and arctic zones have water-impermeable seeds (physical dormancy, PY). However, various authors have reported that seeds of some Caragana species are water-permeable and thus non-dormant. We (1) tested seeds of 15 species of Caragana matured in the same site in 2014, 2016 and/or 2017 ...

journal_title：PeerJ

authors： Chen D,Zhang R,Baskin CC,Hu X

更新日期：2019-05-09 00:00:00

abstract：:Background. Low molecular weight heparin (LMWH) is an effective anti-coagulant for thrombotic events. However, due to its predominant renal clearance, there are concerns that it might be associated with increased bleeding in patients with renal disease. Objectives. We systematically evaluated the efficacy and safety o...

journal_title：PeerJ

authors： Palamaner Subash Shantha G,Kumar AA,Sethi M,Khanna RC,Pancholy SB

更新日期：2015-03-10 00:00:00

abstract：:Background. Child undernutrition and flooding are highly prevalent public health issues in many developing countries, yet we have little understanding of preventive strategies for effective coping in these circumstances. Education has been recently highlighted as key to reduce the societal impacts of extreme weather e...

journal_title：PeerJ

authors： Rodriguez-Llanes JM,Ranjan-Dash S,Mukhopadhyay A,Guha-Sapir D

更新日期：2016-03-01 00:00:00

abstract：:Natural and anthropogenic changes (e.g., land use change, pollution) will alter many environmental factors in the coming years, including the amount of solar radiation reaching the earth's surface. Alterations in solar radiation exposure is likely to impact the ecologies of many living organisms, including invertebrat...

journal_title：PeerJ

authors： Villena OC,Momen B,Sullivan J,Leisnham PT

更新日期：2018-12-18 00:00:00

abstract：:Grazing and litter removal can alter understory structure and composition after afforestation, posing a serious threat to sustainable forest development. Enclosure is considered to be an effective measure to restore degraded forest restoration. However, little is known about the dynamics of soil nutrients and microbia...

journal_title：PeerJ

authors： Deng J,Zhou Y,Zhu W,Yin Y

更新日期：2020-03-25 00:00:00

abstract：Objectives:The purpose of this study is to investigate the patterns of complementary and alternative medicine use and its association with time to conventional treatment. Design:A cross-sectional study design was designed. Setting and participants:The study was performed at the Chonburi Cancer Hospital, with chart re...

journal_title：PeerJ

authors： Chotipanich A,Sooksrisawat C,Jittiworapan B

更新日期：2019-06-14 00:00:00

abstract：OBJECTIVE:To determine the profile of 14 polybrominated diphenyl ethers (PBDEs) and 23 polychlorinated biphenyls (PCBs) in serum of domestic canines and whether this was predictive of thyroid hormone status. SAMPLES:Serum samples were collected from 51 client-owned dogs visiting the University of California Davis Will...

journal_title：PeerJ

authors： Lau G,Walter K,Kass P,Puschner B

更新日期：2017-09-12 00:00:00

abstract：:The combination of different approaches has successfully delimited new species within many Neotropical species complexes traditionally classified as a single nominal organism. Recent studies have shown that the Amazonian endemic genus Amazophrynella, currently composed of 12 small-sized species, could harbor several a...

journal_title：PeerJ

authors： Mângia S,Koroiva R,Santana DJ

更新日期：2020-09-18 00:00:00

abstract：BACKGROUND:Digital medicine and smartphone-enabled health technologies provide a novel source of human health and human biology data. However, in part due to its intricacies, few methods have been established to analyze and interpret data in this domain. We previously conducted a six-month interventional trial examinin...

journal_title：PeerJ

authors： Gollamudi SS,Topol EJ,Wineinger NE

更新日期：2016-08-02 00:00:00

abstract：Background:Among Buddhist or Taoist Taiwanese residents, burning incense is a common source of indoor particulate matter (PM), including PM10 and PM2.5, and can adversely affect the health status of patients with chronic obstructive pulmonary diseases (COPD). However, few studies have focused on the effects of intermit...

journal_title：PeerJ

authors： Guo SE,Chi MC,Lin CM,Yang TM

更新日期：2020-08-31 00:00:00

abstract：:Madagascar's subfossil record preserves a diverse community of animals including elephant birds, pygmy hippopotamus, giant lemurs, turtles, crocodiles, bats, rodents, and carnivorans. These fossil accumulations give us a window into the island's past from 80,000 years ago to a mere few hundred years ago, recording the...

journal_title：PeerJ

authors： Mathews JC,Samonds KE

更新日期：2016-09-15 00:00:00

abstract：:Porcine epidemic diarrhea virus (PEDV) outbreaks on pig farms have caused significant economic loss in the swine industry since it was first reported in Thailand a decade ago. Anecdotal evidence suggests that PEDV is now endemic in this region, therefore genome information of circulating PEDV is important for molecula...

journal_title：PeerJ

authors： Tuanthap S,Vongpunsawad S,Phupolphan C,Duang-In A,Wattanaphansak S,Assavacheep P,Theamboonlers A,Luengyosluechakul S,Amonsin A,Poovorawan Y

更新日期：2019-04-30 00:00:00

abstract：Background:In horses and ponies numerous medical conditions are known to be linked with inflammation in different tissues, especially in the liver. Besides affecting other metabolic pathways such as the expression of certain interleukins (IL), inflammation is associated with stress of the endoplasmic reticulum (ER). In...

journal_title：PeerJ

authors： Starzonek J,Roscher K,Blüher M,Blaue D,Schedlbauer C,Hirz M,Raila J,Vervuert I

更新日期：2019-11-12 00:00:00

abstract：Background:Mimusops coriacea (A.DC.) Miq., (Sapotaceae), originated from Africa, were introduced to coastal areas in Ecuador where it is not extensively used as a traditional medicine to treat various human diseases. Different therapeutically uses of the species include: analgesic, antimicrobial, hypoglycemic, inflamma...

journal_title：PeerJ

authors： Bustamante K,Santos-Ordóñez E,Miranda M,Pacheco R,Gutiérrez Y,Scull R

更新日期：2019-10-11 00:00:00

abstract：:Ocean acidification threatens the foundation of tropical coral reefs. This study investigated three aspects of ocean acidification: (i) the rates at which perforate and imperforate coral-colony skeletons passively dissolve when pH is 7.8, which is predicted to occur globally by 2100, (ii) the rates of passive dissolut...

journal_title：PeerJ

authors： van Woesik R,van Woesik K,van Woesik L,van Woesik S

更新日期：2013-11-21 00:00:00

abstract：Background:The fecal microbiota from obese individuals can induce obesity in animal models. In addition, studies in humans, animal models and dogs have revealed that the fecal microbiota of subjects with obesity is different from that of lean subjects and changes after weight loss. However, the impact of weight loss on...

journal_title：PeerJ

authors： Bermudez Sanchez S,Pilla R,Sarawichitr B,Gramenzi A,Marsilio F,Steiner JM,Lidbury JA,Woods GRT,German AJ,Suchodolski JS

更新日期：2020-10-05 00:00:00

abstract：Background:Cognitive dysfunction in fibromyalgia (FM) encompasses objective cognitive difficulties, as measured in neuropsychological tests, and self-reported cognitive complaints. Although it has been suggested that FM patients display problems in working memory, the data are inconsistent, and the overall working memo...

journal_title：PeerJ

authors： Pidal-Miranda M,González-Villar AJ,Carrillo-de-la-Peña MT,Andrade E,Rodríguez-Salgado D

更新日期：2018-11-21 00:00:00

abstract：:Cold-water corals provide an important habitat for a rich fauna along the continental margins and slopes. Although these azooxanthellate corals are considered particularly sensitive to ocean acidification, their responses to natural variations in pH and aragonite saturation are largely unknown due to the difficulty of...

journal_title：PeerJ

authors： Fillinger L,Richter C

更新日期：2013-10-29 00:00:00

abstract：BACKGROUND:In previous studies, both 17β-estradiol (E2) and resveratrol (RES) were reported to protect intervertebral disc cells against aberrant apoptosis. Given that E2 has a better anti-apoptotic effect with more cancer risk and RES has an anti-apoptotic effect with less cancer risk, the combined use of E2 with RES ...

journal_title：PeerJ

authors： Yang SD,Ma L,Yang DL,Ding WY

更新日期：2016-01-26 00:00:00

abstract：Background:Maize (Zea mays L.) is a principal cereal crop cultivated worldwide for human food, animal feed, and more recently as a source of biofuel. However, as a direct consequence of water insufficiency and climate change, frequent occurrences of both biotic and abiotic stresses have been reported in various regions...

journal_title：PeerJ

authors： Kimotho RN,Baillo EH,Zhang Z

更新日期：2019-07-08 00:00:00

abstract：BACKGROUND:Amoebiasis is the third most common parasitic cause of morbidity and mortality, particularly in countries with poor hygienic settings. There exists an ambiguity in the diagnosis of amoebiasis, and hence there arises a necessity for a better diagnostic approach. Serine-rich Entamoeba histolyticaprotein (SREHP...

journal_title：PeerJ

authors： Manochitra K,Parija SC

更新日期：2017-06-28 00:00:00