Abstract：
:Animal models are extensively used to evaluate the in vivo functionality of novel drug delivery systems (DDS). However, many variations likely exist in vivo between the animals and human physiological environment that significantly alter results obtained with animal models relative to human system. To date, it is not clear if the variation in hemorheology and hemodynamics between common animal and human models affect the functionality of DDS. This study investigates the role of hemorheology of humans and various animal models in dictating the binding efficiency of model vascular-targeted carriers (VTCs) to the wall in physiological blood flows. Specifically, the adhesion of sLe(A)-coated nano- and micro-spheres to inflamed endothelial cells monolayers were conducted via a parallel plate flow chamber assay with steady and disturbed red blood cells (RBCs)-in-buffer and whole blood flows of common animal models. Our results suggest that the ratio of carrier size to RBC size dictate particle binding in blood flow. Additionally, the presence of white blood cells affects the trend of particle adhesion depending on the animal species. Overall, this work sheds light on some deviation in VTC vascular wall interaction results obtained with in vivo animal experimentation from expected outcome and efficiency in vivo in human.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Namdee K,Carrasco-Teja M,Fish MB,Charoenphol P,Eniola-Adefeso Odoi
10.1038/srep11631subject
Has Abstractpub_date
2015-06-26 00:00:00pages
11631issn
2045-2322pii
srep11631journal_volume
5pub_type
杂志文章abstract：:Long non-coding RNAs (lncRNAs) form the largest transcript class in the human transcriptome. These lncRNA are expressed not only in the cells, but they are also present in the cell-derived extracellular vesicles such as exosomes. The function of these lncRNAs in cancer biology is not entirely clear, but they appear to...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep24922
更新日期：2016-04-22 00:00:00
abstract：:As the global prevalence of childhood obesity continues to rise, researchers and clinicians have sought to develop more effective and personalized intervention techniques. In doing so, obesity interventions have expanded beyond the traditional context of nutrition to address several facets of a child's life, including...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-55260-1
更新日期：2019-12-11 00:00:00
abstract：:The transition energies and formation energies of N, C, F, Cl, and S as substitutional dopants in Ag3PO4 are studied using first-principles calculations based on the hybrid Hartree-Fock density functional, which correctly reproduces the band gap and thus provides the accurate defect states. Our results show that NO an...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep12750
更新日期：2015-08-03 00:00:00
abstract：:The stress distribution around endosseous implants is an important determinant of the surgical success. However, no method developed so far to determine the implant stability is sensitive to the loading conditions of the bone-implant interface (BII). The objective of this study is to investigate whether a quantitative...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-50665-4
更新日期：2019-10-02 00:00:00
abstract：:The knowledge of the metallization of warm dense helium has important implications for understanding the thermal histories, stellar structure and magnetic field environment of giant planets. However, it is also a pendent scientific topic. For a revisiting into the properties of warm dense helium, we performed extensiv...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep41885
更新日期：2017-02-03 00:00:00
abstract：:The Batrachosauroididae are an enigmatic group of salamanders known from the Cretaceous and Tertiary of North America and Europe. In Europe, the family is known only by two species of the genus Palaeoproteus. The genus has limited distribution in Western and Central Europe. In the present paper, we describe a new spec...
journal_title：Scientific reports
pub_type： 历史文章,杂志文章
doi：10.1038/s41598-020-59255-1
更新日期：2020-02-17 00:00:00
abstract：:Jagged1 activates Notch signaling and subsequently promotes osteogenic differentiation in human periodontal ligament cells (hPDLs). The present study investigated the participation of the Notch receptor, NOTCH2, in the Jagged1-induced osteogenic differentiation in hPDLs. NOTCH2 and NOTCH4 mRNA expression levels increa...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-70277-7
更新日期：2020-08-07 00:00:00
abstract：:This paper presents an ultracompact tunable device for power splitting and switching by tuning the Fermi energy level of monolayer patternless graphene underneath a slotted multimode interference (MMI) coupler operating in the mid-infrared, λ = 9-11 μm. By introducing a high-index silicon slot in the central region of...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-49186-x
更新日期：2019-09-04 00:00:00
abstract：:Surface plasmon polaritons (SPPs) and standing wave modes provide interesting and exotic properties for infrared metamaterial absorbers. Coupling of these modes promises further development in this field but restricted by the complexity of modes analysis. In this work, we investigate the general phenomenon of modes co...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep46093
更新日期：2017-04-11 00:00:00
abstract：:Turner syndrome (TS) is associated with decreased bone mineral density and increased fracture rate. However, the developmental trajectory of bone density or body composition in patients with TS is still unclear. The present study tested the hypothesis that different karyotypes and/or age contributes to abnormal body c...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章
doi：10.1038/srep38026
更新日期：2016-11-30 00:00:00
abstract：:A total of 185 cases (150 retrospectively and 35 prospectively) of malignant liver masses were collected. In the retrospectively collected cases hyperenhancement during wash-in was the most common feature in HCCs but there was a high percentage of cases showing no enhancement or hypo/isoenhancement. ICCs displayed a l...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-63220-3
更新日期：2020-04-08 00:00:00
abstract：:Strong pinning depends on the pinning force strength and number density of effective defects. Using the hydrostatic pressure method, we demonstrate here that hydrostatic pressure of 1.2 GPa can significantly enhance flux pinning or the critical current density (Jc) of optimally doped Ba0.6K0.4Fe2As2 crystals by a fact...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep23044
更新日期：2016-03-17 00:00:00
abstract：:Genetic alterations identified in adjacent normal appearing tissue in bladder cancer patients are indicative of a field disease. Here we assessed normal urothelium transformation and intra-tumour heterogeneity (ITH) in four patients with bladder cancer. Exome sequencing identified private acquired mutations in a lymph...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-11291-0
更新日期：2017-09-15 00:00:00
abstract：:Domoic acid (DA, 1), a potent neurotoxin that causes amnesic shellfish poisoning, has been found in diatoms and red algae. While biosynthetic pathway towards DA from geranyl diphosphate and L-glutamate has been previously proposed, its late stage is still unclear. Here, six novel DA related compounds, 7'-methyl-isodom...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-18651-w
更新日期：2018-01-10 00:00:00
abstract：:Aryl nitriles are versatile compounds that can be synthesized via transition-metal-mediated cyanation of aryl halides. Most of the supported-heterogeneous catalysts are noble-metals based and there are very limited numbers of efficient non-noble metal based catalysts demonstrated for the cyanation of aryl halides. Her...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-57483-z
更新日期：2020-01-20 00:00:00
abstract：:IgG is an indispensable biological experimental tool as well as a widely-used therapeutic protein. However, cell culture-based expression of monoclonal IgG is costly and time-consuming, making this process difficult to use for high-throughput screening in early-stage evaluation of biologics. With the goal of establish...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-36691-8
更新日期：2019-01-24 00:00:00
abstract：:Selective attention plays a prominent role in prioritizing information in working memory (WM), improving performance for attended representations. However, it remains unclear whether unattended WM representations suffer from information loss. Here we tested the hypothesis that within WM, selectively attending to an it...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章
doi：10.1038/s41598-019-49577-0
更新日期：2019-09-18 00:00:00
abstract：:An atmospheric component of the Philippine-Taiwan Oscillations (PTOa) is used to examine its potential connection with tropical cyclone (TC) frequency in the western North Pacific in the period of 1979-2014. During positive PTOa years, more TCs are observed in the tropical western Pacific south of 18 °N where cyclonic...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-35617-8
更新日期：2018-11-29 00:00:00
abstract：:Conventional crystalline β-MnO2 usually exhibits poor electrochemical activities due to the narrow tunnels in its rutile-type structure. In this study, we synthesized a novel 2D β-MnO2 network with long-range order assembled by β-MnO2 nanowires and demonstrated that the novel 2D β-MnO2 network exhibits enhanced electr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep02193
更新日期：2013-01-01 00:00:00
abstract：:Drug delivery by topical application has higher patient acceptance and lower morbidity than intraocular injection, but many ophthalmic treatments are unable to enter the eye or reach the posterior segment after topical application. The first stage towards posterior segment delivery after topical application is ocular ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-68254-1
更新日期：2020-07-16 00:00:00
abstract：:We describe a spin wave modulator - spintronic device aimed to control spin wave propagation by an electric field. The modulator consists of a ferromagnetic film serving as a spin wave bus combined with a synthetic multiferroic comprising piezoelectric and magnetostrictive materials. Its operation is based on the stre...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-28878-w
更新日期：2018-07-18 00:00:00
abstract：:Age and sleep both affect emotional functioning. Since sleep patterns change over the lifespan, we investigated the effects of short sleep and age on empathic responses. In a randomized cross-over experimental design, healthy young and older volunteers (n = 47 aged 20-30 years and n = 39 aged 65-75 years) underwent fu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-12098-9
更新日期：2017-09-25 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-020-75277-1
更新日期：2020-10-20 00:00:00
abstract：:This paper reports the fabrication and operation of a transmission-type polarization rotator for visible light with a wavelength of 450 nm using indirect-transition-type semiconductor crystalline SiC in which Al atoms were implanted as a p-type dopant. A novel dressed-photon-phonon (DPP)-assisted annealing method was ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-69971-3
更新日期：2020-07-31 00:00:00
abstract：:An aberrant expression of integrin β1 has been implicated in breast cancer progression. Here, we compared the cell behaviors of wild-type (WT), β1 gene deleted (KO), and β1 gene restored (Res) MDA-MB-231 cells. Surprisingly, the expression of β1 exhibited opposite effects on cell proliferation. These effects were depe...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep18430
更新日期：2016-01-05 00:00:00
abstract：:Papillary thyroid carcinoma (PTC) displays strong but so far largely uncharacterized heritability. Here we studied genetic predisposition in a family with six affected individuals. We genotyped all available family members and conducted whole exome sequencing of blood DNA from two affected individuals. Haplotype analy...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep10566
更新日期：2015-07-02 00:00:00
abstract：:The rainbow trout, a carnivorous fish, displays a 'glucose-intolerant' phenotype revealed by persistent hyperglycaemia when fed a high carbohydrate diet (HighCHO). Epigenetics refers to heritable changes in gene activity and is closely related to environmental changes and thus to metabolism adjustments governed by nut...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep32187
更新日期：2016-08-26 00:00:00
abstract：:We study the capillary retraction of a Newtonian semi-infinite liquid filament through analytical methods. We derive a long-time asymptotic-state expansion for the filament profile using a one-dimensional free-surface slender cylindrical flow model based on the three-dimensional axisymmetric Navier-Stokes equations. T...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-51824-3
更新日期：2019-10-29 00:00:00
abstract：:In kidney disease, higher circulating levels of the mineral-regulating hormone fibroblast growth factor (FGF)-23 are predictive of disease progression but direct pathogenic effects on the kidney are unknown. We sought evidence of local renal synthesis in response to unilateral ureteric obstruction in the mouse, and pr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-02709-w
更新日期：2017-06-13 00:00:00
abstract：:Invasive motor Cortex Stimulation (iMCS) was introduced in the 1990's for the treatment of chronic neuropathic orofacial pain (CNOP), although its effectiveness remains doubtful. However, CNOP is known to be a heterogeneous group of orofacial pain disorders, which can lead to different responses to iMCS. Therefore, th...
journal_title：Scientific reports
pub_type： 杂志文章,meta分析
doi：10.1038/s41598-020-64177-z
更新日期：2020-04-28 00:00:00
