Abstract：
:An aberrant expression of integrin β1 has been implicated in breast cancer progression. Here, we compared the cell behaviors of wild-type (WT), β1 gene deleted (KO), and β1 gene restored (Res) MDA-MB-231 cells. Surprisingly, the expression of β1 exhibited opposite effects on cell proliferation. These effects were dependent on cell densities, and they showed an up-regulation of cell proliferation when cells were cultured under sparse conditions, and a down-regulation of cell growth under dense conditions. By comparison with WT cells, the phosphorylation levels of ERK in KO cells were consistently suppressed under sparse culture conditions, but consistently up-regulated under dense culture conditions. The phosphorylation levels of EGFR were increased in the KO cells. By contrast, the phosphorylation levels of AKT were decreased in the KO cells. The abilities for both colony and tumor formation were significantly suppressed in the KO cells, suggesting that β1 plays an important role in cell survival signaling for tumorigenesis. These aberrant phenotypes in the KO cells were rescued in the Res cells. Taken together, these results clearly showed the distinct roles of β1 in cancer cells: the inhibition of cell growth and the promotion of cell survival, which may shed light on cancer therapies.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Hou S,Isaji T,Hang Q,Im S,Fukuda T,Gu Jdoi
10.1038/srep18430subject
Has Abstractpub_date
2016-01-05 00:00:00pages
18430issn
2045-2322pii
srep18430journal_volume
6pub_type
杂志文章abstract：:Alcohol dependence (AD) and aggression-impulsivity are both associated with increased suicide risk. There is a need to evaluate clinical tools in order to improve suicide risk assessment of AD patients. The present study consisted of 95 individuals with a diagnosis of AD, consecutively admitted for addiction treatment...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep19373
更新日期：2016-01-19 00:00:00
abstract：:A frequency reconfigurable dipole antenna based on a silicon radiator is presented. The silicon radiator is activated with the aid of highly dense solid-state plasma by injecting carriers into the intrinsic region of p-i-n diodes. The fabrication and design guideline of the reconfigurable dipole antenna with this plas...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-33278-1
更新日期：2018-10-09 00:00:00
abstract：:Fruit ripening is a complex and genetically programmed process. Brassinosteroids (BRs) play an essential role in plant growth and development, including fruit ripening. As a central component of BR signaling, the transcription factor BZR1 is involved in fruit development in tomato. However, the transcriptional network...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep33635
更新日期：2016-09-29 00:00:00
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pub_type： 杂志文章
doi：10.1038/s41598-017-06078-2
更新日期：2017-07-18 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-80103-9
更新日期：2021-01-08 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2018-08-03 00:00:00
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pub_type： 杂志文章
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更新日期：2016-02-15 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2017-08-21 00:00:00
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pub_type： 杂志文章
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更新日期：2020-02-18 00:00:00
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pub_type： 杂志文章
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更新日期：2017-06-22 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2016-06-22 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2016-05-26 00:00:00
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pub_type： 杂志文章
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更新日期：2018-10-19 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2018-05-18 00:00:00
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pub_type： 杂志文章
doi：10.1038/s41598-017-07638-2
更新日期：2017-08-03 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2017-09-08 00:00:00
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journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/srep46945
更新日期：2018-02-16 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep21298
更新日期：2016-02-19 00:00:00
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journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-018-32881-6
更新日期：2018-10-12 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2016-01-13 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2015-08-13 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep35973
更新日期：2016-10-27 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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journal_title：Scientific reports
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更新日期：2020-04-01 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep29600
更新日期：2016-07-12 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2017-08-17 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep17403
更新日期：2015-12-02 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-50626-x
更新日期：2019-10-01 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-40169-6
更新日期：2019-03-04 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-77327-0
更新日期：2020-11-26 00:00:00
