A Case Report of High 18F-FDG PET/CT Uptake in Progressive Transformation of the Germinal Centers.

Abstract:

:Progressive transformation of the germinal centers (PTGC) is a benign reaction pattern in lymph nodes. An association with Hodgkin disease (HD) has been reported and PTGC may precede, coexist, or present after the diagnosis of HD. This case report describes a patient who presented with unprovoked pulmonary embolism and subsequent investigations showed a solitary abdominal mass, which was subsequently proven to be PTGC. PTGC is usually avid on fluorine-18-labeled fluorodeoxyglucose positron emission tomography with computed tomography for attenuation correction and may be mistaken for neoplastic disease. Being a reactive etiology, the metabolic activity is generally low with a low maximum standardized uptake value (SUVmax), but in our case, the metabolic activity and corresponding SUVmax were relatively high making the diagnosis difficult, as most clinicians would consider a high metabolically active process more likely malignant. Recognition of PTGC is important, as it is not a malignant process. Owing to its reported associations, however, patients with this diagnosis will likely require regular surveillance.

journal_name

Medicine (Baltimore)

journal_title

Medicine

authors

Chang CA,Kumar B,Nandurkar D

doi

10.1097/MD.0000000000000412

subject

Has Abstract

pub_date

2015-06-01 00:00:00

pages

e412

issue

23

eissn

0025-7974

issn

1536-5964

pii

00005792-201506020-00001

journal_volume

94

pub_type

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