Colchicine therapy for deep vein thrombosis in a patient with vascular-type Behçet disease: A case report.

Abstract:

RATIONALE:Behçet Disease (BD) is a chronic inflammatory vasculitis with thrombogenicity and multisystem involvement. Deep vein thrombosis (DVT) in the lower extremities is the most frequent manifestation of vascular involvement in BD. The causes of thrombosis vary widely and include congenital predisposition and acquired factors, but of all the thrombosis, the cause is rarely BD. Furthermore, there are few reports of treatment for thrombosis in BD. PATIENT CONCERNS:We herein describe the case of an Asian male patient aged 40 years, admitted to our hospital for left leg pain, edema, and swelling. DIAGNOSES:We confirmed the DVT and pulmonary artery thrombosis (PAT) by contrast computed tomography angiogram. At the same time, the patient developed oral ulcerations and skin lesions consistent with BD. INTERVENTIONS:The patient was initially treated with anticoagulants. However, because the improvement of DVT was inadequate, we added colchicine in anticipation of anti-inflammatory effects. After that, anticoagulation was discontinued, and only colchicine was continuously prescribed. OUTCOMES:We observed an almost complete resolution of DVT and PAT with no recurrence of thrombosis for 6 months after discharge. LESSONS:This case shows us that we should consider BD as a differential diagnosis of DVT and that colchicine therapy is effective for inflammation-induced thrombosis in BD.

journal_name

Medicine (Baltimore)

journal_title

Medicine

authors

Nonaka D,Takase H,Machii M,Ohno K

doi

10.1097/MD.0000000000019814

subject

Has Abstract

pub_date

2020-04-01 00:00:00

pages

e19814

issue

16

eissn

0025-7974

issn

1536-5964

pii

00005792-202004170-00084

journal_volume

99

pub_type

杂志文章

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