Loeffler endocarditis as a rare cause of heart failure with preserved ejection fraction: A case report and review of literature.

Abstract:

RATIONALE:Hypereosinophilic syndrome (HES) is a rare disease characterized by hypereosinophilia and its ensuing organ damage. Cardiac involvement is divided into 3 chronological stages: an acute necrotic stage; a thrombus formation stage; and a fibrotic stage. Infiltration of the myocardium by eosinophilic cells followed by endomyocardial fibrosis is known as "Loeffler endocarditis." PATIENT CONCERNS:We report a case of a 60-year-old man diagnosed with left-sided restrictive cardiomyopathy. DIAGNOSIS:The patient experienced heart failure with preserved ejection fraction. The cardiac MRI showed intense, linear, delayed gadolinium enhancement of the endocardium of the lateral wall of the left ventricle, and obliteration of the LV apex. He was ultimately identified as Loeffler endocarditis. INTERVENTION:A bone marrow smear and biopsy revealed the FIP1L1-PDGFRA fusion gene was positive in 82% of segmented nucleated cells. OUTCOME:Our patient responded well to prednisone at 1 mg/kg/d. LESSONS:HES is a rare disease that often afflicts the heart. Cardiac involvement in hypereosinophilia, especially Loeffler endocarditis, carries a poor prognosis and significant mortality. Early detection and treatment of the disease is therefore essential. Further studies are needed to ascertain therapeutic corticosteroid dosages and develop targeted gene therapies, both important steps to ameliorate the effects of Loeffler endocarditis and improve patient outcomes.

journal_name

Medicine (Baltimore)

journal_title

Medicine

authors

Gao M,Zhang W,Zhao W,Qin L,Pei F,Zheng Y

doi

10.1097/MD.0000000000010079

subject

Has Abstract

pub_date

2018-03-01 00:00:00

pages

e0079

issue

11

eissn

0025-7974

issn

1536-5964

pii

00005792-201803160-00006

journal_volume

97

pub_type

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