Abstract:
:The purpose of this study was to assess whether breast cancer subtype (BCS) as determined by estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 can predict the axillary lymph node metastasis in breast cancer. Patients who received breast conserving surgery or mastectomy and axillary lymph node dissection were identified from 2 cancer centers. The associations between clinicopathological variables and axillary lymph node involvement were evaluated in univariate and multivariate regression analyses. A total of 3471 patients met the inclusion criteria, and 53.0% had axillary lymph node metastases at diagnosis. Patients with hormone receptor (HR)-/human epidermal growth factor receptor 2 (HER2)- subtype had a higher grade disease and the lowest rate of lymphovascular invasion. Univariate and multivariable logistic regression analyses showed that BCS was significantly associated with lymph node involvement. Patients with the HR-/HER2- subtype had the lowest odds of having nodal positivity than those with other BCSs. HR+/HER2- (odds ratio [OR] 1.651, 95% confidence interval [CI]: 1.349-2.021, P < 0.001), HR+/HER2+ (OR 1.958, 95%CI 1.542-2.486, P < 0.001), and HR-/HER2+ (OR 1.525, 95%CI 1.181-1.970, P < 0.001) tumors had higher risk of nodal positivity than the HR-/HER2- subtype. The other independent predictors of nodal metastases included tumor size, tumor grade, and lymphovascular invasion. Breast cancer subtype can predict the presence of axillary lymph node metastasis in breast cancer. HR-/HER2- is associated with a reduced risk of axillary lymph node metastasis compared to other BCSs. Our findings may play an important role in guiding axillary treatment considerations if further confirmed in larger sample size studies.
journal_name
Medicine (Baltimore)journal_title
Medicineauthors
He ZY,Wu SG,Yang Q,Sun JY,Li FY,Lin Q,Lin HXdoi
10.1097/MD.0000000000002213subject
Has Abstractpub_date
2015-12-01 00:00:00pages
e2213issue
48eissn
0025-7974issn
1536-5964pii
00005792-201512010-00025journal_volume
94pub_type
杂志文章,多中心研究相关文献
MEDICINE文献大全abstract:AIMS:Interleukin(IL)-22 plays an important role in promoting liver regeneration and repair, but its role in chronic HBV-related liver diseasesis not clear. The goal of this study was to evaluate associations between eight IL22 single nucleotide polymorphisms (SNPs) and the development of chronic HBV cirrhosis and HBV-r...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000017867
更新日期:2019-11-01 00:00:00
abstract:BACKGROUND:To systematically review the effects of Danhong injection on endothelial function and inflammatory factors after the percutaneous coronary intervention (PCI) for coronary heart disease (CHD) and to provide a basis for further research. METHODS:Through computer retrieval, including PubMed, Embase, the Cochra...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000020783
更新日期:2020-07-02 00:00:00
abstract:RATIONALE:CRPS after a lumbar surgery has symptoms that are similar to PSSS. However, standard criteria for distinguishing CRPS from PSSS do not exist. We present a case report of a 31-year-old female with CRPS symptoms after lumbar spinal surgery treated by performing SELD. PATIENT CONCERNS:This patient was referred ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000010694
更新日期:2018-05-01 00:00:00
abstract::Twenty-three patients with systemic lupus erythematosus (SLE) and ischemic bone necrosis are reported. All patients had received corticosteroids prior to the onset of ischemic necrosis, although one patient had received none for 13 years previously. Nineteen (83%) patients had multiple bone lesions including the femor...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/00005792-197605000-00004
更新日期:1976-05-01 00:00:00
abstract::Human papillomavirus (HPV) infection is the leading cause of cervical cancer and precancerous lesions. Knowledge regarding the prevalence and genotype distribution of HPV in women is important to establish strategies for cervical cancer screening and HPV vaccination. This study aimed to evaluate the characteristics of...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000017293
更新日期:2019-09-01 00:00:00
abstract:RATIONALE:Angiotensin-converting enzyme (ACE) inhibitors are one of the most used medication among patients with arterial hypertension. In most cases, ACE inhibitors caused side effects are mild; however, from 0.1% to 0.7% of patients can develop life threatening adverse effect, angioedema. Unlike histamine mediated, A...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000011695
更新日期:2018-08-01 00:00:00
abstract:BACKGROUND:This meta-analysis aimed to evaluate the prognostic value of the systemic inflammation response index (SIRI) in malignancy based on existing evidence. METHODS:We searched for relevant literature published in the electronic databases PubMed, Web of Science, Cochrane Library, and Embase before April 10, 2020....
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000023486
更新日期:2020-12-11 00:00:00
abstract:BACKGROUND:Urticaria is a common skin disease that has a high impact on a patient's daily life. Xiaofeng powder (XFP) is one of the most commonly used Chinese herbal formula in China for urticaria. However, due to the lack of systematic evaluations, its clinical efficacy remains controversial. This meta-analysis was pe...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000013039
更新日期:2018-11-01 00:00:00
abstract::Sleep disturbance is a common comorbidity among patients with acromegaly [patients with growth hormone (GH)-secreting tumor] due to somatotropic axis change and sleep apnea. However, no previous studies exist concerning sleep disturbance and delirium in the early postoperative period in patients with acromegaly underg...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000023157
更新日期:2020-11-06 00:00:00
abstract::After a series of clinical relevant examinations. The patient was dignosed as pancreatic tomor in the pancreatic tail accompanied with the symptom of anenmia and dizziness.Until now surgery is the best treatment strategy for pancreatic tumors.So we take a joint multiple organ removal surgery.Before surgery, the main c...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000007441
更新日期:2017-07-01 00:00:00
abstract:RATIONALE:Managing the health of vulnerable groups is an important component of health care. Given the long-term burden of radiation-release incidents among those exposed, managing the health of vulnerable groups following a nuclear disaster is very important. However, there is limited information available concerning ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000017989
更新日期:2019-11-01 00:00:00
abstract::The purpose of this study was to investigate the association of herpes zoster infection with peptic ulcer disease in a Korean population.The Korean National Health Insurance Service selects samples directly from the entire Korean population database, and 1,125,691 participants with 114,369,638 medical claim codes were...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000019318
更新日期:2020-02-01 00:00:00
abstract::Blood pressure (BP) control is the most established practice for preventing the progression and complications of chronic kidney disease (CKD). We examined the influence of BP patterns on target organ damage in hypertensive patients with CKD by using long-term follow-up data of the APrODiTe-2 study.We collected 5 years...
journal_title:Medicine
pub_type: 杂志文章,多中心研究
doi:10.1097/MD.0000000000019209
更新日期:2020-02-01 00:00:00
abstract:RATIONALE:Enterocutaneous fistula (ECF) has long been difficult to treat in clinical settings. The current approaches, including surgery, antibiotics, and nutritional support, cannot achieve satisfactory outcomes. PATIENT CONCERNS:A 54-year-old man presented with intermittent discharge of purulent material from the fi...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000016288
更新日期:2019-07-01 00:00:00
abstract::[This corrects the article DOI: 10.1097/MD.0000000000002998.]. ...
journal_title:Medicine
pub_type: 已发布勘误
doi:10.1097/01.md.0000482729.66173.0b
更新日期:2016-04-18 00:00:00
abstract::Although it is an invasive and unpleasant procedure, esophagogastroduodenoscopy (EGD) is still the gold standard for esophageal varices (EV) detection. The aim of this study was to investigate liver stiffness measurement (LSM) and spleen diameter as simple noninvasive tools for EV prediction in chronic hepatitis C pat...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000008621
更新日期:2017-11-01 00:00:00
abstract::Nocardia is a ubiquitous environmental pathogen that causes infection primarily following inhalation into the lungs. It is generally thought to cause infection primarily in immunocompromised patients, but nonimmunocompromised individuals are also at risk of infection. We sought to compare risk factors, clinical manife...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000012436
更新日期:2018-10-01 00:00:00
abstract::This study aims to analyze the characteristics of F-fluorodeoxyglucose positron emission tomography/computed tomography (F-FDG PET/CT) for cerebral alveolar echinococcosis (CAE).Twenty-five CAE patients underwent F-FDG PET/CT, and the diagnosis was confirmed by clinical and surgical pathology. The F-FDG PET/CT results...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000011801
更新日期:2018-09-01 00:00:00
abstract::Patients with classical heat stroke are different in many ways from those with exertional injury; contrasts included difference in demographic factors, prior general health, in-hospital complications and laboratory abnormalities (lactate, liver enzymes, pH, electrolytes). Severe hyperkalemia, acute renal failure, rhab...
journal_title:Medicine
pub_type: 杂志文章
doi:
更新日期:1982-05-01 00:00:00
abstract::To determine the incidence of permanent visual loss (PVL) in giant cell arteritis (GCA) and the GCA relapse rate during glucocorticoid (GC) tapering.This prospective, longitudinal single secondary/tertiary rheumatology centre study was conducted between September 2011 and September 2014 in Slovenia. Predetermined clin...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000003210
更新日期:2016-04-01 00:00:00
abstract:INTRODUCTION:Reduced bone mineral density and increased risk of falls are related with Alzheimer disease, and these increase likelihood of bone osteoporotic fractures causing serious complications such as disability, fear of falling, loss autonomy, decreased quality of life, and anticipated mortality in elderly patient...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000022385
更新日期:2020-09-18 00:00:00
abstract::[This corrects the article DOI: 10.1097/MD.0000000000007643.]. ...
journal_title:Medicine
pub_type: 杂志文章,已发布勘误
doi:10.1097/MD.0000000000007827
更新日期:2017-08-11 00:00:00
abstract:BACKGROUND:In recent years, the incidence of IBS has gradually increased, and it is considered as one of the most common functional gastrointestinal diseases. However, the etiology of IBS is still unclear, and expectations are rising for more targeted treatments. Many clinical trials have explored the link between Heli...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000022975
更新日期:2020-12-11 00:00:00
abstract::This study is to investigate the expression of methyl CpG binding protein 2 (MECP2) in gastric cancer (GC) and its clinical significance.Expression of MECP2 was analyzed in 69 cases of GC tissues and 12 paracancerous tissues, either by qRT-PCR at the mRNA level or by Western blot and immunochemistry at the protein lev...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000007691
更新日期:2017-08-01 00:00:00
abstract::The aim of the present study is to investigate the value of air bronchogram sign on computed tomography (CT) image in the differential diagnosis of solitary pulmonary consolidation lesions (SPLs).A total of 105 patients (including 39 cases of lung cancer, 43 cases of tuberculosis, and 23 cases of pneumonia) with SPLs ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000011985
更新日期:2018-08-01 00:00:00
abstract::Strength training has, in recent years, been shown to be beneficial for people with Parkinson disease and multiple sclerosis. Consensus regarding its utility for these disorders nevertheless remains contentious among healthcare professionals. Greater clarity is required, especially in regards to the type and magnitude...
journal_title:Medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1097/MD.0000000000000411
更新日期:2015-01-01 00:00:00
abstract::The aquaporins are a family of membrane channel proteins that serve as selective pores through which water crosses the plasma membranes of many human tissues and cell types. The sites where aquaporins are expressed implicate these proteins in renal water reabsorption, cerebrospinal fluid secretion and reabsorption, ge...
journal_title:Medicine
pub_type: 杂志文章,评审
doi:10.1097/00005792-199705000-00001
更新日期:1997-05-01 00:00:00
abstract::Patients with suspected non-ST-segment elevation acute coronary syndromes (NSTEACS) constitute a heterogeneous population with variable outcomes. Risk stratification in this population of patients is difficult due to the complexity in patient risk profile. We conducted this study to characterize the value of clinical ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/00005792-200211000-00004
更新日期:2002-11-01 00:00:00
abstract:BACKGROUND:To evaluate if splenectomy results in severely impaired immune responses against primary cytomegalovirus (CMV) infection compared to the general immunocompetent population. METHODS:We performed a systemic literature review to study CMV infections in splenectomized individuals, a special population group pre...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000017698
更新日期:2019-10-01 00:00:00
abstract::The purpose of this study was to evaluate neutropenia following intravenous immunoglobulin (IVIG) therapy in adults with immune thrombocytopenic purpura (ITP).Our analysis included 88 patients with ITP, who received IVIG from January 2006 to March 2016, at Pusan National University Hospital in Korea. Their white blood...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000018624
更新日期:2020-01-01 00:00:00