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The prevalence and genotype distribution of human papillomaviruses among women in Taizhou, China.

Abstract：

:Human papillomavirus (HPV) infection is the leading cause of cervical cancer and precancerous lesions. Knowledge regarding the prevalence and genotype distribution of HPV in women is important to establish strategies for cervical cancer screening and HPV vaccination. This study aimed to evaluate the characteristics of HPV infection in Taizhou, China. HPV genotype of 10,733 women who visited Taizhou People's Hospital from November 2016 to October 2018 was determined using a PCR and hybridization-based detection test. The prevalence of overall, high risk (HR), and low risk (LR) HPV infections was 34.58%, 29.92%, and 10.12%, respectively. Of HPV-positive cases, 2417 (65.13%) were infected with a single HPV genotype and 1294 (34.87%) were infected with multiple HPV genotypes. HPV-52 was the most prevalent genotype (6.21%), followed by HPV-16 (5.33%), HPV-53 (4.03%), HPV-58 (3.89%), and HPV-81 (3.75%). The highest prevalence of HPV infection was found in women aged ≥60 years (40.72%). Furthermore, the prevalence of HPV increased with the severity of cervical lesions. In conclusions, the prevalence and genotype distribution of HPV varied with age and cervical lesions. The findings might serve as a potential reference for guiding cervical cancer screening and vaccine-based HPV prevention in Taizhou.

journal_name

Medicine (Baltimore)

journal_title

Medicine

authors

Jin R,Qian H,Zhang Y,Yuan D,Bao J,Zhou H,Chen M,Huang J,Yu H

doi

10.1097/MD.0000000000017293

subject

Has Abstract

pub_date

2019-09-01 00:00:00

pages

e17293

issue

39

eissn

0025-7974

issn

1536-5964

pii

00005792-201909270-00059

journal_volume

98

pub_type

杂志文章

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