Abstract:
INTRODUCTION:Reduced bone mineral density and increased risk of falls are related with Alzheimer disease, and these increase likelihood of bone osteoporotic fractures causing serious complications such as disability, fear of falling, loss autonomy, decreased quality of life, and anticipated mortality in elderly patients. Gait and balance disturb are 2 factors to favor falls in elderly, and in patients with cognitive impairment, the risk of falls increases to double. Exercise and Mediterranean diet produce beneficial effects for aging, cognitive decline, and are widely recommended to reduce the effects of osteoporosis, fall risk, and related fragility fractures. The primary objective of this study is to evaluate the short and medium-term effects during 6 months, of a multicomponent physical exercise program with a Mediterranean diet on bone mineral density, fall risk, balance, and gait by a controlled clinical trial in patients with Alzheimer disease. METHODS:The study is a 6-month, randomized controlled parallel-group, single-blinded clinical trial. Institutionalized patients with Alzheimer disease will be included. The intervention group will perform a multicomponent physical exercise program in reduced groups, with a frequency of 3 sessions per week, associated with a Mediterranean diet. This program includes strength, balance, and aerobic resistance exercises, and in the main part of the session, also ludic exercises to improve agility, coordination, and balance. The control group will receive usual care. The outcomes to assess are the change of physical functions, such as gait and balance, and the change of bone mineral density by calcaneal quantitative ultrasound, during the study follow-up at 1, 3, and 6 months. This clinical trial will generate more and new evidence on the effects of a multicomponent physical exercise program and Mediterranean diet in patients with Alzheimer disease on risk of falls and osteoporotic fractures, the relation of these with bone mineral density, gait and balance, and the correlations between them. ETHICS AND DISSEMINATION:This study protocol has been approved by the Ethics Committee of the University of Salamanca. The results will be published in peer-reviewed journals and disseminated in national and international conferences, to the participants and their families, and the general public through the associations of people with AD. TRIAL REGISTRATION ID:ClínicalTrials.gov ID: NCT04439097.
journal_name
Medicine (Baltimore)journal_title
Medicineauthors
Puente-González AS,Sánchez-González F,Hernández-Xumet JE,Sánchez-Sánchez MC,Barbero-Iglesias FJ,Méndez-Sánchez Rdoi
10.1097/MD.0000000000022385subject
Has Abstractpub_date
2020-09-18 00:00:00pages
e22385issue
38eissn
0025-7974issn
1536-5964pii
00005792-202009180-00117journal_volume
99pub_type
杂志文章相关文献
MEDICINE文献大全abstract::Neutrophil-lymphocyte ratio (NLR) is a poor prognostic factor in many tumors including glioblastoma multiforme (GBM), colorectal, and prostate cancer. The aim of this study was to investigate the prognostic value of preoperative NLR in patients with craniopharyngioma.Around 149 patients of craniopharyngioma surgically...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000012375
更新日期:2018-09-01 00:00:00
abstract::The prognostic significance of systemic atherothrombosis in heart failure (HF) with preserved ejection fraction (HFpEF) remains unclear. This study aimed to investigate the relation between the presence of polyvascular disease (PVD) and cardiovascular outcomes in HFpEF patients.A total of 510 consecutive HFpEF patient...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000015959
更新日期:2019-07-01 00:00:00
abstract::Leiomyosarcoma (LMS) is a malignancy which very rarely occurs in maxillofacial location, and the course of the disease is not very characteristic.In this case report, we present a 58-year-old female patient with a painless tumor of the left angle of the mandible causing slight asymmetry of the face. She also reported ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000004011
更新日期:2016-07-01 00:00:00
abstract:BACKGROUND:The study determined the effect of cognitive-behavioral therapy (CBT) with music in reducing physics test anxiety among secondary school students as measured by generalized test anxiety scale. METHODS:Pre-test post-test randomized control trial experimental design was adopted in this study. A total of 83 se...
journal_title:Medicine
pub_type: 杂志文章,随机对照试验
doi:10.1097/MD.0000000000016406
更新日期:2020-04-01 00:00:00
abstract::Fetuin-A is a protein with various biological functions. It plays a role in insulin resistance and arterial calcium deposition. Thyroid dysfunction may affect energy expenditure, glucose metabolism, and the risk of cardiovascular diseases. In the present study, we compared the serum fetuin-A concentrations in hyperthy...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000013254
更新日期:2018-11-01 00:00:00
abstract:INTRODUCTION:Kawasaki disease (KD) is a systemic inflammatory disease. Standard imaging features of KD include interstitial and lobular inflammatory lesions in the lungs, while KD shock syndrome (KDSS), complicated with substantial consolidation and atelectasis in the lung, is rarely reported. PATIENTS CONCERNS:Herein...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000020998
更新日期:2020-07-17 00:00:00
abstract::We studied 121 patients with systemic lupus erythematosus (SLE), of whom 119 were complement typed. Both black and white patients with SLE were more likely than racially matched controls to have a C4A null allotype. Patients with homozygous C4A deficiency had less proteinuria than other patients (p = 0.02) and both ho...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/00005792-199307000-00003
更新日期:1993-07-01 00:00:00
abstract::Exogenous administration of coenzyme Q10 (CoQ10) has been shown in experimental models to have a protective effect against ischemia-reperfusion injury. However, it is unclear whether follow-up plasma CoQ10 concentration is prognostic of left ventricular (LV) performance after primary balloon angioplasty in patients wi...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000004501
更新日期:2016-08-01 00:00:00
abstract::This study is conducted to investigate efficacy of an insulin jet injector and an insulin pen in treatment of type 2 diabetic patients. Sixty patients with type 2 diabetes were treated with rapid-acting insulin (regular insulin) and insulin analog (insulin aspart) using the jet injector and the pen in 4 successive tes...
journal_title:Medicine
pub_type: 杂志文章,随机对照试验
doi:10.1097/MD.0000000000005482
更新日期:2017-01-01 00:00:00
abstract::Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with an increased risk of death compared to general population. Although previous studies showed improvement in survival of SLE, the long-term prognosis has not been elaborated in China.This study aims to integrate the observational studies estimating ...
journal_title:Medicine
pub_type: 杂志文章,评审
doi:10.1097/MD.0000000000000794
更新日期:2015-05-01 00:00:00
abstract:RATIONALE:Unilateral manifestation of lymphedema during everolimus therapy has been described only rarely, mostly in transplant recipients. PATIENT CONCERNS:We report the first case of a patient who developed unilateral abdominal lymphedema, during a short period of everolimus treatment for renal cancer. DIAGNOSIS:Th...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000022634
更新日期:2020-10-16 00:00:00
abstract::This study aimed to examine whether Mandarin-speaking late-talking (LT) toddlers have a higher incidence of behavioral problems than typical language developing (TLD) children in toddlerhood and at preschool age from a community sample in Taiwan.This prospective case-control study comprised 32 LT and 32 TLD toddlers. ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000023341
更新日期:2020-11-25 00:00:00
abstract:RATIONALE:Carbon monoxide (CO) poisoning can cause severe damage to the nervous system, and can also cause serious damage to organs, such as the heart, kidneys, and lungs. CO damage to myocardial cells has been previously reported. This can lead to serious complications, such as myocardial infarction. PATIENT CONCERNS...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000015056
更新日期:2019-04-01 00:00:00
abstract::Several studies have investigated the incidence of and risk factors for acute exacerbation (AE) in patients with interstitial lung disease (ILD) after lung resection surgery. However, the incidence and risk factors for AE-ILD after non-pulmonary surgery are not known. The aim of this study was to investigate the incid...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000014296
更新日期:2019-02-01 00:00:00
abstract::Little research has been done about the effects of allogeneic blood transfusion (ABT) on the recurrence and prognosis in the cases with childhood acute lymphocytic leukemia (cALL). In order to provide a basis for clinical safe blood transfusion, the data of 163 cases with cALL were retrospectively analyzed to explore ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000014518
更新日期:2019-02-01 00:00:00
abstract:INTRODUCTION:Ciliated retroperitoneal foregut cysts are rare, and to obtain a preoperative definitive diagnosis of this condition is relatively difficult. In addition, the exact mechanism and formation of ciliated retroperitoneal foregut cysts remains unknown. CASE PRESENTATION:Here, we report a case of a 47-year-old ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000010783
更新日期:2018-05-01 00:00:00
abstract::We aimed to understand the evaluation of different Bowie-Dick test (B-D test) on the performance of pressure steam sterilization equipment in the case of simulated gas leakage, and we selected a pulsating vacuum steam sterilizer to set 4 different gas leakage levels: 1.1, 1.3, 1.5, and 1.7 mbar/min during the B-D test...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000023653
更新日期:2020-12-11 00:00:00
abstract:BACKGROUND:This study will assess the effect of high-quality nursing (HQN) on alleviating depression and anxiety (DA) in patients with thyroid cancer (TC) during perioperative period (PPP). METHODS:We will search the following electronic databases (MEDLINE, EMBASE, PsycINFO, Cochrane Library, CINAHL, Web of Science, C...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000023018
更新日期:2020-11-06 00:00:00
abstract:BACKGROUND:Hypertension is one of the most common chronic diseases and an increasingly public-health challenge worldwide. Previous meta-analyses evaluated the effects of azilsartan medoxomil compared to placebo or other antihypertensive drugs in patients with hypertension. However, it is still unclear which dose of azi...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000017050
更新日期:2019-09-01 00:00:00
abstract:BACKGROUND:Epileptiform discharges in electroencephalogram (EEG) have been frequently reported in children undergoing sevoflurane mask induction. However, the incidence, characteristics and risk factors of these epileptiform patterns during sevoflurane anesthesia in children are poorly understood. The aim of this study...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000017401
更新日期:2019-10-01 00:00:00
abstract::Coeliac disease (CD) is an autoimmune disorder of the small bowel associated with increased risk of additional autoimmune diseases (ADs).To investigate the prevalence of ADs in a population of adult coeliac patients.This was a retrospective case-control study. Data from coeliac patients and controls referred to a tert...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000008562
更新日期:2017-11-01 00:00:00
abstract:RATIONALE:Orofacial granulomatosis (OFG) is a rare disease characterized by noncaseating granulomatous inflammation. The most common clinical presentation is persistent swelling of the soft tissues in the oral and maxillofacial regions. The precise cause of OFG is unknown. Corticosteroids are the first-line and best tr...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000008102
更新日期:2017-09-01 00:00:00
abstract::[This corrects the article DOI: 10.1097/MD.0000000000000444.]. ...
journal_title:Medicine
pub_type: 已发布勘误
doi:10.1097/MD.0000000000008578
更新日期:2017-11-03 00:00:00
abstract:RATIONALE:Inadequate stent expansion due to rigid calcified may result in restenosis lesions, but the available options are limited. PATIENT CONCERNS:We report a case via the trans-radial approach of the severely underexpanded freshly deployed stent due to heavily calcified plaques DIAGNOSES:: Coronary angiography rev...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000009978
更新日期:2018-02-01 00:00:00
abstract:BACKGROUND:Danshen injection (DSI) is a traditional Chinese medicine preparation extracted from Danshen (Salvia miltiorrhiza), which has the functions of promoting blood circulation and removing blood stasis. Heart failure (HF) is a complex cardiovascular disease, always leading to frequent onset and hospitalization, d...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000015636
更新日期:2019-05-01 00:00:00
abstract:BACKGROUND:Magnesium sulfate combined with low-dose aspirin can significantly reduce adverse reactions and effectively lower blood pressure in patients with pregnancy induced hypertension, but the overall efficacy and safety of the combination of drugs are not clear. The purpose of this study was to evaluate the effica...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000022801
更新日期:2020-11-13 00:00:00
abstract:BACKGROUND:Epithelial ovarian cancer (EOC) has been classified into four molecular subtypes, of which the mesenchymal subtype has the poorest survival. Our goal is to develop an immune-based prognostic signature by incorporating molecular subtypes for EOC patients. METHODS:The gene expression profiles of EOC samples w...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000022549
更新日期:2020-10-09 00:00:00
abstract::Our study questioned whether the outcome of postoperative early oral feeding is different from traditional postoperative feeding in children with Hirschsprung's disease who underwent transanal endorectal pull-through.This was an observational and comparative study. Patients were allocated into 2 groups. Age, gender, f...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000014829
更新日期:2019-03-01 00:00:00
abstract::Fine needle aspiration (FNA) is the procedure of choice for evaluating thyroid nodules. It is indicated for nodules >2 cm, even in cases of very low suspicion of malignancy. FNA has associated risks and expenses. In this study, we developed an image analysis model using a deep learning algorithm and evaluated if the a...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000015133
更新日期:2019-04-01 00:00:00
abstract::The incidence of nontuberculous mycobacterial pulmonary disease (NTMPD) is increasing worldwide. Secondary spontaneous pneumothorax occurs as a complication of underlying lung disease and is associated with higher morbidity, mortality, and recurrence than primary spontaneous pneumothorax. We here investigated the clin...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000004246
更新日期:2016-07-01 00:00:00