Efficacy and safety of low dose aspirin and magnesium sulfate in the treatment of pregnancy induced hypertension: A protocol for systematic review and meta-analysis.

Abstract:

BACKGROUND:Magnesium sulfate combined with low-dose aspirin can significantly reduce adverse reactions and effectively lower blood pressure in patients with pregnancy induced hypertension, but the overall efficacy and safety of the combination of drugs are not clear. The purpose of this study was to evaluate the efficacy and safety of magnesium sulfate combined with low-dose aspirin in the treatment of pregnancy induced hypertension. METHODS:Randomized controlled trials focusing on the administration of magnesium sulfate combined with low-dose aspirin for pregnancy induced hypertension were searched from PubMed, EMbase, Cochrane Library, Web of Science, China National Knowledge Infrastructure (CNKI), WanFang, and the Chongqing VIP Chinese Science and Technology Periodical Database. Two researchers independently screened titles, abstracts, and full texts, and extracted relevant data. The RevMan 5.3 software and Stata 14 software were used for statistical analysis. RESULTS:The effect and safety of magnesium sulfate combined with low-dose aspirin in the treatment of pregnancy induced hypertension were assessed by summarizing the related randomized controlled trials. CONCLUSION:This article provides theoretical support for the clinical application of magnesium sulfate combined with low-dose aspirin in the treatment of pregnancy induced hypertension. OSF REGISTRATION NUMBER:DOI 10.17605/OSF.IO/SZFGB.

journal_name

Medicine (Baltimore)

journal_title

Medicine

authors

He G,Chen Y,Chen M,He G,Liu X

doi

10.1097/MD.0000000000022801

subject

Has Abstract

pub_date

2020-11-13 00:00:00

pages

e22801

issue

46

eissn

0025-7974

issn

1536-5964

pii

00005792-202011130-00018

journal_volume

99

pub_type

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