Chronic autoimmune disorders are increased in coeliac disease: A case-control study.

Abstract:

:Coeliac disease (CD) is an autoimmune disorder of the small bowel associated with increased risk of additional autoimmune diseases (ADs).To investigate the prevalence of ADs in a population of adult coeliac patients.This was a retrospective case-control study. Data from coeliac patients and controls referred to a tertiary center between 2013 and 2016 were collected. The frequency of ADs and the unadjusted and adjusted odds ratios (ORs) for age, gender, disease duration, and body mass index with their 95% confidence intervals (CIs) were evaluated.Two hundred fifty-five patients with CD (median age 37.1 years; 206 women) were matched with 250 controls. ADs were more frequent (35.3%) in coeliac patients than in controls (15.2%). Adjusted ORs for the presence of only 1, at least 1, and more than 1 AD were 3.13 (95% CI 1.81-5.42, P < .0001), 3.31 (95% CI 2.00-5.46, P < .0001), and 3.93 (95% CI 1.49-10.36, P = .006), respectively. Hashimoto thyroiditis was the most prevalent AD (24.3% vs. 10%) OR = 2.55 (95% CI 1.39-4.70, P < .0001), followed by psoriasis (4.3% vs. 1.6%), type 1 diabetes (2.7% vs. 0.4%), and Sjögren syndrome (2.4% vs. 0.4%).These findings suggest a need for a careful surveillance of autoimmune status, especially for Hashimoto thyroiditis in patients with celiac disease.

journal_name

Medicine (Baltimore)

journal_title

Medicine

authors

Bibbò S,Pes GM,Usai-Satta P,Salis R,Soro S,Quarta Colosso BM,Dore MP

doi

10.1097/MD.0000000000008562

subject

Has Abstract

pub_date

2017-11-01 00:00:00

pages

e8562

issue

47

eissn

0025-7974

issn

1536-5964

pii

00005792-201711270-00021

journal_volume

96

pub_type

杂志文章

相关文献

MEDICINE文献大全