Prognostic value of the systemic inflammation response index in human malignancy: A meta-analysis.

Abstract:

BACKGROUND:This meta-analysis aimed to evaluate the prognostic value of the systemic inflammation response index (SIRI) in malignancy based on existing evidence. METHODS:We searched for relevant literature published in the electronic databases PubMed, Web of Science, Cochrane Library, and Embase before April 10, 2020. Hazard ratios (HR) and corresponding 95% confidence intervals (CI) were calculated and pooled to evaluate the relationship between SIRI and malignancy outcomes. RESULTS:We included 14 articles, describing 6,035 patients. Our findings revealed that patients with high SIRI had worse overall survival (OS) (HR = 2.20, 95% CI: 1.85-2.62, P < .001), disease-free survival (DFS) (HR: 1.92, 95% CI: 1.49-2.48, P < .001), time-to-progression (TTP) (HR: 2.00, 95% CI: 1.55-2.58, P < .001), progression-free survival (PFS) (HR: 1.73, 95% CI: 1.38-2.16, P < .001), cancer-specific survival (CSS) (HR: 3.57, 95% CI: 2.25-5.68, P < 0.001), disease-specific survival (DSS) (HR: 1.99, 95% CI: 1.46 - 2.72, P < .001), and metastasis-free survival (MFS) (HR: 2.26, 95% CI: 1.28-3.99, P = .005) than patients with low SIRI. The correlation between SIRI and OS did not change in a subgroup analysis. Meta-regression indicated that heterogeneity may be related to differences in primary therapy strategies. Sensitivity analysis suggested that our results were reliable. CONCLUSIONS:SIRI could be used as a useful predictor of poor prognosis during malignancy treatment.

journal_name

Medicine (Baltimore)

journal_title

Medicine

authors

Wei L,Xie H,Yan P

doi

10.1097/MD.0000000000023486

subject

Has Abstract

pub_date

2020-12-11 00:00:00

pages

e23486

issue

50

eissn

0025-7974

issn

1536-5964

pii

00005792-202012110-00061

journal_volume

99

pub_type

杂志文章,meta分析

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