Abstract:
:Emergent resistance to antibiotics among Streptococcus pneumoniae isolates is a severe problem worldwide. Antibiotic resistance profiles for S pneumoniae isolates identified from pediatric patients in mainland China remains to be established.The clinical features, antimicrobial resistance, and multidrug resistance patterns of S pneumoniae were retrospectively analyzed at 10 children's hospitals in mainland China in 2016.Among the collected 6132 S pneumoniae isolates, pneumococcal diseases mainly occurred in children younger than 5 years old (85.1%). The resistance rate of S pneumoniae to clindamycin, erythromycin, tetracycline, and trimethoprim/sulfamethoxazole was 95.8%, 95.2%, 93.6%, and 66.7%, respectively. The resistance rates of S pneumoniae to penicillin were 86.9% and 1.4% in non-meningitis and meningitis isolates, while the proportions of ceftriaxone resistance were 8.2% and 18.1%, respectively. Pneumococcal conjugate vaccine was administered to only 4.1% of patients. Penicillin and ceftriaxone resistance, underling diseases, antibiotic resistant risk factors, and poor prognosis appeared more frequently in invasive pneumococcal diseases. The incidence of multidrug resistance (MDR) was 46.1% in patients with invasive pneumococcal disease which was more than in patients with non-invasive pneumococcal disease (18.3%). Patients with invasive pneumococcal disease usually have several MDR coexistence.S pneumoniae isolates showed high resistance to common antibiotics in mainland China. Penicillin and ceftriaxone resistance rate of invasive streptococcal pneumonia patients were significantly higher than that of non-invasive S pneumoniae patients. Alarmingly, 46.1% of invasive clinical isolates were multidrug resistant, so it is important to continued monitor the resistance of S pneumoniae when protein conjugate vaccine (PCV13) is coming in mainland China.
journal_name
Medicine (Baltimore)journal_title
Medicineauthors
Wang CY,Chen YH,Fang C,Zhou MM,Xu HM,Jing CM,Deng HL,Cai HJ,Jia K,Han SZ,Yu H,Wang AM,Yin DD,Wang CQ,Wang W,Huang WC,Deng JK,Zhao RZ,Chen YP,Yang JH,Wang C,Che YR,Nie XZ,Wang SF,Hao JH,Zhang CHdoi
10.1097/MD.0000000000015942subject
Has Abstractpub_date
2019-06-01 00:00:00pages
e15942issue
24eissn
0025-7974issn
1536-5964pii
00005792-201906140-00025journal_volume
98pub_type
杂志文章,多中心研究相关文献
MEDICINE文献大全abstract:BACKGROUND:This study was conducted with the aim to investigate the relationship between Tetranectin (TN) and efficiency of posterior spinal V osteotomy in patients with traumatic kyphosis. METHODS:Ninety-two patients with traumatic kyphosis admitted in our hospital from February 2014 to June 2016 were included whose ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000009555
更新日期:2018-02-01 00:00:00
abstract:RATIONALE:Hepatoid adenocarcinoma of lung (HAL) is a rare malignant tumor, which can be defined as a primary alpha-fetoprotein (AFP)-producing lung carcinoma. The majority of hepatoid adenocarcinoma (HAC) expressed AFP in tumor cells, but AFP expression is not required for its diagnosis according to the modified diagno...
journal_title:Medicine
pub_type: 杂志文章,评审
doi:10.1097/MD.0000000000015053
更新日期:2019-04-01 00:00:00
abstract:BACKGROUNDS:Diabetic kidney disease (DKD) is 1 of the common microvascular complications of diabetes, and the therapeutic effect of modern medicine on DKD is limited. At present, patented Chinese medicine Qizhijiangtang (QZJT) capsule has been widely used in the treatment of DKD. We aim to systematically assess the eff...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000021923
更新日期:2020-08-21 00:00:00
abstract::Gynecological laparoscopic surgery is minimally invasive compared with open surgical approaches, but postoperative pain is generally undermanaged. Pain management strategies related to the procedure-specific efficacy are needed. Many studies have shown that dexmedetomidine (DEX) has opioid-sparing properties. It is no...
journal_title:Medicine
pub_type: 杂志文章,随机对照试验
doi:10.1097/MD.0000000000003639
更新日期:2016-05-01 00:00:00
abstract::This case series investigated the efficacy and optimal dose of Escherichia coli-derived bone morphogenetic protein-2 (E.BMP-2) as a bone graft substitute for additional posterolateral spinal fusion, accompanying interbody fusion procedures, for treating lumbar degenerative spinal stenosis. This study focused on the op...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000020477
更新日期:2020-06-12 00:00:00
abstract::The purpose of this study was to evaluate the effects of salvage chemotherapy on recurrent or persistent ovarian clear cell carcinoma (CCC) with the goal of identifying a more rational treatment regimen for this lethal disease.The medical records of patients with CCC were retrospectively reviewed to select patients th...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000001121
更新日期:2015-07-01 00:00:00
abstract::Population aging has rapidly advanced throughout the world and the elderly accounting for out-of-hospital cardiac arrest (OHCA) has increased yearly.We identified all adults who experienced an out-of-hospital cardiac arrest in the All-Japan Utstein Registry of the Fire and Disaster Management Agency, a prospective, po...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000002049
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND:Migraine, ranked as the 7th-highest specific cause of disability worldwide, has caused an enormous burden on the economy and society. Tricyclic antidepressant (TCA) is one of the most commonly drugs for migraine prevention. However, evidence about the efficacy and tolerability of TCAs in the prophylaxis of m...
journal_title:Medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1097/MD.0000000000006989
更新日期:2017-06-01 00:00:00
abstract::Outpatient knee arthroscopy is one of the most commonly performed surgical procedures. Previous research has demonstrated that chronic postsurgical pain (CPSP) after outpatient surgery is prevalent. Our objective was to determine the prevalence and predictive factors of CPSP and Global Surgical Recovery (GSR) 1 year a...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000002017
更新日期:2015-11-01 00:00:00
abstract::The aim of the study was to evaluate the efficacy custom 3D-printed osteosynthesis plates in the treatment of intercondylar humeral fractures.Thirteen patients with distal intercondylar humeral fractures were randomized to undergo surgery using either conventional plates (n = 7) or 3D-printed plates (n = 6) at our ins...
journal_title:Medicine
pub_type: 杂志文章,随机对照试验
doi:10.1097/MD.0000000000002461
更新日期:2016-01-01 00:00:00
abstract:RATIONALE:Tigecycline is the first member of the glycylcycline family. There are rarely reports of tigecycline causing coagulopathy and hypofibrinogenemia until now. We report a case on tigecycline-associated coagulopathy and hypofibrinogenemia and discuss the characteristics of the adverse reaction. PATIENT CONCERNS:...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000009124
更新日期:2017-12-01 00:00:00
abstract::Health information systems are the core support to decision-making in health organizations. Economic and clinical managements often function separately, while a governance system for quality and safety functions with quality checks and performance accountability, could improve efficiency. The aims of this study were, ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000015728
更新日期:2019-05-01 00:00:00
abstract::The ventriculoperitoneal (VP) shunt is a routine procedure for cerebrospinal fluid (CSF) diversion, and is associated with many complications. A delayed hemorrhage after the VP shunt surgery, however, is quite rare. In this study, we report a case involving late-onset hemorrhage. The 67-year-old male patient with a hi...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000002029
更新日期:2015-11-01 00:00:00
abstract::Patients with systemic lupus erythematosus have a poor prognosis of pregnancy, since it is associated with significant maternal and fetal morbidity, including spontaneous miscarriage, pre-eclampsia, intrauterine growth restriction, fetal death and pre-term delivery. We report a case with successful pregnancy in a pati...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000001531
更新日期:2015-09-01 00:00:00
abstract:BACKGROUND:100 mg rectal nonsteroidal anti-inflammatory drugs (NSAIDs) and pancreatic stents both significantly reduce the incidence of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis. Direct comparison of randomized controlled trials (RCTs) between them in high-risk patients is absent. We condu...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000022672
更新日期:2020-10-16 00:00:00
abstract:BACKGROUND:We aimed to conduct a meta-analysis to evaluate the efficacy and safety between once daily (OD) and twice daily (BD) regime dosing of mesalazine for mild-to-moderate ulcerative colitis (UC). METHODS:PubMed, Embase, the Cochrane library, and Web of Science from 1990 to November 2018 were investigated. We sea...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000015113
更新日期:2019-04-01 00:00:00
abstract::Although the association between malignancy and thromboembolic disease is well established, the relative risk of developing initial and recurrent deep vein thrombosis (DVT) or pulmonary embolism (PE) among patients with malignancy versus those without malignancy has not been clearly defined. The Medicare Provider Anal...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/00005792-199909000-00001
更新日期:1999-09-01 00:00:00
abstract::Concomitant influenza and cryptococcal infections are rare. Herein, we describe an unusual case of an avian influenza A (H7N9) infection with several severe mixed bacterial infections and systemic super-infection with Cryptococcus neoformans presenting as ventilator-associated pneumonia (VAP) and bloodstream infection...
journal_title:Medicine
pub_type: 杂志文章,评审
doi:10.1097/MD.0000000000015544
更新日期:2019-05-01 00:00:00
abstract:BACKGROUND:Shared decision making (SDM) is a process within the physician-patient relationship applicable to any clinical action, whether diagnostic, therapeutic, or preventive in nature. It has been defined as a process of mutual respect and participation between the doctor and the patient. The aim of this study is to...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000021389
更新日期:2020-08-07 00:00:00
abstract:INTRODUCTION:The clinical treatment is complicated for patients with placenta previa who must terminate pregnancy due to fetal malformation, death, or inevitable abortion in the second trimester. It is difficult to manage excessive bleeding during pregnancy termination; and those patients face risks of removing the ute...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000022499
更新日期:2020-09-25 00:00:00
abstract:BACKGROUND:Knee osteoarthritis (KOA) is a disabling joint disease with an increasingly prevalence among the older individuals. Tai Chi, one of the ancient meditative movements, has been recognized to have clinical benefits for KOA. We aim to evaluate the efficacy and safety of Tai Chi for patients with KOA through this...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000020242
更新日期:2020-05-01 00:00:00
abstract:BACKGROUND:The argument on whether extracorporeal shock-wave therapy (ESWT) and corticosteroid injections (CSIs) exert an equivalent pain control or which is the better treatment for plantar fasciitis (PF) in adults remains to be resolved. It is important and necessary to conduct a meta-analysis to make a relatively mo...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000013687
更新日期:2018-12-01 00:00:00
abstract:BACKGROUND:Coronavirus disease 2019 (COVID-19) is a global pandemic caused by the severe acute respiratory syndrome coronavirus-2.COVID-19 is highly pathogenic and infectious. COVID-19 epidemic is still spreading all over the world, and there is no sign of stopping at present. There is no specific cure for this disease...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000022962
更新日期:2020-11-13 00:00:00
abstract::Pseudoaneurysm of the mitral-aortic intervalvular fibrosa (P-MAIVF) is a rare but potentially fatal entity. Early diagnosis and surgical treatment are particularly important to decrease risk of mortality. The purpose of this study was to explore the echocardiographic characteristics and outcome of P-MAIVF and to evalu...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000003116
更新日期:2016-03-01 00:00:00
abstract:BACKGROUND:Residual postoperative neuromuscular blockade is an important clinical issue. Neuromuscular monitoring is usually used to evaluate neuromuscular recovery in patients undergoing general anesthesia. However, this procedure is inconvenient and not widely adopted. We aimed to examine the correlation between grip...
journal_title:Medicine
pub_type: 杂志文章,随机对照试验
doi:10.1097/MD.0000000000013940
更新日期:2019-01-01 00:00:00
abstract::Idiopathic pulmonary fibrosis (IPF) is a progressive disease with a poor prognosis. A number of studies reported the association between MUC5B promoter polymorphism rs35705950 and IPF, but substantial inconsistent findings were observed and the strength of association remains unclear.The aim of the study was to invest...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000001901
更新日期:2015-10-01 00:00:00
abstract::Pancreatic cancer (PaCa) is one of the most fatal cancers in the world. Although great efforts have made to explore the mechanisms of PaCa oncogenesis, the prognosis of PaCa patients is still unsatisfactory. Thus, it is imperative to further understand the potential carcinogenesis of PaCa and reliable prognostic model...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000022092
更新日期:2020-09-11 00:00:00
abstract:RATIONALE:Hemolymphangioma is a rare developmental defect of combined vasal and lymphatic vasculature. It is very rare that hemolymphangioma affects the bones and bladder simultaneously, and this condition has never been reported in PubMed. PATIENT CONCERNS:A 12-year-old male has a history of hospitalization for recur...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000015213
更新日期:2019-04-01 00:00:00
abstract::This study examined the safety and usefulness of minimally invasive surgery (MIS) for malignant abdominal tumors in pediatric patients and analyzed the factors affecting the resection margin, operative time, and hospital stay of neuroblastoma (NBL) patients.We retrospectively reviewed data of pediatric patients who un...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000016776
更新日期:2019-08-01 00:00:00
abstract::This study is to determine accuracy of abdominal ultrasound and nuclear magnetic resonance imaging (MRI) for placenta accreta in the second and third trimester of pregnancy and to define the most relevant features of abdominal ultrasound and MRI for placenta accreta prediction.Between September 2012 and September 2018...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000017908
更新日期:2020-01-01 00:00:00