Brain gray matter alterations in Chinese patients with chronic knee osteoarthritis pain based on voxel-based morphometry.

Abstract:

:Altered cerebral gray matter volume (GMV) is commonly found in patients with chronic pain. Chronic pain is the prominent characteristic of knee osteoarthritis (KOA), yet little is known about its morphological changes in the brain. Here an MRI study was performed to examine the structural brain abnormalities in 30 KOA patients with knee pain and age-matched healthy subjects. We detected that the patients exhibited significant almost 2-fold age-related decreases of GMV compared to healthy controls. Moreover, KOA patients also had significant loss of regional GMV including in the bilateral orbital frontal cortex (OFC), the right lateral prefrontal cortex (lPFC), and precentral and postcentral cortices. In addition, a high proportion of KOA patients exerted abnormal scores of Hamilton Depression Rating Scale (HAMD), Hamilton Anxiety Scale (HAMA), Mini Mental State examination (MMSE), and Montreal Cognitive Assessment (MoCA) compare to controls. Our results imply that chronic pain conditions which preferentially involve PFC might consider as a "cognitive state." And emotion and cognitive function about chronic pain should be highly regarded.

journal_name

Medicine (Baltimore)

journal_title

Medicine

authors

Liao X,Mao C,Wang Y,Zhang Q,Cao D,Seminowicz DA,Zhang M,Yang X

doi

10.1097/MD.0000000000010145

subject

Has Abstract

pub_date

2018-03-01 00:00:00

pages

e0145

issue

12

eissn

0025-7974

issn

1536-5964

pii

00005792-201803230-00015

journal_volume

97

pub_type

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