99mTc-MIBI single photon emission computed tomography/computed tomography for the incidental detection of rare parathyroid carcinoma.


:This study aimed to evaluate the characteristics of parathyroid carcinoma and to validate the diagnostic value of Tc-methoxyisobutylisonitrile (MIBI) single photon emission computed tomography/x-ray computed tomography (SPECT/CT) for differentiating between parathyroid carcinoma and hyperparathyroidism. Four consecutive patients with suspected primary hyperparathyroidism were enrolled in this study and underwent Tc-MIBI SPECT/CT, ultrasonography, enhanced CT, and MRI. Serum parathyroid hormone (PTH) and calcium were measured. All primary and recurrent lesions showed high focal uptake on Tc-MIBI image, whereas metastatic lymph nodes gave false negative results. The serum PTH was 165.14 ± 90.26 pmol/L, which declined rapidly after surgery. One patient with a persistently high PTH (147.5 pmol/L) after surgery presented with multiple lymphadenopathy in the neck. Higher expression of chromogranin A (CgA) further confirmed parathyroid carcinoma as a rare endocrine tumor. Parathyroid carcinoma is thus usually diagnosed incidentally based on nonspecific multiorgan symptoms of hypercalcemia and hyperparathyroidism. Tc-MIBI SPECT/CT may help to localize the parathyroid carcinoma, while MRI is valuable for detecting metastasis. Serum PTH and CgA serve as circulating biomarkers in parathyroid carcinoma, and raised levels of PTH and CgA together with locoregional lymphadenopathy may indicate parathyroid carcinoma. Further studies are needed.


Medicine (Baltimore)




Chen Z,Fu J,Shao Q,Zhou B,Wang F




Has Abstract


2018-10-01 00:00:00
















  • Tamoxifen for amyotrophic lateral sclerosis: A randomized double-blind clinical trial.

    abstract:INTRODUCTION:Amyotrophic lateral sclerosis (ALS) is the most common cause of motor neuron disease, and effective treatment for ALS is still lacking. Transactive response (TAR) -DNA-binding protein-43 (TDP-43) is aggregated in the neurons of ALS patients. Animal studies shown TDP-43 aggregation can be attenuated by enha...


    pub_type: 杂志文章,随机对照试验


    authors: Chen PC,Hsieh YC,Huang CC,Hu CJ

    更新日期:2020-05-29 00:00:00

  • A systematic review and meta-analysis including GRADE qualification of the risk of surgical site infections after prophylactic negative pressure wound therapy compared with conventional dressings in clean and contaminated surgery.

    abstract:OBJECTIVE:Systematically review and Grading of Recommendations Assessment, Development, and Evaluation (GRADE) studies on prophylactic negative pressure wound therapy (pNPWT) to prevent surgical site infections (SSIs). INTRODUCTION:pNPWT has been suggested as a new method to prevent wound complications, specifically S...


    pub_type: 杂志文章,meta分析,评审


    authors: De Vries FEE,Wallert ED,Solomkin JS,Allegranzi B,Egger M,Dellinger EP,Boermeester MA

    更新日期:2016-09-01 00:00:00

  • Splenic abscess owing to cancer at the splenic flexure: A case report and comprehensive review.

    abstract:BACKGROUND:The cancer of the splenic flexure of the colon is a rare medical entity with severe morbidity because of its insidious onset. METHODS:We present the case of a 59-year-old male patient with dull left upper quadrant pain, leukocytosis, and anemia. A splenic abscess described as an air-fluid level with splenoc...


    pub_type: 杂志文章,评审


    authors: Awotar GK,Luo F,Zhao Z,Guan G,Ning S,Ren J,Liu Y,Wang G,Liu P

    更新日期:2016-09-01 00:00:00

  • Inflammatory cytokine depletion in severe coronavirus disease 2019 infectious pneumonia: A case report.

    abstract:RATIONALE:Multiorgan/system injury was observed in severely infected coronavirus disease 2019 (COVID-19) patients, in addition to viral pneumonia. Recognizing and correcting the key and immediate dysfunctions may reduce mortality. PATIENT CONCERNS:A 66-year-old previously healthy male patient was referred to the isola...


    pub_type: 杂志文章


    authors: Yang B,Yang J,Zhou L,Xue C,Li H,Hu W,Liu N

    更新日期:2020-12-04 00:00:00

  • Multiple primary central nervous system lymphoma in the elderly: A case report.

    abstract:RATIONALE:Multiple primary central nervous system lymphoma (MPCNSL) is a rare disease with differential diagnosis and treatment. As the underlying pathogenesis is not yet clarified, the early-stage clinical manifestations are occult and atypical. Also, the imaging manifestations are not specific, which is challenging f...


    pub_type: 杂志文章


    authors: Chen G,Xu M,Wang X,Gao Y,He C,Chang M,Zhang J

    更新日期:2019-08-01 00:00:00

  • Efficacy of erlotinib and celecoxib for patients with advanced non-small cell lung cancer: A retrospective study.

    abstract::This study evaluated the efficacy and toxicity of erlotinib and celecoxib (EC) for treating Chinese patients with advanced non-small cell lung cancer (ANSCLC) and epidermal growth factor receptor (EGFR) wild type.Totally, 75 subjects with ANSCLC and EGFR wild type were included. They all underwent EC treatment. The ou...


    pub_type: 杂志文章


    authors: Jin YH,Li WH,Bai Y,Ni L

    更新日期:2019-03-01 00:00:00

  • Approach to diagnosis of factitious disorder with unexplained hemoptysis: A case report.

    abstract:RATIONALE:Hemoptysis or hematemesis is a common clinical symptom in adults, but is unusually to be observed in children. Hemoptysis can occur with circulatory diseases, injuries, several types of systemic diseases, or systemic factors including factitious disorder (FD), which is difficult to be diagnosed. Here, we repo...


    pub_type: 杂志文章


    authors: Yue P,Zhou K,Hua Y,Fang J,Li Y

    更新日期:2019-02-01 00:00:00

  • Does increased serum d-lactate mean subclinical hyperpermeability of intestinal barrier in middle-aged nonobese males with OSA?

    abstract::Few attention has been directed to the potential effects of intermittent hypoxia experienced in obstructive sleep apnea on the integrity and permeability of intestinal barrier, particularly in adults. Therefore, we evaluated alteration in serum d-lactate concentration in middle-aged males with obstructive sleep apnea ...


    pub_type: 杂志文章


    authors: Heizati M,Li N,Shao L,Yao X,Wang Y,Hong J,Zhou L,Zhang D,Chang G,Abulikemu S

    更新日期:2017-12-01 00:00:00

  • Application of vascularized fibular graft for reconstruction and stabilization of multilevel cervical tuberculosis: A case report.

    abstract::Multilevel cervical reconstruction and fusion after cervical tuberculosis has always been a challenge. The current implantation materials for cervical fusion, including titanium mesh, cage, and plate are limited by its inferior biological mechanical characteristics and the properties of the metallic material. This has...


    pub_type: 杂志文章


    authors: Zhang J,He WS,Wang C,Yan YG,Ouyang ZH,Xue JB,Li XL,Wang WJ

    更新日期:2018-01-01 00:00:00

  • Primary malignant mesenchymoma of bladder: Case report and review of the literature.

    abstract:RATIONALE:Malignant mesenchymoma (MM) is defined as a heterogeneous malignant soft tissue tumor that consists of 2 or more distinctly different mesenchymal components in addition to fibrosarcomatous elements. Bladder MM was rarely reported in the literature and there are only 5 cases of primary bladder MM documented in...


    pub_type: 杂志文章


    authors: Yang Z,Yang X,Lu X,Gao L,Li G,Zhang X

    更新日期:2017-08-01 00:00:00

  • The effect of metabolic health and obesity phenotypes on risk of hypertension: A nationwide population-based study using 5 representative definitions of metabolic health.

    abstract::Although obesity is clearly identified as a risk factor for hypertension, the association between its different metabolic phenotypes and hypertension remains unclear. We aimed to investigate this association and compare the degree of association between metabolic health and obesity phenotypes defined by 5 representati...


    pub_type: 杂志文章


    authors: Tian S,Xu Y,Dong H

    更新日期:2018-09-01 00:00:00

  • A novel technique of using a miniature plate in combination with tension band wiring to treat comminuted patellar fractures.

    abstract::Traditionally, tension band fixation has been used for treating simple fracture patterns; however, fixation remains a challenge, especially for comminuted fractures. We describe a new method of operation using a combination of a miniature plate with tension band wiring to treat comminuted patellar fractures. The aim o...


    pub_type: 杂志文章


    authors: Gao S,Zhang F,Gao T,Liu X,Zhang Z,Dai M

    更新日期:2018-04-01 00:00:00

  • Correlation of cervical and thoracic inlet sagittal parameters by MRI and radiography in patients with cervical spondylosis.

    abstract::To investigate the relationship between cervical and thoracic sagittal alignment parameters measured by magnetic resonance imaging (MRI) and x-ray in patients with cervical spondylosisData from 120 symptomatic patients who presented with cervical spondylosis between April 2015 and January 2016 were retrospectively ana...


    pub_type: 杂志文章


    authors: Cheng J,Liu P,Sun D,Ma Z,Liu J,Wang Z,Mou J

    更新日期:2019-02-01 00:00:00

  • Prognostic Value of KIF2A and HER2-Neu Overexpression in Patients With Epithelial Ovarian Cancer.

    abstract::Kinesin family member 2A (KIF2A) is a member of Kinesin-13 family and involved in cell migration and cell signaling. Human epidermal growth factor receptor 2 (HER2-neu) is implicated in the development of many cancers. Both of these 2 proteins are upstream inducer of PI3K/AKT signaling pathway that plays an important ...


    pub_type: 杂志文章


    authors: Wang D,Zhu H,Ye Q,Wang C,Xu Y

    更新日期:2016-02-01 00:00:00

  • Endovascular repair of bilateral common iliac artery aneurysms using GORE Excluder iliac branch endoprosthesis without aortobi-iliac stent graft conjunction: A case report.

    abstract:INTRODUCTION:Bilateral common iliac artery (CIA) aneurysm (CIAA) is a rare entity. In the past decade, different endovascular approaches have been adopted for patients with several comorbidities or unfit for open repair (OR). Recently, the use of iliac branch stent graft has been proposed, resulting in satisfactory pat...


    pub_type: 杂志文章


    authors: Ardita V,Giaquinta A,Veroux M,Sanfiorenzo A,Virgilio C,D'Arrigo G,Veroux P

    更新日期:2017-02-01 00:00:00

  • Nuclear factor-kappa B1 is associated with gastric cancer in a Chinese population.

    abstract::Activated nuclear factor-κB (NF-κB) is associated with the pathogenesis of numerous cancers, such as gastric cancer (GC). Genetic polymorphisms in the genomic region containing nuclear factor-κB1 (NFKB1) have a plausible role in modulating the risk of GC. To identify markers contributing to the genetic susceptibility ...


    pub_type: 杂志文章


    authors: Hua T,Qinsheng W,Xuxia W,Shuguang Z,Ming Q,Zhenxiong L,Jingjie W

    更新日期:2014-12-01 00:00:00

  • Worse clinical outcomes following percutaneous coronary intervention with a high SYNTAX score: A systematic review and meta-analysis.

    abstract:BACKGROUND:The synergy between percutaneous coronary intervention (PCI) with TAXUS and Cardiac Surgery (SYNTAX) score is an angiographic tool which is used to determine the complexity of coronary artery disease (CAD). We aimed to compare PCI versus coronary artery bypass surgery (CABG) in patients with a high SYNTAX sc...


    pub_type: 杂志文章,meta分析,评审


    authors: Bundhun PK,Bhurtu A,Huang F

    更新日期:2017-06-01 00:00:00

  • Investigation of the Psychological disorders in the healthcare nurses during a coronavirus disease 2019 outbreak in China.

    abstract::The first case of atypical pneumonia caused by coronavirus disease 2019 (COVID-19) was reported in Wuhan, China in December 2019. Since then, cases of novel coronavirus-infected pneumonia (NCIP) have been reported throughout China as well as in 25 other countries. With the rapid growth of this global outbreak, psychol...


    pub_type: 杂志文章


    authors: Xie H,Cheng X,Song X,Wu W,Chen J,Xi Z,Shou K

    更新日期:2020-08-21 00:00:00

  • Geographic coverage of male circumcision in western Kenya.

    abstract::Voluntary Medical Male Circumcision (VMMC) for human immunodeficiency virus (HIV) prevention has scaled up rapidly among young men in western Kenya since 2008. Whether the program has successfully reached uncircumcised men evenly across the region is largely unknown. Using data from two cluster randomized surveys from...


    pub_type: 杂志文章


    authors: Akullian A,Onyango M,Klein D,Odhiambo J,Bershteyn A

    更新日期:2017-01-01 00:00:00

  • Impact of tumor size on outcome after stereotactic body radiation therapy for inoperable hepatocellular carcinoma.

    abstract::Stereotactic body radiation therapy (SBRT) for inoperable hepatocellular carcinoma (HCC) offers excellent local control rates. This study retrospectively analyzed the influence of different tumor size on treatment outcomes after SBRT.Between December 2008 and February 2014, 141 HCC patients were treated with Cyberknif...


    pub_type: 杂志文章


    authors: Kuo HT,Que J,Lin LC,Yang CC,Koay LB,Lin CH

    更新日期:2017-12-01 00:00:00

  • Huangqi Guizhi Wuwu decoction for diabetic peripheral neuropathy: Protocol for a systematic review.

    abstract:BACKGROUND:Diabetic peripheral neuropathy (DPN) is one of the most common causes of disability in diabetic population, and its pathogenesis is related to a variety of factors. There is currently no effective treatment for such chronic disease. Traditional Chinese medicine has a long clinical history for the prevention ...


    pub_type: 杂志文章


    authors: Zhang Y,Gong G,Zhang X,Zhou L,Xie H,Tian Y,Xie C

    更新日期:2019-08-01 00:00:00

  • Increasing Coverage of Hepatitis B Vaccination in China: A Systematic Review of Interventions and Implementation Experiences.

    abstract::This study used a system evaluation method to summarize China's experience on improving the coverage of hepatitis B vaccine, especially the strategies employed to improve the uptake of timely birth dosage. Identifying successful methods and strategies will provide strong evidence for policy makers and health workers i...


    pub_type: 杂志文章,评审


    authors: Wang S,Smith H,Peng Z,Xu B,Wang W

    更新日期:2016-05-01 00:00:00

  • Associations Between the Periodontal Disease in Women Before Menopause and Menstrual Cycle Irregularity: The 2010-2012 Korea National Health and Nutrition Examination Survey.

    abstract::The association between menstrual cycle irregularities and system disease has been evaluated in previous studies. However, the association between periodontal disease and menstrual cycle irregularity has not been fully investigated. The study aimed to evaluate the relationship between periodontal disease and tooth los...


    pub_type: 杂志文章


    authors: Han K,Ko Y,Park YG,Park JB

    更新日期:2016-02-01 00:00:00

  • The effect of neck-specific exercise with or without a behavioral approach on psychological factors in chronic whiplash-associated disorders: A randomized controlled trial with a 2-year follow-up.

    abstract:BACKGROUND:To investigate the effect of neck-specific exercise with (NSEB) or without (NSE) a behavioural approach and prescribed physical activity (PPA) on general pain disability and psychological factors in chronic whiplash-associated disorders (WAD), grade 2 and 3, with a 2-year follow-up. METHODS:A randomized con...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Overmeer T,Peterson G,Landén Ludvigsson M,Peolsson A

    更新日期:2016-08-01 00:00:00

  • Docetaxel, oxaliplatin, 5FU, and trastuzumab as first-line therapy in patients with human epidermal receptor 2-positive advanced gastric or gastroesophageal junction cancer: Preliminary results of a phase II study.

    abstract::The aim of this study is to report first preliminary results of patients enrolled in a phase II study that will investigate the activity and safety of docetaxel, oxaliplatin, and 5-fluorouracil (DOF) in combination with trastuzumab in human epidermal receptor-2 (HER-2) positive patients with advanced gastric or gastro...


    pub_type: 杂志文章


    authors: Roviello G,Petrioli R,Nardone V,Rosellini P,Multari AG,Conca R,Aieta M

    更新日期:2018-05-01 00:00:00

  • Medical malpractice related to drug-induced anaphylaxis: An analysis of lawsuit judgments in South Korea.

    abstract::Drug-induced anaphylaxis (DIA) is a highly paradoxical disorder involving a fatal response to medicines prescribed for therapeutic purposes. This study aimed to improve the awareness on DIA and to prevent errors through an analysis of lawsuit judgments.Sentenced judgments involving DIA from 1998 to 2017 using the data...


    pub_type: 杂志文章


    authors: Hyeon CW,Lee JY,Jang S,Cho SI,Kim S,Lee W,Shin S

    更新日期:2019-06-01 00:00:00

  • Improving functional outcome and quality of life for patients with metastatic lesion of acetabulum undergoing cement augmentation.

    abstract::There is an increased enthusiasm in treating osteolytic metastatic acetabulum via injecting polymethyl-methacrylate (PMMA) as a bone filler to provide pain relief and potential structural support. The aim of this respective study is to determine the function and quality of life improvement after cement acetabuloplasty...


    pub_type: 杂志文章


    authors: Yan T,Zhao Z,Tang X,Guo W,Yang R,Tang S,Dong S

    更新日期:2019-09-01 00:00:00

  • Evidence for Chronic Kidney Disease-Mineral and Bone Disorder Associated With Metabolic Pathway Changes.

    abstract::Abnormalities in the levels of calcium, phosphorus, and parathyroid hormone (PTH) in serum are typical for patients with chronic kidney disease (CKD). They are used routinely to predict the onset of CKD-mineral and bone disorder (MBD). However, CKD-MBD associated with metabolic pathway imbalance is not well understood...


    pub_type: 杂志文章


    authors: Wu Q,Lai X,Zhu Z,Hong Z,Dong X,Wang T,Wang H,Lou Z,Lin Q,Guo Z,Chai Y

    更新日期:2015-08-01 00:00:00

  • Could platelet-to-lymphocyte ratio be a predictor for contrast-induced nephropathy in patients with acute coronary syndrome?: A systematic review and meta-analysis.

    abstract:BACKGROUND:Contrast-induced nephropathy (CIN) is acute renal failure observed after administration of iodinated contrast media during angiographic or other medical procedures. In recent years, many studies have focused on biomarkers that recognize CIN and/or predict its development in advance. One of the many biomarker...


    pub_type: 杂志文章,meta分析


    authors: Jiang J,Ji HY,Xie WM,Ran LS,Chen YS,Zhang CT,Quan XQ

    更新日期:2019-08-01 00:00:00

  • The role of stereotactic body radiation therapy in oligometastatic colorectal cancer: Clinical case report of a long-responder patient treated with regorafenib beyond progression.

    abstract:RATIONALE:Regorafenib is the new standard third-line therapy in metastatic colorectal cancer (mCRC). However, the reported 1-year overall survival rate does not exceed 25%. PATIENT CONCERNS:A 55-year-old man affected by mCRC, treated with regorafenib combined with stereotactic body radiotherapy (SBRT), showing a durab...


    pub_type: 杂志文章


    authors: Roberto M,Falcone R,Mazzuca F,Archibugi L,Castaldi N,Botticelli A,Osti MF,Marchetti P

    更新日期:2017-12-01 00:00:00