99mTc-MIBI single photon emission computed tomography/computed tomography for the incidental detection of rare parathyroid carcinoma.


:This study aimed to evaluate the characteristics of parathyroid carcinoma and to validate the diagnostic value of Tc-methoxyisobutylisonitrile (MIBI) single photon emission computed tomography/x-ray computed tomography (SPECT/CT) for differentiating between parathyroid carcinoma and hyperparathyroidism. Four consecutive patients with suspected primary hyperparathyroidism were enrolled in this study and underwent Tc-MIBI SPECT/CT, ultrasonography, enhanced CT, and MRI. Serum parathyroid hormone (PTH) and calcium were measured. All primary and recurrent lesions showed high focal uptake on Tc-MIBI image, whereas metastatic lymph nodes gave false negative results. The serum PTH was 165.14 ± 90.26 pmol/L, which declined rapidly after surgery. One patient with a persistently high PTH (147.5 pmol/L) after surgery presented with multiple lymphadenopathy in the neck. Higher expression of chromogranin A (CgA) further confirmed parathyroid carcinoma as a rare endocrine tumor. Parathyroid carcinoma is thus usually diagnosed incidentally based on nonspecific multiorgan symptoms of hypercalcemia and hyperparathyroidism. Tc-MIBI SPECT/CT may help to localize the parathyroid carcinoma, while MRI is valuable for detecting metastasis. Serum PTH and CgA serve as circulating biomarkers in parathyroid carcinoma, and raised levels of PTH and CgA together with locoregional lymphadenopathy may indicate parathyroid carcinoma. Further studies are needed.


Medicine (Baltimore)




Chen Z,Fu J,Shao Q,Zhou B,Wang F




Has Abstract


2018-10-01 00:00:00
















  • Intralesional and subcutaneous application of Viscum album L. (European mistletoe) extract in cervical carcinoma in situ: A CARE compliant case report.

    abstract:RATIONALE:Carcinoma in situ (CIS) of the uterine cervix is a premalignant condition of squamous epithelium. The standard treatments are excision and ablation procedures; for women with positive margins, hysterectomy is recommended. PATIENT CONCERNS:A 47-year-old Peruvian woman with recurrent candidal vaginitis had bee...


    pub_type: 杂志文章


    authors: Reynel M,Villegas Y,Kiene H,Werthmann PG,Kienle GS

    更新日期:2018-11-01 00:00:00

  • Increased mean aliphatic lipid chain length in left ventricular hypertrophy secondary to arterial hypertension: A cross-sectional study.

    abstract::About 77.9 million (1 in 4) American adults have high blood pressure. High blood pressure is the primary cause of left ventricular hypertrophy (LVH), which represents a strong predictor of future heart failure and cardiovascular mortality. Previous studies have shown an altered metabolic profile in hypertensive patien...


    pub_type: 杂志文章


    authors: Evaristi MF,Caubère C,Harmancey R,Desmoulin F,Peacock WF,Berry M,Turkieh A,Barutaut M,Galinier M,Dambrin C,Polidori C,Miceli C,Chamontin B,Koukoui F,Roncalli J,Massabuau P,Smih F,Rouet P

    更新日期:2016-11-01 00:00:00

  • Risk of Peripheral Arterial Occlusive Disease in Patients With Systemic Lupus Erythematosus: A Nationwide Population-Based Cohort Study.

    abstract::Systemic lupus erythematosus (SLE) is associated with atherosclerosis, but the relationship between SLE and peripheral arterial occlusive disease (PAOD) remains unclear. We sought to investigate this relationship by comparing cardiovascular complications in patients with and without SLE.Data on patients from 2000 to 2...


    pub_type: 杂志文章


    authors: Chuang YW,Yu MC,Lin CL,Yu TM,Shu KH,Kao CH

    更新日期:2015-11-01 00:00:00

  • Treatment of multicentric Castleman disease through combination of tocilizumab, lenalidomide and glucocorticoids: Case report.

    abstract:RATIONALE:Castleman's disease (CD) is a rare lymphoproliferative disease. Compared to unicentric CD, multicentric Castleman disease (MCD) displays poorer prognosis and great variance to different therapies. Though chemotherapy, immunization therapy, and glucocorticoids have been used in the treatment of MCD, its optima...


    pub_type: 杂志文章


    authors: Cai S,Zhong Z,Li X,Wang HX,Wang L,Zhang M

    更新日期:2019-11-01 00:00:00

  • Delayed intracranial subdural empyema following burr hole drainage: Case series and literature review.

    abstract:RATIONALE:A subdural empyema (SDE) following burr hole drainage of a chronic subdural hematoma (CSDH) can be difficult to distinguish from a recurrence of the CSDH, especially when imaging data is limited to a computed tomography (CT) scan. PATIENTS CONCERNS:All patients underwent burr hole drainage of the CSDH at fir...


    pub_type: 杂志文章


    authors: Kim YS,Joo SP,Song DJ,Kim SH,Kim TS

    更新日期:2018-05-01 00:00:00

  • Gemstone spectral imaging in lung cancer: A preliminary study.

    abstract::The present study aimed to evaluate the application of gemstone spectral imaging (GSI) for multi-parameter quantitative measurement in lung cancer.The study retrospectively enrolled 30 patients with lung cancer who underwent chest contrast enhanced CT scan with GSI mode. The GSI viewer was used for image display and d...


    pub_type: 杂志文章


    authors: Jia Y,Xiao X,Sun Q,Jiang H

    更新日期:2018-07-01 00:00:00

  • Comparing Burnout Across Emergency Physicians, Nurses, Technicians, and Health Information Technicians Working for the Same Organization.

    abstract::Studies on the topic of burnout measure the effects of emotional exhaustion (EE), depersonalization (DP) (negative or cynical attitudes toward work), and reduced sense of personal accomplishment (PA). While the prevalence of burnout in practicing emergency medicine (EM) professionals has been studied, little is known ...


    pub_type: 杂志文章


    authors: Schooley B,Hikmet N,Tarcan M,Yorgancioglu G

    更新日期:2016-03-01 00:00:00

  • The relationship between HER2 overexpression and angiogenesis in gastric cancer.

    abstract::In gastric cancer, HER2 protein overexpression is considered to be conducive to the higher proliferation activity of the tumor cells. Tumor formation is associated with angiogenesis in order to secure an abundant supply of oxygen and glucose to cancer cells. The aim of the study was to assess if HER2 overexpression is...


    pub_type: 杂志文章


    authors: Ciesielski M,Szajewski M,Pęksa R,Lewandowska MA,Zieliński J,Walczak J,Szefel J,Kruszewski WJ

    更新日期:2018-10-01 00:00:00

  • Risk factors of gender for renal progression in patients with early chronic kidney disease.

    abstract::Risk factors for chronic kidney disease (CKD), such as hypertension, hyperglycemia, albuminuria, renal structure, and sex hormones, have been reported to have different effects on males and females. Thus, CKD progression may differ depending on sex. In addition to CKD management, treatment at earlier stages can reduce...


    pub_type: 杂志文章


    authors: Chang PY,Chien LN,Lin YF,Wu MS,Chiu WT,Chiou HY

    更新日期:2016-07-01 00:00:00

  • Herbal medicine (zhishi xiebai guizhi decoction) for unstable angina: Protocol for a systematic review and meta-analysis.

    abstract:BACKGROUND:Unstable angina (UA) is a clinically common coronary heart disease. Zhishi xiebai guizhi decoction (ZXGD) has been widely used in the management of UA, although its effective evidence is not clear and there is no systematic review regarding its efficacy and safety. Therefore, we conduct this systematic revie...


    pub_type: 杂志文章,meta分析,评审


    authors: Tang Y,Cai H,Zhan Z,Luo Y,Huang Y,Chen D,Chen B

    更新日期:2018-12-01 00:00:00

  • Characteristics of diurnal ventricular premature complex variation in right ventricular outflow tract arrhythmias after catheter ablation.

    abstract::Diurnal variations in ventricular tachyarrhythmias (VAs) have been demonstrated in idiopathic arrhythmogenic heart disease. The electrophysiological characteristics of diurnal variations in idiopathic right ventricular outflow tract (RVOT) VA have not previously been elucidated. Sixty-two consecutive patients undergoi...


    pub_type: 杂志文章


    authors: Jhuo SJ,Lo LW,Chang SL,Lin YJ,Chung FP,Hu YF,Chao TF,Tuan TC,Liao JN,Lin CY,Chang YT,Lin CH,Walia R,Te ALD,Yamada S,Raharjo SB,Tang WH,Lee KT,Lai WT,Chen SA

    更新日期:2017-04-01 00:00:00

  • X-linked hypophosphatemia: a clinical, biochemical, and histopathologic assessment of morbidity in adults.

    abstract::Research and management of XLH have concentrated on the disease in childhood, and the natural history and morbidity of XLH in adult life are thus poorly understood. We have studied 22 adults (6 men) with XLH to clarify these aspects of this most common inherited form of rickets and osteomalacia. Most study participant...


    pub_type: 杂志文章


    authors: Reid IR,Hardy DC,Murphy WA,Teitelbaum SL,Bergfeld MA,Whyte MP

    更新日期:1989-11-01 00:00:00

  • Hemiarthroplasty versus total hip arthroplasty for displaced femoral neck fracture in patients older than 80 years: A randomized trial protocol.

    abstract:BACKGROUND:The forms of treatment which are available for these patients include internal fixation, hemiarthroplasty (HA), or total hip arthroplasty (THA). Both HA and THA are widely used methods of hip replacement after displaced femoral neck fracture (DFNF). Our purpose is to analyze the long-term outcomes of these 2...


    pub_type: 杂志文章


    authors: Peng L,Liu H,Hu X,Liu J

    更新日期:2020-12-11 00:00:00

  • Scapular metastasis of hepatocellular carcinoma presenting as acute bleeding and hematoma: A case report of safe and effective treatment.

    abstract:RATIONALE:The occurrence of bleeding and hematoma from bone metastasis of hepatocellular carcinoma (HCC) is extremely rare. PATIENT CONCERNS:We present a case of scapular metastasis of HCC in a 69-year-old man who presented with acute bleeding and hematoma. DIAGNOSES:Chest computed tomography showed a large hematoma ...


    pub_type: 杂志文章


    authors: Kim KH,Oh HH,Son DJ,Hong JY,Jeong YH,Jung JS,Yu HM,Myung DS,Cho SB,Lee WS,Kim JW,Joo YE

    更新日期:2017-11-01 00:00:00

  • The financial burden of complications following rectal resection: A cohort study.

    abstract::To investigate the costs associated with postoperative complications following rectal resection.Rectal resection is a major surgical procedure that carries a significant risk of complications. The occurrence of complications following surgery has both health and financial consequences. There are very few studies that ...


    pub_type: 杂志文章


    authors: Johnston SA,Louis M,Churilov L,Ma R,Marhoon N,Bui A,Christophi C,Weinberg L

    更新日期:2020-05-01 00:00:00

  • Evaluation of the depiction ability of the microanatomy of the temporal bone in quarter-detector CT: Model-based iterative reconstruction vs hybrid iterative reconstruction.

    abstract::Little is known regarding differences between model-based iterative reconstruction (MBIR) and hybrid iterative reconstruction (HIR) in temporal bone computed tomography (CT). This study compared the ability to depict microstructures in temporal bone in quarter-detector CT (QDCT) between MBIR and HIR.Sixty-two temporal...


    pub_type: 杂志文章


    authors: Kurokawa R,Maeda E,Mori H,Amemiya S,Sato J,Ino K,Torigoe R,Abe O

    更新日期:2019-06-01 00:00:00

  • Association of human serotonin receptor 4 promoter methylation with autism spectrum disorder.

    abstract::Human serotonin receptor 4 (HTR4) encodes a 5-HT4 receptor involved in learning, memory, depression, anxiety, and feeding behavior. The aim of this study was to investigate the association between the deoxyribonucleic acid (DNA) methylation of HTR4 promoter and autism spectrum disorder (ASD), a disease characterized b...


    pub_type: 杂志文章


    authors: Hu Z,Ying X,Huang L,Zhao Y,Zhou D,Liu J,Zhong J,Huang T,Zhang W,Cheng F,Duan S

    更新日期:2020-01-01 00:00:00

  • Acupoint-tuina therapy promotes lactation in postpartum women with insufficient milk production who underwent caesarean sections.

    abstract::Breast milk is recognized and strongly recommended by the World Health Organization (WHO) as the optimal feeding for all babies. Breastfeeding is associated with better nutritional and non-nutritional outcomes when compared to formula feeding, and has proven health benefits to both infants and their mothers. This clin...


    pub_type: 杂志文章,随机对照试验


    authors: Lu P,Ye ZQ,Qiu J,Wang XY,Zheng JJ

    更新日期:2019-08-01 00:00:00

  • Synchronous Resectable Metastatic Colorectal Cancer: Lymph Node Involvement Predicts Poor Outcome.

    abstract::To evaluate the value of lymph node status of primary tumors in predicting the prognosis of synchronous resectable metastatic colorectal cancer (mCRC).The characteristics of resectable mCRC are substantially different from other cancers, and the prognostic factors of resectable mCRC are still controversial.The data of...


    pub_type: 杂志文章


    authors: Fu J,Jiang M,Tan Y,Yang J,Wu L,Feng L,Zheng S,Yuan Y

    更新日期:2015-07-01 00:00:00

  • Effect of modified laparoscopic hysterectomy on pelvic floor function: A retrospective observational study.

    abstract::Hysterectomy is a potential risk factor for subsequent surgery for pelvic organ prolapse, especially when the prolapse exists before hysterectomy. Women without prolapse before hysterectomy may also experience prolapse after hysterectomy. This study aimed to describe a surgical modification of laparoscopic colposuspen...


    pub_type: 杂志文章


    authors: Lee CY,Tseng CJ,Chang CH,Lee MC,Ou YC,Yang SF

    更新日期:2019-02-01 00:00:00

  • Supportive psychological intervention on psychological disorders in clinical medicine students with English Learning Difficulties: A protocol of systematic review.

    abstract:BACKGROUND:This study aims to examine the effect of supportive psychological intervention (SPI) on psychological disorders (PD) in clinical medicine students (CMS) with English Learning Difficulties (ELD). METHODS:We will perform a comprehensive literature search from the following databases: Cochrane Library, MEDLINE...


    pub_type: 杂志文章


    authors: Wen HL,Feng C,Zhang SL,Li XW

    更新日期:2020-11-20 00:00:00

  • Diastolic dysfunction is associated with an increased risk of postcontrast acute kidney injury.

    abstract:STUDY OBJECTIVE:Computed tomography (CT) is an important imaging modality in diagnosing a variety of disorders. Although systolic heart failure is a well-known risk factor for postcontrast acute kidney injury (PC-AKI), few studies have evaluated the association between diastolic dysfunction and PC-AKI. Therefore, the a...


    pub_type: 杂志文章


    authors: Lee MJ,Park JS,Kim HH

    更新日期:2019-11-01 00:00:00

  • Erector spinae plane block for multimodal analgesia after wide midline laparotomy: A case report.

    abstract:RATIONALE:The most commonly used regional techniques for analgesia following laparotomy thoracic epidural analgesia and paravertebral blocks are technically difficult to perform and carry a risk of severe complications. Recently, the erector spinae plane block (ESPB) has been reported to effectively treat neuropathic p...


    pub_type: 杂志文章


    authors: Bang S,Chung J,Kwon W,Yoo S,Soh H,Lee SM

    更新日期:2019-05-01 00:00:00

  • Burnout level and job satisfaction in Chinese pediatrics residents: A web-based cross-sectional study.

    abstract::To study the prevalence of burnout and job satisfaction in Chinese pediatrics residents.Prospective participants were invited via a WeChat group to participate from October 1, 2018 to January 31, 2019. The Maslach Burnout Inventory-Human Services Survey was used to measure physician burnout, and the Minnesota Satisfac...


    pub_type: 杂志文章


    authors: Ji L,Xiaowei Z,Ling K,Yao F,Qingkun S,Jun Z

    更新日期:2020-02-01 00:00:00

  • Diagnostic performance of serum pepsinogen assay for the prediction of atrophic gastritis and gastric neoplasms: Protocol for a systematic review and meta-analysis.

    abstract:BACKGROUND:Serum pepsinogen assay (sPGA) combining concentration of pepsinogen I (PG I), and the ratio of PG I/II is the noninvasive biomarker for predicting chronic atrophic gastritis (CAG) and neoplasms reflecting mucosal secretory status. Although various cut-off values have been suggested, PG I ≤70 ng/mL and PG I/I...


    pub_type: 杂志文章


    authors: Bang CS,Lee JJ,Baik GH

    更新日期:2019-01-01 00:00:00

  • The high prevalence of subclinical atherosclerosis in patients with ankylosing spondylitis without clinically evident cardiovascular disease.

    abstract::We conducted the present study to determine whether subclinical macrovascular atherosclerotic disease was present in patients with ankylosing spondylitis (AS) without clinical history of cardiovascular disease. We also sought to establish whether demographic or clinical features of the disease may influence the develo...


    pub_type: 杂志文章


    authors: Gonzalez-Juanatey C,Vazquez-Rodriguez TR,Miranda-Filloy JA,Dierssen T,Vaqueiro I,Blanco R,Martin J,Llorca J,Gonzalez-Gay MA

    更新日期:2009-11-01 00:00:00

  • Post-transplant malignancy in liver transplantation: a single center experience.

    abstract::We aim to determine the incidence of malignancy after liver transplantation (LT) compared to general population. The records of patients who received LTs at our center from October 1989 and November 2012 were retrospectively reviewed. The standardized incidence ratio (SIR) of cancer in the patients was compared to gen...


    pub_type: 杂志文章


    authors: Hsiao CY,Lee PH,Ho CM,Wu YM,Ho MC,Hu RH

    更新日期:2014-12-01 00:00:00

  • Comparative Assessment of the Anticoagulant Activity of Rivaroxaban and Dabigatran in Patients With Nonvalvular Atrial Fibrillation: A Noninterventional Study.

    abstract::There is a shortage of data in everyday clinical practice about the anticoagulant effects caused by the new oral anticoagulants (NOAs). Our aim was to estimate the intensity of anticoagulant activity induced by rivaroxaban 20 mg qd and dabigatran 110 mg bid among patients with nonvalvular atrial fibrillation (NV-AF).W...


    pub_type: 杂志文章


    authors: Tsantes AE,Kyriakou E,Ikonomidis I,Katogiannis K,Papadakis I,Douramani P,Kopterides P,Kapsimali V,Lekakis J,Tsangaris I,Bonovas S

    更新日期:2016-04-01 00:00:00

  • Folic Acid Intake and Neural Tube Defects: Two Egyptian Centers Experience.

    abstract::Neural tube defects (NTDs) are a group of congenital malformations with worldwide distribution and complex etiopathogenesis. Folic acid plays a pivotal role in their prevention. We aimed to identify the protective effect of folic acid intake against NTDs and its dependence on different socioeconomic and environmental ...


    pub_type: 杂志文章,多中心研究


    authors: El-Shabrawi MH,Kamal NM,Elhusseini MA,Hussein L,Abdallah EAA,Ali YZA,Azab AA,Salama MA,Kassab M,Krawinkel M

    更新日期:2015-09-01 00:00:00

  • Roentgenographic Evaluation of the Spine in Patients With Osteogenesis Imperfecta.

    abstract::Osteogenesis imperfecta (OI) is a hereditary connective tissue disorder that leads to bone weakness and deformities, especially in the spine, which can lead to poor outcomes.The aim of this study was to find patterns and risk factors in spinal deformities in patients with OI.In a retrospective study, 70 patients with ...


    pub_type: 杂志文章


    authors: de Lima MV,de Lima FV,Akkari M,Resende VR,Santili C

    更新日期:2015-11-01 00:00:00