Genetic studies of human apolipoproteins. XI. The effect of the apolipoprotein C-II polymorphism on lipoprotein levels in Nigerian blacks.

abstract：:Steroids are primarily present in human fluids in their sulfated forms. Profiling of these compounds is important from both diagnostic and physiological points of view. Here, we present a novel method for the quantification of 11 intact steroid sulfates in human serum by LC-MS/MS. The compounds analyzed in our method,...

journal_title：Journal of lipid research

authors： Sánchez-Guijo A,Oji V,Hartmann MF,Traupe H,Wudy SA

更新日期：2015-09-01 00:00:00

abstract：:Adipose tissue contains one of the largest reservoirs of cholesterol in the body. Adipocyte dysfunction in obesity is associated with intracellular cholesterol accumulation, and alterations in cholesterol homeostasis have been shown to alter glucose metabolism in cultured adipocytes. ABCA1 plays a major role in choles...

journal_title：Journal of lipid research

authors： de Haan W,Bhattacharjee A,Ruddle P,Kang MH,Hayden MR

更新日期：2014-03-01 00:00:00

abstract：:The 3-thia fatty acids, tetradecylthioacetic acid and 3,10-dithiadicarboxylic acid are mitochondrion and peroxisome proliferators. Administration of these promotes an increased transport of endogenous fatty acids to these organelles and a higher capacity of beta-oxidation. Administration of 3-thia fatty acids to rats ...

journal_title：Journal of lipid research

authors： Madsen L,Frøyland L,Dyrøy E,Helland K,Berge RK

更新日期：1998-03-01 00:00:00

abstract：:Activation of cultured hepatic stellate cells correlated with an enhanced expression of proteins involved in uptake and storage of fatty acids (FA translocase CD36, Acyl-CoA synthetase 2) and retinol (cellular retinol binding protein type I, CRBP-I; lecithin:retinol acyltransferases, LRAT). The increased expression of...

journal_title：Journal of lipid research

authors： Hellemans K,Rombouts K,Quartier E,Dittié AS,Knorr A,Michalik L,Rogiers V,Schuit F,Wahli W,Geerts A

更新日期：2003-02-01 00:00:00

abstract：:Genetic polymorphisms of apolipoprotein A-IV (apoA-IV) have been detected by isoelectric focusing of serum proteins. Because genetic variation in apoA-IV has significant effects on lipid risk factors, we used restriction enzyme isoform genotyping (restriction isotyping) to determine apoA-IV isoform genotypes at the DN...

journal_title：Journal of lipid research

authors： Hixson JE,Powers PK

更新日期：1991-09-01 00:00:00

abstract：:Exosomes are bioactive vesicles released from multivesicular bodies (MVB) by intact cells and participate in intercellular signaling. We investigated the presence of lipid-related proteins and bioactive lipids in RBL-2H3 exosomes. Besides a phospholipid scramblase and a fatty acid binding protein, the exosomes contain...

journal_title：Journal of lipid research

authors： Subra C,Grand D,Laulagnier K,Stella A,Lambeau G,Paillasse M,De Medina P,Monsarrat B,Perret B,Silvente-Poirot S,Poirot M,Record M

更新日期：2010-08-01 00:00:00

abstract：:The secondary bile acid lithocholic acid (LCA) and its derivatives act as selective modulators of the vitamin D receptor (VDR), although their structures fundamentally differ from that of the natural hormone 1α,25-dihydroxyvitamin D3 [1,25(OH)2D3)]. Here, we have determined the crystal structures of the ligand-binding...

journal_title：Journal of lipid research

authors： Masuno H,Ikura T,Morizono D,Orita I,Yamada S,Shimizu M,Ito N

更新日期：2013-08-01 00:00:00

abstract：:Male Sprague-Dawley rats were fed diets that contained 20% by weight soybean oil or rapeseed oil (21% and 43% erucic acid) for 7 days. The rapeseed oil diets increased the cardiac triacylglycerol content 5-fold and 25-fold, respectively, above control values. Hearts were removed from the animals and perfused with modi...

journal_title：Journal of lipid research

authors： Stewart LC,Kramer JK,Sauer FD,Clarke K,Wolynetz MS

更新日期：1993-09-01 00:00:00

abstract：:Human striated muscle samples, from male control and Duchenne muscular dystrophy-affected children, were subjected to cluster-time-of-flight secondary ion mass spectrometry (cluster-ToF-SIMS) imaging using a 25 keV Bi(3)(+) liquid metal ion gun under static SIMS conditions. Spectra and ion density maps, or secondary i...

journal_title：Journal of lipid research

authors： Tahallah N,Brunelle A,De La Porte S,Laprévote O

更新日期：2008-02-01 00:00:00

abstract：:An elevated plasma concentration of lipoprotein (a) [Lp(a)] is an independent risk factor for cardiovascular disease. Life style modification and currently available drugs either fail to effectively lower plasma Lp(a) levels or do not result in clinical benefit. However, lipoprotein apheresis is very efficient in decr...

journal_title：Journal of lipid research

authors： Waldmann E,Parhofer KG

更新日期：2016-10-01 00:00:00

abstract：:The chemical composition and metabolism of lipoproteins in a population of Benedictine nuns were studied after 5-month periods during which the predominant dietary fats were sunflower oil, peanut oil, palm oil, or milk fats (butter and cream). The population was divided into three groups. The control group (C) include...

journal_title：Journal of lipid research

authors： Baudet MF,Dachet C,Lasserre M,Esteva O,Jacotot B

更新日期：1984-05-01 00:00:00

abstract：:Labeled cholesterol esters were incorporated into chylomicrons in vitro by adding an acetone solution of the cholesterol ester to a suspension of washed chylomicrons. The physical and metabolic properties of the added labeled ester were the same as those of cholesterol esters incorporated into chylomicrons in vivo, ex...

journal_title：Journal of lipid research

authors： Quarfordt SH,Goodman DS

更新日期：1966-09-01 00:00:00

abstract：:Reduced estrogen levels result in loss of protection from coronary heart disease in postmenopausal women. Enhanced and diminished atherosclerosis have been associated with plasma levels of cholesteryl ester transfer protein (CETP); however, little is known about the role of CETP-ovarian hormone interactions in atherog...

journal_title：Journal of lipid research

authors： Cazita PM,Berti JA,Aoki C,Gidlund M,Harada LM,Nunes VS,Quintão EC,Oliveira HC

更新日期：2003-01-01 00:00:00

abstract：:Low density lipoproteins (LDL), isolated by ultracentrifugal flotation, were oxidized (LDLOXID) slowly during dialysis against 0.15 M NaCl and subsequent incubation in 96% air-4% CO2 at 37 degrees C. Butylated hydroxytoluene prevented LDL oxidation. LDL preparations from different sera were oxidized at different rates...

journal_title：Journal of lipid research

authors： Zhang HF,Davis WB,Chen XS,Whisler RL,Cornwell DG

更新日期：1989-02-01 00:00:00

abstract：:Cholesterol 7alpha-hydroxylase (CYP7A1) plays a crucial role in cholesterol metabolism and has been implicated in genetic susceptibility to atherosclerosis. Thus, an understanding of its transcriptional regulation is of considerable importance. We evaluated the effect of a common -203A>C polymorphism in the CYP7A1 pro...

journal_title：Journal of lipid research

authors： Lenícek M,Komárek V,Zimolová M,Kovár J,Jirsa M,Lukás M,Vítek L

更新日期：2008-12-01 00:00:00

abstract：:Of the six fatty acid elongase (Elovl) subtypes expressed in mammals, adult rat liver expresses four subtypes: Elovl-5 > Elovl-1 = Elovl-2 = Elovl-6. Overnight starvation and fish oil-enriched diets repressed hepatic elongase activity in livers of adult male rats. Diet-induced changes in elongase activity correlate wi...

journal_title：Journal of lipid research

authors： Wang Y,Botolin D,Christian B,Busik J,Xu J,Jump DB

更新日期：2005-04-01 00:00:00

abstract：:Ceramides are the predominant lipids in the stratum corneum (SC) and are crucial components for normal skin barrier function. Although the composition of various ceramide classes in the human SC has been reported, that in mice is still unknown, despite mice being widely used as animal models of skin barrier function. ...

journal_title：Journal of lipid research

authors： Kawana M,Miyamoto M,Ohno Y,Kihara A

更新日期：2020-06-01 00:00:00

abstract：:It was postulated that specialized microdomains of the plasma membrane, consistent with caveolae, might play a role in cholesterol trafficking in intestinal cells. The existence, therefore, of caveolin and the role of detergent-resistant microdomains of the plasma membrane in cholesterol trafficking were investigated ...

journal_title：Journal of lipid research

authors： Field FJ,Born E,Murthy S,Mathur SN

更新日期：1998-10-01 00:00:00

abstract：:Isolated rat livers were perfused at 37 degrees C with blood-free, defined medium containing delipidized bovine serum albumin (BSA), BSA-oleate, or BSA-palmitate. Very low density lipoproteins (VLDL) were isolated from the perfusate at 12 degrees C and lipid components were extracted and purified. Differential scannin...

journal_title：Journal of lipid research

authors： Hale JE,Schroeder F

更新日期：1981-07-01 00:00:00

abstract：:C26 Bile of the 24-nor-5beta-cholestane series were prepared starting from methyl cholate. A Grignard reaction of methyl magnesium iodide with methyl cholate yielded 24-nor-5beta-cholestane-3alpha, 7alpha, 12alpha, 25-tetrol which was dehydrated TO FORM a mixture of 24-nor-5beta-cholest-23-ene-3alpha, 7alpha, 12 alpha...

journal_title：Journal of lipid research

authors： Dayal B,Shefer S,Tint GS,Salen G,Mosbach EH

更新日期：1976-09-01 00:00:00

abstract：:Oligosaccharyl phosphates (OSPs) are hydrolyzed from oligosaccharide-diphosphodolichol (DLO) during protein N-glycosylation by an uncharacterized process. An OSP-generating activity has been reported in vitro, and here we asked if its biochemical characteristics are compatible with a role in endoplasmic reticulum (ER)...

journal_title：Journal of lipid research

authors： Massarweh A,Bosco M,Iatmanen-Harbi S,Tessier C,Auberger N,Busca P,Chantret I,Gravier-Pelletier C,Moore SE

更新日期：2016-06-01 00:00:00

abstract：:A new method for the purification of apolipoprotein H by affinity chromatography followed by continuous-elution electrophoresis is described. It is both simpler and less complicated than the chromatographic and electrophoretic methods usually used. In addition, apolipoprotein H is isolated in a pure, structurally uncl...

journal_title：Journal of lipid research

authors： Gambino R,Ruiu G,Cassader M,Pagano G

更新日期：1996-04-01 00:00:00

abstract：:An enzyme-coupled, colorimetric method for the assay of acyl-CoA synthetase is described. Acyl-CoA formed from fatty acid and CoA by acyl-CoA synthetase was dehydrogenated by acyl-CoA oxidase. Hydrogen peroxide produced was then converted into formaldehyde in the presence of methanol by catalase. The formaldehyde reac...

journal_title：Journal of lipid research

authors： Ichihara K,Shibasaki Y

更新日期：1991-10-01 00:00:00

abstract：:The activities of hepatic fatty acid oxidation enzymes in rats fed perilla oil rich in alpha-linolenic acid (alpha-18:3) were compared with those fed saturated fats or safflower oil (the mixture of safflower oil and olive oil, 94:8, w/w) containing the same amount of polyunsaturated fatty acids with perilla oil exclus...

journal_title：Journal of lipid research

authors： Ide T,Murata M,Sugano M

更新日期：1996-03-01 00:00:00

abstract：:The extent of hypercholesterolemia varies considerably in patients with familial hypercholesterolemia (FH). We hypothesized that the variability of the FH phenotype might be partly explained by variation in proprotein convertase subtilisin kexin type 9 (PCSK9) activity. Individuals between 18 and 53 years of age who h...

journal_title：Journal of lipid research

authors： Huijgen R,Fouchier SW,Denoun M,Hutten BA,Vissers MN,Lambert G,Kastelein JJ

更新日期：2012-05-01 00:00:00

abstract：:Liver and kidney microsomes have been found to catalyze a rapid decarboxylation of retinoic acid in vitro. The reaction requires NADPH and Fe(2+), and is further stimulated by the presence of pyrophosphate. Thiamine pyrophosphate contained sufficient iron as an impurity to provide strong enhancement of the reaction in...

journal_title：Journal of lipid research

authors： Roberts AB,DeLuca HF

更新日期：1968-07-01 00:00:00

abstract：:N-acylethanolamines (NAEs) are a group of lipid mediators synthesized in response to a number of physiological and pathological stimuli. Because of the low tissue concentrations of NAEs, analyses often include liquid extraction followed by solid-phase extraction and subsequent quantitation by LC/MS or GC/MS. Reported ...

journal_title：Journal of lipid research

authors： Skonberg C,Artmann A,Cornett C,Hansen SH,Hansen HS

更新日期：2010-10-01 00:00:00

abstract：:We previously showed that immunization of guinea pigs with reductively glucosylated guinea pig low density lipoprotein (LDL) or albumin resulted in the formation of antibodies specific for the glucosylated protein. The present studies were done to determine if modifications of homologous LDL or albumin, other than add...

journal_title：Journal of lipid research

authors： Steinbrecher UP,Fisher M,Witztum JL,Curtiss LK

更新日期：1984-10-01 00:00:00

abstract：:In a randomized, cross-over feeding trial involving 10 men with polygenic hypercholesterolemia, a control, Mediterranean-type cholesterol-lowering diet, and a diet of similar composition in which walnuts replaced approximately 35% of energy from unsaturated fat, were given for 6 weeks each. Compared with the control d...

journal_title：Journal of lipid research

authors： Muñoz S,Merlos M,Zambón D,Rodríguez C,Sabaté J,Ros E,Laguna JC

更新日期：2001-12-01 00:00:00

abstract：:The binding of monoacylglycerides of long-chain fatty acids to human serum albumin has been examined using monooleoylglycerol as the ligand. Binding was investigated using changes in tryptophan fluorescence and also the displacement of a variety of well-studied fluorescent ligands from human serum albumin (HSA). Monoo...

journal_title：Journal of lipid research

authors： Thumser AE,Buckland AG,Wilton DC

更新日期：1998-05-01 00:00:00