PML induces compaction, TRF2 depletion and DNA damage signaling at telomeres and promotes their alternative lengthening.

abstract：:Neuronal morphology plays an essential role in neuronal function. The establishment and maintenance of neuronal morphology is intimately linked to the actin cytoskeleton; however, the molecular mechanisms that regulate changes in neuronal morphology are poorly understood. Here we identify a novel myosin-Va (MyoVa)-int...

journal_title：Journal of cell science

authors： Lisé MF,Srivastava DP,Arstikaitis P,Lett RL,Sheta R,Viswanathan V,Penzes P,O'Connor TP,El-Husseini A

更新日期：2009-10-15 00:00:00

abstract：:The monoclonal antibody Bx63 recognizes a centrosomal antigen of Drosophila melanogaster by indirect immunofluorescence and identifies two proteins, with apparent molecular weights of 185 x 10(3) and 66 x 10(3), on Western blots. We have used this antibody to isolate five clones (lambda cs1, -2, -3, -4 and lambda j63)...

journal_title：Journal of cell science

authors： Whitfield WG,Millar SE,Saumweber H,Frasch M,Glover DM

更新日期：1988-04-01 00:00:00

abstract：:The endoplasmic reticulum-Golgi intermediate compartment (ERGIC) defined by the cycling lectin ERGIC-53 consists of tubulovesicular clusters, but it is unknown if these membranes are transport vehicles or stationary entities. Here, we show by live imaging that GFP-ERGIC-53 mainly localizes to long-lived stationary and...

journal_title：Journal of cell science

authors： Ben-Tekaya H,Miura K,Pepperkok R,Hauri HP

更新日期：2005-01-15 00:00:00

abstract：:We have identified a novel mammalian protein, MIR1, with microtubule-binding activity. MIR1 is a relative of MID1/midin, the protein implicated in Opitz G/BBB syndrome. In tissue culture cells, MIR1 is enriched at the centrosome. MIR1 dissociates from centrosomes at the G2/M transition and is recruited back to spindle...

journal_title：Journal of cell science

authors： Stein PA,Toret CP,Salic AN,Rolls MM,Rapoport TA

更新日期：2002-09-01 00:00:00

abstract：:Brain-derived neurotrophic factor (BDNF) is known to be a crucial regulator of neuronal survival and synaptic plasticity in the mammalian brain. Furthermore, BDNF positively influences differentiation of embryonic neural precursors, as well as that of neural stem cells from adult neurogenic niches. To study the impact...

journal_title：Journal of cell science

authors： Leschik J,Eckenstaler R,Nieweg K,Lichtenecker P,Brigadski T,Gottmann K,Lessmann V,Lutz B

更新日期：2013-11-01 00:00:00

abstract：:T cell activation is accompanied by actin-mediated receptor clustering and reorganization of lipid rafts. It has been suggested that costimulatory molecules might be involved in these processes. We here provide evidence that engagement of the adhesion molecule CD44 initiates cytoskeletal rearrangement and membrane reo...

journal_title：Journal of cell science

authors： Föger N,Marhaba R,Zöller M

更新日期：2001-03-01 00:00:00

abstract：:Mutations in inositol polyphosphate 5-phosphatase E (INPP5E) cause the ciliopathies known as Joubert and MORM syndromes; however, the role of INPP5E in ciliary biology is not well understood. Here, we describe an interaction between INPP5E and AURKA, a centrosomal kinase that regulates mitosis and ciliary disassembly,...

journal_title：Journal of cell science

authors： Plotnikova OV,Seo S,Cottle DL,Conduit S,Hakim S,Dyson JM,Mitchell CA,Smyth IM

更新日期：2015-01-15 00:00:00

abstract：:Increases in cytosolic Ca(2+) concentration ([Ca(2+)](c)) mediated by inositol (1,4,5)-trisphosphate [Ins(1,4,5)P(3), hereafter InsP(3)] regulate activities that include division, contraction and cell death. InsP(3)-evoked Ca(2+) release often begins at a single site, then regeneratively propagates through the cell as...

journal_title：Journal of cell science

authors： Olson ML,Sandison ME,Chalmers S,McCarron JG

更新日期：2012-11-15 00:00:00

abstract：:The working mechanism of the eukaryotic flagellar axoneme remains one of nature's most enduring puzzles. The basic mechanical operation of the axoneme is now a story that is fairly complete; however, the mechanism for coordinating the action of the dynein motor proteins to produce beating is still controversial. Altho...

journal_title：Journal of cell science

authors： Lindemann CB,Lesich KA

更新日期：2010-02-15 00:00:00

abstract：:Several properties of cadherin-4 and cadherin-5 were characterized by using the cDNA transfection approach. The proteins of both cadherins had a relative molecular mass of about 130 kDa and were present at the cell periphery, especially at cell-cell contact sites. These cadherins were easily digested with trypsin, and...

journal_title：Journal of cell science

authors： Tanihara H,Kido M,Obata S,Heimark RL,Davidson M,St John T,Suzuki S

更新日期：1994-06-01 00:00:00

abstract：:In diverse epithelia, cytoskeletal keratin intermediate filaments (IFs) associated with the cytoplasmic face of intercellular junctional desmosomes. The processes underlying desmosome formation and keratin IF interactions remain unclear. We have examined F9 embryonal carcinoma (EC) cell differentiation as a model for ...

journal_title：Journal of cell science

authors： Trevor KT,Steben LS

更新日期：1992-09-01 00:00:00

abstract：:SARA, an early endosomal protein, plays a key role in TGFβ signalling, as it presents SMAD2 and SMAD3 for phosphorylation by the activated TGFβ receptors. Here, we show that ERBIN is a new SARA-interacting protein that can be recruited by SARA to early endosomes. ERBIN was recently shown to bind and segregate phosphor...

journal_title：Journal of cell science

authors： Sflomos G,Kostaras E,Panopoulou E,Pappas N,Kyrkou A,Politou AS,Fotsis T,Murphy C

更新日期：2011-10-01 00:00:00

abstract：:Mammalian homologs of the Drosophila TRP protein have been shown to form cation-permeable channels in the plasma membrane but very little is known about the mechanisms that control their cell surface localization. Recently it has been demonstrated that the last three C-terminal amino acids (TRL) of TRPC4 comprise a PD...

journal_title：Journal of cell science

authors： Mery L,Strauss B,Dufour JF,Krause KH,Hoth M

更新日期：2002-09-01 00:00:00

abstract：:Arf GTPases regulate both the morphological and protein sorting events that are essential for membrane trafficking. Guanine nucleotide exchange factors (GEFs) specific for Arf proteins determine when and where Arf GTPases will be activated in cells. The yeast Gea2p Arf GEF is a member of an evolutionarily conserved fa...

journal_title：Journal of cell science

authors： Chantalat S,Park SK,Hua Z,Liu K,Gobin R,Peyroche A,Rambourg A,Graham TR,Jackson CL

更新日期：2004-02-15 00:00:00

abstract：:The main pathology of cystic fibrosis results from obstruction of ducts in several organs by mucous secretions. The cause of this obstruction remains unclear. We have examined expression of the cystic fibrosis transmembrane conductance regulator (CFTR) and of the major pancreatic mucin, MUC1, in primary pancreatic duc...

journal_title：Journal of cell science

authors： Chambers JA,Harris A

更新日期：1993-06-01 00:00:00

abstract：:Changes in the cytoskeletal structure of cultured A10 smooth muscle cells induced by calyculin-A (CL-A), a potent inhibitor of types 1 and 2A protein phosphatases, were analyzed using indirect fluorescence techniques. In the presence of 1 x 10(-7) M CL-A the cells became round and subsequently detached from the substr...

journal_title：Journal of cell science

authors： Hosoya N,Mitsui M,Yazama F,Ishihara H,Ozaki H,Karaki H,Hartshorne DJ,Mohri H

更新日期：1993-08-01 00:00:00

abstract：:Eukaryogenesis - the emergence of eukaryotic cells - represents a pivotal evolutionary event. With a fundamentally more complex cellular plan compared to prokaryotes, eukaryotes are major contributors to most aspects of life on Earth. For decades, we have understood that eukaryotic origins lie within both the Archaea ...

journal_title：Journal of cell science

authors： Dacks JB,Field MC,Buick R,Eme L,Gribaldo S,Roger AJ,Brochier-Armanet C,Devos DP

更新日期：2016-10-15 00:00:00

abstract：:To optimally perform the diversity of metabolic functions that occur within peroxisomes, cells must dynamically regulate peroxisome size, number and content in response to the cell state and the environment. Except for transcriptional regulation little is known about the mechanisms used to perform this complicated fea...

journal_title：Journal of cell science

authors： Yifrach E,Chuartzman SG,Dahan N,Maskit S,Zada L,Weill U,Yofe I,Olender T,Schuldiner M,Zalckvar E

更新日期：2016-11-01 00:00:00

abstract：:Re-epithelialization after skin wounding requires both migration and hyperproliferation of keratinocytes. Laminin-332 is deposited during migration over the provisional matrix. To investigate the function of the laminin-332 binding integrin alpha3beta1 in wound re-epithelialization, we generated Itga3flox/flox; K14-Cr...

journal_title：Journal of cell science

authors： Margadant C,Raymond K,Kreft M,Sachs N,Janssen H,Sonnenberg A

更新日期：2009-01-15 00:00:00

abstract：:Cryo-ultramicrotomy and X-ray microanalysis were used to study the elemental composition of HeLa S3 cells. Quantitation was achieved by reference to elemental standards of known concentration made up in 25% gelatin. Analysis of standards showed linear calibration for each of the elements studied: Na, P, S, Cl, K. Stan...

journal_title：Journal of cell science

authors： Warley A,Stephen J,Hockaday A,Appleton TC

更新日期：1983-03-01 00:00:00

abstract：:Many pathways dysregulated in prostate cancer are also involved in epithelial differentiation. To better understand prostate tumor initiation, we sought to investigate specific genes and mechanisms required for normal basal to luminal cell differentiation. Utilizing human prostate basal epithelial cells and an in vitr...

journal_title：Journal of cell science

authors： Frank SB,Berger PL,Ljungman M,Miranti CK

更新日期：2017-06-01 00:00:00

abstract：:The Cep63-Cep152 complex located at the mother centriole recruits Plk4 to initiate centriole biogenesis. How the complex is targeted to mother centrioles, however, is unclear. In this study, we show that Cep57 and its paralog, Cep57l1, colocalize with Cep63 and Cep152 at the proximal end of mother centrioles in both c...

journal_title：Journal of cell science

authors： Zhao H,Yang S,Chen Q,Duan X,Li G,Huang Q,Zhu X,Yan X

更新日期：2020-07-03 00:00:00

abstract：:Tetrahymena cells secrete a factor which inhibits RNA synthesis in vivo and in vitro. The factor is a relatively small peptide with a molecular weight between 300 and 1500 Daltons. Other, non-specific peptides in the broth medium or added to a chemically defined medium have a stimulatory effect on RNA synthesis in viv...

journal_title：Journal of cell science

authors： Andersen HA,Lykkesfeldt AE,Nielsen SJ

更新日期：1980-10-01 00:00:00

abstract：:Here we report Drosophila Waharan (Wah), a 170-kD predominantly nuclear protein with two potential human homologues, as a newly identified regulator of endosomal trafficking. Wah is required for neuromuscular-junction development and muscle integrity. In muscles, knockdown of Wah caused novel accumulations of tightly ...

journal_title：Journal of cell science

authors： Lone M,Kungl T,Koper A,Bottenberg W,Kammerer R,Klein M,Sweeney ST,Auburn RP,O'Kane CJ,Prokop A

更新日期：2010-07-15 00:00:00

abstract：:Nervous system development and function are tightly regulated by metabolic processes, including the metabolism of lipids such as fatty acids. Mutations in long-chain acyl-CoA synthetase 4 (ACSL4) are associated with non-syndromic intellectual disabilities. We previously reported that Acsl, the Drosophila ortholog of m...

journal_title：Journal of cell science

authors： Huang Y,Huang S,Lam SM,Liu Z,Shui G,Zhang YQ

更新日期：2016-11-01 00:00:00

abstract：:Mutations in the maternal-effect gene abnormal chromatin (abc) in Drosophila melanogaster result in a variety of defects involving nuclear replication/division. Three recessive alleles of this gene, which maps near 51F on chromosome 2, all result in female sterility. They cause slower embryonic development that is usu...

journal_title：Journal of cell science

authors： Vessey KB,Ludwiczak RL,Briot AS,Underwood EM

更新日期：1991-02-01 00:00:00

abstract：:New crystal structures of the kinesin motors differ from previously described motor-ADP atomic models, showing striking changes both in the switch I region near the nucleotide-binding cleft and in the switch II or 'relay' helix at the filament-binding face of the motor. The switch I region, present as a short helix fl...

journal_title：Journal of cell science

authors： Kull FJ,Endow SA

更新日期：2002-01-01 00:00:00

abstract：:The glucocorticoid receptor and the mineralocorticoid receptor are hormone-dependent transcription factors. They regulate the excitability of rat hippocampus CA1 neurons in a coordinated fashion. We studied the spatial distribution of these transcription factors in nuclei of CA1 neurons by dual labeling immunocytochem...

journal_title：Journal of cell science

authors： van Steensel B,van Binnendijk EP,Hornsby CD,van der Voort HT,Krozowski ZS,de Kloet ER,van Driel R

更新日期：1996-04-01 00:00:00

abstract：:The small GTP-binding protein Rho rapidly stimulates the formation of focal adhesions and actin stress fibres when microinjected into serum-starved Swiss 3T3 fibroblasts. This response is inhibited by tyrosine kinase inhibitors. Addition of growth factors such as lysophosphatidic acid and bombesin to Swiss 3T3 cells s...

journal_title：Journal of cell science

authors： Flinn HM,Ridley AJ

更新日期：1996-05-01 00:00:00

abstract：:The metabolism of PI(3,5)P2 is regulated by the PIKfyve, VAC14 and FIG4 complex, mutations in which are associated with hypopigmentation in mice. These pigmentation defects indicate a key, but as yet unexplored, physiological relevance of this complex in the biogenesis of melanosomes. Here, we show that PIKfyve activi...

journal_title：Journal of cell science

authors： Bissig C,Croisé P,Heiligenstein X,Hurbain I,Lenk GM,Kaufman E,Sannerud R,Annaert W,Meisler MH,Weisman LS,Raposo G,van Niel G

更新日期：2019-02-28 00:00:00