当前位置： SCI文献检索 > Asian Pacific Journal of Tropical Medicine期刊下所有文献 > Suppressive effect of pectic polysaccharides extracted from Rauwolfia verticillata (Lour.) Baill.var.hainanensis Tsiang on inflammation by regulation of NF- κ B pathway and interleukin-17 in mice with dextran sulphatesodium-induced ulcerative colitis.

Suppressive effect of pectic polysaccharides extracted from Rauwolfia verticillata (Lour.) Baill.var.hainanensis Tsiang on inflammation by regulation of NF- κ B pathway and interleukin-17 in mice with dextran sulphatesodium-induced ulcerative colitis.

Abstract：

OBJECTIVE:To investigate the effects of pectic polysaccharides extracted from Rauwolfia verticillata (Lour.) Baill.var.hainanensis Tsiang on an experimental murine colitis model. METHODS:Experimental colitis was induced by dextran sulfate sodium (DSS), and mice were divided into 4 groups: control, DSS alone, DSS plus SASP, DSS plus pectic polysaccharides. The disease activity index (DAI) and histological score were observed. The tumor necrosis factor (TNF)- α and interleukin (IL)-17 levels were measured by enzyme-linked immunosorbent assay. I κ B and NF- κ B p65 expression were assessed by western blot analysis. Myeloperoxidase (MPO) activity was determined by using MPO assay kit. RESULTS:Administration of pectic polysaccharides significantly reduced the severity of DSS-induced colitis as assessed by DAI and histological score, and resulted in down regulation of MPO activity and NF- κ B p65 expression and subsequent degradation of I κ B protein, strikingly reduced the production of TNF- a and IL-17. CONCLUSIONS:Pectic polysaccharides extracted from Rauvolfia verticillata (Lour.)Baill.var. hainanensis Tsiang exerts beneficial effects in experimental colitis and may therefore provide a useful therapeutic approach for the treatment of UC.

journal_name

Asian Pac J Trop Med

journal_title

Asian Pacific journal of tropical medicine

authors

Miao XP,Sun XN,Cui LJ,Cao QF,Zhuang GF,Deng TZ,Zhang DY

doi

10.1016/S1995-7645(14)60306-0

subject

Has Abstract

pub_date

2015-02-01 00:00:00

pages

147-52

issue

2

eissn

1995-7645

issn

2352-4146

pii

S1995-7645(14)60306-0

journal_volume

8

pub_type

杂志文章

相关文献

Asian Pacific Journal of Tropical Medicine文献大全
  • Anti-tubercular peptides: A quest of future therapeutic weapon to combat tuberculosis.

    abstract：:Tuberculosis (TB) is a symbolic menace to mankind, infecting almost one third of the world's populace and causing over a million mortalities annually. Mycobacterium tuberculosis (Mtb) is the key pathogen of TB that invades and replicates inside the host's macrophage. With the emerging dilemma of multi-drug resistant t...

    journal_title：Asian Pacific journal of tropical medicine

    pub_type： 杂志文章,评审

    doi：10.1016/j.apjtm.2016.09.005

    authors： Khusro A,Aarti C,Agastian P

    更新日期：2016-11-01 00:00:00

  • Hepatoprotective and cytoprotective properties of Hyptis suaveolens against oxidative stress-induced damage by CCl(4) and H(2)O(2).

    abstract：OBJECTIVE:To investigate capacity of Hyptis suaveolens (H. suaveolens) methanol extract as an antioxidant to protect against carbon tetrachloride (CCl(4))-induced oxidative stress, hepatotoxicity in Albino Wistar rats and cytoprotective effect of hydrogen peroxide (H(2)O(2)) induced cell death in HepG(2) cell line. ME...

    journal_title：Asian Pacific journal of tropical medicine

    pub_type： 杂志文章

    doi：10.1016/S1995-7645(12)60162-X

    authors： Ghaffari H,Ghassam BJ,Prakash HS

    更新日期：2012-11-01 00:00:00

  • Effects of rhBNP after PCI on non-invasive hemodynamic in acute myocardial infarction patients with left heart failure.

    abstract：OBJECTIVE:To investigate the effects of exogenous recombinant human brain natriuretic peptide (rhBNP) after primary percutaneous coronary intervention (PCI) on non-invasive hemodynamic in acute myocardial infarction patients with left ventricular failure. METHODS:A number of 96 acute myocardial infarction patients acc...

    journal_title：Asian Pacific journal of tropical medicine

    pub_type： 杂志文章

    doi：10.1016/j.apjtm.2016.06.006

    authors： He XM,Chen L,Luo JB,Feng XX,Zhang YB,Chen QJ,Ji XL,Wang TS

    更新日期：2016-08-01 00:00:00

  • Geohelminths eggs contamination of sandpits in Vladivostok, Russia.

    abstract：OBJECTIVE:To detect nematode eggs in sandpits in urban area in Vladivostok. METHODS:Totally 60 samples were collected from five districts. Sand samples were analysed using combined flotation-sedimentation method. In result, 18 sand samples were positive for at one or two parasites species. RESULTS:Overall, only 3 gen...

    journal_title：Asian Pacific journal of tropical medicine

    pub_type： 杂志文章

    doi：10.1016/j.apjtm.2016.11.002

    authors： Moskvina TV,Bartkova AD,Ermolenko AV

    更新日期：2016-12-01 00:00:00

  • Screening, phylogenetic analysis and antibiotic sensitivity pattern of Salmonella enterica serovar Typhi isolates from typhoid asymptomatic carriers.

    abstract：OBJECTIVE:To isolate the Salmonella enterica serovar Typhi (S. typhi) from asymptomatic typhoid carriers in the local population. To assess the antibiotic sensitivity and resistant pattern of S. typhi isolates against viable antibiotics and phylogenetic analysis of S. typhi isolates on the basis of 16S rDNA gene. METH...

    journal_title：Asian Pacific journal of tropical medicine

    pub_type： 杂志文章

    doi：10.1016/S1995-7645(11)60191-0

    authors： Chandrasekaran B,Balakrishnan S

    更新日期：2011-10-01 00:00:00

  • RETRACTED: Effect of thioredoxin-interacting protein on Wnt/β-catenin signaling pathway and diabetic myocardial infarction.

    abstract：OBJECTIVE:To explore the regulatory role of thioredoxin-interacting protein (TXNIP) in Wnt/β-catenin signaling pathway and therefore to elucidate its function in diabetic myocardial infarction. METHODS:Diabetic myocardial infarction models were generated in mice. The expression levels of TXNIP and β-catenin and level ...

    journal_title：Asian Pacific journal of tropical medicine

    pub_type： 杂志文章,撤回出版物

    doi：10.1016/j.apjtm.2015.10.010

    authors： Yu H,Zhao XX,Shan XH,Li P,Chen T

    更新日期：2015-11-01 00:00:00

  • Role of Moringa oleifera in regulation of diabetes-induced oxidative stress.

    abstract：OBJECTIVE:To evaluate the antioxidant activity of aqueous extract of Moringa oleifera (M. oleifera) young leaves by in vivo as well as in vitro assays. METHODS:In vitro study included estimation of total phenolic, total flavonol, total flavonoid and total antioxidant power (FRAP assay). In addition, in vivo study was ...

    journal_title：Asian Pacific journal of tropical medicine

    pub_type： 杂志文章

    doi：10.1016/S1995-7645(13)60068-1

    authors： Jaiswal D,Rai PK,Mehta S,Chatterji S,Shukla S,Rai DK,Sharma G,Sharma B,Khair S,Watal G

    更新日期：2013-06-01 00:00:00

  • Nephroprotective effect of Murraya koenigii on cyclophosphamide induced nephrotoxicity in rats.

    abstract：OBJECTIVE:To evaluate the nephroprotective effect of defatted methanolic extract and aqueous extract of Murraya koenigii (M. koenigii) against cyclophosphamide drug. METHODS:Nephrotoxicity was induced by cyclophosphamide in 7 days at 150 mg/kg body weight through intraperitoneal route in rat model. Nephroprotective ac...

    journal_title：Asian Pacific journal of tropical medicine

    pub_type： 杂志文章

    doi：10.1016/j.apjtm.2017.08.005

    authors： Mahipal P,Pawar RS

    更新日期：2017-08-01 00:00:00

  • Asymptomatic malaria parasitemia does not induce additional oxidative stress in pregnant women of South East Nigeria.

    abstract：OBJECTIVE:To determine the relationship between asymptomatic malaria parasitemia and some oxidative stress parameters in pregnant Nigerian women. METHODS:This is a cross-sectional study involving 130 normal pregnant women at various trimesters, who were attending antenatal clinic at the University of Nigeria Teaching ...

    journal_title：Asian Pacific journal of tropical medicine

    pub_type： 杂志文章

    doi：10.1016/S1995-7645(11)60076-X

    authors： Nwagha UI,Okeke TC,Nwagha TU,Ejezie FE,Ogbodo SO,Dim CC,Anyaehie BU

    更新日期：2011-03-01 00:00:00

  • Anti-encystment and amoebicidal activity of Lonicera japonica Thunb. and its major constituent chlorogenic acid in vitro.

    abstract：OBJECTIVE:To examine the acanthamoebicidal effects of ethyl acetate, aqueous and butanol fractions of dried flower buds of Lonicera japonica (L. japonica) Thunb. (Flos Lonicerae) in vitro. METHODS:Acanthamoeba triangularis isolates were obtained from environmental water samples and identified by PCR. They were exposed...

    journal_title：Asian Pacific journal of tropical medicine

    pub_type： 杂志文章

    doi：10.1016/j.apjtm.2016.07.008

    authors： Mahboob T,Azlan AM,Tan TC,Samudi C,Sekaran SD,Nissapatorn V,Wiart C

    更新日期：2016-09-01 00:00:00

  • In vitro antiplasmodial effect of ethanolic extracts of traditional medicinal plant Ocimum species against Plasmodium falciparum.

    abstract：OBJECTIVE:To identify the possible antiplasmodial compounds from leaf, stem, root and flower extracts of Ocimum canum (O. canum), Ocimum sanctum (O. sanctum) and Ocimum basilicum (O. basilicum). METHODS:The O. canum, O. sanctum and O. basilicum were collected from Ramanathapuram District, Tamil Nadu and the extraction...

    journal_title：Asian Pacific journal of tropical medicine

    pub_type： 杂志文章

    doi：10.1016/S1995-7645(12)60004-2

    authors： Inbaneson SJ,Sundaram R,Suganthi P

    更新日期：2012-02-01 00:00:00

  • Hibiscus sabdariffa extractivities on cadmium-mediated alterations of human U937 cell viability and activation.

    abstract：OBJECTIVE:To investigate the effect of the anthocyanin-rich extract of Hibiscus sabdariffa (H. sabdariffa) calyx on the viability of cadmium-treated U937 cells and cadmium-mediated activation of U937-derived macrophages. METHODS:The macrophage cell line U937 was treated with cadmium (0.1 μ mol/L) and later incubated w...

    journal_title：Asian Pacific journal of tropical medicine

    pub_type： 杂志文章

    doi：10.1016/S1995-7645(11)60241-1

    authors： Okoko T,Ere D

    更新日期：2012-01-01 00:00:00

  • Effect of WNT5A on epithelial-mesenchymal transition and its correlation with tumor invasion and metastasis in nasopharyngeal carcinoma.

    abstract：OBJECTIVE:To investigate the correlation between nasopharyngeal carcinoma cell WNT5A and epithelial-mesenchymal transition (emt)/metastasis, and investigate its possible mechanisms. METHODS:RT-PCR and gene transfection were used to detect the expression of nasopharyngeal carcinoma cell strains WNT5A and EMT related fa...

    journal_title：Asian Pacific journal of tropical medicine

    pub_type： 杂志文章

    doi：10.1016/S1995-7645(14)60080-8

    authors： Zhu HH,Zhu XY,Zhou MH,Cheng GY,Lou WH

    更新日期：2014-06-01 00:00:00

  • Current perspectives on dengue episode in Malaysia.

    abstract：:Prevalence of dengue transmission has been alarmed by an estimate of 390 million infections per annum. Urban encroachment, ecological disruption and poor sanitation are all contributory factors of increased epidemiology. Complication however arises from the fact that dengue virus inherently exists as four different se...

    journal_title：Asian Pacific journal of tropical medicine

    pub_type： 杂志文章,评审

    doi：10.1016/j.apjtm.2016.03.004

    authors： Pang EL,Loh HS

    更新日期：2016-04-01 00:00:00

  • Phytochemical analysis, hepatoprotective and antioxidant activity of Alchornea cordifolia methanol leaf extract on carbon tetrachloride-induced hepatic damage in rats.

    abstract：OBJECTIVE:To investigate the hepatoprotective and antioxidant activities of Alchornea cordifolia (A. cordifolia) leaf extract. METHODS:Various solvent fractions of the methanol extract of the leaf of the plant A. cordifolia Mull. Arg (Fam: Euphorbiaceae) were evaluated for hepatoprotective activity by carbon tetrachlo...

    journal_title：Asian Pacific journal of tropical medicine

    pub_type： 杂志文章

    doi：10.1016/S1995-7645(12)60041-8

    authors： Osadebe PO,Okoye FB,Uzor PF,Nnamani NR,Adiele IE,Obiano NC

    更新日期：2012-04-01 00:00:00

  • Clostridium difficile infection: a review of the literature.

    abstract：:Clostridium difficile is a Gram-positive, strictly anaerobic, spore-forming bacterium. It is the most common cause of antibiotic-associated diarrhea in hospitals and other healthcare facilities and is of significant concern because of the increasing morbidity and mortality rates as well as increased health care costs....

    journal_title：Asian Pacific journal of tropical medicine

    pub_type： 杂志文章

    doi：10.1016/S1995-7645(14)60197-8

    authors： Khan FY,Elzouki AN

    更新日期：2014-09-01 00:00:00

  • Ultrasonic diagnosis of patients with clonorchiasis and preliminary study of pathogenic mechanism.

    abstract：OBJECTIVE:To discuss the liver function damage mechanism of patients with clonorchiasis by analyzing the ultrasound characteristics, liver function, change of the serum inflammatory factors and cell apoptosis factors. METHODS:Color Doppler ultrasound technique was adopted to detect the portal vein and blood flow chang...

    journal_title：Asian Pacific journal of tropical medicine

    pub_type： 杂志文章

    doi：10.1016/j.apjtm.2016.05.009

    authors： Fan M,Lu L,Su C,Xue M,Dou JM,Li P,Feng HQ,Fan YB

    更新日期：2016-07-01 00:00:00

  • Study on prevention effect of Zishen Yutai pill combined with progesterone for threatened abortion in rats.

    abstract：OBJECTIVE:To observe preventive and therapeutic effects and the mechanism of actions on Zishen Yutai pill combined with progesterone on threatened abortion in rats. METHODS:After pregnancy, 50 SPF female SD rats were selected and divided into control group, model group, progesterone group, Zishen Yutai pill group, and...

    journal_title：Asian Pacific journal of tropical medicine

    pub_type： 杂志文章

    doi：10.1016/j.apjtm.2016.04.002

    authors： Zhang Y,Yan W,Ge PF,Li Y,Ye Q

    更新日期：2016-06-01 00:00:00

  • Molecular cloning of virB12 gene of Brucella melitensis 16M strain in pET28a vector.

    abstract：OBJECTIVE:To clone the virB12 gene in pET28a expression vector for production of recombinant protein to be used as antigenic component for future serological test development. METHODS:Brucella melitensis (B. melitensis) 16M strain was cultured and bacterial DNA was extracted by Bioneer AccuPrep® Genomic DNA Extraction...

    journal_title：Asian Pacific journal of tropical medicine

    pub_type： 杂志文章

    doi：10.1016/S1995-7645(12)60089-3

    authors： Mirkalantari S,Amirmozafari N,Kazemi B,Irajian G

    更新日期：2012-07-01 00:00:00

  • Tissue tropism and parasite burden of Toxoplasma gondii RH strain in experimentally infected mice.

    abstract：OBJECTIVE:To evaluate parasite distribution and tissue tropism of Toxoplasma gondii tachyzoites in experimentally infected mice using real time QPCR. METHODS:In this survey 16 Balb/c mice were inoculated with 1 × 10(4) alive tachyzoites of Toxoplasma gondii RH strain. After 1, 2, 3 days post infection and the last day...

    journal_title：Asian Pacific journal of tropical medicine

    pub_type： 杂志文章

    doi：10.1016/S1995-7645(14)60087-0

    authors： Dadimoghaddam Y,Daryani A,Sharif M,Ahmadpour E,Hossienikhah Z

    更新日期：2014-07-01 00:00:00

  • Colonization or spontaneous resolution: expanding the role for Burkholderia pseudomallei.

    abstract：:A 19-year-old Asian Indian female presented with productive cough since the past one month and low grade fever since the past two weeks. She was diagnosed with pulmonary tuberculosis and treated with antitubercular drugs. Subsequently, delayed cultures of bronchoalveolar lavage fluid grew Burkholderia pseudomallei (B....

    journal_title：Asian Pacific journal of tropical medicine

    pub_type： 杂志文章

    doi：10.1016/S1995-7645(14)60031-6

    authors： Naha K,Shastry BA,Saravu K

    更新日期：2014-03-01 00:00:00

  • A comparative in vitro antioxidant potential profile of extracts from different parts of Fagonia cretica.

    abstract：OBJECTIVE:To evaluate antioxidant and radical scavenging activities of organic extracts from fruit, roots and aerial parts of Fagonia cretica. METHODS:Shed dried and powdered plant parts were initially extracted in methanol and subsequently partitioned in n-hexane, chloroform, ethyl acetate and 1-butanol successively....

    journal_title：Asian Pacific journal of tropical medicine

    pub_type： 杂志文章

    doi：10.1016/S1995-7645(14)60277-7

    authors： Iqbal P,Ahmed D,Asghar MN

    更新日期：2014-09-01 00:00:00

  • Malaria helminth co-infections and their contribution for aneamia in febrile patients attending Azzezo health center, Gondar, Northwest Ethiopia: a cross sectional study.

    abstract：OBJECTIVE:To assess the prevalence of malaria helminth co-infections and their contribution for aneamia in febrile patients attending Azzezo health center, Gondar, Northwest Ethiopia. METHODS:A cross section study was conducted among febrile patients attending Azezo health center from February-March 30, 2011. Convenie...

    journal_title：Asian Pacific journal of tropical medicine

    pub_type： 杂志文章

    doi：10.1016/S1995-7645(12)60147-3

    authors： Alemu A,Shiferaw Y,Ambachew A,Hamid H

    更新日期：2012-10-01 00:00:00

  • Antibiotic susceptibility profiling and virulence potential of Campylobacter jejuni isolates from different sources in Pakistan.

    abstract：OBJECTIVE:To determine antibiotic resistance patterns and virulence potential of Campylobacter jejuni (C. jejuni) isolates from clinical human diarrheal infections, cattle and healthy broilers. METHODS:Antibiotic sensitivity patterns of C. jejuni isolates were determined by Kirby Bauer Disc Diffusion assay. These isol...

    journal_title：Asian Pacific journal of tropical medicine

    pub_type： 杂志文章

    doi：10.1016/S1995-7645(14)60314-X

    authors： Siddiqui FM,Akram M,Noureen N,Noreen Z,Bokhari H

    更新日期：2015-03-01 00:00:00

  • Duffy blood group genotypes among malaria Plasmodium vivax patients of Baoulch population in Southeastern Iran.

    abstract：OBJECTIVE:To determine the distribution of Duffy blood group genotypes in Balouch population as a major ethnic group that living in a sub-tropical area in south East of Iran. METHODS:In this study, the Duffy blood group FY phenotypes were determined using indirect anti-globulin technique and also genotype by PCR-RFLP ...

    journal_title：Asian Pacific journal of tropical medicine

    pub_type： 杂志文章

    doi：10.1016/S1995-7645(14)60021-3

    authors： Miri-Moghaddam E,Bameri Z,Mohamadi M

    更新日期：2014-03-01 00:00:00

  • Acetylcholinesterase, butyrylcholinesterase and paraoxonase 1 activities in rats treated with cannabis, tramadol or both.

    abstract：OBJECTIVE:To investigate the effect of Cannabis sativa resin and/or tramadol, two commonly drugs of abuse on acetylcholinesterase and butyrylcholinesterase activities as a possible cholinergic biomarkers of neurotoxicity induced by these agents. METHODS:Rats were treated with cannabis resin (5, 10 or 20 mg/kg) (equiva...

    journal_title：Asian Pacific journal of tropical medicine

    pub_type： 杂志文章

    doi：10.1016/j.apjtm.2016.09.009

    authors： Abdel-Salam OM,Youness ER,Khadrawy YA,Sleem AA

    更新日期：2016-11-01 00:00:00

  • Effect of Rheum palmatum L. on NF-κB signaling pathway of mice with acute liver failure.

    abstract：OBJECTIVE:To explore the regulation effect of Rheum palmatum (R. palmatum) L. on NF-κB signaling pathway of ALF mice. METHODS:The intraperitoneal injection of d-GalN/LPS was employed for the model building. Mice in the treatment group and positive control group were given the R. palmatum L. and bifendate before the mo...

    journal_title：Asian Pacific journal of tropical medicine

    pub_type： 杂志文章

    doi：10.1016/j.apjtm.2015.09.011

    authors： Zhang RZ,Qiu H,Wang N,Long FL,Mao DW

    更新日期：2015-10-01 00:00:00

  • Acalculous cholecystitis: a rare presentation of leptospirosis progressing to Weil's disease.

    abstract：:Leptospirosis is a zoonotic infection with higher incidence in tropics. Leptospirosis, is known for its variable manifestations, and is a clinical challenge for physicians in the tropics. Experienced clinicians, at times can mistake leptospirosis for non-medical conditions. A few reports of leptospirosis presenting as...

    journal_title：Asian Pacific journal of tropical medicine

    pub_type： 杂志文章

    doi：10.1016/S1995-7645(11)60235-6

    authors： Peter G,Narasimha H

    更新日期：2011-12-01 00:00:00

  • Anti-hyperglycemic activity of leaves extract of Hyptis suaveolens L. Poit in streptozotocin induced diabetic rats.

    abstract：OBJECTIVE:To evaluate the antihyperglycemic activity of leaves of Hyptis suaveolens using streptozotocin model. METHODS:Hyptis suaveolens extract (HSE) 250 and 500 mg/kg body weight was administered orally to streptozotocin induced diabetes, once daily for 21 days. RESULTS:A significant reduction in blood glucose was...

    journal_title：Asian Pacific journal of tropical medicine

    pub_type： 杂志文章

    doi：10.1016/S1995-7645(11)60175-2

    authors： Mishra SB,Verma A,Mukerjee A,Vijayakumar M

    更新日期：2011-09-01 00:00:00

  • Antitumor effect of thymoquinone combined with resveratrol on mice transplanted with breast cancer.

    abstract：OBJECTIVE:To test the anticancer potential activity of the combination of thymoquinone (TQ) and resveratrol (RES) against breast cancer in mice. METHODS:The antiproliferative activity of TQ, RES and their combination was assessed against three breast cancer cell lines and one normal cells using MTT assay. The combinat...

    journal_title：Asian Pacific journal of tropical medicine

    pub_type： 杂志文章

    doi：10.1016/j.apjtm.2017.03.026

    authors： Alobaedi OH,Talib WH,Basheti IA

    更新日期：2017-04-01 00:00:00