Duffy blood group genotypes among malaria Plasmodium vivax patients of Baoulch population in Southeastern Iran.

Abstract:

OBJECTIVE:To determine the distribution of Duffy blood group genotypes in Balouch population as a major ethnic group that living in a sub-tropical area in south East of Iran. METHODS:In this study, the Duffy blood group FY phenotypes were determined using indirect anti-globulin technique and also genotype by PCR-RFLP in 160 vivax malaria patients and 160 control individuals. RESULTS:The results showed that the most common Duffy genotype was FYA/FYB (46.6%) followed by FYA/FYA (15.3%), FYA/FYO (14.4%), FYB/FYO (11.9%), FYB/FYB (10%) and FYO/FYO (1.9%). In case individuals, frequency of FYA, FYB and FYO alleles were 0.471, 0.431 and 0.097, respectively compaired to 0.444, 0.353 and 0.203, respectively in control (non-infected) group. CONCLUSIONS:This data provide evidence that individuals with the FYA/FYB genotype have higher susceptibility to malaria and there are significant associations between Duffy blood group variants and susceptibility or resistance to vivax malaria.

journal_name

Asian Pac J Trop Med

authors

Miri-Moghaddam E,Bameri Z,Mohamadi M

doi

10.1016/S1995-7645(14)60021-3

subject

Has Abstract

pub_date

2014-03-01 00:00:00

pages

206-7

issue

3

eissn

1995-7645

issn

2352-4146

pii

S1995-7645(14)60021-3

journal_volume

7

pub_type

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